KEGG   ENZYME: 2.5.1.41
Entry
EC 2.5.1.41                 Enzyme                                 
Name
phosphoglycerol geranylgeranyltransferase;
glycerol phosphate geranylgeranyltransferase;
geranylgeranyl-transferase (ambiguous);
prenyltransferase (ambiguous);
(S)-3-O-geranylgeranylglyceryl phosphate synthase;
(S)-geranylgeranylglyceryl phosphate synthase;
GGGP synthase;
(S)-GGGP synthase;
GGGPS;
geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase;
geranylgeranyl diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranylgeranyl-diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [RN:R04158]
Reaction(KEGG)
R04158
Substrate
geranylgeranyl diphosphate [CPD:C00353];
sn-glycerol 1-phosphate [CPD:C00623]
Product
diphosphate [CPD:C00013];
3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04590]
Comment
This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5].
History
EC 2.5.1.41 created 1992, modified 2009
Pathway
ec00564  Glycerophospholipid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K17104  phosphoglycerol geranylgeranyltransferase
Genes
SLFJEQ17_04745
MJAMJ_1250
MFEMefer_0372
MVUMetvu_0909
MFSMFS40622_0685
MIFMetin_0740
MJHJH146_0475
MESGMLAUSG7_1285
MESAMLASG1_0491
MIGMetig_1082
MMPMMP0007
MMQMmarC5_1677
MMXMmarC6_0942
MMZMmarC7_1004
MMDGYY_00040
MMAKMMKA1_00070
MMAOMMOS7_00070
MMADMMJJ_10930
MAEMaeo_1165
MVNMevan_1213
MVOMvol_1417
MOKMetok_0736
METFCFE53_04705
MTHMTH_552
MMGMTBMA_c09410
MWOMWSIV6_0917
MTEEMTTB_09860
METCMTCT_0480
METEtca_00524(pcrB)
METZMETMT2_0829
METKFVF72_08760
MTHMFZP57_04400
METJFZP68_04865
MSTMsp_1291(pcrB)
METBAW729_09185
MRUmru_1102
MSIMsm_0124
MEBAbm4_0883
MMILsm9_0933
MEYETL18_05650
MOLYLM1_0765
MAROMarbSA_02470
METVK4897_01035
MELMetbo_2269
MEWMSWAN_0376
METHMBMB1_0428
MFCBRM9_1833
MFIDSM1535_0016
MCUBMCBB_0391
MSUBBK009_00180
METNBK008_07970
METTCIT01_10475
METOCIT02_04670
MEMEHYG87_00325
MFVMfer_0282
MKAMK0642
AFUAF_0403
AFGAFULGI_00004070
APOArcpr_0988
AVEArcve_0345
ASTAsulf_00438
FPLFerp_2022
GACGACE_1575
GAHGAH_00156
PFUPF1039
PFIPFC_04430
PHOPH1124(PH1124)
PABPAB0735
PYNPNA2_1786
PYAPYCH_06020
PYSPy04_0956
PYCTQ32_06100
TKOTK1026
TONTON_1065
TGATGAM_1175(gggPS)
TSITSIB_0683
TBATERMP_01020
THEGQS_10240
THATAM4_2030
THMCL1_1622
TLTOCC_02732
THSTES1_1095
TNUBD01_0972
TEUTEU_10660
TGYX802_09560
THVADU37_CDS06810
TCHCHITON_1469
TPEPA0127_00030
TPIEA7C91_00815
TGGA3K92_02365
TCEA3L02_05075
TBSA3L01_06055
THHCDI07_06010
TSLA3L11_10070
TTDA3L14_08455
TPRFA3L09_04095
TRLA3L10_00545
TPAFA3L08_09200
THYA3L12_06710
TICFH039_08020
TCQTIRI35C_1523
THEMFPV09_01420
THEIK1720_06560
PPACPAP_08105
MBAMbar_A0675
MBYMSBRM_3248
MBWMSBRW_0328
MBARMSBR2_3210
MBAKMSBR3_3195
MACMA_3969
MMAMM_0943
MMAZMmTuc01_0970
MMJMSMAS_0361
MMACMSMAC_0379
MVCMSVAZ_3248
MEKMSKOL_3213
MLSMSLAZ_0576
METMMSMTP_0421
MEFMSWH1_2769
MEQMSWHS_2267
MSJMSSAC_3705
MSZMSSIH_3241
