Entry
Name
4-hydroxybenzoate polyprenyltransferase;
nonaprenyl-4-hydroxybenzoate transferase;
4-hydroxybenzoate transferase;
p-hydroxybenzoate dimethylallyltransferase;
p-hydroxybenzoate polyprenyltransferase;
p-hydroxybenzoic acid-polyprenyl transferase;
p-hydroxybenzoic-polyprenyl transferase;
4-hydroxybenzoate nonaprenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase
Reaction(IUBMB)
a polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate [RN:
R05000 ]
Reaction(KEGG)
Substrate
polyprenyl diphosphate [CPD:
C05847 ];
4-hydroxybenzoate [CPD:
C00156 ]
Product
diphosphate [CPD:
C00013 ];
4-hydroxy-3-polyprenylbenzoate [CPD:
C05848 ]
Comment
This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency [2,4,5].
History
EC 2.5.1.39 created 1992, modified 2010
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K03179 4-hydroxybenzoate polyprenyltransferase
K06125 4-hydroxybenzoate polyprenyltransferase
Genes
MORG : 121441011(Coq2) 121460938
LVE : 103072505 103084815(COQ2)
DLE : 111174086 111187624(COQ2)
PCAD : 102975693 102989894(COQ2)
PSIU : 116744760 116754663(COQ2)
NASI : 112394244 112406880(COQ2)
MNA : 107527100 107537104(COQ2)
SANH : 107672553 107699757
CAUA : 113049658 113080767
CGIB : 127957171 127997795
OAU : 116312324(coq2) 120443071
ARUT : 117409244 117973132
LPIC : 129260226 129262017
APLC : 110979789 110984072
DSI : Dsimw501_GD15120(Dsim_GD15120)
AALB : 109411868 109412716
APLN : 112904111 112904118
BTAB : 109030654 109041562
PPOI : 119108015 119108019 119108026
CBR : CBG_16481(Cbr-coq-2)
RPHI : 132721764 132737698 132740246
CSAT : 104717938 104722646 104785734
BNA : 106376325 106438455 111207886 125580119
RSZ : 108818712 108829836 108831321 108853258
MINC : 123213071 123220100
TCC : 108660772 18608518 18608672
GHI : 107932616 107937599 107946115 107947569 121210941
HSYR : 120114436 120117366 120119738 120120286 120186656 120199784
TPRA : 123889405 123892846
AIP : 107624256 107639731 107647254
AHF : 112716100 112743880 112784849 112797252
PCIN : 129291417 129299667 129300174
QSA : O6P43_004157 O6P43_008072 O6P43_012369 O6P43_012372 O6P43_020182 O6P43_020953 O6P43_020955 O6P43_020956 O6P43_020957 O6P43_020965 O6P43_021075
PPER : 18781045 18789410 18793931
PMUM : 103321066 103321067 103327039
PAVI : 110745789 110754560 110754625
PDUL : 117626090 117637196 117637241
MDM : 103413003 103447741 114821595
