KEGG   ENZYME: 2.5.1.82
Entry
EC 2.5.1.82                 Enzyme                                 
Name
hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
HexPS(ambiguous);
(all-E) hexaprenyl diphosphate synthase;
(all-trans) hexaprenyl diphosphate synthase;
hexaprenyl pyrophosphate synthase (ambiguous);
HexPPs (ambiguous);
hexaprenyl diphosphate synthase (ambiguous);
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranylgeranyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 2 units of 3-methylbut-3-en-1-yl)
Reaction(IUBMB)
geranylgeranyl diphosphate + 2 (3-methylbut-3-en-1-yl diphosphate) = 2 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09246]
Reaction(KEGG)
R09246
Substrate
geranylgeranyl diphosphate [CPD:C00353];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]
Comment
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate. Requires Mg2+ [1].
History
EC 2.5.1.82 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.82
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05355  hexaprenyl-diphosphate synthase
K21268  hexaprenyl diphosphate synthase
Genes
QSU111992756 112011202
CMECYME_CMJ246C
SCEYBR003W(COQ1)
AGOAGOS_AER004W
ERCEcym_5300
KLAKLLA0_E17183g
KMXKLMA_60114(COQ1)
LTHKLTH0G16368g
VPOKpol_1036p41
ZROZYRO0A04620g
CGRCAGL0C04257g
NCSNCAS_0I01970(NCAS0I01970)
NDINDAI_0A06570(NDAI0A06570)
TPFTPHA_0A04460(TPHA0A04460)
TBLTBLA_0F00560(TBLA0F00560)
TDLTDEL_0D04200(TDEL0D04200)
TGBHG536_0G03050
KAFKAFR_0F02550(KAFR0F02550)
ZMKHG535_0C02340
PPAPAS_chr4_0819
DHADEHA2B02640g
PICPICST_86778(COQ1)
PGUPGUG_02562
SPAASPAPADRAFT_59987
LELLELG_00499
CALCAALFM_CR00570WA(CaO19.7478)
CTPCTRG_01016
COTCORT_0A03790
CDUCD36_25670
CTENCANTEDRAFT_111901
YLIYALI0C18755g
CLUCLUG_04350
CLUSA9F13_04g01595
CAURCJI97_000697
SLBAWJ20_394(COQ1)
PKZC5L36_0D01990
BNNFOA43_001379
BBRXBRETT_002538
NCRNCU02305
NTENEUTE1DRAFT124027(NEUTE1DRAFT_124027)
SMPSMAC_08723
PANPODANSg1807
TTTTHITE_2117141
MTMMYCTH_2308814
CTHRCTHT_0016730
MGRMGG_03343
SSCKSPSK_04068
FGRFGSG_10933
FPUFPSE_06046
FVRFVEG_11617
FOXFOXG_12870
NHENECHADRAFT_93238
TRETRIREDRAFT_68728
TRRM419DRAFT_38563
MAWMAC_09061
MAJMAA_03330
CMTCCM_00496
PLJVFPFJ_02060 VFPFJ_08069
VALVDBG_03289
VDAVDAG_02194
CFJCFIO01_07326
SAPOSAPIO_CDS3842
ELAUCREL1_11765
PFYPFICI_14449
SSLSS1G_11088
BFUBCIN_02g05540(Bccoq1)
MBEMBM_07123
PSCOLY89DRAFT_649566
GLZGLAREA_07665
AFMAFUA_3G06120
ACTACLA_034080
NFINFIA_071130
AORAO090020000085
ANGANI_1_1348094(An11g10370)
AFVAFLA_010570
ALUCAKAW2_80893A(COQ1)
ACHEACHE_70473A(COQ1)
PCSPc20g07830
PDPPDIP_00870
TMFPMAA_004110
TRGTRUGW13939_11219
CIMCIMG_00484
CPWCPC735_057400
UREUREG_00522
PBLPAAG_05961
