KEGG   ENZYME: 2.5.1.22
Entry
EC 2.5.1.22                 Enzyme                                 
Name
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase;
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN:R02869]
Reaction(KEGG)
R02869
Substrate
S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
spermidine [CPD:C00315]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750]
Comment
The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).
History
EC 2.5.1.22 created 1982, modified 2013
Pathway
ec00270  Cysteine and methionine metabolism
ec00330  Arginine and proline metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00802  spermine synthase
Genes
HSA6611(SMS)
PTR107966193(SMS) 739762
PPS100974711 100976750 100989256(SMS)
GGO101136287(SMS)
PON100447565 100455032(SMS)
PPYG129024637(SMS) 129038886
NLE100592294(SMS) 100603217
HMH116469176 116811569(SMS)
MCC698179(SMS)
MCF102139114(SMS)
MTHB126945251
MNI105478217(SMS)
CSAB103231701(SMS)
CATY105574631(SMS)
PANU100998733(SMS)
TGE112615671(SMS)
MLEU105545204(SMS)
RRO104676688(SMS)
RBB108512250
TFN117077430(SMS)
PTEH111536276(SMS)
CANG105527424(SMS)
CJC100411404(SMS)
SBQ101037456(SMS)
CIMI108312672(SMS)
ANAN105734578(SMS)
CSYR103251904(SMS) 103268643
MMUR105855748 105882359(SMS)
PCOQ105819977(SMS)
OGA100956181(SMS)
MMU20603(Sms)
MCAL110287180(Sms)
MPAH110313434(Sms) 110326795
RNO363469(Sms) 498273(Smsl1)
MCOC116090052(Sms)
ANU117694536(Sms)
MUN110539961(Sms)
CGE100753198(Sms) 100765797 100769528 100769680
MAUA101834283(Sms) 121138094
PLEU114695779(Sms)
MORG121441196 121441330
MFOT126515039
AAMP119805072(Sms) 119826682
NGI103730144(Sms)
HGL101696715(Sms) 101718865
CPOC100722335(Sms)
CCAN109685258(Sms) 109685259
DORD105993288(Sms)
DSP122099613(Sms) 122117770
PLOP125343635(Sms)
NCAR124972135
MMMA107144146(Sms)
OCU100340020
OPI101523443(SMS)
TUP102479200 102482622(SMS) 102492216
GVR103587015(SMS)
CFA100685416
CLUD112654131(SMS)
VVP112916263 112919114(SMS)
VLG121483312(SMS) 121488958
NPO129518628(SMS)
AML100469558(SMS)
UMR103668176(SMS)
UAH113242233(SMS)
UAR123796537(SMS)
ELK111150447
LLV125091805
MPUF101676869(SMS)
MNP132006892(SMS)
MLK131821178(SMS)
NVS122896341(SMS)
ORO101364730(SMS) 101371201
EJU114223636(SMS)
ZCA113912163 113927441 113931549(SMS)
MLX118005364 118007648(SMS)
NSU110569656(SMS) 110584967
LWW102749321(SMS)
FCA101090842(SMS)
PYU121026096(SMS)
PCOO112871633(SMS)
PBG122477248(SMS)
PVIV125157783(SMS)
LRUF124509410
PTG102954471(SMS)
PPAD109257443(SMS)
PUC125931544
AJU106968260
HHV120224316(SMS) 120227719
BTA534520 615950(SMS)
BOM102270205 102283485(SMS)
BIU109554942(SMS) 109559006
BBUB102399518(SMS)
BBIS105001608
CHX102190676(SMS)
OAS101107419(SMS) 101112287
BTAX128060526 128069929(SMS)
ODA120879009 120882634(SMS)
CCAD122435037(SMS)
MBEZ129564441(SMS)
SSC100153052(SMS)
CFR102512656(SMS)
CBAI105081182(SMS)
CDK105105052(SMS)
VPC102542013(SMS) 102543981
BACU103019290(SMS)
BMUS118883086 118884363 118889188(SMS)
LVE103068984
OOR101272903(SMS) 101278511
DLE111167517(SMS)
PCAD102987295(SMS)
PSIU116747534 116747760(SMS)
NASI112395978(SMS)
ECB100051857(SMS)
EPZ103566846(SMS)
EAI106835513(SMS)
MYB102251500 102257010(SMS)
MYD102760281(SMS)
MMYO118653959(SMS) 118677002
MLF102430076(SMS)
PKL118719888(SMS) 118723672
EFUS103294832 103297843(SMS) 103304817
MNA107526796(SMS)
