KEGG   ENZYME: 2.5.1.46
Entry
EC 2.5.1.46                 Enzyme                                 
Name
deoxyhypusine synthase;
spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
[eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming)
Reaction(IUBMB)
[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine (overall reaction) [RN:R05329];
(1a) spermidine + NAD+ = dehydrospermidine + NADH [RN:R07477];
(1b) dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine [RN:R07479];
(1c) N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine [RN:R07480];
(1d) N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+ [RN:R07478]
Reaction(KEGG)
Substrate
[eIF5A-precursor]-lysine [CPD:C07281];
spermidine [CPD:C00315];
NAD+ [CPD:C00003];
dehydrospermidine [CPD:C15853];
[enzyme]-lysine [CPD:C07281];
N-(4-aminobutylidene)-[enzyme]-lysine [CPD:C15854];
N-(4-aminobutylidene)-[eIF5A-precursor]-lysine [CPD:C15854];
NADH [CPD:C00004];
H+ [CPD:C00080]
Product
[eIF5A-precursor]-deoxyhypusine [CPD:C07282];
propane-1,3-diamine [CPD:C00986];
dehydrospermidine [CPD:C15853];
NADH [CPD:C00004];
N-(4-aminobutylidene)-[enzyme]-lysine [CPD:C15854];
N-(4-aminobutylidene)-[eIF5A-precursor]-lysine [CPD:C15854];
[enzyme]-lysine [CPD:C07281];
NAD+ [CPD:C00003]
Comment
The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. This enzyme catalyses the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor. The reaction occurs in four steps: NAD+-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme; 1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d). Hence the overall reaction is transfer of a 4-aminobutyl group. For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase.
History
EC 2.5.1.46 provisional version created 1999 as EC 1.1.1.249 deleted 1999, revised and reinstated 2001 as EC 2.5.1.46
Orthology
K00809  deoxyhypusine synthase
Genes
HSA1725(DHPS)
PTR455746(DHPS)
PPS100977998(DHPS)
GGO101136731(DHPS)
PON100443233(DHPS)
NLE100597140(DHPS)
MCC716213(DHPS)
MCF102138960(DHPS)
CSAB103233979(DHPS)
CATY105601520(DHPS)
PANU100999800(DHPS)
TGE112612222(DHPS)
RRO104661101(DHPS)
RBB108539610(DHPS)
TFN117075669(DHPS)
PTEH111523812(DHPS)
CJC100396022(DHPS)
SBQ101050408(DHPS)
CSYR103250455(DHPS)
MMUR105885521(DHPS)
LCAT123637126(DHPS)
OGA100947694(DHPS)
MMU330817(Dhps)
MCAL110299744(Dhps)
MPAH110337223(Dhps)
RNO288923(Dhps)
MCOC116069750(Dhps)
MUN110545818(Dhps)
CGE100755665(Dhps)
MAUA101840335(Dhps)
PLEU114687647(Dhps)
MORG121447000(Dhps)
AAMP119801686(Dhps)
NGI103751894(Dhps)
HGL101708097(Dhps)
CPOC100730909(Dhps)
CCAN109681277(Dhps)
DORD105999268(Dhps)
DSP122100240(Dhps)
NCAR124968085
OCU100352059(DHPS)
OPI101524987(DHPS)
TUP102485533(DHPS)
CFA476702(DHPS)
CLUD112666565(DHPS)
VVP112908051(DHPS)
VLG121495890(DHPS)
AML100474462(DHPS)
UMR103682157(DHPS)
UAH113247138(DHPS)
UAR123777693(DHPS)
ELK111162428
LLV125084262
MPUF101684402(DHPS)
ORO101368037(DHPS)
EJU114197704(DHPS)
ZCA113916976(DHPS)
MLX118005793(DHPS)
FCA101083659(DHPS)
PYU121014029(DHPS)
PBG122486922(DHPS)
PTG102959277(DHPS)
PPAD109254040(DHPS)
AJU106985534(DHPS)
HHV120245302(DHPS)
BTA444988(DHPS)
BOM102270034(DHPS)
BIU109561548(DHPS)
BBUB102397116(DHPS)
CHX102171505(DHPS)
OAS101107277(DHPS)
ODA120864043(DHPS)
CCAD122440487(DHPS)
SSC100519413(DHPS)
CFR102505713(DHPS)
CBAI105068343(DHPS)
CDK105104065(DHPS)
VPC102544410(DHPS)
BACU103000331(DHPS)
LVE103087338(DHPS)
OOR101284267(DHPS)
DLE111166583(DHPS)
PCAD102989701(DHPS)
PSIU116751308(DHPS)
ECB100063550(DHPS)
EPZ103542773(DHPS)
EAI106826924(DHPS)
MYB102255457(DHPS)
MYD102755857(DHPS)
MMYO118652664(DHPS)
MLF102432914(DHPS)
MNA107541538(DHPS)
PKL118710401(DHPS)
HAI109394256(DHPS)
DRO112301507(DHPS)
SHON118984135(DHPS)
AJM119049642(DHPS)
PDIC114503931(DHPS)
PHAS123828400(DHPS)
MMF118615190(DHPS)
RFQ117038026(DHPS)
PALE102898526(DHPS)
PGIG120618544(DHPS)
PVP105307157(DHPS)
RAY107519404(DHPS)
MJV108388720(DHPS)
TOD119240991(DHPS)
SARA101548068(DHPS)
LAV100656596(DHPS)
TMU101343153
DNM101423720
MDO100010290(DHPS)
GAS123242481(DHPS)
SHR100920525(DHPS)
PCW110214159(DHPS)
OAA103170595(DHPS)
GGA107057627(DHPS)
CJO107307164(DHPS)
LSR110481139(DHPS)
SCAN103825301(DHPS)
PMOA120505352(DHPS)
OTC121339163(DHPS)
PRUF121363739(DHPS)
PHI102101132(DHPS)
CCW120412244(DHPS)
CBRC103624297(DHPS)
ETL114071216(DHPS)
FPG106112398(DHPS)
ACHC115337961(DHPS)
LDI104342196(DHPS)
AAM106486625(DHPS)
AROW112962289(DHPS)
ASN102377261(DHPS)
AMJ102562780(DHPS)
PSS102453700(DHPS)
CMY102935067(DHPS)
CPIC101953196(DHPS)
TST117888743(DHPS)
CABI116817739(DHPS)
