KEGG   ENZYME: 2.5.1.42
Entry
EC 2.5.1.42                 Enzyme                                 
Name
geranylgeranylglycerol-phosphate geranylgeranyltransferase;
geranylgeranyloxyglycerol phosphate geranylgeranyltransferase;
geranylgeranyltransferase II;
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase;
DGGGP synthase;
DGGGPS;
geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranylgeranyl-diphosphate:3-(O-geranylgeranyl)-sn-glycerol 1-phosphate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate [RN:R04520]
Reaction(KEGG)
R04520
Substrate
geranylgeranyl diphosphate [CPD:C00353];
3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04590]
Product
diphosphate [CPD:C00013];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04638]
Comment
This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [2]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 [CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase] to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [3]. Belongs in the UbiA prenyltransferase family [2].
History
EC 2.5.1.42 created 1992, modified 2009
Pathway
ec00564  Glycerophospholipid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K17105  geranylgeranylglycerol-phosphate geranylgeranyltransferase
Genes
PAROCUV01_15945
SHUMSTHU_03260
SVCSTVA_04620
STELSTAQ_38700
PETRQKW49_01505
DORDesor_2061
DMIDesmer_2108
HMOHM1_3117(ubiA)
HCVFTV88_0100
CALKHUE98_07755
MKYIWGMT90018_06960
NTPCRH09_14125
NAHF5544_21415
SVLStrvi_5133
SRCM271_47045
SMALSMALA_0222
SSOII1A49_04550
SAUOBV401_04850
SBROGQF42_07570
SLIAHA039_00410(ubiA)
SANTQR300_39870
PACDEGX94_11605
SENSACE_4647
SACGFDZ84_19505 FDZ84_37265
SACCEYD13_10985
AMYYYIM_15140
PHHAFB00_04200
APRECNX65_21945
AMIAmir_4380
SSYIEKG83_31040
ALOCRK61972
CROSN8J89_18590
MAUMicau_3714
MILML5_4685
MICBMicB006_2813
MICHFJK98_09310
MTEMGCE86_08820
MCHLPVK74_08990
MFEUH1D33_24630
PLABC6361_00375
PLATC6W10_21275
PRYPrubr_63960
RXYRxyl_2757
CYNCyan7425_2123
AMRAM1_D0196(ubiA)
ACAMHRE53_28955
KOVK9N68_33410
LSKJ5X98_09625
CTHEChro_3310
PLPPle7327_1407
RRSRoseRS_3669
LEKhrd7_12650
PBFCFX0092_A2572
PBUL21SP3_01479
PBPSTSP1_01285
ALUSSTSP2_00942
SCORJ3U87_21885
GPHGEMMAAP_12495
RCGN7E81_03590
ATKAUTU_09070
CTECT1291
CLZBIU88_04485
CPHCpha266_1693
CTSCtha_2526
IALIALB_0629(ubiA)
CABYCabys_1573
MJAMJ_0279
MFEMefer_0645
MVUMetvu_1074
MFSMFS40622_0265
MIFMetin_1268
MJHJH146_0231
MESGMLAUSG7_1495
MESAMLASG1_1175
MIGMetig_1016
MMPMMP1677
MMQMmarC5_1730
MMXMmarC6_0995
MMZMmarC7_0950
MMDGYY_09240
MMAKMMKA1_19090
MMAOMMOS7_17900
MMADMMJJ_11550(ctaB)
MAEMaeo_1040
MVNMevan_0977
MVOMvol_1278
MOKMetok_0988
METFCFE53_04045
MTHMTH_1098
MMGMTBMA_c14830
MWOMWSIV6_1492
MTEEMTTB_03140
METCMTCT_0992
METEtca_01055
METZMETMT2_1119
METKFVF72_06080
MTHMFZP57_07135
METJFZP68_03545
MSTMsp_0634
METBAW729_04545(ubiA)
MEISPXD04_06245
MRUmru_1885
MSIMsm_0941
MEBAbm4_0306
MMILsm9_1892
MEYETL18_08915(ubiA)
MOLYLM1_1336
MAROMarbSA_16070 MarbSA_18870
METVK4897_06770
MELMetbo_0516 Metbo_1685
MEWMSWAN_1868
METHMBMB1_1509
MFCBRM9_0738
MFIDSM1535_0692
MCUBMCBB_1754
