KEGG   ENZYME: 2.5.1.46
Entry
EC 2.5.1.46                 Enzyme                                 

Name
deoxyhypusine synthase;
spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
[eIF5A-precursor]-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming)
Reaction(IUBMB)
[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine (overall reaction) [RN:R05329];
(1a) spermidine + NAD+ = dehydrospermidine + NADH [RN:R07477];
(1b) dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine [RN:R07479];
(1c) N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine [RN:R07480];
(1d) N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+ [RN:R07478]
Reaction(KEGG)
Substrate
[eIF5A-precursor]-lysine [CPD:C07281];
spermidine [CPD:C00315];
NAD+ [CPD:C00003];
dehydrospermidine [CPD:C15853];
[enzyme]-lysine [CPD:C07281];
N-(4-aminobutylidene)-[enzyme]-lysine [CPD:C15854];
N-(4-aminobutylidene)-[eIF5A-precursor]-lysine [CPD:C15854];
NADH [CPD:C00004];
H+ [CPD:C00080]
Product
[eIF5A-precursor]-deoxyhypusine [CPD:C07282];
propane-1,3-diamine [CPD:C00986];
dehydrospermidine [CPD:C15853];
NADH [CPD:C00004];
N-(4-aminobutylidene)-[enzyme]-lysine [CPD:C15854];
N-(4-aminobutylidene)-[eIF5A-precursor]-lysine [CPD:C15854];
[enzyme]-lysine [CPD:C07281];
NAD+ [CPD:C00003]
Comment
The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. This enzyme catalyses the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor. The reaction occurs in four steps: NAD+-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme; 1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d). Hence the overall reaction is transfer of a 4-aminobutyl group. For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase.
History
EC 2.5.1.46 provisional version created 1999 as EC 1.1.1.249 deleted 1999, revised and reinstated 2001 as EC 2.5.1.46
Orthology
K00809  deoxyhypusine synthase
Genes
HSA: 1725(DHPS)
PTR: 455746(DHPS)
PPS: 100977998(DHPS)
GGO: 101136731(DHPS)
PON: 100443233(DHPS)
NLE: 100597140(DHPS)
MCC: 716213(DHPS)
MCF: 102138960(DHPS)
CSAB: 103233979(DHPS)
CATY: 105601520(DHPS)
PANU: 100999800(DHPS)
RRO: 104661101(DHPS)
RBB: 108539610(DHPS)
TFN: 117075669(DHPS)
CJC: 100396022(DHPS)
SBQ: 101050408(DHPS)
MMUR: 105885521(DHPS)
MMU: 330817(Dhps)
MCAL: 110299744(Dhps)
MPAH: 110337223(Dhps)
RNO: 288923(Dhps)
MCOC: 116069750(Dhps)
MUN: 110545818(Dhps)
CGE: 100755665(Dhps)
PLEU: 114687647(Dhps)
NGI: 103751894(Dhps)
HGL: 101708097(Dhps)
CCAN: 109681277(Dhps)
OCU: 100352059(DHPS)
OPI: 101524987(DHPS)
TUP: 102485533(DHPS)
CFA: 476702(DHPS)
VVP: 112908051(DHPS)
VLG: 121495890(DHPS)
AML: 100474462(DHPS)
UMR: 103682157(DHPS)
UAH: 113247138(DHPS)
ORO: 101368037(DHPS)
ELK: 111162428
MPUF: 101684402(DHPS)
EJU: 114197704(DHPS)
MLX: 118005793(DHPS)