MRV120391104(DHPS)
ACS100553765(dhps)
PVT110077395(DHPS)
SUND121926296(DHPS)
PBI103053909(DHPS)
PMUR107299753
TSR106546538(DHPS)
PGUT117665391(DHPS)
VKO123033669(DHPS)
PMUA114596556(DHPS)
ZVI118078946 118085565(DHPS)
GJA107120598(DHPS)
STOW125432078(DHPS)
XLA108711712(dhps.L) 431985(dhps.S)
XTR394501(dhps)
NPR108794974(DHPS)
RTEM120933371(DHPS)
BBUF120986463(DHPS)
BGAR122927258(DHPS)
DRE406329(dhps)
SRX107718601 107753765(dhps)
SANH107653447 107661880
SGH107563249 107565620(dhps)
CCAR109047440
CAUA113050933(dhps)
PPRM120473101(dhps)
MAMB125266780(dhps)
IPU100528141(dhps)
PHYP113528412(dhps)
SMEO124396331(dhps)
TFD113639678(dhps)
AMEX103031482(dhps)
EEE113575196(dhps)
TRU101063502 101074180
TNGGSTEN00036416G001
LCO104934332(dhps)
NCC104942955(dhps) 104945527
CGOB115011786 115012790(dhps)
ELY117263054 117267991(dhps) 117267993 117268058
EFO125879031 125879654 125879718 125904585
PLEP121956579 121956974
SLUC116042048 116042049 116059627(dhps)
ECRA117938538 117958573(dhps)
PFLV114549871 114569747(dhps)
GAT120827501(dhps) 120827527
PPUG119221111(dhps)
MSAM119888279(dhps) 119888323 119896725
CUD121503318(dhps) 121503951 121529619 121529620
ALAT119013497(dhps) 119013591 119013592
MZE101473440 112432601
ONL100711407(dhps)
OAU116315651(dhps)
OLA101171006(dhps)
OML112138938 112146996
XMA102227615(dhps)
XCO114159822(dhps)
XHE116736033(dhps)
PRET103469305(dhps)
PFOR103145471(dhps)
PLAI106962238(dhps)
PMEI106930938(dhps)
GAF122822428(dhps)
CVG107091146(dhps)
CTUL119777665(dhps)
GMU124862322(dhps) 124864653
NFU107376607(dhps)
KMR108239332(dhps)
ALIM106520408(dhps)
NWH119420949(dhps)
AOCE111568935(dhps)
MCEP124997740(dhps)
CSEM103392943(dhps) 103392944
POV109639383 109639447(dhps)
SSEN122784723(dhps)
HHIP117765878 117766092 117766183 117766646(dhps)
HSP118122779 118122835 118123550(dhps)
LCF108880452 108880462 108880495
SDU111227129(dhps)
SLAL111645815(dhps)
XGL120805030(dhps)
HCQ109527046(dhps)
BPEC110171128 110171140 110171805
MALB109969539(dhps)
BSPL114859993(dhps)
SASA100196722(dhys) 106592861
OTW112226258
OMY110486929 110537861
OGO123999107 124018875
SALP112075224(dhps)
SNH120041234 120042043
CCLU121551446 121568771
ELS105012887 105012888
SFM108926075(dhps)
PKI111843297(dhps)
AANG118215996(dhps)
LOC102690878(dhps)
PSPA121304536(dhps)
LCM102358518(DHPS)
CMK103187570(dhps)
RTP109925040(dhps)
BFO118408104 118411007 118420662
BBEL109468936 109482520
CIN100187438
SCLV120345011
SPU579530 582547 584309 591689 763984
APLC110981409
SKO100373608
DMEDmel_CG8005(CG8005)
DER6544397
DSE6604835
DSIDsimw501_GD14061(Dsim_GD14061)
DYADyak_GE20716
DAN6507728
DSR110183631
DPO6900945
DPE6599480
DMN108153296
DWI6639496
DGR6557928
DMODmoj_GI16771
DAZ108614000
DNV108652063
DHE111592836
DVI6622442
CCAT101459523
BOD106621098
MDE101900686
SCAC106089838
LCQ111690007
HIS119649304
AGAAgaP_AGAP006531
ACOZ120952342
AARA120897317
ASTE118509911
AAG5574567
AALB109403047 109404272 115270344
CQUCpipJ_CPIJ002993
CPII120424499
CNS116346883
BCOO119075088
AME100578266
ACER107993774
ALAB122719316
BIM100745513
BBIF117205497
BVK117238720
BVAN117161549
BTER100646643
BPYO122568310
CCAL108629867
OBB114878900
MGEN117218467
NMEA116428789
CGIG122399280
SOC105201636
MPHA105841008
AEC105144800
ACEP105624652
PBAR105422536
VEM105559641
HST105186729
DQU106748959
CFO105259058
FEX115244472
LHU105678597
PGC109862400
OBO105276666
PCF106788380
PFUC122526474
VPS122635154
NVI100114756
CSOL105367451
TPRE106648512
MDL103572297
CGLO123267464
FAS105270845
DAM107041313
AGIF122851227
LHT122510004
CCIN107267578
TCA659163
DPA109546818
SOY115878168
ATD109601652
CSET123317523
AGB108916336
LDC111507781
NVL108557196
APLN108735531
PPYR116173863 116174138
OTU111419688
BMOR100190959(Dhs)
BMAN114241054
MSEX115450514
DPLKGM_205506
BANY112058117
PMAC106708105
PPOT106108901
PXU106115079 106119883 106120501 106125675
PRAP111002931
ZCE119836059
HAW110377856
HZE124643103
TNL113505198
SLIU111357978
OFU114361487
PXY105385059
API100160249
DNX107172072
AGS114131298 114131365
RMD113548303
BTAB109031358
DCI103518598
CLEC106665126
HHAL106689684
NLU111045731
PHUPhum_PHUM115060
FOC113209691
TPAL117640635
ZNE110839256
CSEC111865614
FCD110851734
DPXDAPPUDRAFT_114373 DAPPUDRAFT_228087
DMK116926662
PVM113821642
PJA122250888
HAME121875358
PCLA123757289
PTRU123503446
HAZT108666446
EAF111716124
LSM121122562
PPOI119099998 119100007 119100009
ISCIscW_ISCW022659
DSV119435349 119436420
RSAN119401771
RMP119187772
VDE111247767
VJA111260156
TUT107368689
DPTE113788682 113790387 113794502
DFR124492637
CSCU111614541
