| Entry |
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| Name |
heptaprenyl diphosphate synthase;
all-trans-heptaprenyl-diphosphate synthase;
heptaprenyl pyrophosphate synthase;
heptaprenyl pyrophosphate synthetase;
HepPP synthase;
HepPS;
heptaprenylpyrophosphate synthetase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 4 isopentenyl units)
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| Reaction(IUBMB) |
(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate [RN: R09247]
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| Reaction(KEGG) |
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| Substrate |
(2E,6E)-farnesyl diphosphate [CPD: C00448];
isopentenyl diphosphate [CPD: C00129]
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| Product |
diphosphate [CPD: C00013];
all-trans-heptaprenyl diphosphate [CPD: C04216]
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| Comment |
This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
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| History |
EC 2.5.1.30 created 1984, modified 2010
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00805 | heptaprenyl diphosphate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Takahashi I, Ogura K, Seto S. |
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| Title |
Heptaprenyl pyrophosphate synthetase from Bacillus subtilis. |
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| Journal |
J Biol Chem 255:4539-43 (1980) |
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| Reference |
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| Authors |
Zhang YW, Koyama T, Marecak DM, Prestwich GD, Maki Y, Ogura K |
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| Title |
Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex. |
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| Journal |
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| Reference |
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| Authors |
Zhang YW, Li XY, Sugawara H, Koyama T |
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| Title |
Site-directed mutagenesis of the conserved residues in component I of Bacillus subtilis heptaprenyl diphosphate synthase. |
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| Journal |
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| Reference |
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| Authors |
Suzuki T, Zhang YW, Koyama T, Sasaki DY, Kurihara K |
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| Title |
Direct observation of substrate-enzyme complexation by surface forces measurement. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.30 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.30 |
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