FCA: 101083659(DHPS)
PYU: 121014029(DHPS)
PBG: 122486922(DHPS)
PTG: 102959277(DHPS)
PPAD: 109254040(DHPS)
AJU: 106985534(DHPS)
HHV: 120245302(DHPS)
BTA: 444988(DHPS)
BOM: 102270034(DHPS)
BIU: 109561548(DHPS)
BBUB: 102397116(DHPS)
CHX: 102171505(DHPS)
OAS: 101107277(DHPS)
ODA: 120864043(DHPS)
CCAD: 122440487(DHPS)
SSC: 100519413(DHPS)
CFR: 102505713(DHPS)
CBAI: 105068343(DHPS)
CDK: 105104065(DHPS)
BACU: 103000331(DHPS)
LVE: 103087338(DHPS)
OOR: 101284267(DHPS)
DLE: 111166583(DHPS)
PCAD: 102989701(DHPS)
ECB: 100063550(DHPS)
EPZ: 103542773(DHPS)
EAI: 106826924(DHPS)
MYB: 102255457(DHPS)
MYD: 102755857(DHPS)
MMYO: 118652664(DHPS)
MNA: 107541538(DHPS)
HAI: 109394256(DHPS)
DRO: 112301507(DHPS)
SHON: 118984135(DHPS)
AJM: 119049642(DHPS)
MMF: 118615190(DHPS)
PALE: 102898526(DHPS)
PGIG: 120618544(DHPS)
RAY: 107519404(DHPS)
MJV: 108388720(DHPS)
TOD: 119240991(DHPS)
LAV: 100656596(DHPS)
TMU: 101343153
MDO: 100010290(DHPS)
SHR: 100920525(DHPS)
PCW: 110214159(DHPS)
OAA: 103170595(DHPS)
GGA: 107057627(DHPS)
CJO: 107307164(DHPS)
LSR: 110481139(DHPS)
SCAN: 103825301(DHPS)
PMOA: 120505352(DHPS)
OTC: 121339163(DHPS)
PRUF: 121363739(DHPS)
PHI: 102101132(DHPS)
CCW: 120412244(DHPS)
ETL: 114071216(DHPS)
FPG: 106112398(DHPS)
AAM: 106486625(DHPS)
AROW: 112962289(DHPS)
ASN: 102377261(DHPS)
AMJ: 102562780(DHPS)
PSS: 102453700(DHPS)
CMY: 102935067(DHPS)
CPIC: 101953196(DHPS)
TST: 117888743(DHPS)
CABI: 116817739(DHPS)
ACS: 100553765(dhps)
PVT: 110077395(DHPS)
PBI: 103053909(DHPS)
PMUR: 107299753
TSR: 106546538(DHPS)
PGUT: 117665391(DHPS)
PMUA: 114596556(DHPS)
ZVI: 118078946 118085565(DHPS)
GJA: 107120598(DHPS)
XLA: 108711712(dhps.L) 431985(dhps.S)
XTR: 394501(dhps)
NPR: 108794974(DHPS)
DRE: 406329(dhps)
SRX: 107718601 107753765(dhps)
SGH: 107563249 107565620(dhps)
CCAR: 109047440
CAUA: 113050933(dhps)
IPU: 100528141(dhps)
PHYP: 113528412(dhps)
AMEX: 103031482(dhps)
EEE: 113575196(dhps)
LCO: 104934332(dhps)
NCC: 104942955(dhps) 104945527
CGOB: 115011786 115012790(dhps)
ECRA: 117938538 117958573(dhps)
PFLV: 114549871 114569747(dhps)
GAT: 120827501(dhps) 120827527
PPUG: 119221111(dhps)
ONL: 100711407(dhps)
OAU: 116315651(dhps)
OLA: 101171006(dhps)
XMA: 102227615(dhps)
XCO: 114159822(dhps)
XHE: 116736033(dhps)
PRET: 103469305(dhps)
CVG: 107091146(dhps)
CTUL: 119777665(dhps)
NFU: 107376607(dhps)
KMR: 108239332(dhps)
ALIM: 106520408(dhps)
AOCE: 111568935(dhps)
CSEM: 103392943(dhps) 103392944
POV: 109639383 109639447(dhps)
SDU: 111227129(dhps)
SLAL: 111645815(dhps)
XGL: 120805030(dhps)
HCQ: 109527046(dhps)
MALB: 109969539(dhps)
SASA: 100196722(dhys) 106592861
OTW: 112226258
SALP: 112075224(dhps)
SFM: 108926075(dhps)
PKI: 111843297(dhps)
AANG: 118215996(dhps)
LOC: 102690878(dhps)
PSPA: 121304536(dhps)