DRO112313352(SMS)
SHON118987192(SMS) 119003352
AJM119037308(SMS) 119052450
PDIC114496528 114505041(SMS)
PHAS123830033(SMS) 123831549
MMF118626871 118635642(SMS)
PPAM129069096 129076007 129076941(SMS)
HAI109395813(SMS)
RFQ117023620 117030210(SMS)
PALE102896435(SMS)
PGIG120594270(SMS)
PVP105304389(SMS)
RAY107521441(SMS)
MJV108396545(SMS)
TOD119243723 119246280(SMS)
SARA101548256 101558705(SMS)
SETR125999387(SMS)
LAV100658418(SMS)
TMU101354696
ETF101651493(SMS) 101659462
DNM101416490(SMS) 101442206
MDO100012760(SMS)
GAS123242412(SMS) 123254646
SHR100928879(SMS)
AFZ127553969
PCW110210823(SMS)
TVP118838265(SMS)
OAA100083114(SMS)
GGA418602(SMS)
PCOC116232749(SMS)
MGP100549711(SMS)
CJO107324967(SMS)
TPAI128076309(SMS)
LMUT125697749(SMS)
NMEL110404540(SMS)
APLA101791698(SMS)
ACYG106037821(SMS)
CATA118245714(SMS)
AFUL116489651(SMS)
TGU100228014(SMS)
LSR110483279(SMS)
SCAN103815851(SMS)
PMOA120504616(SMS)
OTC121333493(SMS)
PRUF121356209(SMS)
GFR102034236(SMS)
FAB101806851(SMS)
OMA130260523(SMS)
PHI102114400(SMS)
PMAJ107201826(SMS)
CCAE111922892(SMS)
CCW104686193(SMS)
CBRC103611689(SMS)
ETL114067188(SMS)
ZAB102072121(SMS)
ZLE135445220(SMS)
ACHL103806492(SMS)
SVG106855241(SMS)
MMEA130583720(SMS)
HRT120748767(SMS)
FPG101922863(SMS)
FCH102049429(SMS)
CLV102096362(SMS)
EGZ104135174(SMS)
NNI104022508(SMS)
PCRI104030714(SMS)
PLET104620873(SMS)
EHS104514953(SMS)
PCAO104039521(SMS)
ACUN113478646
TALA104368634(SMS)
PADL103914492(SMS)
AFOR103896965(SMS)
ACHC115343741(SMS)
HALD104322309(SMS)
HLE104834150(SMS)
AGEN126053152
GCL127020292
CCRI104166665(SMS)
CSTI104555720(SMS)
CMAC104484003(SMS)
MUI104545999(SMS)
BREG104642771(SMS)
FGA104080674(SMS)
GSTE104251380(SMS)
LDI104343660(SMS)
MNB103771048(SMS)
OHA104336393(SMS)
NNT104412406(SMS)
SHAB115603761(SMS)
DPUB104300483(SMS)
PGUU104458776(SMS)
ACAR104524711(SMS)
CPEA104388343(SMS)
AVIT104279728(SMS)
CVF104293590(SMS)
RTD128917229(SMS)
CUCA104063378(SMS)
TEO104374492(SMS)
BRHI104498813(SMS)
AAM106492122(SMS)
AROW112964571(SMS)
NPD112958431(SMS)
TGT104567160(SMS)
DNE112995629(SMS)
SCAM104137984(SMS)
ASN102388291(SMS)
AMJ102559699(SMS)
CPOO109305979(SMS)
GGN109302737(SMS)
PSS102445830(SMS)
CMY102933684(SMS)
CCAY125642127(SMS)
DCC119846230(SMS)
CPIC101931607(SMS)
TST117868910(SMS)
CABI116825316(SMS)
MRV120381777(SMS)
ACS100552713(sms) 100561005
ASAO132771728(SMS)
PVT110076724(SMS)
SUND121926744(SMS)
PBI103049999(SMS)
PMUR107286125(SMS)
CTIG120312995(SMS)
TSR106553354(SMS)
PGUT117675369(SMS)
APRI131199123(SMS)
PTEX113445210(SMS)
NSS113416827(SMS)
VKO123029246(SMS)
PMUA114596224(SMS)
PRAF128413144(SMS)
ZVI118085468(SMS)
HCG128349589(SMS)
GJA107120288(SMS)
STOW125430898(SMS)
EMC129326512(SMS)
XLA108708014(sms.L)
XTR100497747(sms)
NPR108791842(SMS)
RTEM120927518(SMS)
BBUF120994832(SMS)
BGAR122930506(SMS)
MUO115469520(SMS)
GSH117362427(SMS)
DRE80872(sms)
SRX107715334 107756125
SANH107669379 107700049
SGH107548201 107567162
CCAR109063996 109063998
CAUA113038572 113063973
CGIB127941692 127946543 127986462
PTET122326872(sms)
LROH127152896(sms)
OMC131528791(sms)
PPRM120494645(sms)
RKG130072143(sms)
MAMB125252842(sms)
CIDE127503454
MASI127428474 127431325
TROS130569822(sms)
TDW130407682(sms)
MANU129424125(sms)
IPU108279239
IFU128622528(sms)
PHYP113541383(sms)
SMEO124397780(sms)
TFD113649691(sms)
TVC132860145(sms)
