KEGG   ENZYME: 2.5.1.57
Entry
EC 2.5.1.57                 Enzyme                                 
Name
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]
Reaction(KEGG)
R02769 > R04435
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acyl-D-mannosamine 6-phosphate [CPD:C00686];
H2O [CPD:C00001]
Product
N-acylneuraminate 9-phosphate [CPD:C01200];
phosphate [CPD:C00009]
Comment
Acts on N-glycoloyl and N-acetyl-derivatives.
History
EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57
Pathway
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
Orthology
K05304  sialic acid synthase
Genes
HSA54187(NANS)
PTR743934(NANS)
PPS100982112(NANS)
GGO101124502(NANS)
PON100446862(NANS)
PPYG129043970(NANS)
NLE100603154(NANS)
HMH116475313(NANS)
SSYN129479125(NANS)
MCC715459(NANS)
MCF102120030(NANS)
MTHB126938070
MNI105477199(NANS)
CSAB103219150(NANS)
CATY105593048(NANS)
PANU101020165(NANS)
TGE112607835(NANS)
MLEU105549289(NANS)
RRO104657773(NANS)
RBB108539113(NANS)
TFN117098940(NANS)
PTEH111536614(NANS)
CANG105509947(NANS)
CJC100411585(NANS)
SBQ101027621(NANS)
CIMI108303891(NANS)
ANAN105733368(NANS)
CSYR103273474(NANS)
MMUR105873791(NANS)
LCAT123645941(NANS)
ERUF138387427(NANS)
PCOQ105805371(NANS)
OGA100951418(NANS)
MMU94181(Nans)
MCAL110292645(Nans)
MPAH110323062(Nans)
RNO298071(Nans)
MCOC116095967(Nans)
ANU117709646(Nans)
ASYL127680771(Nans)
MUN110551128(Nans)
CGE100767837(Nans)
MAUA101830178(Nans)
PROB127224641(Nans)
PLEU114702354(Nans)
PMAV102920893(Nans)
MORG121458558(Nans)
MFOT126509881
AAMP119826497(Nans)
CNL130887937(Nans)
NGI103749137(Nans)
HGL101721582(Nans)
CPOC100716456(Nans)
CCAN109697287(Nans)
DORD105990839(Nans)
DSP122121805(Nans)
DMER138819151(Nans)
PLOP125345837(Nans)
NCAR124964919
MMMA107147766(Nans)
ITI101969015(Nans)
OCU100356934
OPI101522937(NANS)
OCZ121144756(NANS)
TUP102496776(NANS)
GVR103590728(NANS)
CFA481624(NANS)
CLUD112649641(NANS)
VVP112930767(NANS)
VLG121494904(NANS)
NPO129495242(NANS)
AML100471912(NANS)
UMR103678504(NANS)
UAH113260417(NANS)
UAR123781029(NANS)
ELK111146174
LLV125083268
MPUF101687668(NANS)
MNP132024576(NANS)
MLK131812492(NANS)
NVS122917426(NANS)
ORO101377441(NANS)
EJU114213569(NANS)
ZCA113934273(NANS)
MLX118017911(NANS)
MANO123849820(NANS)
NSU110581438(NANS)
LWW102730978(NANS)
FCA101092303(NANS)
PYU121034713(NANS)
PCOO112872235(NANS)
PBG122474611(NANS)
PVIV125149821(NANS)
LRUF124502196
LGF123593273(NANS)
AJU106981299
PTG102952743(NANS)
PPAD109270098(NANS)
PUC125920084
PLEZ122204412(NANS)
HHV120233531(NANS)
CCRU144225025(NANS)
BTA540602(NANS)
BOM102266035(NANS)
BIU109563072(NANS)
BJV133252816(NANS)
BBUB102402717(NANS)
BKE129651615(NANS)
BBIS104993691(NANS)
CHX102171423(NANS)
OAS101104048(NANS)
OCAN138432629(NANS)
BTAX128052274(NANS)
CSUM138081240(NANS)
ODA120862645(NANS)
CCAD122452923(NANS)
MREE136148472(NANS)
OVR110145332(NANS)
MBEZ129556850(NANS)
SSC100155883(NANS)
CFR102511644(NANS)
CBAI105067382(NANS)
CDK105086903(NANS)
VPC102528094(NANS)
BACU103016138(NANS)
BMUS118897102(NANS)
LVE103074242(NANS)
OOR101286113(NANS)
LALB132523500(NANS)