PTEP107454335
SDM118180497
CELCELE_Y17G7B.4(dhps-1)
CBRCBG_21024(Cbr-dhps-1)
BMYBM_BM14681(Bma-dhps-1)
LOALOAG_12575
NAINECAME_13448
TSPTsp_06824
HROHELRODRAFT_184989
LGILOTGIDRAFT_222351
PCAN112575140
BGT106054684
GAE121383981
HRF124114391
HRJ124256903
CRG105339234
MYI110453567
PMAX117333104
MMER123549416
OBI106874794
OSN115222894
LAK106160869
SMMSmp_065120
SHXMS3_0017039
OVIT265_13117
NVE5506016
EPA110250271
ATEN116289206 116304187
ADF107332977
AMIL114961128
PDAM113676972
SPIS111339446
DGT114518865
XEN124438823
TADTRIADDRAFT_20912
AQU100640245
ATHAT5G05920(DHS)
ALY9307259
CRB17881605
CSAT104708521 104734595 104768784
EUSEUTSA_v10013870mg
BRP103846938 103850601
BNA106419026 106432222
BOE106315513 106323134
RSZ108817722
THJ104816571 104826863
CPAP110819197
CIT102616285
CICCICLE_v10008698mg
PVY116110285 116110289 116119694 116130503
MINC123195044 123200017 123206881 123220554
TCC18585734
GRA105777942 105777943
GHI107896250 107896253 107915737 107915738
GAB108489297 108489298
DZI111310078
EGR104436515
GMX100305453
GSJ114418892
PVUPHAVU_004G172700g
VRA106764595
VAR108345960
VUN114162857 114175909 114181781
CCAJ109818884
APRC113867431
CAM101496105 101505901
LJALj1g3v3646510.1(Lj1g3v3646510.1) Lj1g3v3646510.2(Lj1g3v3646510.2)
ADU107490155
AIP107644469
AHF112751318 112802036
LANG109351093
FVE101308495
RCN112186377
PPER18769561
PMUM103340771 107880259
PAVI110750964
PDUL117634334
MDM103406800 103425002
PXB103943952
ZJU107424009
MNT21409860
CSV101220126
CMO103501495 103503305
BHJ120067306 120092780
MCHA111011849
CMAX111487606 111488986
CMOS111431036 111445229
CPEP111796682 111808129
RCU8271139
JCU105650962
HBR110671250
MESC110600979
POP7462832
PEU105122879
PALZ118054698
JRE109000289 109009972
QSU111992409 112001225 112010780
QLO115976163
TWL120010436 120014608
VVI100247561
VRI117904856
SLY101249422 543666(DHS)
SPEN107008871 107010726
SOT102601936 102602266 102602600
SSTN125848425
CANN107859602
NTA107783753 107796463(DHS1)
NSY104231513
NTO104090458
NAU109231043
INI109162634 109162871 109186632
ITR115996247 116014441
SIND105173586
OEU111400184 111400185 111400190 111407788
EGT105952866
SSPL121796347 121800069
HAN110879054 110934209 110936893
ECAD122586082 122593146
LSV111918366 111918369
CCAV112506980
DCR108213029
CSIN114321468
BVG104896269
SOE110779300 110795491 110801832
CQI110686043 110716609 110716797 110721127
NNU104604419
MING122060659
TSS122641995 122657540
PSOM113342681 113347948 113349422
NCOL116248473
OSA4334056
DOSAOs03t0740600-01(Os03g0740600) Os09t0421100-00(Os09g0421100)
OBR102708647 102711517
BDI100823824
ATS109756786 109782584 109782592
TDC119266755 119274522 119303076 119306202 119311753
TAES100415871 123059922 123068379 123076923 123104957 123104959 123116944 123122768 123122769
TUA125510552 125510553
SBI8070931 8085965
ZMA100191910 100282705
SITA101756334
SVS117840761
PVIR120649822 120691317 120691900
PHAI112878140
PDA103721451
EGU105039714
MUS103987529
DCT110107690 110108276
PEQ110028744 110031045
AOF109835081 109835082
ATR18443737
SMOSELMODRAFT_235300 SELMODRAFT_430970
PPP112274284 112285162
CRECHLRE_01g018950v5 CHLRE_08g369800v5
VCNVOLCADRAFT_105354
CSLCOCSUDRAFT_11840
CVRCHLNCDRAFT_19955
APROF751_4451
OLUOSTLU_35514
OTAOT_ostta07g03635 OT_ostta07g03700
BPGBathy04g03920
MISMICPUN_83166
MPPMICPUCDRAFT_28267
CMECYME_CMA098C
GSLGasu_63510
CCPCHC_T00005094001
SCEYHR068W(DYS1)
SEUBDI49_2471
SPAOSPAR_H01090
AGOAGOS_AAL036W
ERCEcym_3222
KLAKLLA0_E12695g
KMXKLMA_70371(DYS1)
LTHKLTH0H14652g
VPOKpol_1005p14
ZROZYRO0C14366g
CGRCAGL0H07249g
NCSNCAS_0H01680(NCAS0H01680)
NDINDAI_0C02010(NDAI0C02010)
TPFTPHA_0D02020(TPHA0D02020)
TBLTBLA_0C03540(TBLA0C03540)
TDLTDEL_0E02840(TDEL0E02840)
TGBHG536_0E02970
KAFKAFR_0K02250(KAFR0K02250)
KNGKNAG_0B01990(KNAG0B01990)
ZMKHG535_0C03180
PPAPAS_chr1-3_0211
DHADEHA2G02376g
PICPICST_88952
PGUPGUG_00666
SPAASPAPADRAFT_62037
LELLELG_02746
CALCAALFM_C302180CA(CaO19.1626)
CTPCTRG_02401
COTCORT_0C04490
CDUCD36_82160
CTENCANTEDRAFT_114628
YLIYALI0B00726g
CLUCLUG_02668
CLUSA9F13_07g01892
CAURCJI97_002691
SLBAWJ20_4378(DYS1)
PKZC5L36_0E00710
BNNFOA43_004101(DYS1)
BBRXBRETT_002848(DYS1)
OPAHPODL_02875
SLUDSCDLUD_004654
NCRNCU05418(dys-1)
NTENEUTE1DRAFT65655(NEUTE1DRAFT_65655)
SMPSMAC_04154
PANPODANSg6799
TTTTHITE_2124621
MTMMYCTH_2312865
CTHRCTHT_0015690
MGRMGG_09173
PPEIPpBr36_07500
TMNUCRPA7_7425
SSCKSPSK_00293
FGRFGSG_00323
FPUFPSE_07687
FVRFVEG_00771
FOXFOXG_00745
NHENECHADRAFT_32075
TRETRIREDRAFT_54448(dhyS)
TRRM419DRAFT_70115
MAWMAC_06555
MAJMAA_07630
CMTCCM_04765
PLJVFPFJ_07025