MSUBBK009_06495
METNBK008_02090
METTCIT01_04030 CIT01_07190
METOCIT02_10465
MEMEHYG87_03390 HYG87_04605
MFEGGCM10025860_00190 GCM10025860_15240 GCM10025860_29200
MFVMfer_0640
MKAMK0953(ubiA)
AFUAF_0404
AFGAFULGI_00004080
APOArcpr_0776
AVEArcve_0344
ASTAsulf_00439
FPLFerp_2021
GACGACE_1576
GAHGAH_00157
PFUPF1963
PFIPFC_08765(ubiA)
PHOPH0027(PH0027)
PABPAB0018(ubiA-like)
PYNPNA2_0551
PYAPYCH_00590
PYSPy04_0089
PYCTQ32_06920(ubiA)
TKOTK1957
TONTON_1950
TGATGAM_1764
TSITSIB_0711
TBATERMP_02000
THEGQS_05375(ubiA)
THATAM4_1485
THMCL1_0718 CL1_1374
TLTOCC_02582(ubiA)
THSTES1_1952
TNUBD01_2040
TEUTEU_04265(ubiA)
TGYX802_01740(ubiA)
THVADU37_CDS07090
TCHCHITON_0105
TPEPA0127_04680(ubiA)
TPIEA7C91_05800
TGGA3K92_03080(ubiA)
TCEA3L02_06675(ubiA)
TBSA3L01_00495(ubiA) A3L01_07425
THHCDI07_00540 CDI07_08145
TSLA3L11_00580 A3L11_04245(ubiA)
TTDA3L14_01860(ubiA)
TPRFA3L09_05275(ubiA)
TRLA3L10_06835 A3L10_10205(ubiA)
TPAFA3L08_03605(ubiA)
THYA3L12_03475(ubiA)
TICFH039_03545 FH039_10620
TCQTIRI35C_0314
THEMFPV09_05575
THEIK1720_06700
PPACPAP_00080(ubiA)
MBAMbar_A0315 Mbar_A1863
MBYMSBRM_0817 MSBRM_2639
MBWMSBRW_0682 MSBRW_2873
MBARMSBR2_1575 MSBR2_2599
MBAKMSBR3_1580 MSBR3_2828
MACMA_0961(ubiA)
MMAMM_2075
MMAZMmTuc01_2144
MMJMSMAS_2610
MMACMSMAC_1809
MVCMSVAZ_0598 MSVAZ_0765
MEKMSKOL_0577 MSKOL_0750
MLSMSLAZ_2513
METMMSMTP_2076 MSMTP_2127 MSMTP_2525
MEFMSWH1_2322
MEQMSWHS_2692
MSJMSSAC_0883
MSZMSSIH_0823
MSWMSSIT_0852
MTHRMSTHT_1331
MTHEMSTHC_1961
MHORMSHOH_2577 MSHOH_3274
MFZAOB57_005810
MBUMbur_1679 Mbur_1782 Mbur_2065
MMETMCMEM_2160
MELOJ7W08_09785 J7W08_10255
MMHMmah_1979
MHAZBHR79_03730 BHR79_03950
MEVMetev_1020
MZHMzhil_0387
MPYMpsy_1283(ubiA) Mpsy_1441(ubiA2)
MZIHWN40_02220 HWN40_08450
MMAVRE476_07985
MSEBRE474_04570
MHZMetho_0338 Metho_1408
MEHFMmiHf6_10950(cyoE_2)
MEESMmiEs2_13550(cyoE_2)
MTPMthe_1142
MCJMCON_0147
MHIMhar_1249
MHUMhun_0625
MRTJKHC33_10320
MLAMlab_0795
MEMMemar_1697
MBGBN140_0748(ubiA1)
MEMAMMAB1_0967
MCHKMchiMG62_18910
MSUMOH143_02710
MRCR6Y96_04990
MPIMpet_0930
MENDL6E24_11615
MEFWF1737_06750
MAQERJ40_10025
MOUOU421_01925
MESBL1S32_05440
MANQL1994_03515
MBNMboo_1843
MFOMetfor_1133
MPLMpal_1338 Mpal_2544
MPDMCP_2782
MEZMtc_2488
RCILRC477(ubiA-1) RCIX497 RCIX579(ubiA-2)
HALVNG_0610G(hhoA)
HSLOE_1921R(ubiA2)
HANRLJ422_02555
HDLHALDL1_07245(ubiA)
HHBHhub_1691
HAGSJT689_03835
HABOJRZ79_02340
HNOLT974_03415
HLULT972_09700
HALHHTSR_1199
HHSRHSR6_1234
HSUHLASF_1077
HSFHLASA_1066
HAHSHSRCO_1295(ubiA2)
SALRFQU85_11795
HALREFA46_007380
HJEHacjB3_11200(ubiA)
HDOMUK72_12440
SALIL593_14740(ubiA)
SAIMK0C01_11575
HARAAArcS_1854(ubiA)
NPHNP_4470A(ubiA2)
NMONmlp_2958(ubiA2)
NHOHWV23_04880
NSALHWV07_04770
HALIBV210_15085
HAADMW046_01590
HWAHQ_1884A(ubiA2)
HWCHqrw_2024(ubiA2)
HVOHVO_1436(ubiA2)
HMEHFX_1501(ubiA)
HGIABY42_06985(ubiA)
HALEG3A49_10340
HLSKU306_12220
HLNSVXHx_1386(ubiA2)
HBOHbor_18050
HLMDV707_09095
HALMFCF25_14035
HLAHlac_2079
HALPDOS48_09840
HALBEKH57_14755
HEZZEO776_11180
HALQHrr1229_012015
HSSJ7656_05140
HSAIHPS36_10375
HAZZKI388_09560
HAEhalTADL_0012
HALGHUG10_06250
HALUHUG12_10165
HMPK6T50_04910