LCM: 102358518(DHPS)
CMK: 103187570(dhps)
RTP: 109925040(dhps)
CIN: 100187438
SCLV: 120345011
APLC: 110981409
SKO: 100373608
DME: Dmel_CG8005(CG8005)
DER: 6544397
DSE: 6604835
DSI: Dsimw501_GD14061(Dsim_GD14061)
DAN: 6507728
DSR: 110183631
DPE: 6599480
DMN: 108153296
DWI: 6639496
DGR: 6557928
DAZ: 108614000
DNV: 108652063
DHE: 111592836
DVI: 6622442
CCAT: 101459523
BOD: 106621098
MDE: 101900686
SCAC: 106089838
LCQ: 111690007
ACOZ: 120952342
AARA: 120897317
AAG: 5574567
CPII: 120424499
AME: 100578266
ACER: 107993774
BIM: 100745513
BBIF: 117205497
BVK: 117238720
BVAN: 117161549
BTER: 100646643
CCAL: 108629867
OBB: 114878900
MGEN: 117218467
NMEA: 116428789
CGIG: 122399280
SOC: 105201636
MPHA: 105841008
AEC: 105144800
ACEP: 105624652
PBAR: 105422536
VEM: 105559641
HST: 105186729
DQU: 106748959
CFO: 105259058
FEX: 115244472
LHU: 105678597
PGC: 109862400
OBO: 105276666
PCF: 106788380
NVI: 100114756
CSOL: 105367451
TPRE: 106648512
MDL: 103572297
FAS: 105270845
DAM: 107041313
CCIN: 107267578
TCA: 659163
DPA: 109546818
ATD: 109601652
AGB: 108916336
LDC: 111507781
NVL: 108557196
APLN: 108735531
OTU: 111419688
BMOR: 100190959(Dhs)
BMAN: 114241054
MSEX: 115450514
BANY: 112058117
PMAC: 106708105
PPOT: 106108901
PRAP: 111002931
ZCE: 119836059
HAW: 110377856
TNL: 113505198
PXY: 105385059
API: 100160249
DNX: 107172072
RMD: 113548303
BTAB: 109031358
DCI: 103518598
CLEC: 106665126
HHAL: 106689684
NLU: 111045731
FOC: 113209691
ZNE: 110839256
CSEC: 111865614
FCD: 110851734
DMK: 116926662
PVM: 113821642
HAME: 121875358
EAF: 111716124
RSAN: 119401771
RMP: 119187772
VDE: 111247767
VJA: 111260156
TUT: 107368689
CSCU: 111614541
PTEP: 107454335
SDM: 118180497
CEL: CELE_Y17G7B.4(dhps-1)
CBR: CBG21024
BMY: BM_BM14681(Bma-dhps-1)
TSP: Tsp_06824
PCAN: 112575140
BGT: 106054684
GAE: 121383981
CRG: 105339234
MYI: 110453567
PMAX: 117333104
OBI: 106874794
OSN: 115222894
LAK: 106160869
NVE: 5506016
EPA: 110250271
ADF: 107332977
AMIL: 114961128
PDAM: 113676972
SPIS: 111339446
DGT: 114518865
AQU: 100640245
ATH: AT5G05920(DHS)
ALY: 9307259
CRB: 17881605
RSZ: 108817722
CPAP: 110819197
CIT: 102616285
TCC: 18585734
DZI: 111310078
EGR: 104436515
GMX: 100305453
GSJ: 114418892
VRA: 106764595
VAR: 108345960
CCAJ: 109818884
APRC: 113867431
LJA: Lj1g3v3646510.1(Lj1g3v3646510.1) Lj1g3v3646510.2(Lj1g3v3646510.2)
ADU: 107490155
AIP: 107644469
LANG: 109351093
FVE: 101308495
RCN: 112186377
PPER: 18769561
PAVI: 110750964
PDUL: 117634334
PXB: 103943952
ZJU: 107424009
MNT: 21409860
CSV: 101220126
MCHA: 111011849
RCU: 8271139
JCU: 105650962
HBR: 110671250
MESC: 110600979
POP: 7462832
PEU: 105122879
PALZ: 118054698
QLO: 115976163
VVI: 100247561
VRI: 117904856
SLY: 101249422 543666(DHS)
CANN: 107859602
NTA: 107783753 107796463(DHS1)
NSY: 104231513