VALVDBG_05377
VDAVDAG_07027
CFJCFIO01_07239
CHIGCH63R_10268
SAPOSAPIO_CDS6674
ELAUCREL1_894
PFYPFICI_09276
SSLSS1G_02065
BFUBCIN_07g02080(Bcdys1)
MBEMBM_05481
PSCOLY89DRAFT_598859
GLZGLAREA_03936
ANIAN8075.2
AFMAFUA_5G01740
ACTACLA_003580
NFINFIA_040360
AORAO090003001350
ANGANI_1_190144(An16g01480)
AFVAFLA_000324
ALUCAKAW2_70116S(DYS1)
ACHEACHE_51121A(DYS1)
APUUAPUU_41484S(DYS1)
PCSPc21g14310
PDPPDIP_47640
TMFPMAA_039450
TRGTRUGW13939_02597
CIMCIMG_06385
CPWCPC735_028910
UREUREG_04017
PBLPAAG_01690
PBNPADG_00089
ABEARB_00858
TVETRV_07899
AJEHCAG_04893 HCAG_08656
BGHBDBG_02658
PTEPTT_18821
BZECOCCADRAFT_83972
BSCCOCSADRAFT_111773
BORCOCMIDRAFT_3802
AALTCC77DRAFT_134670
ZTRMYCGRDRAFT_45907
PFJMYCFIDRAFT_43324
FFUCLAFUR5_06950
BCOMBAUCODRAFT_441265
NPAUCRNP2_1740
TMLGSTUM_00005312001
SPOSPBC1271.04c
CNECNJ02480
CNBCNBJ0980
CNGCNAG_04822
CGICGB_I3380C
TMSTREMEDRAFT_67569
TASAA1Q1_07185
TVSTRAVEDRAFT_162595
DSQDICSQDRAFT_160655
PCOPHACADRAFT_249359
SHSSTEHIDRAFT_76424
HIRHETIRDRAFT_311840
PSQPUNSTDRAFT_100533
ADLAURDEDRAFT_79941
FMEFOMMEDRAFT_141672
GTRGLOTRDRAFT_136142
LBCLACBIDRAFT_246018
MRRMoror_17463
MOREE1B28_004387
CCICC1G_00276
SCMSCHCO_02622993(SCHCODRAFT_02622993)
ABPAGABI1DRAFT113512(AGABI1DRAFT_113512)
ABVAGABI2DRAFT191839(AGABI2DRAFT_191839)
PCUBJR316_0005154
CPUTCONPUDRAFT_54699
SLASERLADRAFT_367471
WSEWALSEDRAFT_61466
WICJ056_001649
UMAUMAG_00071
PFPPFL1_00478
MGLMGL_0173
MRTMRET_1145
PGRPGTG_12673
MLRMELLADRAFT_35929
ECUECU09_0910
EINEint_090870
EHEEHEL_090880
EROEROM_091310
NCENCER_100851
MBRMONBRDRAFT_15470
SREPTSG_09846
DDIDDB_G0285725(dhps)
DPPDICPUDRAFT_148566 DICPUDRAFT_75703
DFADFA_09448(dhps)
EHIEHI_006030(83.t00016) EHI_098350(77.t00015)
EDIEDI_161760 EDI_198820
EIVEIN_026590 EIN_175720
ACANACA1_094910
PFAPF3D7_1412600
PFDPFDG_02674
PFHPFHG_05096
PREIPRSY57_1411900
PGABPGSY75_1412600
PYOPY17X_1032400
PCBPCHAS_103080(PC301479.00.0)
PBEPBANKA_1030000
PVVPVVCY_1003540
PKNPKNH_1345700
PVXPVX_085825
PCYPCYB_134410
TANTA13570
TPVTP02_0058
TOTTOT_020000038
BEQBEWA_017830
BBOBBOV_III010890(17.m07937)
BMICBMR1_01G02065
BBIGBBBOND_0101110
CPVcgd2_3930
CHOChro.20420
TGOTGME49_235620
TETTTHERM_00819550
PTMGSPATT00037461001 GSPATT00039607001
PTIPHATRDRAFT_46999
FCYFRACYDRAFT_226218
TPSTHAPSDRAFT_268986(dhs1)
PIFPITG_00661
PSOJPHYSODRAFT_509984
SPARSPRG_01451
EHXEMIHUDRAFT_315150 EMIHUDRAFT_420637
GTTGUITHDRAFT_72253
TBRTB927.1.870 Tb10.70.4900
TBGTbgDal_I280 TbgDal_X3430
TCR504119.29 511421.60
LMALMJF_20_0250 LMJF_34_0330(DHS34)
LIFLINJ_20_0270(DHS20) LINJ_34_0350(DHS34)
LDOLDBPK_200270 LDBPK_340350
LMILMXM_20_0250 LMXM_33_0330
LBZLBRM_20_0300 LBRM_20_4450
LPANLPMP_200340 LPMP_204470
NGRNAEGRDRAFT_56201
TVATVAG_359990
GLAGL50803_0015535
CBUCBU_0721
CBSCOXBURSA331_A0839
CBDCBUD_0732
CBGCbuG_1281
CBCCbuK_1537
CEYCleRT_04830 CleRT_06270
CEAZ664_01055
CENDEGQ50_01045
CENOCEAn_00640
RVIRVIR1_13600
ALGAQULUS_00160
ASIPAQUSIP_23830
CEQB1F76_01045
THIPN838_13025
WOCBA177_16805
ENWMJO57_13090
DFLDFE_2296
DSDGD606_07335
DMADMR_24290
DCBC3Y92_09330
DGGDGI_1717
DMSE8L03_01980
DSXGD604_05110
DRTDret_1312
DOVDSCO28_26530
DWDDSCW_22130
ADEAdeh_3097
ACPA2cp1_3292
AFWAnae109_1276
ANKAnaeK_3197
MXAMXAN_1678 MXAN_2140
MSDMYSTI_00068 MYSTI_03148
MYMA176_005278
MFBMFUL124B02_10200
CCXCOCOR_01828(dys) COCOR_05301
MFULILAB_00280 LILAB_21405
MMASMYMAC_001805 MYMAC_002703
SURSTAUR_1129 STAUR_3493
AGEAA314_00352 AA314_06915
AVMJQX13_15235 JQX13_49045
MBDMEBOL_000403 MEBOL_004472
CFUSCYFUS_003266 CYFUS_007989
VINAKJ08_0486 AKJ08_3547
SCLsce5982 sce7004(dys)
SCUSCE1572_22810 SCE1572_35550
CCROCMC5_011820 CMC5_059810(dhs)
PAUUE8A73_025545 E8A73_028940
SAMYDB32_008675
LLUAKJ09_02127 AKJ09_03198
MRMA7982_06053 A7982_13354
SATSYN_02461
DAODesac_0724
SFUSfum_3135
BBAEFRD01_10125
AOLS58_72380
CCRCC_0359
CCSCCNA_00364
CAKCaul_0257
CSECseg_3779
CHQAQ619_15495
CMBCSW64_20130
CFHC1707_06835
CAUFCSW63_20745
CAULKCG34_21725
PZUPHZ_c3320
PHBHYN04_01430
BSBBresu_3252
BNEDA69_13875
BRGA4249_14930
BRLBZG35_16085
BVCCEP68_10200
BDMEQG53_06195
BRFE4M01_04360
BREVE7T10_00415
BMEDGYM46_10020
BVYNCTC9239_02849
BNDKWG56_12725
BPONIFE19_14510
BVITJIP62_12235
BALBM8231_15660
AEXAstex_0281
TSVDSM104635_03323
TMDKUV46_13120
MMRMmar10_0376
GAKX907_0967
HYTHXX25_09295
CBOTATE48_13610
HBCAEM38_00465
ZMOZMO1019
ZMNZa10_0286
ZMMZmob_0291
ZMBZZ6_0291
ZMIZCP4_0299
ZMCA265_00298
ZMRA254_00298
ZMPZymop_0259
SWISwit_4663
SPHDHY78_01820
RDICMV14_15235
SPHMG432_03450
STAXMC45_03740
SPHITS85_12070
SSANNX02_16895
SNJA7E77_12325
SMYBJP26_17315
SPANAWL63_16565