GMF115838675(NANS)
DDP132427220(NANS)
DLE111187968(NANS)
PCAD102975186(NANS)
PSIU116755813(NANS)
PPHC136124377(NANS)
NASI112392669(NANS)
ECB100064126(NANS)
EPZ103550229(NANS)
EAI106842931(NANS)
MYB102254698(NANS)
MYD102770256(NANS)
MMYO118667273(NANS)
MLF102435662(NANS)
MDT132212182(NANS)
MYUM139020982(NANS)
PKL118716275(NANS)
EFUS103286401(NANS)
MNA107544993(NANS)
DRO112304493(NANS)
SHON118979589(NANS)
AJM119045927(NANS)
PDIC114509777(NANS)
PHAS123819942(NANS)
MMF118629683(NANS)
PPAM129079673(NANS)
HAI109386412(NANS)
RFQ117032312(NANS)
PALE102882391(NANS)
PGIG120597479(NANS)
PVP105296243(NANS)
RAY107511690(NANS)
MJV108386331(NANS)
TOD119231857(NANS)
SARA101558462(NANS)
SFUM130026316(NANS)
SETR126023700(NANS)
LAV100659127(NANS)
TMU101361417
ETF101653381(NANS)
DNM101415935(NANS)
MDO100014569(NANS)
GAS123231260(NANS)
SHR100915225(NANS)
AFZ127560750
PCW110220562(NANS)
TVP118834988(NANS)
PBRV138166878(NANS)
OAA100074951(NANS)
TACU119948107(NANS)
GGA427283(NANS)
PCOC116234839(NANS)
MGP100540972(NANS)
CJO107306381(NANS)
TPAI128089605 128089615
LMUT125687047 125687392
NMEL110389693(NANS)
APLA101793548(NANS)
AACU137847902(NANS)
OJA118156144(NANS)
ACYG106046483(NANS)
CATA118256861(NANS)
AFUL116500909(NANS)
TGU100227675(NANS)
LSR110472303(NANS)
VMC128822454(NANS)
VCHA128782352(NANS)
AIB137464572(NANS)
SCAN103821217(NANS)
PMOA120509468(NANS)
OTC121334701(NANS)
PRUF121355663(NANS)
ATRC139588866(NANS)
MATE118699727(NANS)
MAEN136569205(NANS)
GFR102036907(NANS)
FAB101817049(NANS)
OMA130264714(NANS)
PHI102108606(NANS)
PMAJ107198262(NANS)
CCAE111940921(NANS)
CCW104689769(NANS)
CBRC103616433(NANS)
ACOE138103000(NANS)
ETL114056942(NANS)
ZAB102065706(NANS)
ZLE135460015(NANS)
ACHL103804865(NANS)
SVG106859673(NANS)
MMEA130577596(NANS)
HRT120765301(NANS)
SATI136374431(NANS)
CFAI136288422(NANS)
CCIC134056231(NANS)
FPG101910977(NANS)
FCH102058691(NANS)
FRS119141112(NANS)
CCRI104155775(NANS)
NNT104409114(NANS)
SHAB115601192(NANS)
POCC134166664(NANS)
ACUN113489989(NANS)
ANOC141973163(NANS)
SURA141937424(NANS)
TALA104366421(NANS)
ACHC115336739(NANS)
HALD104312067(NANS)
HLE104830508(NANS)
AGEN126036494
HHAR128136549(NANS)
BBUT142027225(NANS)
GCL127027665
CSTI104550675(NANS)
LDI104355132(NANS)
MNB103774718(NANS)
DPUB104304859(NANS)
PPUS135173207(NANS)
IIN128979732(NANS)
AVIT104274354(NANS)
BRHI104489142(NANS)
EGZ104135026(NANS)
NNI104014067(NANS)
PCRI104025538(NANS)
PCAO104046970(NANS)
PARX142050103(NANS)
PADL103923247(NANS)
AFOR103896158(NANS)
FGA104074239(NANS)
CBOR142075860(NANS)
GSTE104263825(NANS)
CBOY140651032(NANS)
MAME142421792(NANS)
CLV102088004(NANS)
CNIC136001827(NANS)
PGUU104469406(NANS)
PLET104620779(NANS)
EHS104517044(NANS)
CMAC104481639(NANS)
CUCA104059924(NANS)
PCUR138733083(NANS)
TEO104375228(NANS)
GAME129199900(NANS)
OHA104331297(NANS)
ACAR104518859(NANS)
CPEA104394483(NANS)
CVF104285719(NANS)
RTD128902703(NANS)
CRID134508272(NANS)
LMIC141736088(NANS)
NARQ141477461(NANS)
AAM106487451(NANS)
AROW112968978(NANS)
NPD112946284(NANS)
TGT104577698(NANS)
DNE112982754(NANS)
SCAM104151902(NANS)
ASN102371122(NANS)