NTO: 104090458
NAU: 109231043
SIND: 105173586
EGT: 105952866
ECAD: 122586082
CCAV: 112506980
DCR: 108213029
CSIN: 114321468
BVG: 104896269
NNU: 104604419
MING: 122060659
NCOL: 116248473
OSA: 4334056
DOSA: Os03t0740600-01(Os03g0740600) Os09t0421100-00(Os09g0421100)
BDI: 100823824
SITA: 101756334
PHAI: 112878140
PDA: 103721451
EGU: 105039714
MUS: 103987529
ATR: 18443737
APRO: F751_4451
SCE: YHR068W(DYS1)
ERC: Ecym_3222
KMX: KLMA_70371(DYS1)
NCS: NCAS_0H01680(NCAS0H01680)
NDI: NDAI_0C02010(NDAI0C02010)
TPF: TPHA_0D02020(TPHA0D02020)
TBL: TBLA_0C03540(TBLA0C03540)
TDL: TDEL_0E02840(TDEL0E02840)
KAF: KAFR_0K02250(KAFR0K02250)
CAL: CAALFM_C302180CA(CaO19.1626)
SLB: AWJ20_4378(DYS1)
BNN: FOA43_004101(DYS1)
BBRX: BRETT_002848(DYS1)
NCR: NCU05418(dys-1)
NTE: NEUTE1DRAFT65655(NEUTE1DRAFT_65655)
MGR: MGG_09173
SSCK: SPSK_00293
TRE: TRIREDRAFT_54448(dhyS)
MAW: MAC_06555
MAJ: MAA_07630
CMT: CCM_04765
BFU: BCIN_07g02080(Bcdys1)
MBE: MBM_05481
ANI: AN8075.2
ANG: ANI_1_190144(An16g01480)
ABE: ARB_00858
TVE: TRV_07899
PTE: PTT_18821
CNE: CNJ02480
CNB: CNBJ0980
TASA: A1Q1_07185
ABP: AGABI1DRAFT113512(AGABI1DRAFT_113512)
ABV: AGABI2DRAFT191839(AGABI2DRAFT_191839)
MGL: MGL_0173
MRT: MRET_1145
DDI: DDB_G0285725(dhps)
DFA: DFA_09448(dhps)
EHI: EHI_006030(83.t00016) EHI_098350(77.t00015)
PCB: PCHAS_103080(PC301479.00.0)
TAN: TA13570
TPV: TP02_0058
BBO: BBOV_III010890(17.m07937)
CPV: cgd2_3930
TPS: THAPSDRAFT_268986(dhs1)
SPAR: SPRG_01451
LIF: LINJ_20_0270(DHS20) LINJ_34_0350(DHS34)
CBU: CBU_0721
CBD: CBUD_0732
CBG: CbuG_1281
CBC: CbuK_1537
CENO: CEAn_00640
THIP: N838_13025
DMA: DMR_24290
DGG: DGI_1717
DFL: DFE_2296
DRT: Dret_1312
ADE: Adeh_3097
SCL: sce5982 sce7004(dys)
SAT: SYN_02461
SFU: Sfum_3135
AOL: S58_72380
CCR: CC_0359
CAK: Caul_0257
CSE: Cseg_3779
PZU: PHZ_c3320
GAK: X907_0967
ZMO: ZMO1019
ZMN: Za10_0286
ZMM: Zmob_0291
ZMB: ZZ6_0291
ZMI: ZCP4_0299
SWI: Swit_4663
SPHD: HY78_01820
SPHM: G432_03450
STAX: MC45_03740
SPHI: TS85_12070
SSAN: NX02_16895
SPKC: KC8_01335
SMIC: SmB9_25960
PUB: SAR11_0205(dys2)
BBA: Bd2349(dys)
BBAT: Bdt_2302(dys)
BBW: BDW_08730
BBAC: EP01_07995
BEX: A11Q_1017
CYA: CYA_2657
CYB: CYB_2420
TEL: tlr0818
KOV: K9N68_11705(speY)
GVI: glr1045
GLJ: GKIL_1895
ANA: alr3804
NSH: GXM_05989
NAZ: Aazo_1485
CALH: IJ00_03960
CTHE: Chro_1131
RCA: Rcas_3399
CAU: Caur_0545
CAG: Cagg_3460
HAU: Haur_3346
TRA: Trad_0088
TTH: TT_C1205
TTJ: TTHA1570(TTHA1570)
TAQ: TO73_0420
MRB: Mrub_2079
PNL: PNK_1142(dys)
PUV: PUV_04440
OTE: Oter_1628
MIN: Minf_2205(dys1)
MKC: kam1_2015
MEAP: MTHMO_0094
RBA: RB1381(dys1)
PSL: Psta_0402
RUL: UC8_15860
AHEL: Q31a_00040
TTF: THTE_3185
IPA: Isop_1096
KST: KSMBR1_3542(dys-1)
ACA: ACP_1729
ABAS: ACPOL_0481
SUS: Acid_1177
EMI: Emin_1464
GAU: GAU_2131
GBA: J421_3735
