KEGG ENZYME: 2.5.1.30

ENZYME: 2.5.1.30

Entry

EC 2.5.1.30                 Enzyme

Name

heptaprenyl diphosphate synthase;
all-trans-heptaprenyl-diphosphate synthase;
heptaprenyl pyrophosphate synthase;
heptaprenyl pyrophosphate synthetase;
HepPP synthase;
HepPS;
heptaprenylpyrophosphate synthetase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 4 isopentenyl units)

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate [RN:R09247]

Reaction(KEGG)

R09247

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448];
isopentenyl diphosphate [CPD:C00129]

Product

diphosphate [CPD:C00013];
all-trans-heptaprenyl diphosphate [CPD:C04216]

Comment

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.

History

EC 2.5.1.30 created 1984, modified 2010

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K00805

heptaprenyl diphosphate synthase component 1

K24873

heptaprenyl diphosphate synthase component 2

Genes

SDO:	SD1155_09465 SD1155_09475

VEG:	SAMN05444156_1482

BSU:	BSU22740(hepT) BSU22760(hepS)

BSR:	I33_2334(hepT) I33_2336

BSL:	A7A1_2963 A7A1_2965

BSH:	BSU6051_22740(hepT) BSU6051_22760(hepS)

BSY:	I653_10855 I653_10865

BSUT:

BSUB_02441(hepT) BSUB_02443(hepS)

BSUL:

BSUA_02441(hepT) BSUA_02443(hepS)

BSUS:

Q433_12390 Q433_12400

BSO:	BSNT_08671(hepT) BSNT_08673(hepS)

BSN:	BSn5_01850 BSn5_01860

BSQ:	B657_22740(hepT) B657_22760(hepS)

BSX:	C663_2149(hepS)

BSP:	U712_11025 U712_11035

BSS:	BSUW23_11155(hepT) BSUW23_11165(hepS)

BST:	GYO_2502(hepT) GYO_2504

BIT:	BIS30_01020 BIS30_01030

BLI:	BL02782(hepT) BL02784(hepS)

BLD:	BLi02409(hepT) BLi02411(hepS)

BLH:	BaLi_c24980(hepT) BaLi_c25000(hepS)

BAY:	RBAM_020900(hepT) RBAM_020920

BAQ:	BACAU_2098(hepT) BACAU_2100(hepS)

BYA:	BANAU_2241(hepT) BANAU_2243(hepS)

BQY:	MUS_2523(hepT) MUS_2525(hepS)

BAMP:

B938_10795 B938_10805

BAML:

BAM5036_2017(hepT) BAM5036_2019(hepS)

BAMA:

RBAU_2229(hepT) RBAU_2231(hepS)

BAMN:

BASU_2018(hepT) BASU_2020(hepS)

BAMB:

BAPNAU_1495(hepS) BAPNAU_1497(hepT)

BAMT:

AJ82_11855 AJ82_11865

BAMY:

V529_23580(hepT) V529_23600(hepS)

BMP:	NG74_02189(hepT) NG74_02191(hepS)

BAO:	BAMF_2175(hepT) BAMF_2177(hepS)

BAZ:	BAMTA208_05585(hepS) BAMTA208_05595(hepT)

BQL:	LL3_02459(hepT) LL3_02461(hepS)

BXH:	BAXH7_01167(hepS) BAXH7_01169(hepT)

BAMI:

KSO_008960 KSO_008970

BAMC:

U471_21560 U471_21580

BAMF:

U722_11405 U722_11415

BSIA:

CWD84_10500 CWD84_10510(hepT)

BAE:	BATR1942_09240 BATR1942_09250

BVM:	B9C48_10625 B9C48_10635

BSON:

S101395_02192 S101395_02194

BHT:	DIC78_20095 DIC78_20105(hepT)

BMOJ:

HC660_21540(hepT) HC660_21560(hepS)

BTEQ:

G4P54_11910(hepT) G4P54_11920

BIQ:	AN935_11075 AN935_11085

BSTR:

QI003_11290(hepT) QI003_11300(hepS) QI003_14720(hepT) QI003_14730(hepS)

BAN:	BA_1533 BA_1535(hepT)

BAR:	GBAA_1533 GBAA_1535(hepT)

BAT:	BAS1422 BAS1424

BAH:	BAMEG_3058(hepT) BAMEG_3060

BAI:	BAA_1602 BAA_1604(hepT)

BAX:	H9401_1442 H9401_1444

BANT:

A16_15770 A16_15790

BANR:

A16R_15940 A16R_15960

BANS:

BAPAT_1448 BAPAT_1450

BANH:

HYU01_07770 HYU01_07780

BANV:

DJ46_355(hepS) DJ46_357(hepT)

BAL:	BACI_c15550(hepS) BACI_c15570(hepT)

BCE:	BC1512 BC1514

BCA:	BCE_1639 BCE_1641(hepT)

BCZ:	BCE33L1394(hepS) BCE33L1396(hepT)

BCR:	BCAH187_A1675 BCAH187_A1677(hepT)

BCB:	BCB4264_A1568 BCB4264_A1570(hepT)

BCU:	BCAH820_1606 BCAH820_1608(hepT)

BCG:	BCG9842_B3775(hepT) BCG9842_B3777

BCQ:	BCQ_1581(hepS) BCQ_1583(hepT)

BCX:	BCA_1571 BCA_1573(hepT)

BNC:	BCN_1492 BCN_1494

BCF:	bcf_07655 bcf_07665

BCER:

BCK_00805 BCK_00815

BCEF:

BcrFT9_01287 BcrFT9_01289

BCY:	Bcer98_1235 Bcer98_1237

BTK:	BT9727_1394(hepS) BT9727_1396(hepT)

BTL:	BALH_1366 BALH_1368(hepT)

BTB:	BMB171_C1345 BMB171_C1347(hepT)

BTT:	HD73_1741 HD73_1743

BTHR:

YBT1520_08665 YBT1520_08675

BTHI:

BTK_08850 BTK_08860

BTC:	CT43_CH1439 CT43_CH1441(hepT)

BTF:	YBT020_08210 YBT020_08220

BTM:	MC28_0746 MC28_0748

BTG:	BTB_c15530(hepS) BTB_c15550(hepT)

BTI:	BTG_13170 BTG_13180

BTN:	BTF1_05265 BTF1_05275

BTHT:

H175_ch1457 H175_ch1459

BTHU:

YBT1518_08590 YBT1518_08600

BTW:	BF38_2731(hepS) BF38_2733(hepT)

BTHY:

AQ980_22235 AQ980_22245

BWE:	BcerKBAB4_1436 BcerKBAB4_1438

BWW:	bwei_3478(hepT) bwei_3480(hepS)

BMYO:

BG05_4377(hepT) BG05_4379

BTY:	Btoyo_4149 Btoyo_4151

BMYC:

DJ92_4161 DJ92_4163(hepT)

BBY:	CY96_06730 CY96_06740

BWD:	CT694_08370 CT694_08380(hepT)

BTRO:

FJR70_00280 FJR70_00290(hepT)

BMOB:

MLA2C4_07955 MLA2C4_07965(hepT)

BNT:	GSN03_07660 GSN03_07670(hepT)

BPAC:

LMD38_18780(hepT) LMD38_18790

BPAN:

NLJ82_07830 NLJ82_07840(hepT)

BALU:

QRY64_09975 QRY64_09985(hepT)

BPU:	BPUM_2005 BPUM_2007

BPUM:

BW16_10935 BW16_10945

BPUS:

UP12_10210 UP12_10220

BIF:	N288_17040 N288_17050

BMET:

BMMGA3_10760(hepT) BMMGA3_10770(hepS)

BSM:	BSM4216_2341 BSM4216_2343

BGY:	BGLY_2684(hepT) BGLY_2686(hepS)

BWH:	A9C19_07460 A9C19_07470

BXI:	BK049_16895 BK049_16905

BALT:

CFN77_10760(hepT) CFN77_10770

BAER:

BAE_17925(hepT) BAE_17935

BSAF:

BSL056_11210 BSL056_11220

BFD:	NCTC4823_02031(hepS) NCTC4823_02033(hepT)

BSHI:

LGQ02_08510 LGQ02_08535(hepT)

BCAB:

EFK13_11530(hepT) EFK13_11540(hepS)

BRY:	M0696_11230(hepT) M0696_11240(hepS)

BJS:	MY9_2281 MY9_2283

BACI:

B1NLA3E_14805 B1NLA3E_14815

GST:	HW35_03350 HW35_03360

BACW:

QR42_10165 QR42_10175

BACP:

SB24_18255 SB24_18265

BACB:

OY17_13730 OY17_13740

BACO:

OXB_2339 OXB_2341

BACY:

QF06_09565 QF06_09575

BACL:

BS34A_25030(hepT) BS34A_25050(hepS)

BALM:

BsLM_2218 BsLM_2220

BACS:

AUL54_19360 AUL54_19370

BACQ:

DOE78_16085(hepT) DOE78_16095

BACA:

FAY30_15990(hepT) FAY30_16000

BAQU:

K6959_09900(hepT)

BZH:	NF868_09065(hepT) NF868_09075

BHAI:

KJK41_14305(hepT) KJK41_14315

BCAO:

LC087_06300(hepT) LC087_06310

BARD:

QRY57_09335 QRY57_09345(hepT)

BAEI:

RE735_09680 RE735_09690(hepT)

BASB:

M662_10335(hepT) M662_10345

BACF:

AM500_10185 AM500_10195

BAFC:

K3G25_07015(hepS) K3G25_07025(hepT)

BKN:	WDJ61_11115(hepT) WDJ61_11125

BASD:

LCG60_21510(hepT) LCG60_21520

BHAM:

ABN702_06975 ABN702_06985(hepT)

BACV:

I7V34_08855(hepT) I7V34_08865

BCO:	Bcell_1865 Bcell_1870

BHK:	B4U37_12820 B4U37_12830

BCOH:

BC6307_13630 BC6307_13640

BCIR:

C2I06_08260(hepT) C2I06_08270

NTX:	NQZ71_09245 NQZ71_09255(hepT)

NIL:	L8T27_012490(hepT) L8T27_012500

NTGC:

AB3U99_14520(hepT) AB3U99_14530

BMQ:	BMQ_4328(hepT) BMQ_4330(hepS)

BMD:	BMD_4315(hepT) BMD_4317(hepS)

BMH:	BMWSH_0902(hepS) BMWSH_0904(hepT)

BMEG:

BG04_1247(hepT) BG04_1249

BEO:	BEH_18870 BEH_24435

BFX:	BC359_06085 BC359_06095

PKS:	IE339_17920(hepT) IE339_17930

BHA:	BH1648(gerCA) BH1653(gerCC)

BKW:	BkAM31D_10955(hepS) BkAM31D_10980(hepT)

BCL:	ABC1885 ABC1889(hepA)

BLE:	BleG1_2032 BleG1_2035

SHUA:

PQ477_19040(hepT) PQ477_19055

BGI:	BGM20_05090 BGM20_05100

BPF:	BpOF4_15395(hepS) BpOF4_15420(hepT)

