Entry |
|
Name |
cystathionine gamma-synthase;
O-succinyl-L-homoserine succinate-lyase (adding cysteine);
O-succinylhomoserine (thiol)-lyase;
homoserine O-transsuccinylase (ambiguous);
O-succinylhomoserine synthase;
O-succinylhomoserine synthetase;
cystathionine synthase;
cystathionine synthetase;
homoserine transsuccinylase (ambiguous);
4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
|
Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
|
Sysname |
O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
|
Reaction(IUBMB) |
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate [RN: R03260]
|
Reaction(KEGG) |
|
Substrate |
O4-succinyl-L-homoserine [CPD: C01118];
L-cysteine [CPD: C00097]
|
Product |
|
Comment |
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
|
History |
EC 2.5.1.48 created 1972 as EC 4.2.99.9, transferred 2002 to EC 2.5.1.48
|
Pathway |
ec00270 | Cysteine and methionine metabolism |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K01739 | cystathionine gamma-synthase |
|
Genes |
» show all
|
Reference |
|
Authors |
Flavin M, Slaughter C. |
Title |
Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine. |
Journal |
|
Reference |
|
Authors |
Kaplan MM, Flavin M. |
Title |
Cystathionine gamma-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis. |
Journal |
J Biol Chem 241:4463-71 (1966) |
Reference |
|
Authors |
Wiebers JL, Garner HR. |
Title |
Homocysteine and cysteine synthetases of Neurospora crassa. Purification, properties, and feedback control of activity. |
Journal |
J Biol Chem 242:12-23 (1967) |
Reference |
|
Authors |
Wiebers JL, Garner HR. |
Title |
Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli. |
Journal |
J Biol Chem 242:5644-9 (1967) |
Reference |
|
Authors |
Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A. |
Title |
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Ravanel S, Gakiere B, Job D, Douce R |
Title |
Cystathionine gamma-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli. |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.5.1.48 |
ExPASy - ENZYME nomenclature database: | 2.5.1.48 |
|