AMJ102562418(NANS)
CPOO109323518(NANS)
CIZ142013319(NANS)
CMY102930222(NANS)
CCAY125636602(NANS)
LKP140911837(NANS)
NDS141987808(NANS)
DCC119855742(NANS)
CPIC101940249(NANS)
TST117878892(NANS)
EOB135880109(NANS)
CABI116832497(NANS)
MRV120408042(NANS)
EMQ137156488(NANS)
ACS100558551(nans)
ASAO132768113(NANS)
PVT110077827(NANS)
SUND121924222(NANS)
PBI103051012(NANS)
PMUR107293127(NANS)
CTIG120308567(NANS)
TSR106556782(NANS)
PGUT117661676(NANS)
PCAE139311098(NANS)
APRI131193653(NANS)
PTEX113444069(NANS)
NSS113415520(NANS)
VKO123030229(NANS)
PMUA114587657(NANS)
PRAF128405086(NANS)
ZVI118097903(NANS)
HCG128346307(NANS)
GJA107122992(NANS)
STOW125437185(NANS)
EMC129334514(NANS)
XLA432051(nans.S) 447417(nans.L)
XTR100492893(nans)
NPR108783786(NANS)
RTEM120946942(NANS)
ACAT141102798(NANS)
PADS140326181(NANS)
BBUF120989333(NANS)
BGAR122920937(NANS)
DTC141052420(NANS)
HSQ130271914(NANS)
PCOB134905454(NANS)
PWL138299440 138299488 138299495
MUO115459142 115463653
GSH117347248 117347256
DRE322780(nansa) 492779(nansb)
DAES130217031(nansa) 130219431(nansb)
SRX107723182 107754352 107754390 107758866
SANH107665955 107686966 107686967 107692601
SGH107557947 107566238 107566239
CCAR109080082 109090623 109090659 122142494
CAUA113044320 113066551 113066555 113066556 113066635 113085422 113105679
CGIB127946856 127946857 127948763 127975766
PTET122322880(nansa)
LROH127156361(nansb) 127172436(nansa)
GRF141301789(nansb) 141337216(nansa)
OMC131524664 131534998(nansb) 131541588(nansa)
PPRM120475377(nansb) 120475384 120475385 120475386 120478311(nansa)
RKG130097610 130097653 130106509 130106510
MAMB125247499 125247713 125247908 125247921 125248041 125251616 125251645 125272478(nansa)
CIDE127507296 127519832
CERY137014595 137014597 137015002 137015052 137015105 137015157 137032172(nansa)
MASI127443667 127445253
TROS130553152(nansa)
TDW130407907(nansa) 130414328 130414329 130414351 130414352 130414355 130414375
MANU129433135 129433751 129444857(nansa) 129445965
PDAB135718171 135735826(nansa) 135781109 135781110
IPU100528493(nansa) 108260162
IFU128603812 128604222(nansa)
PHYP113531522(nans)
SMEO124378730 124381237(nansa)
TFD113635339(nansa)
TVC132842025(nansa)
CGAR128508667(nansa) 128511979
NGRA132875401 132875934 132882784 132883322
TRN134326114 134326424(nansa) 134327107
AMEX111195185(nansa) 125798999(nansb)
CMAO118811935 118811936 118816978(nansa)
EEE113568448(nans) 113589926
CHAR105903578(nansa)
SPIL134060036(nansa) 134094212
ASAD121687800(nansa)
TRU778024(nans)
TFS130527938(nansa)
TNGGSTEN00033532G001
LCO104922341(nans)
TBEN117474709(nansa)
CGOB115010173 115010214
PGEO117439291(nansa) 117450755
GACU117555257 117561263(nansa) 117561638
EMAC134864542(nansa)
ELY117254746(nansa)
EFO125885917(nansa)
PLEP121942582(nansa)
SLUC116042899(nansa)
SVIT144536103(nansa)
ECRA117956637(nansa)
ESP116698406(nans)
PFLV114570372(nans)
PFLT120564957(nansa)
GAT120825501 120825503
PPUG119218410(nansa)
AFB129095925 129096028(nansa)
CLUM117737471(nansa)
PSWI130190092(nansa)
CANA137795113 137795188
CVE137885278 137885382(nansa)