SPLMBXU08_01720
SPLKAV944_13775
SPKCKC8_01335
SPHCCVN68_07300
SPHFDM480_00870
SPHAD3Y57_18495
SPAUDRN02_006620
SLUTH9L13_07855
SRHIH9L12_04865
SDHH9L15_10675
SSEDH9L14_06415
SPAPH3Z74_07300
SXAFMM02_00535
SPAIFPZ24_09585
SPIIG7077_00400
SSING7078_06520
SSAUH8M03_03345
SARIH5J25_05925
SCHYGVO57_08210
SPHJBSL82_06390
SPZRG5C33_13415
HGNE6W36_02665
SMICSmB9_25960
SPHSETR14_20260
SANDH3309_11250
POQKZX46_15955
ANHA6F65_01926
ERYCP97_08915
EGNBMF35_a2134
PUBSAR11_0205(dys2)
PELSAR11G3_00315
PEGE5R92_05295
APMHIMB5_00000520
SNEANBZ79_14820
BBABd2349(dys)
BBATBdt_2302(dys)
BBWBDW_08730
BBACEP01_07995
BDQCIK05_10010
BDCDOE51_11930
BDZDOM22_12620
BEXA11Q_1017
HAXBALOs_0932
BSTOC0V70_11085
CYACYA_2657
CYBCYB_2420
SYNESyn6312_3306
SYNPSyn7502_01970
TVNNIES2134_111020
TELtlr0818
THNNK55_03660 NK55_10600
THECFFX45_01920
LETO77CONTIG1_04289
KOVK9N68_11705(speY)
LSCKIK02_20705
LSKJ5X98_08605
PSERABRG53_3508
THEUHPC62_20520
GLPGlo7428_0896
CYNCyan7425_4976
OXYHCG48_18270
GEIGEI7407_1060
OACOscil6304_5784
MPROBJP34_01695 BJP34_29575
CEPCri9333_3886
GVIglr1045
GLJGKIL_1895
GMLISF26_11000
ANAalr3804
NPUNpun_F1484
NOSNos7107_0706
NOPNos7524_4516
NONNOS3756_47350
NFLCOO91_00427
NOECLI64_03350
NSHGXM_05989
NEDHUN01_02560 HUN01_03875
AVAAva_1896 Ava_B0166
NAZAazo_1485
ANBANA_C20336
ACYAnacy_4682
AWAAA650_19490
ANNEH233_15925 EH233_26610
CSGCylst_0842
RSINB6N60_03640
CALOCal7507_5152
CALHIJ00_03960
CALNNIES2098_40530
NSPBMF81_01355
NSPHBDGGKGIB_02845
DOUBMF77_02902
DFSHGD76_21740
CCURIAR63_14015
CRKL3I90_14830(speY)
AFLOHEQ12_20390
TOQHCG51_15245
NCNBZZ01_00720
CTHEChro_1131
RRSRoseRS_1218
RCARcas_3399
CAUCaur_0545
CHLChy400_0585
CAGCagg_3460
HAUHaur_3346
CAPCLDAP_14210
PBFCFX0092_A2082
KBSEPA93_27910 EPA93_43155
TRATrad_0088
TTHTT_C1205
TTJTTHA1570(TTHA1570)
TTSThthe16_1588
TTLTtJL18_0473
TSCTSC_c22010
THCTCCBUS3UF1_5060
TOSTheos_0631
TAQTO73_0420
TPARAV541_02910
TBCA0O31_01500
TANTKNN15_02575
MRBMrub_2079
MREK649_12140
MSVMesil_2448
MTAIMtai_v1c09080
PNLPNK_1142(dys)
PUVPUV_04440
SNGSNE_A06130
OTEOter_1628
OBGVerru16b_02296
VBHCMV30_05605
OLEK0B96_12910
OBTOPIT5_07415
XIIAMD24_00377
MINMinf_2205(dys1)
MKCkam1_2015
MEAPMTHMO_0094
VBAIMCC26134_14030
RBARB1381(dys1)
PSLPsta_0402
PIRVN12_16310
RULUC8_15860
RMLFF011L_37110
MFFMFFC18_44940
ROLCA51_41060
AHELQ31a_00040
LCREPla8534_15720
AAGGETAA8_07500
BVOPan97_08350
RLCK227x_51770
TTFTHTE_3185
PBSPlabr_2627
PLSVT03_26200
PLHVT85_11100
FMRFuma_04783
GMRGmarT_28430
GIMF1728_00665
GPNPan110_27340
MRIMal4_14290
SDYNMal52_03090
PLONPla110_33270
GESVT84_22240 VT84_27525
GOGC1280_20940
GMSSOIL9_22480 SOIL9_46680
TIMGMBLW1_29720
LRSPX52LOC_04925
FTJFTUN_2521 FTUN_8314
ULIETAA1_30520
TSPHKIH39_14580
IPAIsop_1096
SACISinac_2869 Sinac_4928
PBORBSF38_03206
AGVOJF2_56920
KSTKSMBR1_3542(dys-1)
BROCIPI25_02725 IPI25_06630
BPITBPIT_07140 BPIT_08680
JETL3J17_02530(speY)
PHMPSMK_02180
MCADPan265_17970
HBSIPV69_01545
ABAAcid345_1942
ACAACP_1729
ACMAciX9_1051
GMAAciX8_1078
GRWFTO74_15525
GRBGOB94_04420
TSAAciPR4_0657
TRSTerro_3836
TALBFTW19_11440
ABASACPOL_0481
EDAGWR55_06790
ADINH7849_04790
SUSAcid_1177
PFERIRI77_35520
CTMCabther_A1572 Cabther_A2074
CVLJ8C06_01350 J8C06_10280
CHLOJ8C02_07760 J8C02_10215
ABACLuPra_03100
EMIEmin_1464
GAUGAU_2131
GPHGEMMAAP_11120
GGRHKW67_03475
GBAJ421_3735
BUYD8S85_13975
BVIRI6J59_02100
ALDGFH31_11265
AITAI2BBH_00700
TTZFHG85_12430
BACCBRDCF_p1197
MBASALGA_4366
RBARAWN76_008520
CPICpin_0490
CBAECOR50_03650
CHITFW415_02790
CHIHGWR21_18080
COYHF329_26720
CFILMYF79_02520
CHFKTO58_25390
NKONiako_6577
NSONIASO_17855
NIAA8C56_19755
FLASY85_12370
FGGFSB75_17715
ARBA9P82_04015
ARKD6B99_04505
AGIFSB73_18330
ARACE0W69_004315
ATEEK9M52_16965
FLNFLA_5889
PSEGD3H65_21770
PGINFRZ67_16205
PGOFSB84_05615
FLSGLV81_17180
LACSH4075_00530
FEIK9M53_15180
FLPLK994_05615
FLCKJS93_17305
FLVKJS94_13895
PHEPhep_0287
PEPAQ505_24620
PCMAY601_3841
PSTYBFS30_11435
PGSCPT03_20185
PEJFYC62_15795
PEKFFJ24_018385
PROEH9L23_19125
PEXIZT61_15560
PMUOLOK61_15350
PSNPedsa_2629
SHGSph21_1547
SHTKO02_03575
SPHNBV902_05370
SMIZ4412673_00593
SPSCE2P86_03760 E2P86_05195 E2P86_15575
SPHZE3D81_03045
SPHEGFH32_02690
SPDRG6053_04170
SDJNCTC13534_00641
STHANCTC11429_00794
SSPII6J01_11700
SMUII6J00_20805
SSIYJVX97_27785
SCNSolca_3370
MUPA0256_08315
MUCMuYL_0599
MGOTMgSA37_00158
MUHHYN43_027320
MGINFRZ54_24200
MGKFSB76_08985
MRUBDEO27_029505
MGOSDIU38_030785
MMABHQ865_14635
MGIKGO620_011130
MDJLLH06_03075
AGDFRZ59_02330
OLIFKG96_04680
SBXCA265_17855
CMRCycma_3726
CAMUCA2015_3659
BBDBelba_3057
EVIEchvi_3296
ESTDN752_01685