MBAS: ALGA_4366
CPI: Cpin_0490
FLN: FLA_5889
PHE: Phep_0287
MUC: MuYL_0599
CHU: CHU_1939
HSW: Hsw_2920
FLM: MY04_4887
GFO: GFO_3623
GFL: GRFL_1787
FPS: FP1709
FJO: Fjoh_2810
FIN: KQS_06770
COC: Coch_1873
ZPR: ZPR_4204
MARM: YQ22_09765
CBAL: M667_06550
CBAT: M666_06570
DOK: MED134_05899(dhys)
DDO: I597_2169
MLT: VC82_1630
NDO: DDD_1957
TMAR: MARIT_0341
MARF: CJ739_902
MESQ: C7H62_0677
FBA: FIC_00242
RAI: RA0C_1041
RAR: RIA_1448
RAG: B739_1077
RAE: G148_0821
RAT: M949_1544
EAO: BD94_0576
CHZ: CHSO_4280
BPI: BPLAN_485
BMM: MADAR_463
BCP: BLBCPU_138(dys1)
BBG: BGIGA_478(dys1)
BLP: BPAA_486
BLU: K645_731
CTE: CT0011
CPC: Cpar_2043
CCH: Cag_0073
CLI: Clim_2480
PVI: Cvib_1729
PLT: Plut_2089
PPH: Ppha_2876
PAA: Paes_2235
CTS: Ctha_1417
IAL: IALB_0664(dys)
MRO: MROS_1683
NDE: NIDE3977
MJA: MJ_0814
MESG: MLAUSG7_1213(dys)
MMP: MMP0137(dys)
MMD: GYY_00695
MMAK: MMKA1_01420(dhs)
MMAO: MMOS7_01680(dhs)
MMAD: MMJJ_09490
MAE: Maeo_1473
MVO: Mvol_1228
MTH: MTH_127
MMG: MTBMA_c05770(dys)
METC: MTCT_0092
MWO: MWSIV6_0542(dys)
METE: tca_00111
MST: Msp_0395(dys)
MRU: mru_1053(dys)
MSI: Msm_1615
MEB: Abm4_0746(dhys)
MMIL: sm9_1413(dys)
MEYE: TL18_03975
MOL: YLM1_0596
METH: MBMB1_0656(dys)
MFC: BRM9_1536(dys)
MFI: DSM1535_2240(dys)
MCUB: MCBB_0671(dys)
MFV: Mfer_0088
MKA: MK0737(dys1)
GAC: GACE_0691
GAH: GAH_02017
PFU: PF0292
PFI: PFC_00525
PHO: PH1397(PH1397)
PAB: PAB0511(dys1)
PYN: PNA2_0805
PYS: Py04_0650
TKO: TK0671
TON: TON_0701
TGA: TGAM_1020(dhys)
TSI: TSIB_0958
THE: GQS_01375
THA: TAM4_660
THM: CL1_1999
TLT: OCC_07294
THS: TES1_1326
TNU: BD01_0653
TEU: TEU_07815
TCQ: TIRI35C_1108(dys)
PPAC: PAP_08250
MAC: MA_0968 MA_3013(dys)
MBU: Mbur_1868
MMET: MCMEM_0098
MMH: Mmah_1888
MCJ: MCON_3059(dysA) MCON_3163(dysB)
MLA: Mlab_0154
MEMA: MMAB1_0754(dys) MMAB1_3348(dys)
MPI: Mpet_0152
MBN: Mboo_0184
MPD: MCP_0098(dys-1) MCP_1441(dys-2)
MEZ: Mtc_0598(dys-1) Mtc_1365(dys-2)
RCI: RCIX304(dys-1) RRC163(dys-2)
HAL: VNG_1432G(dhs)
HSL: OE_3059F(dhs)
HHB: Hhub_2865(dhs)
HALH: HTSR_0419
HHSR: HSR6_0404(dhs)
HMA: rrnAC1918(dhs)
HHI: HAH_2429(dhs)
NPH: NP_4578A(dhs)
NMO: Nmlp_3450(dhs)
HUT: Huta_2574
HMU: Hmuk_1329
HALL: LC1Hm_0549(dys1)
HWA: HQ_2852A(dhs)
HWC: Hqrw_3242(dhs)
HVO: HVO_2297(dhs1) HVO_B0182(dhs2)
HME: HFX_2305(dhs) HFX_5233(dhs)
HLA: Hlac_1997
HDF: AArcSl_1374(dys)
HTU: Htur_3109
NMG: Nmag_3738(dhs)
NAT: NJ7G_2657
SALI: L593_03400
TAC: Ta0356
TVO: TVG0406345(TVG0406345)
PTO: PTO1252
FAI: FAD_0214
CDIV: CPM_0264
MARC: AR505_1375
ABI: Aboo_0041
APE: APE_0698.1(dys)
ACJ: ACAM_0515(dys)
IHO: Igni_0631
IIS: EYM_05545
HBU: Hbut_0040
STO: STK_12930(dys)
SSO: SSO0967
SOL: Ssol_1946
SSOA: SULA_1978
SSOL: SULB_1979
SSOF: SULC_1977
SAI: Saci_1316
SID: M164_1240
SII: LD85_1368
SIH: SiH_1201
SIR: SiRe_1119
SIC: SiL_1116
