| Entry |
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| Name |
cystathionine gamma-synthase;
O-succinyl-L-homoserine succinate-lyase (adding cysteine);
O-succinylhomoserine (thiol)-lyase;
homoserine O-transsuccinylase (ambiguous);
O-succinylhomoserine synthase;
O-succinylhomoserine synthetase;
cystathionine synthase;
cystathionine synthetase;
homoserine transsuccinylase (ambiguous);
4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
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| Reaction(IUBMB) |
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate [RN: R03260]
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| Reaction(KEGG) |
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| Substrate |
O4-succinyl-L-homoserine [CPD: C01118];
L-cysteine [CPD: C00097]
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| Product |
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| Comment |
A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
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| History |
EC 2.5.1.48 created 1972 as EC 4.2.99.9, transferred 2002 to EC 2.5.1.48
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| Pathway |
| ec00270 | Cysteine and methionine metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01739 | cystathionine gamma-synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Flavin M, Slaughter C. |
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| Title |
Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine. |
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| Journal |
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| Reference |
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| Authors |
Kaplan MM, Flavin M. |
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| Title |
Cystathionine gamma-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis. |
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| Journal |
J Biol Chem 241:4463-71 (1966) |
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| Reference |
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| Authors |
Wiebers JL, Garner HR. |
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| Title |
Homocysteine and cysteine synthetases of Neurospora crassa. Purification, properties, and feedback control of activity. |
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| Journal |
J Biol Chem 242:12-23 (1967) |
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| Reference |
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| Authors |
Wiebers JL, Garner HR. |
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| Title |
Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurospora crassa, yeast, and Escherichia coli. |
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| Journal |
J Biol Chem 242:5644-9 (1967) |
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| Reference |
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| Authors |
Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A. |
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| Title |
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Ravanel S, Gakiere B, Job D, Douce R. |
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| Title |
Cystathionine gamma-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.48 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.48 |
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