KEGG   ENZYME: 2.5.1.22Help
Entry
EC 2.5.1.22                 Enzyme                                 

Name
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase;
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN:R02869]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
spermidine [CPD:C00315]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750]
Comment
The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).
History
EC 2.5.1.22 created 1982, modified 2013
Pathway
ec00270  Cysteine and methionine metabolism
ec00330  Arginine and proline metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00802  spermine synthase
Genes
HSA: 6611(SMS)
PTR: 107966193(SMS) 739762
PPS: 100974711 100989256(SMS)
GGO: 101136287(SMS)
PON: 100447565 100455032(SMS)
NLE: 100592294(SMS) 100603217
MCC: 698179(SMS)
MCF: 102139114(SMS)
CSAB: 103231701(SMS)
RRO: 104676688(SMS)
RBB: 108512250
CJC: 100411404(SMS)
SBQ: 101037456(SMS)
MMU: 20603(Sms)
MCAL: 110287180(Sms) 110292244
MPAH: 110313434(Sms) 110326795
RNO: 363469(Sms)
MUN: 110539961(Sms)
CGE: 100753198(Sms)
NGI: 103730144(Sms)
HGL: 101696715(Sms) 101718865
CCAN: 109685258(Sms) 109685259
OCU: 100340020(SMS)
CFA: 480861(SMS)
VVP: 112916263 112919114(SMS)
AML: 100469558(SMS)
UMR: 103668176(SMS)
UAH: 113242233(SMS)
ORO: 101364730(SMS) 101371201
ELK: 111150447
FCA: 101090842(SMS)
PTG: 102954471(SMS)
PPAD: 109257443(SMS)
AJU: 106968260(SMS)
BTA: 615950(SMS)
BOM: 102270205 102283485(SMS)
BIU: 109554942(SMS) 109559006
BBUB: 102399518(SMS)
CHX: 102190676(SMS)
OAS: 101107419(SMS) 101112287
SSC: 100153052(SMS)
CFR: 102512656(SMS)
CDK: 105105052(SMS)
BACU: 103019290(SMS)
LVE: 103068984
OOR: 101272903(SMS)
DLE: 111167517(SMS)
PCAD: 102987295(SMS)
ECB: 100051857(SMS)
EPZ: 103566846(SMS)
EAI: 106835513(SMS)
MYB: 102251500 102257010(SMS)
MYD: 102760281(SMS)
MNA: 107526796(SMS)
HAI: 109395813(SMS)
DRO: 112313352(SMS)
PALE: 102896435(SMS)
RAY: 107521441(SMS)
MJV: 108396545(SMS)
LAV: 100658418(SMS)
TMU: 101354696
MDO: 100012760(SMS)
SHR: 100928879(SMS)
PCW: 110210823(SMS)
OAA: 100083114(SMS)
GGA: 418602(SMS)
MGP: 100549711(SMS)
CJO: 107324967(SMS)
NMEL: 110404540(SMS)
APLA: 101791698(SMS)
ACYG: 106037821(SMS)
TGU: 100228014(SMS)
LSR: 110483279(SMS)
SCAN: 103815851(SMS)
GFR: 102034236(SMS)
FAB: 101806851(SMS)
PHI: 102114400(SMS)
PMAJ: 107201826(SMS)
CCAE: 111922892(SMS)
CCW: 104686193(SMS)
ETL: 114067188(SMS)
FPG: 101922863(SMS)
FCH: 102049429(SMS)
CLV: 102096362(SMS)
EGZ: 104135174(SMS)
NNI: 104022508(SMS)
ACUN: 113478646
PADL: 103914492(SMS)
AAM: 106492122(SMS)
ASN: 102388291(SMS)
AMJ: 102559699(SMS)
PSS: 102445830(SMS)
CMY: 102933684(SMS)
CPIC: 101931607(SMS)
ACS: 100552713(sms) 100561005
PVT: 110076724(SMS)