HREK6T36_04720
HRMK6T25_11205
HACBHbl1158_11560
HTUHtur_1016
HSALJMJ58_03840
HAKZJ0X25_12365
NMGNmag_3192(ubiA2)
HXAHalxa_2905 Halxa_3209
NATNJ7G_3597
NPENatpe_2728
NVRFEJ81_12580
NPLFGF80_12355
NAYHYG81_15940
HALYHYG82_20805
HJTDVR14_03585
HLOJ0X27_02455
NGENatgr_0626
HRUHalru_0929
SAWLNGM29_16080
HALVNGM15_07165
NOUNatoc_1065 Natoc_1281
HLRHALLA_10005(ubiA)
HLCCHINAEXTREME17425
NAJB1756_17065
NAGAArcMg_1437
NANAArc1_2159
NARAQQ977_14335
NBGDV706_01495 DV706_15775
NASGCU68_12060
HDABB347_03355
MELUMTLP_04880 MTLP_08250
MEAMMU439_00595
MEAEQEN48_02075
TACTa0996
TVOTVG0751384(TVG0751384)
PTOPTO0182
FACFACI_IFERC01G0303
FAIFAD_1222
CDIVCPM_1186
TARTALC_00273
MAXMMALV_02570
MERMMINT_05970 MMINT_12600
MEARMpt1_c10940
MEUZKRP56_01370
MARCAR505_1587
ABIAboo_0771
ACFAciM339_0295
SMRSmar_1155
SHCShell_1316
IHOIgni_0416
IISEYM_02685
DKADKAM_1012
DFDDesfe_1130
DMUDesmu_0064
TAGTagg_0063
IAGIgag_1473
THGTCELL_0468
HBUHbut_0025
PFMPyrfu_0922
PDLPyrde_0563
PABIPABY_03200
PAREPYJP_15200
STOSTK_14510
SOHD1869_08160
SSOSSO0583(ubiA-2)
SOLSsol_1647
SSOASULA_1675
SSOLSULB_1676
SSOFSULC_1674
SSHIJ5U23_02817
SCASSACC_03940
SAISaci_1565
SACNSacN8_07590
SACRSacRon12I_07600
SACSSUSAZ_07395
SISLS215_1657
SIAM1425_1549
SIMM1627_1664
SIDM164_1546
SIYYG5714_1553
SINYN1551_1283
SIILD85_1756
SIHSiH_1515
SIRSiRe_1424
SICSiL_1427
SULABFU36_03105
SULEGFS03_08810
SULOGFS33_00585
SULLEWF20_09330
MSEMsed_1933
MEMJMJ1HA_2201
MCNMcup_0351
MHKDFR87_08840
MPRUDFR88_08510
MTENGWK48_03165(ubiA)
MJNMjAS7_0233
AHOAhos_1160
AMANB6F84_09885
ABRIDFR85_09510
ASULDFR86_08570
AAMBD1866_00680
ACIHHS5_25560
SACDHS1genome_2384
SAZOD1868_05200
CSTYKN1_26460
STEPIC006_1304
SMETRQ359_000608
SAHSHS7_04590
PAIPAE1784
PISPisl_1733
PCLPcal_0555
PASPars_0740
PYRP186_0096
POGPogu_1603
TNETneu_0749
PYWPYWP30_00799
CMACmaq_0958
TTNTTX_1501(ubiA)
TUZTUZN_2035
VDIVdis_0353
VMOVMUT_1279
TPETpen_0636 Tpen_1449
THBN186_04520 N186_07865
TCBTCARB_0658 TCARB_1931
THELIG193_03900 IG193_08480
ASCASAC_0782
ACIASE86_05850
CLGCalag_0209
FFOFFONT_1134
NUEC5F50_03160
NGANgar_c24630 Ngar_c29690
NVNNVIE_026430
NEVNTE_00860 NTE_01304 NTE_01529
NCVNCAV_1261 NCAV_1471
CSUCSUB_C0346
NDVNDEV_0648
CCAINAS2_0234
KCRKcr_1480
BARBAOA66_0405
MARHMia14_0921
FLTSv326_0940
MIYMicr_01020(ubiA-2)
LOKILokiarch_49020
LOBNEF87_003745
PSYTDSAG12_00789
AGWQT03_C0001G0008 QT03_C0001G0188
 » show all
Reference
1
  Authors
Zhang, D.-L., Daniels, L. and Poulter, C.D.
  Title
Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction.
  Journal
J Am Chem Soc 112:1264-1265 (1990)
Reference
2  [PMID:15356000]
  Authors
Hemmi H, Shibuya K, Takahashi Y, Nakayama T, Nishino T
  Title
(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids.
  Journal
J Biol Chem 279:50197-203 (2004)
DOI:10.1074/jbc.M409207200
  Sequence
[sso:SSO0583]
Reference
3  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.42
IUBMB Enzyme Nomenclature: 2.5.1.42
ExPASy - ENZYME nomenclature database: 2.5.1.42
BRENDA, the Enzyme Database: 2.5.1.42
CAS: 124650-68-6

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