MSAM119884880 119899378 119899379
SCHU122873785 122873786
EARM139292787
CUD121507902 121508708 121508709
SPUL138594617(nansa)
LMIX132985410 132985440
HTC141787148(nansa) 141810802
ALAT119028006
ASTR137599651 137600245
PKLU139199069(nansa)
MZE101481190 106674567
ONL100695579 100695847 100696106
OAU116310552 116310553 116310587
OLA101166198(nans)
OML112137589(nansa)
CSAI133444310(nansa)
XMA102234709(nans)
XCO114145362(nans)
XHE116720640(nans)
PRET103467988(nans) 103472627
PFOR103148741(nans)
PLAI106938624(nans)
PMEI106905478(nans)
GAF122829775(nansa)
PPRL129367361(nansa)
CVG107083396(nans) 107083415 107083416
CTUL119787144 119787154 119787177
GMU124868545 124868562
NFU107390917 107390934
KMR108241432 108241509
ALIM106528334(nans)
NWH119422378 119422379
LTU140305609(nansa)
AOCE111575007(nansa)
EJA138208666 138208668 138209314 138209396 138209520 138209521
BFRE138614487 138615127
MCEP125003896 125004087 125004788
CSEM103384124 103384125
POV109627210 109627438
SSEN122770577 122771631
SSOE131466991 131466992
HHIP117769790 117769798
HSP118122966 118126039
PPLT128436994 128436995
SMAU118312620 118312971
LCF108885367 108885368
SDU111229256 111229269
SLAL111659703
XGL120800959(nansa)
HCQ109519806 109519931
SSCV125969199 125969200
SBIA133506019 133506020
PEE133404376 133404378
PTAO133476244 133476245
BPEC110166192 110166235
ENY140376541 140377163 140377164 140377250
MALB109953770(nans)
BSPL114858266 114858277 114858282
SJO128374734(nansa)
SSCO133988251(nansa)
TTY137176138(nansa)
GMH115540714(nans)
SASA100195066(sias) 106594767 106609889
STRU115191851 115202178 115202179 115202180 115202181
OTW112231840 112261351
OMY110497423 110497424 110534455
OGO124001941 124001943 124012735
ONE115137363 115137722 115145762 115146546
OKI109894131 109901155
OKE118362993 118362994 118395463
OMM135506831 135507743 135507744
OCLA139374135 139374136 139418884
SALP111971593 112068285 112080022
SNH120034903 120051990 120052901
SFON129840954 129841014 129841015
CCLU121534521 121535761 121535762
ELS105022900(nans)
OEP134034363(nansa)
SFM108920829
PKI111855408(nans)
AANG118227907(nansa)
AROT135255851(nansa)
CCOG133131112(nansa)
LOC102687418(nans)
PSPA121319344(nansa)
ARUT117420829(nansa)
PSEX120532357 120532358 120532359
CMK103177631(nansa) 103177633
RTP109938218(nansa)
CPLA122539555(nansa) 122547124
CPUN140485530(nansa)
HOC132833232(nansa)
SCAU119963574(nansa)
LERI129702205(nansa)
HAKA140726224(nansa) 140726225
PMRN116951617(NANS)
LRJ133340871
BFO118412951 118412952
BBEL109471483 109471485
SCLV120347367
SPU577884
LPIC129272734
LVG121424983
AJJ139967908
APLC110979925
ARUN117294985
AAMU139941046
AFIL140162881
AJC117102584
SKO100367009 100376912
PFLL139119946
DMEDmel_CG5232(NANS)
DER6553702
DSE6606666
DSIDsimw501_GD18832(Dsim_GD18832)
DYADyak_GE26192
DAN6500737
DSR110190443
DPO4800832
DPE6598731
DMN108156913
DWI6650267
DGR6568185
DMODmoj_GI24828
DAZ108621816
DNV108653385
DHE111601415
DVI6629848(NANS)
CCAT101459749
BOD106619099(NANS)
BDR105230863
RZE108365099
AOQ129252978
ALUD128865303
TDA119676011
MDE101899077
SCAC106086863
LCQ111687367