TRN134330182(sms)
AMEX103023143(sms)
CMAO118820356(sms)
EEE113575324(sms)
CHAR105890536(sms)
TRU101072716(sms)
TFS130538102(sms)
TNGGSTEN00019017G001
LCO104924594(sms)
NCC104965977(sms)
TBEN117490220(sms)
CGOB115013944 115019225(sms)
PGEO117458621(sms)
GACU117535964(sms)
EMAC134872663(sms)
ELY117261145(sms)
EFO125898949(sms)
PLEP121952586 121952587
SLUC116064798(sms)
ECRA117955450(sms)
ESP116700396(sms)
PFLV114566513(sms)
GAT120822438(sms)
PPUG119215611(sms)
AFB129113641
CLUM117743184(sms)
PSWI130191896(sms)
MSAM119895376(sms)
SCHU122888489(sms)
CUD121518389(sms)
ALAT119031141(sms)
MZE101475695(sms)
ONL100708530(sms)
OAU116336211(sms)
OLA101166897(sms)
OML112141953(sms)
CSAI133459542(sms)
XMA102233412(sms)
XCO114153519(sms)
XHE116716541 116728402
PRET103475438(sms)
PFOR103141419(sms)
PLAI106952252(sms)
PMEI106921782(sms)
GAF122844452(sms)
PPRL129368549(sms)
CVG107086975(sms)
CTUL119778121(sms)
GMU124876685(sms)
NFU107386402(sms)
KMR108236978(sms)
ALIM106514045(sms)
NWH119420057(sms)
AOCE111567113(sms)
MCEP125021348(sms)
CSEM103395717(sms)
POV109628585(sms)
SSEN122779389(sms)
HHIP117774519(sms)
HSP118122195(sms)
PPLT128456626(sms)
SMAU118301097(sms)
LCF108893544
SDU111234621(sms)
SLAL111666195(sms)
XGL120802706(sms)
HCQ109517965(sms)
SSCV125981828
SBIA133491607(sms)
PEE133415704(sms)
PTAO133466986(sms)
BPEC110158443(sms)
MALB109959604(sms)
BSPL114869317(sms)
SJO128371167(sms)
SASA100195133(spsy) 106603082
STRU115154759 115204368
OTW112228885 112231243
OMY110510052 110534059
OGO124006947(sms) 124007539
ONE115101397 115135569
OKI109872795 109874012
OKE118385058 118390429
SALP111950654 111964261
SNH120021449 120057277
CCLU121541911 121579545
ELS105010858(sms)
SFM108939723(sms)
PKI111860978(sms)
AANG118235458(sms)
LOC102697794(sms)
PSPA121302769(sms)
ARUT117405458 117407045
PSEX120523883(sms)
LCM102363084(SMS)
CMK103189993(sms)
RTP109931901(sms)
CPLA122554894(sms)
LERI129702768(sms)
BFO118407326 118423464
BBEL109485609
CIN100184953
SCLV120331198 120331225 120331244 120331254 120331256 120331395 120343898 120345154 120345155
SPU115919270 584264
APLC110984481
DMEDmel_CG4300(Sms)
DER6545024
DSE6605422
DSIDsimw501_GD12732(Dsim_GD12732)
DYADyak_GE20131
DAN6507617
DSR110179980
DPO4813516
DPE6596081
DMN108152781
DWI6645203
DGR6556730
DMODmoj_GI12338
DAZ108614587
DNV108652249
DHE111598765
DVI6623526
CCAT101462635
BOD106617611
BDR125775281
RZE108354772 108363500
AOQ129240265
TDA119669207 119669539
MDE101896722
SCAC106093541
LCQ111677486
LSQ119608366
GFS119632052
ECOE129944437
CLON129608654
HIS119648940
AGA1276036
ACOZ120948801
AARA120893525
AMER121592571
ASTE118509365
AFUN125771582
AMOU128301867
AALI118466250
AAG5570348
AALB109423788 109430626
ASUA134211525
CQUCpipJ_CPIJ002256
CPII120417464
CNS116339096 116346830
BCOO119075224
AME410080
ACER108001864
ALAB122715767
ADR102672490
AFLR100864645
BIM100742708
BBIF117215753
BVK117237102
BVAN117159053
BTER100647449
BAFF126919886
BPYO122566252
BPAS132910682
CCAL108622646
OBB114878120
OLG117600590
MGEN117220393
NMEA116429087
CGIG122399365
SOC105201107
MPHA105832350
AEC105145851
ACEP105618948
PBAR105434139
VEM105570564
HST105184220
DQU106740768
CFO105258881
FEX115236388
LHU105667455
PGC109857572
OBO105283669
PCF106790811
PFUC122518217
VPS122631095
VCRB124426327
VVE124951753
NVI100116075
CSOL105366297