MSWMSSIT_3312
MTHRMSTHT_1546
MTHEMSTHC_1743
MHORMSHOH_0454
MFZAOB57_006815
MBUMbur_1652
MMETMCMEM_2137
MELOJ7W08_09650
MMHMmah_1962
MHAZBHR79_03825
MEVMetev_1519
MZHMzhil_0369
MPYMpsy_1329
MZIHWN40_02045
MHZMetho_0329
MTPMthe_1238
MCJMCON_1916
MHIMhar_0199
MHUMhun_1010
MRTJKHC33_11900
MLAMlab_1138
MEMMemar_0769
MBGBN140_2339
MEMAMMAB1_3107
MCHKMchiMG62_08940
MSUMOH143_10565
MPIMpet_1935
MENDL6E24_00755
MBNMboo_0860
MFOMetfor_2140
MPLMpal_1300
MPDMCP_0258 MCP_2780
MEZMtc_2486
RCIRCIX581 RCIX582
HALVNG_0252C VNG_1918C
HSLOE_1398R(pcrB1) OE_3699R(pcrB2)
HDLHALDL1_05460 HALDL1_09625
HHBHhub_1410(pcrB)
HAGSJT689_02430 JT689_09055
HABOJRZ79_00935 JRZ79_07465
HNOLT974_02075
HLULT972_01815 LT972_11520
HANRLJ422_01145 LJ422_07725
HJEHacjB3_02500 HacjB3_13025 HacjB3_18758
HALHHTSR_1475
HHSRHSR6_1547
HSUHLASF_0583
HSFHLASA_0579
SALRFQU85_02410
HALREFA46_005885
HAADMW046_08620
HALXM0R89_10565 M0R89_11495
HAXZM0R88_10955 M0R88_11955
SALIL593_04125
SAIMK0C01_03090
HARAAArcS_2630(pcrB)
HMArrnAC1650(pcrB)
HHIHAH_2191(pcrB)
HHNHISP_11165
HABSG26_03535 SG26_19305
HTABVU17_10680
HALJG9465_07155
HSINKDQ40_02435
NPHNP_1224A(pcrB)
NMONmlp_2072(pcrB)
NHOHWV23_12105
NSALHWV07_06090
HUTHuta_2960
HTIHTIA_2549
HALAHrd1104_04755
HMUHmuk_0293 Hmuk_3016
HALZE5139_02350 E5139_04750
HALLLC1Hm_2400(pcrB)
HAZPGBQ70_02350 GBQ70_04745
HALIBV210_05505
HSNDV733_16670
HDSHSR122_1249(pcrB)
HRRHZS55_08765 HZS55_21180
HPELHZS54_09880 HZS54_24710
HLTI7X12_05240 I7X12_12865
HARCHARCEL1_00260
HDOMUK72_05205
SSAIN0B31_03390
HWAHQ_1269A(pcrB)
HWCHqrw_1298(pcrB)
HVOHVO_0680(pcrB1) HVO_1086(pcrB2)
HMEHFX_0542 HFX_0642
HGIABY42_03240
HALEG3A49_03460
HLSKU306_07960 KU306_10110
HBOHbor_22430 Hbor_25380
HAQDU484_06795
HAJDU500_07065
HAERDU502_04730 DU502_10580
HRAEI982_09010
HLMDV707_12695
HALMFCF25_10385
HLAHlac_0199
HALPDOS48_00985
HALBEKH57_10395
HEZZEO776_01025
HALQHrr1229_005920
HSSJ7656_00150
HSAIHPS36_05665
HAZZKI388_14710
SRUBC2R22_04090
HAEhalTADL_1085
HALNB4589_004795 B4589_008105
HALGHUG10_14840
HALUHUG12_01355
HMPK6T50_11055
HREK6T36_10845
HRMK6T25_05200
HACBHbl1158_03290
HDFAArcSl_2174 AArcSl_2191(pcrB)
HAHHalar_2377 Halar_3226
HTUHtur_1301 Htur_2683
HDABB347_02560 BB347_08760
HSALJMJ58_02305 JMJ58_15430
HLOJ0X27_05125
HAKZJ0X25_01645 J0X25_13355
NMGNmag_1070(pcrB1) Nmag_2771(pcrB2)
HXAHalxa_2474 Halxa_4034
NATNJ7G_1988
NPENatpe_0946
NVRFEJ81_04880
NPLFGF80_05970
NAYHYG81_05975
HALYHYG82_09055
HJTDVR14_14030
NGENatgr_0591 Natgr_1269 Natgr_2083
HRUHalru_0157
NOUNatoc_0656 Natoc_2675
HLRHALLA_07705 HALLA_12930
HLCCHINAEXTREME00365 CHINAEXTREME09750
NAJB1756_06220 B1756_12310
NAGAArcMg_0535 AArcMg_0918
NANAArc1_0548 AArc1_2828
NBGDV706_01315 DV706_10880 DV706_15955
NASGCU68_01215 GCU68_12380
SAWLNGM29_17055
MELUMTLP_01470
MEAMMU439_00360
TACTa0995
TVOTVG0750626(TVG0750626)
PTOPTO0183
FACFACI_IFERC01G0508
FAIFAD_1427
CDIVCPM_1185
TARTALC_00272