BON:	A361_19470 A361_19480

BKO:	CKF48_18900 CKF48_18910(hepT)

CGOT:

J1899_14175(hepT) J1899_14185

CFIR:

NAF01_17570(hepT) NAF01_17580

CSOA:

LIS82_18220(hepT) LIS82_18230

CSPG:

LS684_13315(hepT) LS684_13325

CPSS:

M5V91_01470

BDA:	FSZ17_14960(hepT) FSZ17_14970

CSUA:

IM538_15770(hepT) IM538_15780

OIH:	OB1788(gerCC) OB1790(gerCA)

OCN:	CUC15_10635(hepT) CUC15_10645

OCB:	CV093_11190

OJD:	NP439_12840(hepT)

OON:	NP440_12090(hepT)

LSP:	Bsph_1932(gerCA) Bsph_1934

LGY:	T479_07445 T479_07455

LFU:	HR49_16615 HR49_16625

LYS:	LBYS11_06850 LBYS11_06860(hepT)

LYB:	C3943_08355 C3943_08365(hepT)

LYZ:	DCE79_06040 DCE79_06050(hepT)

LYG:	C1N55_08245 C1N55_08255(hepT)

LPAK:

GDS87_07465 GDS87_07475(hepT)

LAGR:

FJQ98_08410 FJQ98_08420(hepT)

LMAC:

I6G82_11105(hepT) I6G82_11115

LYC:	FH508_0007865 FH508_0007875(hepT)

LCAP:

ICJ70_17350(hepT) ICJ70_17360

LYP:	MTP04_15160(hepS) MTP04_15180(hepT)

LIU:	OU989_06705 OU989_06715(hepT)

LLB:	R6U77_17815(hepT) R6U77_17825

LYQ:	MY533_06530 MY533_06540(hepT)

LYO:	NV349_07130 NV349_07140(hepT)

HHD:	HBHAL_3282(hepT) HBHAL_3284(hepS)

HMN:	HM131_10530 HM131_10540

HLI:	HLI_00460 HLI_00470(hepT)

HNZ:	P9989_11860(hepT) P9989_11870

HSAN:

MUN89_12075 MUN89_12085(hepT)

HSHI:

MUO14_00810(hepT) MUO14_00820

HAMY:

MUO15_02770 MUO15_02780(hepT)

TAP:	GZ22_08415

TAID:

KS242_09515(hepT) KS242_09525

VIR:	X953_10850 X953_10860

VHL:	BME96_09715 BME96_09725

VIG:	BKP57_00195 BKP57_00205

VIL:	CFK37_14815 CFK37_14825(hepT)

VNE:	CFK40_11045 CFK40_11055(hepT)

VPN:	A21D_03370(hepS) A21D_03372(hepT)

VIM:	GWK91_06330(hepT)

VPT:	KBP50_08625 KBP50_08635(hepT)

VNT:	OLD84_10200(hepT)

VSS:	PD280_16125 PD280_16135(hepT)

LAO:	AOX59_04665 AOX59_04675

LEX:	Len3610_05905(hepT)

SJE:	AAV35_006125 AAV35_14170

SAPL:

U0355_06950 U0355_06960(hepT)

APAK:

AP3564_17195 AP3564_17205

ACOP:

RI196_11715(hepT) RI196_11725

BSJ:	UP17_15400

BMUR:

ABE28_014270 ABE28_014280

PBUT:

DTO10_02310(hepT) DTO10_02320

PASA:

BAOM_3531(hepST) BAOM_3533(hepST)

PPSR:

I6J18_21635 I6J18_21645(hepT)

PFRI:

L8956_16115(hepT) L8956_16125

PERI:

RE409_17940(hepT) RE409_17950

AQT:	FN924_09865(hepT) FN924_09875

RAX:	KO561_10350(hepT) KO561_10360

BTHV:

CQJ30_11350(hepT) CQJ30_11360

PSYH:

D0S48_03675(hepT) D0S48_03685

PSYO:

PB01_07585 PB01_07595(hepT)

PSYB:

KD050_19390 KD050_19400(hepT)

PRD:	F7984_11500(hepT) F7984_11510

GRC:	GI584_12455(hepT)

GCS:	MUN88_16140 MUN88_16150(hepT)

GSM:	MUN87_02945(hepT) MUN87_02955

RUE:	DT065_01860

SALE:

EPH95_01185(hepT)

SCIB:

HUG20_08140 HUG20_08165

SCIA:

HUG15_10880 HUG15_10905

POF:	GS400_10970(hepT) GS400_10980

PCHU:

QNI29_11545(hepT) QNI29_11555

PONA:

IMZ31_10105(hepT) IMZ31_10115

NMK:	CHR53_18855(hepT) CHR53_18865

NTM:	BTDUT50_10440(hepT) BTDUT50_10450

NDT:	L1999_20590(hepT) L1999_20600

NCM:	QNK12_22000(hepT) QNK12_22010

NNV:	QNH39_17510(hepT) QNH39_17520

MEKU:

HUW50_26310(hepT) HUW50_26320

MSEM:

GMB29_16570(hepT) GMB29_16580

MDG:	K8L98_16490(hepT) K8L98_16500

MLIT:

KDJ21_014640 KDJ21_014650(hepT)

MENL:

MVE64_04170(hepT) MVE64_04180

MEBZ:

LPC09_16090(hepT) LPC09_16100

MRL:	WCV66_13370 WCV66_13380(hepT)

MSEE:

WCV65_12190(hepT) WCV65_12200

AIA:	AWH56_024895(hepT) AWH56_024920

BLEN:

NCTC4824_01941(hepS) NCTC4824_01943(hepT)

SEDD:

ERJ70_10305(hepT) ERJ70_10315

BVQ:	FHE72_13975(hepT) FHE72_13985

RMF:	D5E69_13505(hepT) D5E69_13515

RAZ:	U9J35_14220(hepT) U9J35_14230

ROD:	P8596_14470(hepT) P8596_14480

ROSS:

V2W31_14130(hepT) V2W31_14140

BCK:	BCO26_1557 BCO26_1559

BAG:	Bcoa_2956 Bcoa_2958

BCOA:

BF29_608(hepT) BF29_610

BVJ:	I5776_09100 I5776_09110(hepT)

BOU:	I5818_10350 I5818_10360(hepT)

HSPO:

JGZ69_17150 JGZ69_17160(hepT)

CTHU:

HUR95_09960 HUR95_09970(hepT)

BBEV:

BBEV_1441(hepT)

BSE:

Bsel_2132

MCUI:

G8O30_06860(hepT) G8O30_06870

GAJ:	MY490_09070 MY490_09080(hepT)

PSUA:

FLK61_30705 FLK61_30725(hepT)

SLMS:

MM221_19100(hepT)

MJO:	FOF60_16060(hepT) FOF60_16070

MSUT:

LC048_06480 LC048_06490(hepT)

FHL:	OE105_06580(hepT)

FAF:	OE104_04355(hepT)

SFOR:

QNH23_05775 QNH23_05785(hepT)

ECTO:

MUG87_04940(hepT) MUG87_04950

TEI:	QS257_10700 QS257_10710(hepT)

ALKL:

MM271_13900(hepT) MM271_13925

ALKG:

MOJ78_12345(hepT) MOJ78_12355

DOM:	RRU94_15115(hepT)

AHAL:

FTX54_007975 FTX54_007995(hepT)

ACHP:

QR721_07180 QR721_07190

BBAD:

K7T73_11605(hepT) K7T73_11615

BBAM:

RJD24_06230 RJD24_06255(hepT)

FPN:	ABE65_013100 ABE65_013125

FAR:	ABE41_011835 ABE41_011860

FEC:	QNH15_14350(hepT) QNH15_14370

PHJ:	LC071_02585(hepT) LC071_02595

GKA:	GK2210(gerCC) GK2212(gerCA)

GTE:	GTCCBUS3UF5_24980 GTCCBUS3UF5_25000

GTK:	GT3570_10525 GT3570_10535

GTM:	GT3921_08445 GT3921_08455

GLI:	GLN3_03975 GLN3_03985

BCAL:

CWI35_17360 CWI35_17370(hepT)

GTN:	GTNG_2144 GTNG_2146

GWC:	GWCH70_2149 GWCH70_2151

GYC:	GYMC61_0468 GYMC61_0470

GYA:	GYMC52_2192 GYMC52_2194

GCT:	GC56T3_1290 GC56T3_1292

GMC:	GY4MC1_1348 GY4MC1_1350

GGH:	GHH_c22990(hepT) GHH_c23010(hepS)

GJF:	M493_11370 M493_11380

GEA:	GARCT_02187(hepT) GARCT_02189(hepS)

GEL:	IB49_02825 IB49_02835

GSE:	GT50_16125 GT50_16135

GSR:	GS3922_04985 GS3922_04995

GEJ:	A0V43_09030 A0V43_09040

GZA:	IC807_07205(hepT) IC807_07215

GTH:	Geoth_1458 Geoth_1460

PTL:	AOT13_15605 AOT13_15615

PTB:	DER53_15590(hepT) DER53_15600

PARG:

PspKH34_12990(hepS) PspKH34_13010(hepT)

PCAL:

BV455_03200(hepS) BV455_03202(hepT)

AFL:	Aflv_1093 Aflv_1095(hepT)

AGN:	AFK25_08935 AFK25_08945

ANM:	GFC28_141 GFC28_143(hepT)

ANL:	GFC29_1482(hepT) GFC29_1484

AND:	GRQ40_11820(hepT) GRQ40_11830

AAYD:

B379_13365 B379_13375(hepT)

ACAI:

ISX45_09030(hepT) ISX45_09040

AAMY:

GFC30_2409(hepT) GFC30_2411(hepS)

HYI:	K2M58_08375 K2M58_08400

STEA:

C0679_08210 C0679_08220

PUK:	PU629_14530(hepT) PU629_14540

SAU:	SA1302(gerCC) SA1304

SAV:	SAV1470(gerCC) SAV1472

SAW:	SAHV_1458(gerCC) SAHV_1460

SAH:	SaurJH1_1557 SaurJH1_1559

SAJ:	SaurJH9_1527 SaurJH9_1529

SAM:	MW1359(gerCC) MW1361

SAS:	SAS1411 SAS1413

SAR:	SAR1479 SAR1481

SAC:	SACOL1510 SACOL1512

SAX:	USA300HOU_1407(gerC) USA300HOU_1409

SAA:	SAUSA300_1359 SAUSA300_1361

SAO:	SAOUHSC_01486 SAOUHSC_01488

SAE:	NWMN_1379(hepT) NWMN_1381

SAD:	SAAV_1457 SAAV_1459

SUU:	M013TW_1417 M013TW_1419

SUV:	SAVC_06600 SAVC_06610

SUE:	SAOV_1476 SAOV_1478

SUJ:	SAA6159_01334 SAA6159_01336

SUK:	SAA6008_01438(gerCC) SAA6008_01440

SUC:	ECTR2_1322 ECTR2_1324

SUT:	SAT0131_01558 SAT0131_01560

SUQ:	HMPREF0772_11734 HMPREF0772_11736

SUZ:	MS7_1424(hepT) MS7_1426

SUD:	ST398NM01_1468 ST398NM01_1470

SUX:	SAEMRSA15_13300 SAEMRSA15_13320

SUW:	SATW20_14670 SATW20_14690

SUG:	SAPIG1468 SAPIG1470

SUF:	SARLGA251_13820 SARLGA251_13840

SAUA:

SAAG_02078 SAAG_02080

SAUE:

RSAU_001340(gerCC) RSAU_001342

SAUN:

SAKOR_01412 SAKOR_01414

SAUS:

SA40_1343 SA40_1345

SAUU:

SA957_1358 SA957_1360

SAUG:

SA268_1363 SA268_1365

SAUZ:

SAZ172_1481 SAZ172_1483

SAUT:

SAI1T1_2010620(gerCC) SAI1T1_2010640

SAUJ:

SAI2T2_1010640(gerCC) SAI2T2_1010660

SAUK:

SAI3T3_1010630(gerCC) SAI3T3_1010650

SAUQ:

SAI4T8_1010630(gerCC) SAI4T8_1010650

SAUV:

SAI7S6_1010640(gerCC) SAI7S6_1010660

SAUW:

SAI5S5_1010590(gerCC) SAI5S5_1010610

SAUX:

SAI6T6_1010600(gerCC) SAI6T6_1010620

SAUY:

SAI8T7_1010630(gerCC) SAI8T7_1010650

SAUF:

X998_1477 X998_1479

SAB:	SAB1332c SAB1334c

SUY:	SA2981_1426(gerCC) SA2981_1428

SAUB:

C248_1509 C248_1511

SAUM:

BN843_14050 BN843_14070

SAUC:

CA347_1406(hepT) CA347_1408

SAUR:

SABB_00045 SABB_00047(hepT)

SAUI:

AZ30_07180 AZ30_07190

SAUD:

CH52_11715 CH52_11725

SAMS:

NI36_07260 NI36_07270

SUH:	SAMSHR1132_13090 SAMSHR1132_13110

SER:	SERP1038 SERP1040

SEP:	SE_1157 SE_1159

SEPP:

SEB_01181 SEB_01183

SEPS:

DP17_120(hepT) DP17_122

SHA:	SH1442 SH1444(gerCC)

SHH:	ShL2_01325 ShL2_01327(gerCC)

SSP:	SSP1274 SSP1276

SCA:	SCA_1102(gerCC) SCA_1104

SLG:	SLGD_01435 SLGD_01437

SLN:	SLUG_14330 SLUG_14350

SSD:	SPSINT_1171 SPSINT_1173

SDT:	SPSE_1323 SPSE_1325

SDP:	NCTC12225_01535 NCTC12225_01537(hepT)

SWA:	A284_06320 A284_06330

SPAS:

STP1_0056 STP1_0058

SXY:	BE24_04720 BE24_04730

SXL:	SXYLSMQ121_1314 SXYLSMQ121_1316

SXO:	SXYL_01379 SXYL_01381

SHU:	SHYC_07180 SHYC_07190(hepT)

SCAP:

AYP1020_0778(hepT) AYP1020_0780

SSCH:

LH95_06380 LH95_06390

SSCZ:

RN70_06555 RN70_06565

SAGQ:

EP23_03235 EP23_03245

SEQO:

SE1039_13100 SE1039_13120

SSIF:

AL483_04410 AL483_04420

SCV:	A4G25_01950 A4G25_01960

SPET:

CEP67_01890 CEP67_01900

SLZ:	B5P37_11405 B5P37_11415

SCOH:

BZ166_10970 BZ166_10980

SURY:

MUA21_06115 MUA21_06125

SNL:	BJD96_06940 BJD96_06950

SKL:	C7J89_08470 C7J89_08480

SFQ:	C7J90_08955 C7J90_08965

SHOM:

EGX58_10585 EGX58_10595

SMUS:

C7J88_02600 C7J88_02610

SCAR:

DWB96_06925 DWB96_06935

SCHR:

DWB92_06680 DWB92_06690

SARL:

SAP2_13700 SAP2_13720

SPIC:

SAMEA4384060_1467 SAMEA4384060_1469(gerCC)

SSH:	NCTC13712_01460(hepT) NCTC13712_01462

SSIM:

SAMEA4384339_1365(hepT) SAMEA4384339_1367

SDB:	CNQ82_07350 CNQ82_07360

SLLO:

ISP08_06825 ISP08_06835

SAUL:

I6G39_06170 I6G39_06180

SSAC:

I6I31_09455 I6I31_09465

SRAI:

LN051_06045 LN051_06055

SPSD:

JMB28_07290 JMB28_07300

STAS:

HYI43_06700 HYI43_06710

SEDA:

MNY58_07150 MNY58_07160

SCAQ:

QMO72_07170 QMO72_07180

SDEV:

Q2T90_00640 Q2T90_00650

SROT:

ML435_06845 ML435_06855

STAP:

AOB58_461 AOB58_463

SHSI:

QQM35_08535 QQM35_08545

SGAI:

K3U27_04870 K3U27_04880

SSCU:

CEP64_05955 CEP64_05965

SFF:	FOB90_01340 FOB90_01350

SSTE:

SAMEA4384403_1306 SAMEA4384403_1308(hepT)

MLEN:

H3V22_02330 H3V22_02340

MVT:	I6J10_04785 I6J10_04795

SHV:	AAT16_07435

SBAH:

RQP18_06965

JEA:	JEM45_01950

NAMP:

KPF49_04185

NMY:	CJ229_001960

LMO:	lmo1930 lmo1932

LMN:	LM5578_2131 LM5578_2133

LMY:	LM5923_2082 LM5923_2084

LMT:	LMRG_01077 LMRG_01079

LMOC:

LMOSLCC5850_1992(hepT) LMOSLCC5850_1994(hepS)

LMOE:

BN418_2319 BN418_2321

LMOB:

BN419_2320 BN419_2322

LMOD:

LMON_1998 LMON_2000

LMOW:

AX10_03890 AX10_03900

LMOQ:

LM6179_02699(hepT) LM6179_02701

LMR:	LMR479A_2039(hepT) LMR479A_2041

LMOM:

IJ09_00170 IJ09_00180

LMF:	LMOf2365_1959(hepB) LMOf2365_1961

LMC:	Lm4b_01947 Lm4b_01949

LMOG:

BN389_19550(hepT) BN389_19570

LMP:	MUO_09900 MUO_09910

LMOL:

LMOL312_1940(hepT) LMOL312_1942(hepS)

LMOJ:

LM220_14808 LM220_14818

LMOZ:

LM1816_11877(hepT) LM1816_11887

LMOX:

AX24_07425 AX24_07435

LMH:	LMHCC_0624 LMHCC_0626(hepT)

LMQ:	LMM7_2023(ispB) LMM7_2025

LML:	lmo4a_1987(hepT) lmo4a_1989(hepS)

LMG:	LMKG_00402 LMKG_00404

LMS:	LMLG_0501 LMLG_0503

LMJ:	LMOG_01309 LMOG_01311

LMW:	LMOSLCC2755_1990(hepT) LMOSLCC2755_1992(hepS)

LMX:	LMOSLCC2372_1996(hepT) LMOSLCC2372_1998(hepS)

LMZ:	LMOSLCC2482_1991(hepT) LMOSLCC2482_1993(hepS)

LMON:

LMOSLCC2376_1892(hepT) LMOSLCC2376_1894(hepS)

LMOS:

LMOSLCC7179_1902(hepT) LMOSLCC7179_1904(hepS)

LMOO:

LMOSLCC2378_1953(hepT) LMOSLCC2378_1955(hepS)

LMOY:

LMOSLCC2479_1993(hepT) LMOSLCC2479_1995(hepS)

LMOT:

LMOSLCC2540_2011(hepT) LMOSLCC2540_2013(hepS)

LMOA:

LMOATCC19117_1948(hepT) LMOATCC19117_1950(hepS)

LMOK:

CQ02_10005 CQ02_10015

LMV:	Y193_05895 Y193_05905(hepT)

LIN:	lin2044 lin2046

LWE:	lwe1956(hepB) lwe1958(hepS)

LSG:	lse_1916(hepB) lse_1918

LIV:	LIV_1910 LIV_1912

LII:	JL52_10065 JL52_10075

LIW:	AX25_10230 AX25_10240

LIA:	JL58_10265 JL58_10275

LIO:	JL53_10735 JL53_10745

LWI:	UE46_06830 UE46_06840

LGZ:	NCTC10812_00886(hepS) NCTC10812_00888(hepT_1)

LMAR:

LAX80_009490(hepT) LAX80_009500

LNW:	OTR81_14665(hepT) OTR81_14675

BTHS:

CNY62_09835

ESI:	Exig_1798 Exig_1800

EAT:	EAT1b_2993 EAT1b_2995

EAN:	Eab7_1648(hepT) Eab7_1650(hepS)

EXM:	U719_10210 U719_10220

EXU:	ESP131_12315 ESP131_12325

EAP:	KB235_10445 KB235_10455

EACE:

KKI46_10145 KKI46_10155

EAUR:

NMQ00_09090 NMQ00_09100

EMM:	PTI97_06045 PTI97_06055

EPF:	OE059_08655 OE059_08665

EXI:	A0126_08850 A0126_08860

EXH:	HNY42_10780 HNY42_10790

BBE:	BBR47_24620(hepS) BBR47_24670(hepB)

BLR:	BRLA_c019100 BRLA_c019150

BFM:	BP422_07525 BP422_07550

BAGR:

BA6348_16760 BA6348_16785

BRW:	GOP56_02420 GOP56_02445

BCHS:

JNE38_12740 JNE38_12765

BCOP:

JD108_12415 JD108_12440

BPAB:

PSE45_12200 PSE45_12225

BHUI:

LOK74_09920(hepT)

BAYD:

BSPP4475_11010 BSPP4475_11035

BBOR:

RFB14_14620 RFB14_14645

BRUM:

NDK47_15135 NDK47_15160

BREH:

HP435_12755 HP435_12780

ASED:

IRT44_14370 IRT44_14395

PJD:	Pjdr2_2406 Pjdr2_2411

GYM:	GYMC10_2198 GYMC10_2203

PPY:	PPE_02747 PPE_02752

PPM:	PPSC2_14605(hepT) PPSC2_14630(hepS)

PPO:	PPM_2936(hepT) PPM_2941(hepS)

PPOL:

X809_31010 X809_31035

PPQ:	PPSQR21_029050(ispA) PPSQR21_029100

PPOY:

RE92_22075 RE92_22100

PMS:	KNP414_02780 KNP414_02784

PMQ:	PM3016_3022 PM3016_3026

PMW:	B2K_15325 B2K_15345

PTA:	HPL003_23400 HPL003_23425

PLV:	ERIC2_c13580 ERIC2_c13630(hepT2)