TPRE106657745
LHT122502223
LBD127289521
MDL103571989
CGLO123263386
FAS105272296
DAM107044162
AGIF122852494
CINS118073321
VCAN122407459
CCIN107266090
DSM124415868
NPT124224673
NFB124180359
NLO107223906
NVG124307559
AROA105688439
TCA656524
DPA109542993
AGRG126750588
ATD109600146
CSET123319801
AGB108908009
LDC111505454
NVL108563491
APLN108734563
PPYR116161871
OTU111413098
BMOR101742636
BMAN114241374
MSEX115452428
DPLKGM_210067
BANY112047403
MJU123866961
NIQ126768683
VCD124530556
MCIX123654176
PMAC106710981
PPOT106102126
PXU106125501
PRAP110997871
PBX123713933
PNAP125060173
ZCE119831457
CCRC123692326
LSIN126972998
AAGE121730833
HAW110374554
HZE124630253
TNL113502268
SLIU111349681
OFU114360753
ATRA106143575
GMW113511480
PXY105390261
PGW126367072
LGLY125226084
CFEL113370318
CCRN123305883
BTAB109032705
DCI103520479 103520480
CLEC106662819
HHAL106681334
NLU111061098 120356460
HVI124356724 124356725
MQU128985499 128985500 128986359 128986955
PHUPhum_PHUM601200
FOC113212513
TPAL117644121
ZNE110837290
CSEC111869314
SGRE126284548 126284808
BROR134542509
IEL124161221
FCD110843713 110850947
DPXDAPPUDRAFT_227209
DMK116921067
DPZ124316375
PVM113821773 113825151
PJA122246305
PCHN125040044
PMOO119597196
PCLA123764823
CQD128704626
PTRU123512773
ESN126985491
MNZ135201414
HAZT108675144
EAF111706948
LSM121116743 121124775
TCF131878253 131880507 131892070
PPOI119100881 119100882
ISC8030447
DSV119461286
RSAN119396262
RMP119174498
VDE111250423
VJA111267393
TUT107372126
DPTE113796146
DFR124497823
CSCU111623623
PTEP107447974
ABRU129985265
UDV129225073
SDM118205472
LPOL106469879
HROHELRODRAFT_104383
PCAN112556767
MYI110453256
PMAX117315557
LAK106150669 106156768 106157994 106170740
LLON135484462 135491398 135500300
NVE5516689
EPA110239386 110251781
PDAM113671991 113685811
SPIS111322739 111334447 111334508
TADTRIADDRAFT_31833
SCEYLR146C(SPE4)
SEUBDI49_3670
SPAOSPAR_L01930
KLAKLLA0_D17094g
KMXKLMA_50519(SPE4)
LTHKLTH0G11484g
VPOKpol_397p12
ZROZYRO0F14124g
CGRCAGL0M04609g
NCSNCAS_0C03110(NCAS0C03110)
NDINDAI_0G02420(NDAI0G02420)
TPFTPHA_0A01420(TPHA0A01420)
TBLTBLA_0A04140(TBLA0A04140)
TGBHG536_0C01020
TDLTDEL_0F04780(TDEL0F04780)
KAFKAFR_0H02120(KAFR0H02120)
KNGKNAG_0A02830(KNAG0A02830)
ZMKHG535_0F03980
PPAPAS_chr4_0648
DHADEHA2E16456g
PICPICST_40259
PGUPGUG_03218
SPAASPAPADRAFT_61556
LELPVL30_002895(SPE4)
CALCAALFM_C113330CA(CaO19.4960)
CTPCTRG_03607
COTCORT_0D02780
CDUCD36_12370
CTENCANTEDRAFT_112520
CLUCLUG_04679
CLUSA9F13_11g01012
CAURCJI96_0002513
PKZC5L36_0B07920
BNNFOA43_002197
BBRXBRETT_003792
MBRMONBRDRAFT_30201
SREPTSG_11290
 » show all
Reference
1  [PMID:7396856]
  Authors
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
  Title
Studies of inhibition of rat spermidine synthase and spermine synthase.
  Journal
Biochem J 187:419-28 (1980)
DOI:10.1042/bj1870419
Reference
2  [PMID:520313]
  Authors
Pajula RL, Raina A, Eloranta T.
  Title
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain.
  Journal
Eur J Biochem 101:619-26 (1979)
DOI:10.1111/j.1432-1033.1979.tb19756.x
Reference
3  [PMID:6798961]
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.22
IUBMB Enzyme Nomenclature: 2.5.1.22
ExPASy - ENZYME nomenclature database: 2.5.1.22
BRENDA, the Enzyme Database: 2.5.1.22
CAS: 74812-43-4

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