KEGG   ENZYME: 2.5.1.76
Entry
EC 2.5.1.76                 Enzyme                                 
Name
cysteate synthase;
sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
sulfite:O-phospho-L-serine sulfonotransferase (phosphate-hydrolysing, L-cysteate-forming)
Reaction(IUBMB)
O-phospho-L-serine + sulfite = L-cysteate + phosphate [RN:R09530]
Reaction(KEGG)
R09530
Substrate
O-phospho-L-serine [CPD:C01005];
sulfite [CPD:C00094]
Product
L-cysteate [CPD:C00506];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).
History
EC 2.5.1.76 created 2009
Orthology
K15527  cysteate synthase
Genes
SBHSBI_01127(thrC1)
SLSSLINC_0745
SSPBCP982_37255
SROIIAG44_03570
KAUB6264_25020
SESPBN6_58880(sam27)
ATLAthai_14040
MPROBJP34_24920
OSPOdosp_0306
BUYD8S85_04840
BVIRI6J59_10235
AFDAlfi_3017
ALDGFH31_10570
AOKA3BBH6_26810
ACOUA5CBH24_22940
ADAA5CPEGH6_21060
AITAI2BBH_17830
APUTL6V35_09585
RBCBN938_1527
BACCBRDCF_p1063
DORIFH5T_07005
DRCG0Q07_00405
MCOSGM418_10265
ASXCDL62_02870
MBASALGA_4376
FPLFerp_0996
GACGACE_0966
GAHGAH_01909
MBAMbar_A3541
MBYMSBRM_2301
MBWMSBRW_1194
MBARMSBR2_0111
MBAKMSBR3_0082
MACMA_3297(thrC)
MMAMM_0133
MMAZMmTuc01_0142
MMJMSMAS_1199
MMACMSMAC_2537
MVCMSVAZ_2304
MEKMSKOL_2312
MLSMSLAZ_2127
METMMSMTP_1160
MEFMSWH1_1038
MEQMSWHS_1109
MSJMSSAC_1624
MSZMSSIH_1219
MSWMSSIT_1277
MTHRMSTHT_0114
MTHEMSTHC_0614
MHORMSHOH_1390
MFZAOB57_001890
MBUMbur_1454
MMETMCMEM_1953
MELOJ7W08_08675
MMHMmah_1753
MHAZBHR79_04915
MZHMzhil_0778
MPYMpsy_2145
MZIHWN40_11505
MHZMetho_1762
MTPMthe_0680
MCJMCON_0195
MHIMhar_1114
MHUMhun_2977
MRTJKHC33_02000
MLAMlab_0503
MEMMemar_0111
MBGBN140_0055(thrC1)
MEMAMMAB1_0058
MCHKMchiMG62_02920
MPIMpet_0280
MBNMboo_2116
MPLMpal_2734
MPDMCP_1992
MEZMtc_1468
RCILRC440(thrC-2)
MEAMMU439_06700
MAXMMALV_07780
MERMMINT_17990
 » show all
Reference
1  [PMID:19761441]
  Authors
Graham DE, Taylor SM, Wolf RZ, Namboori SC
  Title
Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase.
  Journal
Biochem J 424:467-78 (2009)
DOI:10.1042/BJ20090999
  Sequence
[mac:MA_3297]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.76
IUBMB Enzyme Nomenclature: 2.5.1.76
ExPASy - ENZYME nomenclature database: 2.5.1.76
BRENDA, the Enzyme Database: 2.5.1.76

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