MSYL : 126588831 126588832 126588833 126603735
PXB : 103930717 103930718 103943273 103959032 103964019 103966541
PEU : 105111533 105119280 105123961
SSPL : 121753200 121802168 121808283
PSOM : 113321198 113359601
TDC : 119310554 119318684 119323682
TAES : 123117613 123129153 123135239 123142252
LPER : 127313956 127313958 127313965 127313966 127319155 127327934 127340764
LRD : 124648078 124648109 124662492 124683349 124683353 124683354 124683531 124683533 124695173 124697478
MFLO : 136468068 136468110 136475264 136478393 136491778 136495681
SITA : 101772033 101784500
PVIR : 120650716 120669178 120671504 120703269
PHAI : 112879070 112890101 112890507
NCOL : 116247473 116247474 116248565 116249121
SMO : SELMODRAFT_24144 SELMODRAFT_24149
CGR : 2886755(GVI51_C03443)
NCS : NCAS_0A05500(NCAS0A05500)
NDI : NDAI_0K02330(NDAI0K02330)
TPF : TPHA_0M01980(TPHA0M01980)
TBL : TBLA_0F00510(TBLA0F00510)
TDL : TDEL_0A07760(TDEL0A07760)
KAF : KAFR_0C04720(KAFR0C04720)
KNG : KNAG_0D00270(KNAG0D00270)
LBG : 92207222(LODBEIA_P20260)
CAL : CAALFM_CR10600CA(CaO19.7643)
YLI : 2907969(YALI2_F00880g)
NTE : NEUTE1DRAFT83541(NEUTE1DRAFT_83541)
SMP : 10808206(SMAC4_02313)
TTT : THITE_2034205 THITE_2123514
MTM : MYCTH_2096317 MYCTH_2311811
PGRI : PgNI_08175 PgNI_10026
FGR : FGSG_10613 FGSG_10732
TRE : TRIREDRAFT_58055 TRIREDRAFT_59771
TRR : M419DRAFT_130060 M419DRAFT_66126
TATV : 25780772(TrAtP1_008021)
TASP : 36618354(TrAFT101_007464)
PLJ : 28888780(PLICBS_009212)
PFY : PFICI_09059 PFICI_11869
SSL : SS1G_06055 SS1G_09724 SS1G_10405
BFU : BCIN_05g03520 BCIN_14g03530 BCIN_17g00020
PSCO : LY89DRAFT_609961 LY89DRAFT_684103
ACT : ACLA_013030 ACLA_045250
ANG : An02g10890 An04g00170
PCS : N7525_004099 N7525_008488
TRG : TRUGW13939_00287 TRUGW13939_03517 TRUGW13939_03783 TRUGW13939_08901
PNO : SNOG_05304 SNOG_07120
PTRR : 6342365(PtrM4_091270)
BOR : COCMIDRAFT_103530 COCMIDRAFT_28433
AALT : CC77DRAFT_1015951 CC77DRAFT_1022609
CDEP : 91085190(L203_100976)
KMG : 30162608(I203_101161)
KNE : 92179482(IAR55_002223)
CCAC : CcaHIS019_0306450(COQ2)
TVS : TRAVEDRAFT_142759 TRAVEDRAFT_173073
DSQ : DICSQDRAFT_112919 DICSQDRAFT_149527 DICSQDRAFT_81420
PCO : PHACADRAFT_116866 PHACADRAFT_167688 PHACADRAFT_249878
SHS : STEHIDRAFT_144301 STEHIDRAFT_53846 STEHIDRAFT_62522 STEHIDRAFT_63208 STEHIDRAFT_96173
HIR : HETIRDRAFT_142593(ppt2) HETIRDRAFT_37087(ppt3) HETIRDRAFT_47794(ppt1)