LSQ119609198
CVJ135949017(NANS)
GFS119638352
ECOE129939471
CLON129606515
HIS119658663
AGA133390932
ACOZ120950612
AARA120897604
AMER121589583
ASTE118508544
AMAP126558334
AFUN125763207
AMOU128309712
AMRS128707124
AALI118457210
ADAR125952204
ACOS131261000
AAG5563645
AALB109400878
ASUA134225434
CQUCpipJ_CPIJ013964
CPII120415920
CBRI134826934
CNS116345828
BCOO119073869
LLL129794412
PPAP129802692
BMOR101744099
BMAN114246626
MSEX115444962
DPLKGM_201756
BANY112054184
MJU123873286
NIQ126781032
VCD124533422
MCIX123656177
PMAC106708951 106709065
PPOT106100777 106100789
PXU106124172 106124788
BPHI137926582 137926679
PRAP110994857
PBX123716686
PNAP125054681
ZCE119829783
CCRC123693416
LSIN126969391
AAGE121730324
HAW110380482
HZE124629863
TNL113496613 113506267
SLIU111353605
OFU114364386
ONU135088530
ATRA106138180
GMW113518207
ECLR140753808(NANS)
PXY105391284
PGW126373167 126377162
LGLY125225310
CSTB134755939
CFUM141437757(NANS)
TCA103312199
TMOL138134526(NANS)
DPA109539228
ESIM136414094(NANS)
EFOR136340738(NANS)
SOY115879752
RFG143195316(NANS)
AGRG126744310
ATD109597067
CSET123315673
HAXR123680853
AGB108917229
LDC111503205
DVV114325108
NVL108567369
DCOR135800237(NANS)
APLN108741788 112904754
PPYR116164831
CCRN123298907
API100166349
DNX107161705
AGS114120104 126550715
RMD113549718
ACOO126833023
DVT126896132
BTAB109035180
DCI103520284
CLEC106666066
HHAL106681070(NANS)
NLU111058090
LDA142325112(NANS)
HVI124352678
PHUPhum_PHUM018360
FOC113212662
TPAL117647422
ZNE110829049
CSEC111874253
PAME138692648(NANS)
SGRE126267101
BROR134530381
IEL124155457
HAMR139694341(NANS)
FCD110842189
DPXDAPPUDRAFT_300651
DMK116933060
DPZ124349840
AFRA136025080
EAF111695997
PVM113802701(NANS)
PJA122265930
PCHN125046868
PMOO119575012
HAME121873235
PCLA123769285(NANS)
CQD128690230(NANS)
PTRU123507890
SPRM135112141
ESN126997930
MNZ135214269
MRJ136854945(NANS)
PORN139749074(NANS)
OOT143040298(NANS)
HAZT108677748
PPOI119112814 119113236
VDE111250001
VJA111258697
GOE100901930
TUT107368038
CSCU111619307
CVS136989545(NANS)
PTEP107452120
ABRU129958113 129958114 129958115
UDV129218419
SDM118205491
LPOL106468194
MMER123559815
CCLM134180559
 » show all
Reference
1  [PMID:13743311]
  Authors
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
  Title
Enzymatic synthesis of sialic acid 9-phosphates.
  Journal
Proc Natl Acad Sci U S A 47:958-61 (1961)
DOI:10.1073/pnas.47.7.958
Reference
2  [PMID:5928202]
  Authors
Watson DR, Jourdian GW, Roseman S.
  Title
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
  Journal
J Biol Chem 241:5627-36 (1966)
Reference
3  [PMID:10873658]
  Authors
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K
  Title
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
  Journal
Biochem Biophys Res Commun 273:642-8 (2000)
DOI:10.1006/bbrc.2000.2983
  Sequence
[mmu:94181]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.57
IUBMB Enzyme Nomenclature: 2.5.1.57
ExPASy - ENZYME nomenclature database: 2.5.1.57
BRENDA, the Enzyme Database: 2.5.1.57
CAS: 9031-58-7

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