ECHIFKX85_17090
EMAIKZP23_18680
ALMAO498_10680
MDAIPZ59_15820
CHUCHU_1939
RHOZGXP67_18720
HSWHsw_2920
HYMN008_14665
HYDPK28_12825
HYEAM218_03620
HYGAUC43_11925
HYPA0257_00975
HYZAXW84_14370
HNVDDQ68_08805
HYHD3Y59_01630
HYJFHG12_15025
HQIH9L05_13340
HRSHER32_04545
HBNGUY19_20510
HTSHMJ29_00470
HMTMTP16_21365
HTBMTX78_15890
PKOPKOR_17265
PACTCA264_04820
RUFTH63_05585
RTIDC20_16440
RUDTH61_13370
NIBGU926_00855
ADDHUW48_11015
ASWUHUW51_18035
MTTFtrac_0148
FLMMY04_4887
FYAKMW28_26515
CHKD4L85_32265
FUVJR347_09415
GFOGFO_3623
GRLLPB144_09025
GFLGRFL_1787
GRSC7S20_03905
FPSFP1709
FPCFPSM_01097
FPYFPG101_05375
FPOFPG3_09500
FPQIB65_08505
FPVIA03_08285
FPWIA04_08220
FPKIA06_08225
FPSZAMR72_00980
FJOFjoh_2810
FJGBB050_03721
FBRFBFL15_1603
FCOFCOL_00350
FINKQS_06770
FGLEM308_11545
FCMBIW12_14250
FFAFFWV33_14045
FATDVK85_10000
FKIFK004_17800
FPALHYN49_13860
FMGHYN48_12670
FALBHYN59_13605
FCRHYN56_18025
FSEDI487_15170
FSNGS03_02264
FNKE1750_00410
FAKFUA48_14580
FFLHYN86_15230
FENJ0383_22760
FCVAWN65_07320
FOEJJC03_11335
FSDLXD69_14660
FLOK1I41_10165
FCCLOS86_08105
COCCoch_1873
CCMCcan_14970
COLAM608_01875
CHGAXF12_05640
CAPNCBG49_10090
CGHCGC50_02905
CLKCGC53_01425
CSPUCGC55_01935
CCYNCGC48_10140
CAPHCGC49_06860
CSTOCGC58_02020
CAPQCGC52_06615
CAPFFOC45_06995
RBIRB2501_05255
ZPRZPR_4204
CATCA2559_00515
MARMYQ22_09765
MARTBTR34_09835
MARBCJ263_06445
MAREEJ994_11890
CAOCelal_1834
CLYCelly_2064
CLHIX49_10250
CBALM667_06550
CBATM666_06570
KDIKrodi_0260
DOKMED134_05899(dhys)
DDOI597_2169
DODDCS32_10895
LANLacal_0652
LVNBWR22_13825
LACICW733_10400
ZGAZOBELLIA_2016
MRSMurru_0163
MLTVC82_1630
MUTGVT53_09725
MAQILDL77_00935
ASLAeqsu_0820
AEVEI546_09240
AICJK629_06775
PTQP700755_002306
NDODDD_1957
NOMAAT17_04630
NSDBST91_01255
NOBCW736_02430
NOJEJ995_04815
POBLPB03_02145
PRNBW723_13680
POLABXQ17_02940
POACW731_02420
PHALH9I45_02965
PLITK8354_06150
PPECH9W90_04680
PBATJL193_00250
PCEAJ3359_03670
MYRMYRA21_2805 MYRA21_2994
MPWMPR_1662 MPR_1786
MODAS202_13745 AS202_14595
MYZBK054_13295 BK054_14245
MOAI6I89_05290 I6I89_06805
WIJBWZ20_06780
SZEAW14_01755
AHZAPS56_08085
SYISB49_10755
TENLPB136_04030
TJETJEJU_2083
TMARMARIT_0341
TMPF9Y86_11440
LULLPB138_14930
FORFORMB_26350
FOPFNB79_06145
SALTAO058_06005
SMISLDL76_03290
SEONBWZ22_12385
AALGAREALGSMS7_01798
OLLCW732_06380
OAQDZC78_12915
TAJC1A40_08640
AUEC5O00_07440
KOSKORDIASMS9_02409
KANIMCC3317_47350
MARFCJ739_902
AQDD1816_01025
EMARD1013_02780
MUREQY75_00340
PSYNE9099_03785
AFLAFHG64_10870
ANPFK178_11165
OCIFEZ18_04300
MGELG5B37_07605
MESQC7H62_0677
GAAHX109_15020
CAGGHYG79_06065
ALTIALE3EI_0558
MARXINR76_06215
LPALLDL79_10250
SINHLS482_20405
SABUMBM09_03880
ZSPMQE36_13860
BIAGMA17_10725
FBEFF125_13795
FBMMQE35_17645
FBAFIC_00242
RANRiean_0802
RAIRA0C_1041
RARRIA_1448
RAGB739_1077
RAEG148_0821
RATM949_1544
WVIWeevi_2100
ORHOrnrh_1883
ORIQ785_09265
EAOBD94_0576
EMNM876_01535
EENBBD30_03995
ELBVO54_02033
EMGBBD33_00685
EGOBBD34_12040
EGMAYC65_14525
ELZFCS00_08085
ELTFGE20_03030
CHZCHSO_4280
CGNOK18_04355
CIHATE47_12725
CHHA0O34_12590
CIOCEQ15_14970
CHRYCEY12_11015
CPIPCJF12_17700
CHRSEAG08_07720
CHRZCO230_01315
CARHEGY05_17915
CSHAEG350_03050
CNKEG343_10165
CJTEG359_11140
CILEG358_18030
CCAUEG346_10375
CBENEG339_01800
CGLENCTC11432_02598
CTAINCTC12078_01117
CLACEG342_01595
CTAK4412677_01169
CSALNBC122_01150
CBPEB354_00755
CNPM0D58_08305
CCAOH5J24_01815
CFAELL667_08180
CRHIKB553_11860
CJGNCTC13459_02448
CCASEIB73_12355
CANTNCTC13489_02466
KDAEIB71_05870
KHIEG338_05370
KBEJ4771_10865
KFAQ73A0000_13945
EVAEIB75_15120
EZEKI430_17095
CNREB819_09690
EBVF0358_12270
EFALFH779_09305
ESTEHNV03_04665
BCADDBX24_02365
APIBG8C43_04335
CIVIMZ16_08780
FBOJ9309_12125
BBLBLBBGE_148
BPIBPLAN_485
BMMMADAR_463
BCPBLBCPU_138(dys1)
BBGBGIGA_478(dys1)
BBQBLBBOR_152
BLPBPAA_486
BLUK645_731
BLCKDM815_00720
BPUNDM780_00705
CRMK6119_16875
OHOOweho_2429
CHYDH4K34_05575
PTANCRYO30217_01697
SHYRLA303_12090
BBAUAEM51_11770
CTECT0011
CPCCpar_2043
CLZBIU88_12425
CCHCag_0073
CPHCpha266_2699
CPBCphamn1_2484
CLIClim_2480
PVICvib_1729
PLTPlut_2089
PPHPpha_2876
PAAPaes_2235
PROCPtc2401_02233
PROSCHL67_11480
CTSCtha_1417
IALIALB_0664(dys)
MROMROS_1683
NDENIDE3977
NMVNITMOv2_4302
NIONITINOP_0356
NJANSJP_0533 NSJP_1672
NKFNkreftii_000399
NIFW02_29140
NLIG3M70_08445
PRFPeribacterA2_0084
BANABARAN1_0482
BIHBIP78_1089
SRBP148_SR1C001G0941
MJAMJ_0814
MFEMefer_1179
MVUMetvu_0081
MFSMFS40622_1348
MIFMetin_0408
MJHJH146_1088
MESGMLAUSG7_1213(dys)
MESAMLASG1_0564(dys)
MIGMetig_0071
MMPMMP0137(dys)
MMQMmarC5_1539
MMXMmarC6_0815