PSQ : PUNSTDRAFT_100203 PUNSTDRAFT_118087 PUNSTDRAFT_121915 PUNSTDRAFT_126822 PUNSTDRAFT_82742
ADL : AURDEDRAFT_115171 AURDEDRAFT_143723 AURDEDRAFT_80821
FME : FOMMEDRAFT_110375 FOMMEDRAFT_148597 FOMMEDRAFT_158055 FOMMEDRAFT_55907 FOMMEDRAFT_92669 FOMMEDRAFT_92946
GTR : GLOTRDRAFT_133116 GLOTRDRAFT_29906 GLOTRDRAFT_34831 GLOTRDRAFT_45519 GLOTRDRAFT_46643
LBC : LACBIDRAFT_160541 LACBIDRAFT_246255
CCI : CC1G_07498 CC1G_11104 CC1G_11111 CC1G_14657
ABP : AGABI1DRAFT73134(AGABI1DRAFT_73134) AGABI1DRAFT75742(AGABI1DRAFT_75742) AGABI1DRAFT75748(AGABI1DRAFT_75748)
ABV : AGABI2DRAFT203037(AGABI2DRAFT_203037) AGABI2DRAFT209373(AGABI2DRAFT_209373) AGABI2DRAFT226364(AGABI2DRAFT_226364)
MRR : Moror_10007 Moror_17568 Moror_7276 Moror_7299
MORE : E1B28_004498 E1B28_006775 E1B28_006792
SCM : SCHCO_02540007(SCHCODRAFT_02540007) SCHCO_02627895(SCHCODRAFT_02627895) SCHCO_02667661(SCHCODRAFT_02667661)
CPUT : CONPUDRAFT_123348 CONPUDRAFT_44583 CONPUDRAFT_58783
SLA : SERLADRAFT_347123 SERLADRAFT_479380 SERLADRAFT_481081
PGR : PGTG_08703 PGTG_16390
PTRC : PtA15_15A434 PtA15_7A671
ECOO : ECRM13514_5175(ubiA)
ECOH : ECRM13516_4912(ubiA)
ELR : ECO55CA74_23295(ubiA)
ECW : EcE24377A_4593(ubiA)
ECOA : APECO78_01020(ubiA)
EDJ : ECDH1ME8569_3897(ubiA)
ECOI : ECOPMV1_04421(ubiA)
SEM : STMDT12_C43700(ubiA)
SETC : CFSAN001921_19245(ubiA)
SEEN : SE451236_04205(ubiA)
SENH : CFSAN002069_10930(ubiA)
SEEH : SEEH1578_07340(ubiA)
SENJ : CFSAN001992_12705(ubiA)
SEEC : CFSAN002050_04000(ubiA)
SEEB : SEEB0189_021275(ubiA)
SENC : SEET0819_04985(ubiA)
ENR : H650_00185 H650_16835(ubiA)
CCON : AFK62_08850 AFK62_17910(ubiA)
REE : electrica_04761(ubiA)
RTG : NCTC13098_06862(ubiA_1)
CLAP : NCTC11466_04301(ubiA)
KIE : NCTC12125_03450(ubiA)
KAS : KATP_42310(ubiA_1) KATP_49580(ubiA_2)
AHN : NCTC12129_04604(ubiA)
METY : MRY16398_53160(ubiA)
PTF : PROFFT_A_03920(ubiA)
PSHI : SAMEA2665130_0183(ubiA)
YPG : YpAngola_A0679(ubiA)
YPI : YpsIP31758_3773(ubiA)
SMW : SMWW4_v1c44310(ubiA)
SERS : SERRSCBI_21400(ubiA)
SOF : NCTC11214_02144(ubiA_1)
SSAR : SSARUM_004325(ubiA)
SERA : Ser39006_022355(ubiA)
PAQU : DMB82_0002960(ubiA)
PARL : PEC302110_34330(ubiA)
EHD : ERCIPSTX3056_167(ubiA)
TPTY : NCTC11468_03419(ubiA)
PHEI : NCTC12003_00441(ubiA)
PRJ : NCTC6933_00510(ubiA)
LRI : NCTC12151_00438(ubiA)
PDAG : 4362423_01647(ubiA)