MSE: Msed_1753
MCN: Mcup_0476
AHO: Ahos_1418
CSTY: KN1_24400
STEP: IC006_1179
PAI: PAE3487
PIS: Pisl_0783
PCL: Pcal_1171
PAS: Pars_1970
PYR: P186_0643
POG: Pogu_0152
TNE: Tneu_0861
CMA: Cmaq_0976
TTN: TTX_0721(dys)
TUZ: TUZN_0371
VDI: Vdis_2347
VMO: VMUT_0699
TPE: Tpen_0413
ASC: ASAC_0219
ACIA: SE86_01890
NGA: Ngar_c06230(dys1) Ngar_c06260(dys2)
NVN: NVIE_025230(dys1) NVIE_025240(dys2)
NCV: NCAV_1189(dys) NCAV_1306(HGP)
NDV: NDEV_1141 NDEV_1183(dys)
CCAI: NAS2_0479
KCR: Kcr_0505
NEQ: NEQ402
NAA: Nps_02765
MARH: Mia14_0922
NCON: LC1Nh_0984(dys)
 » show all
Reference
1  [PMID:2108161]
  Authors
Wolff EC, Park MH, Folk JE
  Title
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of  NAD.
  Journal
J Biol Chem 265:4793-9 (1990)
Reference
2  [PMID:9188485]
  Authors
Wolff EC, Folk JE, Park MH.
  Title
Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase.
  Journal
J Biol Chem 272:15865-71 (1997)
DOI:10.1074/jbc.272.25.15865
Reference
3  [PMID:9285092]
  Authors
Chen KY, Liu AY.
  Title
Biochemistry and function of hypusine formation on eukaryotic initiation factor 5A.
  Journal
Biol Signals 6:105-9 (1997)
DOI:10.1159/000109115
Reference
4  [PMID:10542236]
  Authors
Ober D, Hartmann T
  Title
Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity.
  Journal
J Biol Chem 274:32040-7 (1999)
DOI:10.1074/jbc.274.45.32040
  Sequence
Reference
5  [PMID:10611289]
  Authors
Ober D, Hartmann T
  Title
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase.
  Journal
Proc Natl Acad Sci U S A 96:14777-82 (1999)
DOI:10.1073/pnas.96.26.14777
  Sequence
Reference
6  [PMID:10028184]
  Authors
Wolff EC, Park MH.
  Title
Identification of lysine350 of yeast deoxyhypusine synthase as the site of enzyme intermediate formation.
  Journal
Reference
7  [PMID:10734052]
  Authors
Wolff EC, Wolff J, Park MH.
  Title
Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism.
  Journal
J Biol Chem 275:9170-7 (2000)
DOI:10.1074/jbc.275.13.9170
Reference
8  [PMID:7673224]
  Authors
Joe YA, Wolff EC, Park MH.
  Title
Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins.
  Journal
J Biol Chem 270:22386-92 (1995)
DOI:10.1074/jbc.270.38.22386
  Sequence
[hsa:1725]
Reference
9  [PMID:7592594]
  Authors
Tao Y, Chen KY
  Title
Molecular cloning and functional expression of Neurospora deoxyhypusine synthase cDNA and identification of yeast deoxyhypusine synthase cDNA.
  Journal
J Biol Chem 270:23984-7 (1995)
DOI:10.1074/jbc.270.41.23984
  Sequence
[ncr:NCU05418]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.46
IUBMB Enzyme Nomenclature: 2.5.1.46
ExPASy - ENZYME nomenclature database: 2.5.1.46
BRENDA, the Enzyme Database: 2.5.1.46
CAS: 127069-31-2

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