MMZMmarC7_1136
MMDGYY_00695
MMAKMMKA1_01420(dhs)
MMAOMMOS7_01680(dhs)
MMADMMJJ_09490
MAEMaeo_1473
MVNMevan_1142
MVOMvol_1228
MOKMetok_1504
METFCFE53_06590
MTHMTH_127
MMGMTBMA_c05770(dys)
MWOMWSIV6_0542(dys)
MTEEMTTB_10720
METCMTCT_0092
METEtca_00111
METZMETMT2_0321
METKFVF72_01670
MTHMFZP57_02560
METJFZP68_07590
MSTMsp_0395(dys)
METBAW729_05080
MRUmru_1053(dys)
MSIMsm_1615
MEBAbm4_0746(dhys)
MMILsm9_1413(dys)
MEYETL18_03975
MOLYLM1_0596
MAROMarbSA_02500
METVK4897_08955
MELMetbo_1976
MEWMSWAN_0641
METHMBMB1_0656(dys)
MFCBRM9_1536(dys)
MFIDSM1535_2240(dys)
MCUBMCBB_0671(dys)
MSUBBK009_01520
METNBK008_09405
METTCIT01_10055
METOCIT02_03470
MEMEHYG87_10445
MFVMfer_0088
MKAMK0737(dys1)
AFUAF_2195 AF_2300
AFGAFULGI_00024670 AFULGI_00025990
APOArcpr_0357
AVEArcve_1160 Arcve_1345
ASTAsulf_02013
FPLFerp_0860 Ferp_1295
GACGACE_0691
GAHGAH_02017
PFUPF0292
PFIPFC_00525
PHOPH1397(PH1397)
PABPAB0511(dys1)
PYNPNA2_0805
PYAPYCH_07310
PYSPy04_0650
PYCTQ32_03020
TKOTK0671
TONTON_0701
TGATGAM_1020(dhys)
TSITSIB_0958
TBATERMP_01298
THEGQS_01375
THATAM4_660
THMCL1_1999
TLTOCC_07294
THSTES1_1326
TNUBD01_0653
TEUTEU_07815
TGYX802_09200
THVADU37_CDS06440
TCHCHITON_1257
TPEPA0127_01585
TPIEA7C91_09625
TGGA3K92_05480
TCEA3L02_03835
TBSA3L01_04270
THHCDI07_04180
TSLA3L11_08295
TTDA3L14_06185
TPRFA3L09_07030
TRLA3L10_02290
TPAFA3L08_07610
THYA3L12_07695
TICFH039_07930
TCQTIRI35C_1108(dys)
THEMFPV09_01485
THEIK1720_08005
PPACPAP_08250
MBAMbar_A0061 Mbar_A2038
MBYMSBRM_0810 MSBRM_2463
MBWMSBRW_0934 MSBRW_2699
MBARMSBR2_1584 MSBR2_2432
MBAKMSBR3_1585 MSBR3_2483
MACMA_0968 MA_3013(dys)
MMAMM_0287 MM_2082
MMAZMmTuc01_0290 MmTuc01_2149
MMJMSMAS_1013 MSMAS_2603
MMACMSMAC_1816 MSMAC_2372
MVCMSVAZ_0774 MSVAZ_1212
MEKMSKOL_0758 MSKOL_1163
MLSMSLAZ_1190 MSLAZ_2518
METMMSMTP_2224 MSMTP_2517
MEFMSWH1_2315 MSWH1_2377
MEQMSWHS_2685 MSWHS_2749
MSJMSSAC_0888 MSSAC_3273
MSZMSSIH_0829 MSSIH_1157
MSWMSSIT_0858 MSSIT_1205
MTHRMSTHT_1326 MSTHT_2551
MTHEMSTHC_0732 MSTHC_1966
MHORMSHOH_1206 MSHOH_3267
MFZAOB57_002575 AOB57_005835
MBUMbur_1868
MMETMCMEM_0098
MELOJ7W08_10560
MMHMmah_1888
MHAZBHR79_04210
MEVMetev_0524
MZHMzhil_1083 Mzhil_1149 Mzhil_1233
MPYMpsy_0915 Mpsy_1195
MZIHWN40_03985
MHZMetho_0779
MTPMthe_1180 Mthe_1200
MCJMCON_3059(dysA) MCON_3163(dysB)
MHIMhar_1409 Mhar_2141
MHUMhun_2546 Mhun_2903
MRTJKHC33_02425 KHC33_03950
MLAMlab_0154
MEMMemar_1799 Memar_2349
MBGBN140_0587(dys) BN140_2488
MEMAMMAB1_0754(dys) MMAB1_3348(dys)
MCHKMchiMG62_00790 MchiMG62_20640
MPIMpet_0152
MENDL6E24_04865 L6E24_07345
MBNMboo_0184
MFOMetfor_0008
MPLMpal_0029 Mpal_2389
MPDMCP_0098(dys-1) MCP_1441(dys-2)
MEZMtc_0598(dys-1) Mtc_1365(dys-2)
RCIRCIX304(dys-1) RRC163(dys-2)
HALVNG_1432G(dhs)
HSLOE_3059F(dhs)
HDLHALDL1_12540
HHBHhub_2865(dhs)
HAGSJT689_07150
HABOJRZ79_05585
HNOLT974_11090
HLULT972_03710
HANRLJ422_05835
HJEHacjB3_06035 HacjB3_18878
HALHHTSR_0419
HHSRHSR6_0404(dhs)
HSUHLASF_1839
HSFHLASA_1825
SALRFQU85_01290
HALREFA46_001125
HAADMW046_03385
HALXM0R89_01925
HAXZM0R88_01900
SALIL593_03400
SAIMK0C01_07730
HARAAArcS_1750(dys1)
HMArrnAC1918(dhs)
HHIHAH_2429(dhs)
HHNHISP_12365
HABSG26_04680
HTABVU17_11815
HALJG9465_16285
HSINKDQ40_01285
NPHNP_4578A(dhs)
NMONmlp_3450(dhs)
NHOHWV23_04070
NSALHWV07_18705
HUTHuta_2574
HTIHTIA_p3031
HALAHrd1104_01470
HMUHmuk_1329
HALZE5139_09805
HALLLC1Hm_0549(dys1)
HAZPGBQ70_09800
HALIBV210_13365
HSNDV733_12895
HDSHSR122_0752(dys1)
HRRHZS55_18225
HPELHZS54_10920 HZS54_21765
HLTI7X12_17485
HARCHARCEL1_00985
HDOMUK72_10550
HWAHQ_2852A(dhs)
HWCHqrw_3242(dhs)
HVOHVO_2297(dhs1) HVO_B0182(dhs2)
HMEHFX_2305(dhs) HFX_5233(dhs)
HGIABY42_11430 ABY42_16510
HALEG3A49_07760 G3A49_14700
HLSKU306_01770
HBOHbor_07110 Hbor_31970
HAQDU484_17185
HAJDU500_00225
HAERDU502_15385
HRAEI982_15225
HLMDV707_03375
HALMFCF25_03715
HLAHlac_1997
HALPDOS48_09655
HALBEKH57_14260
HEZZEO776_12030
HALQHrr1229_012220
HSSJ7656_04595
HSAIHPS36_09600
HAZZKI388_10510
SRUBC2R22_16845
HAEhalTADL_0434
HALNB4589_002405
HALGHUG10_09910
HALUHUG12_06570
HMPK6T50_07020
HREK6T36_06805
HRMK6T25_09020
HACBHbl1158_13365
HDFAArcSl_1374(dys)
HAHHalar_2076
HTUHtur_3109
HDABB347_01575
HSALJMJ58_12855
HLOJ0X27_09935
HAKZJ0X25_03845
NMGNmag_3738(dhs)
HXAHalxa_2146
NATNJ7G_2657
NPENatpe_0287 Natpe_1814
NVRFEJ81_01565 FEJ81_19225
NPLFGF80_09330
NAYHYG81_09175 HYG81_21115 HYG81_25060
HALYHYG82_11035
HJTDVR14_10795
NGENatgr_0279
HRUHalru_1500
NOUNatoc_1206 Natoc_2006
HLRHALLA_16430
HLCCHINAEXTREME15860
NAJB1756_12170
NAGAArcMg_2154
NANAArc1_1533
NBGDV706_01200 DV706_16070
NASGCU68_12545
SAWLNGM29_08900