ALIG : NCTC10568_00527(ubiA)
AAP : NT05HA_2097 NT05HA_2098
AVT : NCTC3438_02157(ubiA)
PAET : NCTC13378_00017(ubiA)
XFU : XFF4834R_chr03760(ubiA)
XPH : XppCFBP6546_09865(ubiA)
XHD : LMG31886_04380(ubiA)
LLZ : LYB30171_00093(ubiA)
VAU : VANGNB10_cI0109(ubiA)
VPL : SA104470976_02636(ubiA)
PAEB : NCGM1900_6203(ubiA)
PMOL : CLJ08_05840 CLJ08_13355(ubiA)
PVD : CFBP1590__5343(ubiA)
PPRC : PFLCHA0_c60650(ubiA)
PPRO : PPC_0036 PPC_6059(ubiA)
PMUD : NCTC8068_05316(ubiA)
PFW : PF1751_v1c54470(ubiA)
PFF : PFLUOLIPICF708760(ubiA)
PPUU : PputUW4_05352(ubiA)
PSOS : POS17_0037(BPP0100) POS17_6067(ubiA)
PSEP : C4K39_0036 C4K39_3554
PPII : QL104_00180(ubiA) QL104_30895(ubiA)
PTRT : HU722_0000370(ubiA)
PTW : TUM18999_01290(ubiA)
PTAE : NCTC10697_00120(ubiA)
MSHE : MAALD49_35780(ubiA)
PSYC : DABAL43B_2276(ubiA)
ACAL : BUM88_13420 BUM88_14085
MCAT : MC25239_01300(ubiA)
MCUN : NCTC10297_01037(ubiA)
SCAA : TUM17387_04010(ubiA)
PLZ : S4054249_04775(ubiA)
SALH : HMF8227_00070(ubiA)
CBS : COXBURSA331_A0140(ubiA)
LLG : 44548918_01065(ubiA)
LJR : NCTC11533_01585(ubiA)
LCJ : NCTC11976_02405(ubiA)
LWA : SAMEA4504053_1604(ubiA)
LSS : NCTC12082_00426(ubiA)
LADL : NCTC12735_01107(ubiA)
LANT : TUM19329_17380(ubiA)
MISZ : MishRS11D_28720(ubiA)
FTR : NE061598_04910(ubiA)
TIB : THMIRHAM_22160(ubiA)
TSE : THMIRHAS_24670(ubiA)
TZO : THMIRHAT_01500(ubiA)
TFRI : Thiofri_03577(ubiA)
TNI : TVNIR_0406(ubiA_[H])
GAI : IMCC3135_32580(ubiA)
THIC : TspCOW1_26680(ubiA)
HAXI : HAALTHF_10970n(ubiA)
HAAH : HALA3H3_360137(ubiA)
ALCA : ASALC70_02477(ubiA)
AEL : NCTC12917_03973(ubiA)
CHJ : NCTC10426_00280(ubiA)
CDIZ : CEDIAZO_00590(ubiA)
NMM : NMBM01240149_1354(ubiA)
NMS : NMBM01240355_0736(ubiA)
NMQ : NMBM04240196_1429(ubiA)
NMZ : NMBNZ0533_0785(ubiA)
NMX : NMA510612_1055(ubiA)
NWE : SAMEA3174300_0150(ubiA)
NZO : SAMEA4504057_0902(ubiA)
NCI : NCTC10296_02259(ubiA)
NCZ : NCTC10294_00374(ubiA)
NANI : NCTC12227_00392(ubiA)
ECOR : SAMEA4412678_1952(ubiA)
REH : H16_A3107(h16_A3107)
BMV : BMASAVP1_A0312(ubiA)
BML : BMA10229_A1173(ubiA)
BPM : BURPS1710b_3361(ubiA)
BPL : BURPS1106A_3350(ubiA)
BUE : BRPE67_ACDS03590(ubiA)
PLG : NCTC10937_05178(ubiA)
LMIR : NCTC12852_02304(ubiA)
BUO : BRPE64_ACDS03800(ubiA)
BTRM : SAMEA390648701346(ubiA)
AXX : ERS451415_06074(ubiA)
LIM : L103DPR2_00460(ubiA)
LIH : L63ED372_03076(ubiA)
DAER : H9K75_10040(ubiA) H9K75_22155
SMIO : CATMQ487_39280(ubiA)