PBI: 103049999(SMS)
PMUR: 107286125(SMS)
TSR: 106553354(SMS)
PMUA: 114596224(SMS)
GJA: 107120288(SMS)
XLA: 108708014(sms.L)
XTR: 100497747(sms)
NPR: 108791842(SMS)
DRE: 80872(sms)
IPU: 108279239(sms)
PHYP: 113541383(sms)
AMEX: 103023143(sms)
EEE: 113575324(sms)
TRU: 101072716(sms)
LCO: 104924594(sms)
NCC: 104965977(sms)
MZE: 101475695(sms)
ONL: 100708530(sms)
OLA: 101166897(sms)
XMA: 102233412(sms)
XCO: 114153519(sms)
PRET: 103475438(sms)
CVG: 107086975(sms)
NFU: 107386402(sms)
KMR: 108236978(sms)
ALIM: 106514045(sms)
AOCE: 111567113(sms)
CSEM: 103395717(sms)
POV: 109628585(sms)
LCF: 108893544(sms)
SDU: 111234621(sms)
SLAL: 111666195(sms)
HCQ: 109517965(sms)
BPEC: 110158443(sms)
MALB: 109959604(sms)
SASA: 100195133(spsy) 106603082
ELS: 105010858(sms)
SFM: 108939723(sms)
PKI: 111860978(sms)
LCM: 102363084(SMS)
CMK: 103189993(sms)
RTP: 109931901(sms)
CIN: 100184953
SPU: 584264
APLC: 110984481
DME: Dmel_CG4300(Sms)
DER: 6545024
DSI: Dsimw501_GD12732(Dsim_GD12732)
DSR: 110179980
DPE: 6596081
DMN: 108152781
DWI: 6645203
DAZ: 108614587
DNV: 108652249
DHE: 111598765
MDE: 101896722
LCQ: 111677486
AAG: 5570348
AME: 410080
BIM: 100742708
BTER: 100647449
OBB: 114878120
SOC: 105201107
MPHA: 105832350
AEC: 105145851
ACEP: 105618948
PBAR: 105434139
VEM: 105570564
HST: 105184220
DQU: 106740768
CFO: 105258881
LHU: 105667455
PGC: 109857572
OBO: 105283669
PCF: 106790811
NVI: 100116075
CSOL: 105366297
MDL: 103571989
TCA: 656524
DPA: 109542993
ATD: 109600146
NVL: 108563491
BMOR: 101742636
BMAN: 114241374
PMAC: 106710981
PRAP: 110997871
HAW: 110374554
TNL: 113502268
BTAB: 109032705
CLEC: 106662819
ZNE: 110837290
TUT: 107372126
DPTE: 113796146
CSCU: 111623623
PTEP: 107447974
PCAN: 112556767
MYI: 110453256
SCE: YLR146C(SPE4)
KMX: KLMA_50519(SPE4)
NCS: NCAS_0C03110(NCAS0C03110)
NDI: NDAI_0G02420(NDAI0G02420)
TPF: TPHA_0A01420(TPHA0A01420)
TBL: TBLA_0A04140(TBLA0A04140)
TDL: TDEL_0F04780(TDEL0F04780)
KAF: KAFR_0H02120(KAFR0H02120)
AEH: Mlg_0336
HHA: Hhal_0951
 » show all
Taxonomy
Reference
1  [PMID:7396856]
  Authors
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
  Title
Studies of inhibition of rat spermidine synthase and spermine synthase.
  Journal
Biochem J 187:419-28 (1980)
Reference
2  [PMID:520313]
  Authors
Pajula RL, Raina A, Eloranta T.
  Title
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain.
  Journal
Eur J Biochem 101:619-26 (1979)
DOI:10.1111/j.1432-1033.1979.tb19756.x
Reference
3  [PMID:6798961]
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.22
IUBMB Enzyme Nomenclature: 2.5.1.22
ExPASy - ENZYME nomenclature database: 2.5.1.22
BRENDA, the Enzyme Database: 2.5.1.22
CAS: 74812-43-4

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