PSAB:

PSAB_15890 PSAB_15915

PDU:	PDUR_17475 PDUR_17500

PBD:	PBOR_23315 PBOR_23340

PGM:	PGRAT_20875 PGRAT_20900

POD:	PODO_20625 PODO_20650

PAEN:

P40081_23700 P40081_23725

PAEF:

R50345_20770 R50345_20795

PAEQ:

R50912_21920 R50912_21945

PSTE:

PSTEL_17505 PSTEL_17530

PAEA:

R70723_21360 R70723_21385

PAEE:

R70331_20405 R70331_20430

PAEH:

H70357_23650 H70357_23675

PAEJ:

H70737_21130 H70737_21155

PBJ:	VN24_24725 VN24_24750

PIH:	UB51_05465

PRI:	PRIO_4477(hepT) PRIO_4482

PSON:

JI735_30160 JI735_30185

PPEO:

ABE82_15030 ABE82_15055

PNP:	IJ22_23000 IJ22_23050

POW:	IJ21_23650 IJ21_23700

PBV:	AR543_16540 AR543_16565

PXL:	BS614_22555 BS614_22575

PYG:	AWM70_09845 AWM70_09870

PSWU:

SY83_18580 SY83_18605

PDH:	B9T62_20205 B9T62_20230

PIB:	BBD41_04080 BBD41_04105

PCX:	LPB68_03540 LPB68_03565

PKB:	B4V02_10475 B4V02_10500

PAIH:

ASL14_23310 ASL14_23335

PVO:	PVOR_13509 PVOR_13534

PLW:	D5F53_18645 D5F53_18665

PLEN:

EIM92_14215 EIM92_14240

PPSC:

EHS13_19275 EHS13_19300

PLUT:

EI981_10315 EI981_10340

PALB:

EJC50_14405 EJC50_14430

PCHI:

PC41400_11760 PC41400_11785

PBK:	Back11_23370(hepT) Back11_23420

PPRT:

ET464_06880 ET464_06905

PBAC:

HUB98_04985 HUB98_05005

PRZ:	GZH47_04560 GZH47_04585

PLYC:

GXP70_11700 GXP70_11725

PSOP:

KP014_22320 KP014_22345

PTRI:

KDC22_20905 KDC22_20930

PALO:

E6C60_1843 E6C60_1848

PCEL:

HUB94_14005 HUB94_14030

PTJ:	JRJ22_18140 JRJ22_18165

PALR:

HGI30_10100 HGI30_10125

PTHI:

NDS46_17830(hepT)

PKA:	PQ456_14095 PQ456_14120

PUI:	PUW25_16895

PMAH:

PTQ21_25520 PTQ21_25540

PAMY:

P9222_17715 P9222_17735

PDY:	QJQ58_04185(hepT)

PMAE:

LMZ02_24600

PWN:	QNH46_14515 QNH46_14540

PSPN:

L1F29_11475

PPOG:

QPK24_16260

PAUN:

MJA45_16780(hepT)

PHK:	SK066_09340(hepT)

PNK:	AASFL403_04945 AASFL403_04970

PPAB:

KET34_22160 KET34_22180

PKP:	SK3146_01078(hepT_1)

PGLU:

A3958_19580 A3958_19605

PHEX:

L0M14_14665

PLZH:

C0638_18420 C0638_18445

PACL:

DCC85_12795

PEZZ:

HW560_17425 HW560_17445

PAUB:

PUR_33460(hepT_2) PUR_33510

PROO:

MJB10_15035

PELG:

ACJ7K1_12550

TCO:	Theco_1852 Theco_1857

ANX:	ACH33_12385 ACH33_12410

ASOC:

CB4_03073(hepT) CB4_03078(hepS)

ATHE:

K3F53_06525 K3F53_06550(hepT)

AUD:	PO771_12615(hepT) PO771_12640

ANEU:

PP175_09265 PP175_09280(hepT)

COH:	EAV92_09160 EAV92_09185

COHN:

KCTCHS21_25930 KCTCHS21_25980(hepT)

CCHL:

FPL14_26810 FPL14_26840(hepT)

CHEB:

HH215_03960(hepT)

COHL:

J4772_10885 J4772_10910(hepT)

SACA:

FFV09_00745 FFV09_00770

PLIG:

NAG76_20240

AAC:	Aaci_1692 Aaci_1694

AAD:	TC41_1588(hepST) TC41_1590

AFX:	JZ786_14365 JZ786_14375

AACO:

K1I37_11750 K1I37_11760

ACUR:

JZ785_06170 JZ785_06180

ADAU:

NZD86_12290

AFAS:

NZD89_14500 NZD89_14510

ACYC:

JI721_16260

ALIC:

GI364_12420

BTS:

Btus_1754

KYR:	CVV65_07745

TUM:	CBW65_19825

TAB:	CIG75_09630 CIG75_09660

EFF:	skT53_03690 skT53_03710(hepT)

FFE:	LSG31_17885

SIV:	SSIL_2720 SSIL_2722

SSIL:

SOLI23_04985 SOLI23_04995

SOB:	CSE16_05895 CSE16_05905(hepT)

PLN:	Plano_1786 Plano_1788

PKU:	AUO94_06765 AUO94_06775

PRT:	AUC31_00665 AUC31_00675

PLL:	I858_013955 I858_013965

PANA:

BBH88_10250 BBH88_10260

PDG:	BCM40_06290 BCM40_06300

PHC:	BBI08_05860 BBI08_05870

PMAR:

B0X71_11450 B0X71_11460

PPLA:

BBI15_04720 BBI15_04730

PFAE:

AJGP001_10370 AJGP001_10380

PLX:	CW734_10715

PMAT:

BBI11_10175 BBI11_10185

PDEC:

H1Q58_09355(hepT) H1Q58_09365

PGQ:	FK545_19310(hepT) FK545_19320

PLAY:

DNR44_011095 DNR44_011105(hepT)

PLIQ:

QWY22_11920(hepT) QWY22_11930

PSHE:

QWY16_12055(hepT) QWY16_12065

PSHX:

QWY21_11900(hepT) QWY21_11910

JEO:	JMA_19880 JMA_19900

KUR:	ASO14_1983(hepT) ASO14_1985

KZO:	NCTC404_01702(hepS) NCTC404_01704(hepT)

SPSY:

AZE41_13515 AZE41_13525

SPOR:

SporoP33_15105 SporoP33_15115

SPOP:

SporoP37_15440 SporoP37_15450

SURE:

SporoP32a_15755 SporoP32a_15765

SPOS:

DV702_03440 DV702_03450

SPAE:

E2C16_07455 E2C16_07465

SPOO:

J3U78_04985 J3U78_04995

SURL:

BI350_11325 BI350_11335

STHO:

QNH10_12735

STRB:

QWT68_06325 QWT68_06335

SOW:	QWT69_08365

SJT:	PGH26_05660

SPOH:

GGGNBK_09930 GGGNBK_09940(ispA)

RST:	ATY39_03775 ATY39_03785

PAEK:

D3873_05615 D3873_05625(hepT)

PANC:

E2636_09430(hepT) E2636_09440

VIJ:	JNUCC6_21260 JNUCC6_21270(hepT)

UTH:	DKZ56_08230 DKZ56_08240(hepT)

NTR:	B0W44_13785 B0W44_13795

LFB:	C1X05_07470 C1X05_07495

TVU:	AB849_011965 AB849_011980

KPUL:

GXN76_07440 GXN76_07450

KEB:	GXN75_08600 GXN75_08610

PABS:

JIR001_15640 JIR001_15690(hepT)

CMIC:

caldi_27560

SWO:

Swol_0680

SLP:

Slip_1436

SALQ:

SYNTR_0453

DSY:

DSY2232

DHD:

Dhaf_3361

DDH:	Desde_2807

DDL:	Desdi_2325

DMT:	DESME_09310

SGY:

Sgly_1713

DOR:	Desor_1303

DAI:	Desaci_1926

DMI:	Desmer_1202

DED:	DHBDCA_p973

DEC:	DCF50_p1031

DRS:	DEHRE_09335

DCA:	Desca_1547

PTH:	PTH_0969(IspA)

DRM:

Dred_2166

DRU:	Desru_1618

DFG:	B0537_10775

DAE:

Dtox_1248

DKU:	Desku_1524

TFR:	BR63_05940

FWA:	DCMF_06475

AACX:

DEACI_2414

PHOS:

ABFY19_09510

TJR:	TherJR_1116

DGI:	Desgi_2078

HMO:

HM1_1960

HCV:	FTV88_1664(hepT)

TCP:	Q5761_01010

HFV:

R50_1828

CTHM:

CFE_1715

DAU:

Daud_1350

CHY:	CHY_1206(hepT)

ADG:

Adeg_1262

TPZ:	Tph_c15430(hepT2)

MTA:

Moth_1252

MTHO:

MOTHE_c12330(hepT2)

MTHZ:

MOTHA_c13190(hepT2)

MHUI:

MHLNE_13190(hepT_2)

NCJ:	MCACP_14510(hepT_2)

DBC:	MFMK1_002378

BACG:

D2962_11240 D2962_16780

TFC:	T23_20610(hepT)

TUK:	VXM77_00580

CALK:

HUE98_11605

ACIT:

HPK19_02905 HPK19_02915(hepT)

POK:	SMD14_08890

BALA:

DSM104299_05831(hepT)

DETH:

HX448_00245

LMAJ:

GKN94_12525

CALL:

OZ401_003674

KBB:	ccbrp13_59470

TFLA:

O0235_14640

MVJ:	ACO0C9_01715

» show all

Reference

1 [PMID:6768722]

Authors

Takahashi I, Ogura K, Seto S.

Title

Heptaprenyl pyrophosphate synthetase from Bacillus subtilis.

Journal

J Biol Chem 255:4539-43 (1980)

Reference

2 [PMID:9748348]

Authors

Zhang YW, Koyama T, Marecak DM, Prestwich GD, Maki Y, Ogura K

Title

Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex.

Journal

Biochemistry 37:13411-20 (1998)
DOI:10.1021/bi972926y

Reference

3 [PMID:10545188]

Authors

Zhang YW, Li XY, Sugawara H, Koyama T

Title

Site-directed mutagenesis of the conserved residues in component I of Bacillus subtilis heptaprenyl diphosphate synthase.

Journal

Biochemistry 38:14638-43 (1999)
DOI:10.1021/bi9913653

Reference

4 [PMID:17117872]

Authors

Suzuki T, Zhang YW, Koyama T, Sasaki DY, Kurihara K

Title

Direct observation of substrate-enzyme complexation by surface forces measurement.

Journal

J Am Chem Soc 128:15209-14 (2006)
DOI:10.1021/ja061822k

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.30

IUBMB Enzyme Nomenclature:

2.5.1.30

ExPASy - ENZYME nomenclature database:

2.5.1.30

BRENDA, the Enzyme Database:

2.5.1.30

CAS:	74506-59-5

DBGET integrated database retrieval system