URU : DSM104443_00100(ubiA)
UPL : DSM104440_00098(ubiA)
THAG : CKCBHOJB_03108(ubiA)
FPHO : SHINM1_018700(ubiA)
RTT : RTTH1527_03265(ubiA)
RTB : RTB9991CWPP_03270(ubiA)
ERW : ERWE_CDS_06080(ubiA)
ERG : ERGA_CDS_05990(ubiA)
RBS : RHODOSMS8_00201(ubiA)
SMEL : SM2011_c00988(ubiA)
SFD : USDA257_c05760(ubiA)
SAME : SAMCFNEI73_Ch0904(ubiA)
EAH : FA04_02460 FA04_10070
ENP : JVX98_09520 JVX98_17995
AGR : AGROH133_04150(ubiA)
AVV : RvVAT039_23270(ubiA)
AVF : RvVAR031_10560(ubiA)
ASAL : CFBP5507_01445(ubiA)
ALEG : CFBP4996_01555(ubiA)
REC : RHECIAT_CH0000986(ubiA)
RLT : Rleg2_0543 Rleg2_2235
RLU : RLEG12_14085(ubiA) RLEG12_22715
RTR : RTCIAT899_CH04310(ubiA1) RTCIAT899_CH08885(ubiA2)
RJG : CCGE525_05275 CCGE525_30205
RHR : CKA34_07425 CKA34_12330
RII : FFM53_008375 FFM53_023025
RHID : FFM81_008265 FFM81_016515
RRG : J3P73_05440 J3P73_15315
RAW : NE851_14715(ubiA) NE851_24420(ubiA)
RLW : RlegWSM1455_02795(ubiA)
ARA : Arad_1166(ubiA) Arad_3059(ubiA)
RIF : U5G49_000583(ubiA) U5G49_002542(ubiA)
RHIZ : QMO80_001678(ubiA) QMO80_004321(ubiA)
NEN : NCHU2750_04590(ubiA)
LAS : CLIBASIA_00450(ubiA)
BIO : BR141012304_10144(ubiA)
BSEP : HAP48_0022110(ubiA)
BCAN : BcanWSM471_33035(ubiA)
VGO : GJW-30_1_00380(ubiA)
BHS : BM1374165_00407(ubiA)
BBK : BARBAKC583_0393(ubiA)
BTX : BM1374166_00599(ubiA)
BARA : BA1379B_008300 BA1379B_008310
BEZ : NCTC12898_00280(ubiA)
MAQU : Maq22A_1p31825(ubiA)
MTUN : MTUNDRAET4_2478(ubiA)
FIL : BN1229_v1_0164(ubiA)
FIY : BN1229_v1_0168(ubiA)
BVY : NCTC9239_02476(ubiA)
TSV : DSM104635_01329(ubiA)
PHP : PhaeoP97_03065(ubiA)
PPIC : PhaeoP14_00212(ubiA)
SINL : DSM14862_00614(ubiA)
SPSE : SULPSESMR1_02490(ubiA)
RMM : ROSMUCSMR3_00862(ubiA)
LALG : LentiSH36_00419(ubiA)
LVS : LOKVESSMR4R_02864(ubiA)
AALK : LGT41_0005855(ubiA)
SBIN : SBA_ch1_08270(ubiA)
SPAG : sphantq_02218(COQ2)
SFLA : SPHFLASMR4Y_03266(ubiA)
HPYA : HPAKL117_06480(ubiA)
HPYK : HPAKL86_06835(ubiA)
HCL : NCTC13205_00484(ubiA)
HSH : NHP194022_02810(ubiA)
HPUL : NCTC13154_01359(ubiA)
CJV : MTVDSCj20_0163(ubiA)
CFV : CFVI03293_0218(ubiA)
CAMP : CFT03427_0225(ubiA)
CCOC : CCON33237_0245(ubiA)
CLR : UPTC16701_1400(ubiA)
CLM : UPTC16712_1420(ubiA)
CAMR : CAQ16704_1437(ubiA)
CHV : CHELV3228_1507(ubiA)
CPIN : CPIN18020_0945(ubiA)
CAMZ : CVIC12175_1390(ubiA)
CMUC : CMCT_0117(ubiA1) CMCT_1710(ubiA2)
GEC : GEO60473_33110(ubiA)
BCO : Bcell_1867 Bcell_2833