NACAQV86_00100
MELUMTLP_11130
TACTa0356
TVOTVG0406345(TVG0406345)
PTOPTO1252
FACFACI_IFERC01G1184
FAIFAD_0214
CDIVCPM_0264
TARTALC_00502
MAXMMALV_04340
MERMMINT_06040 MMINT_07050
MEARMpt1_c03680
MEUZKRP56_05910
MARCAR505_1375
ABIAboo_0041
ACFAciM339_0043
APEAPE_0698.1(dys)
ACJACAM_0515(dys)
SMRSmar_0501 Smar_1363
SHCShell_1081
IHOIgni_0631
IISEYM_05545
DKADKAM_0470 DKAM_0944
DFDDesfe_0588 Desfe_1064
DMUDesmu_0729 Desmu_1014
TAGTagg_0666 Tagg_1037
IAGIgag_0062 Igag_1842
THGTCELL_0617 TCELL_0823
HBUHbut_0040
PFMPyrfu_1599
PDLPyrde_0578
STOSTK_12930(dys)
SOHD1869_07490
SSOSSO0967
SOLSsol_1946
SSOASULA_1978
SSOLSULB_1979
SSOFSULC_1977
SSHIJ5U23_02509
SCASSACC_08540
SAISaci_1316
SACNSacN8_06415
SACRSacRon12I_06405
SACSSUSAZ_06285
SISLS215_1343
SIAM1425_1256
SIMM1627_1306
SIDM164_1240
SIYYG5714_1241
SINYN1551_1607
SIILD85_1368
SIHSiH_1201
SIRSiRe_1119
SICSiL_1116
SULABFU36_01585
SULEGFS03_07060
SULOGFS33_12470
SULLEWF20_08665
MSEMsed_1753
MEMJMJ1HA_1998
MCNMcup_0476
MHKDFR87_09895
MPRUDFR88_09470
MTENGWK48_02375
MJNMjAS7_2881
AHOAhos_1418
AMANB6F84_11550
ABRIDFR85_10905
ASULDFR86_09865
AAMBD1866_02025
ACIHHS5_28300
SACDHS1genome_1035
SAZOD1868_04255
CSTYKN1_24400
STEPIC006_1179
SAHSHS7_17950
PAIPAE3487
PISPisl_0783
PCLPcal_1171
PASPars_1970
PYRP186_0643
POGPogu_0152
TNETneu_0861
PYWPYWP30_00957
CMACmaq_0976
TTNTTX_0721(dys)
TUZTUZN_0371
VDIVdis_2347
VMOVMUT_0699
TPETpen_0413
THBN186_03090
TCBTCARB_1682
THFMA03_07490
THELIG193_04900
ASCASAC_0219
ACIASE86_01890
CLGCalag_1390
FFOFFONT_0753
NMRNmar_0648 Nmar_0928
NIRNSED_03340 NSED_05185
NKRNKOR_03365 NKOR_05215
NIDNPIRD3C_1250 NPIRD3C_1617(dys)
NINNADRNF5_1067 NADRNF5_1500(dys)
NIWNisw_00035 Nisw_01660
NCLC5F47_04035 C5F47_05820
NOXC5F49_04000 C5F49_05670
NUEC5F50_04765 C5F50_07300
NIPNsoK4_03180 NsoK4_05120
NCTNMSP_0400 NMSP_0924
NICDSQ20_03455 DSQ20_04005
CSYCENSYa_0253 CENSYa_0380
NGANgar_c06230(dys1) Ngar_c06260(dys2)
NVNNVIE_025230(dys1) NVIE_025240(dys2)
NEVNTE_03041 NTE_03043
TAANMY3_00409 NMY3_00410
NFNNFRAN_1377(dys) NFRAN_1378
NCVNCAV_1189(dys) NCAV_1306(HGP)
CSUCSUB_C0603 CSUB_C1242
NBVT478_0632 T478_0804
TAHSU86_007575 SU86_007580
NIUDSQ19_09300 DSQ19_09305
NDVNDEV_1141 NDEV_1183(dys)
CCAINAS2_0479
KCRKcr_0505
BARCAOA65_1954 AOA65_2332
NEQNEQ402
NAANps_02765
NAERMJ1_0628
MARHMia14_0922
FLTSv326_0529 Sv326_0935
MIYMicr_00993
NCONLC1Nh_0984(dys)
LOKILokiarch_27570 Lokiarch_47990
PSYTDSAG12_02236 DSAG12_02736
AGWQT03_C0001G0297
ARGQT11_C0001G0110
 » show all
Reference
1  [PMID:2108161]
  Authors
Wolff EC, Park MH, Folk JE
  Title
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of  NAD.
  Journal
J Biol Chem 265:4793-9 (1990)
Reference
2  [PMID:9188485]
  Authors
Wolff EC, Folk JE, Park MH.
  Title
Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase.
  Journal
J Biol Chem 272:15865-71 (1997)
DOI:10.1074/jbc.272.25.15865
Reference
3  [PMID:9285092]
  Authors
Chen KY, Liu AY.
  Title
Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A.
  Journal
Biol Signals 6:105-9 (1997)
DOI:10.1159/000109115
Reference
4  [PMID:10542236]
  Authors
Ober D, Hartmann T
  Title
Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity.
  Journal
J Biol Chem 274:32040-7 (1999)
DOI:10.1074/jbc.274.45.32040
  Sequence
Reference
5  [PMID:10611289]
  Authors
Ober D, Hartmann T
  Title
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase.
  Journal
Proc Natl Acad Sci U S A 96:14777-82 (1999)
DOI:10.1073/pnas.96.26.14777
  Sequence
Reference
6  [PMID:10028184]
  Authors
Wolff EC, Park MH.
  Title
Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation.
  Journal
Reference
7  [PMID:10734052]
  Authors
Wolff EC, Wolff J, Park MH.
  Title
Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism.
  Journal
J Biol Chem 275:9170-7 (2000)
DOI:10.1074/jbc.275.13.9170
Reference
8  [PMID:7673224]
  Authors
Joe YA, Wolff EC, Park MH.
  Title
Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins.
  Journal
J Biol Chem 270:22386-92 (1995)
DOI:10.1074/jbc.270.38.22386
  Sequence
[hsa:1725]
Reference
9  [PMID:7592594]
  Authors
Tao Y, Chen KY
  Title
Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast deoxyhypusine synthase cDNA.
  Journal
J Biol Chem 270:23984-7 (1995)
DOI:10.1074/jbc.270.41.23984
  Sequence
[ncr:NCU05418]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.46
IUBMB Enzyme Nomenclature: 2.5.1.46
ExPASy - ENZYME nomenclature database: 2.5.1.46
BRENDA, the Enzyme Database: 2.5.1.46
CAS: 127069-31-2

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