MAXMMALV_02560
MERMMINT_05980
MEARMpt1_c10950
MEUZKRP56_01365
MARCAR505_1588
ABIAboo_0770
ACFAciM339_0296
SMRSmar_0993
SHCShell_1468
IHOIgni_0425
IISEYM_04315
IPCIPA_05490
DKADKAM_1191
DFDDesfe_1302
DMUDesmu_1195
TAGTagg_0823
IAGIgag_0058
THGTCELL_0313
HBUHbut_0005
PFMPyrfu_0154
PDLPyrde_0546
STOSTK_03100
SOHD1869_01095
SSOSSO0259
SOLSsol_1237
SSOASULA_1279
SSOLSULB_1280
SSOFSULC_1278
SSHIJ5U23_03207
SCASSACC_01720
SAISaci_0728
SACNSacN8_03530
SACRSacRon12I_03515
SACSSUSAZ_03285
SISLS215_1988
SIAM1425_1879
SIMM1627_1956
SIDM164_1886
SIYYG5714_1955
SINYN1551_0965
SIILD85_2100
SIHSiH_1816
SIRSiRe_1736
SICSiL_1728
SULABFU36_04740
SULEGFS03_10290
SULOGFS33_02105
SULLEWF20_02560
MSEMsed_2291
MEMJMJ1HA_2620
MCNMcup_2034
MHKDFR87_06930
MPRUDFR88_06730
MTENGWK48_05230
MJNMjAS7_0580
AHOAhos_0786
AMANB6F84_07390
ABRIDFR85_07535
ASULDFR86_06445
AAMBD1866_11765
ACIHHS5_21600
SACDHS1genome_0144
SAZOD1868_01885
CSTYKN1_18710
STEPIC006_1789
SAHSHS7_07230
PAIPAE3045
PISPisl_0443
PCLPcal_0985
PASPars_1793
PYRP186_1474
POGPogu_0338
TNETneu_1677
PYWPYWP30_01805
CMACmaq_0928
TTNTTX_1714
TUZTUZN_1798
VDIVdis_0768
VMOVMUT_1616
VSOVsou_12850
TPETpen_0633
THBN186_04510
TCBTCARB_1929
THFMA03_05950
THELIG193_04075
ASCASAC_1045
ACIASE86_06355
CLGCalag_0530
FFOFFONT_0864
NMRNmar_1795
NIRNSED_09615
NKRNKOR_09545
NIDNPIRD3C_0251
NINNADRNF5_0072
NIWNisw_05030
NCLC5F47_09295
NOXC5F49_09180
NUEC5F50_12615
NIPNsoK4_09320
NCTNMSP_1711
NICDSQ20_10180
CSYCENSYa_1828
NGANgar_c35980
NVNNVIE_020530
NEVNTE_00080
TAANMY3_00623(pcrB)
NFNNFRAN_1692
NCVNCAV_1797
CSUCSUB_C1094
NBVT478_1498
TAHSU86_006215
NIUDSQ19_10505
NDVNDEV_0006
CCAINAS2_1641
KCRKcr_1391
BARCAOA65_2367
BARBAOA66_1442
MARHMia14_0378
FLTSv326_1238
MIYMicr_00713
LOKILokiarch_51250
AGWQT03_C0001G1125
 » show all
Reference
1
  Authors
Zhang, D.-L., Daniels, L. and Poulter, C.D.
  Title
Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction.
  Journal
J Am Chem Soc 112:1264-1265 (1990)
Reference
2  [PMID:8408023]
  Authors
Chen A, Zhang D, Poulter CD
  Title
(S)-geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis.
  Journal
J Biol Chem 268:21701-5 (1993)
  Sequence
Reference
3  [PMID:12801917]
  Authors
Nemoto N, Oshima T, Yamagishi A
  Title
Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum.
  Journal
J Biochem 133:651-7 (2003)
DOI:10.1093/jb/mvg083
  Sequence
[tac:Ta0995]
Reference
4  [PMID:16377641]
  Authors
Payandeh J, Fujihashi M, Gillon W, Pai EF
  Title
The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme.
  Journal
J Biol Chem 281:6070-8 (2006)
DOI:10.1074/jbc.M509377200
  Sequence
[afu:AF_0403]
Reference
5  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.41
IUBMB Enzyme Nomenclature: 2.5.1.41
ExPASy - ENZYME nomenclature database: 2.5.1.41
BRENDA, the Enzyme Database: 2.5.1.41
CAS: 124650-69-7

DBGET integrated database retrieval system