ABEARB_07252
TVETRV_03960
AJEHCAG_01245
BGHBDBG_06739
PNOSNOG_03045
PTEPTT_13690
BZECOCCADRAFT_107085
BSCCOCSADRAFT_169302
BORCOCMIDRAFT_22591
AALTCC77DRAFT_951220
ZTRMYCGRDRAFT_73426(COQ1)
PFJMYCFIDRAFT_72669
BCOMBAUCODRAFT_34812
NPAUCRNP2_7312
TMLGSTUM_00003780001
SPOSPBPJ4664.01(dps1)
CNECNI01740
CNBCNBH1650
CGICGB_H2490W
TMSTREMEDRAFT_15595
PPLPOSPLDRAFT_90841
TVSTRAVEDRAFT_157916
DSQDICSQDRAFT_173926 DICSQDRAFT_176811
PCOPHACADRAFT_168921
SHSSTEHIDRAFT_71092
HIRHETIRDRAFT_308186
PSQPUNSTDRAFT_25993
ADLAURDEDRAFT_110102
FMEFOMMEDRAFT_136957
GTRGLOTRDRAFT_67486
LBCLACBIDRAFT_251291 LACBIDRAFT_335947
MPRMPER_08383
MRRMoror_7207 Moror_8053
CCICC1G_00492 CC1G_05865
SCMSCHCODRAFT_106878 SCHCODRAFT_233425 SCHCODRAFT_35228 SCHCODRAFT_61590
ABPAGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABVAGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
CPUTCONPUDRAFT_116134
SLASERLADRAFT_444711
WSEWALSEDRAFT_59360
WICJ056_004047
UMAUMAG_11674
PFPPFL1_02050
MGLMGL_1241
MRTMRET_2902
MSYMMSY001_0654
PGRPGTG_00683
MLRMELLADRAFT_102532
DFADFA_03641(coq1)
PYOPY17X_0301300
PCBPCHAS_030300(PC000612.04.0)
PBEPBANKA_0300800
PKNPKNH_0418400
PVXPVX_003575
PCYPCYB_042740
FCYFRACYDRAFT_275453
PSOJPHYSODRAFT_336262
GTTGUITHDRAFT_86821
STOSTK_04870
SOHD1869_02255
SSOSSO2345(gdS-2)
SOLSsol_0157
SSOASULA_0149
SSOLSULB_0150
SSOFSULC_0149
SSHIJ5U23_01140
SCASSACC_19450
SAISaci_0995
SACNSacN8_04825
SACRSacRon12I_04815
SACSSUSAZ_04575
SISLS215_0173
SIAM1425_0142
SIMM1627_0142
SIDM164_0161
SIYYG5714_0146
SINYN1551_2745
SIILD85_0146
SIHSiH_0146
SIRSiRe_0142
SICSiL_0133
SULABFU36_10510
SULEGFS03_02260
SULOGFS33_08965
SULLEWF20_03780
MSEMsed_0691
MCNMcup_1409
MHKDFR87_03200
MPRUDFR88_03125
MTENGWK48_08915
MJNMjAS7_1457
AHOAhos_2145
AMANB6F84_03375
ABRIDFR85_06020
ASULDFR86_03380
AAMBD1866_05705
ACIHHS5_09560
SAZOD1868_10440
CSTYKN1_02790
STEPIC006_2729
SAHSHS7_16810
THELIG193_06965
 » show all
Reference
1  [PMID:11790729]
  Authors
Hemmi H, Ikejiri S, Yamashita S, Nishino T
  Title
Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.
  Journal
J Bacteriol 184:615-20 (2002)
DOI:10.1128/JB.184.3.615-620.2002
  Sequence
[sso:SSO2345]
Reference
2  [PMID:12372398]
  Authors
Hemmi H, Noike M, Nakayama T, Nishino T
  Title
Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus  solfataricus by introducing mimetic mutations.
  Journal
Biochem Biophys Res Commun 297:1096-101 (2002)
DOI:10.1016/S0006-291X(02)02348-3
Reference
3  [PMID:16291686]
  Authors
Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH
  Title
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.
  Journal
J Bacteriol 187:8137-48 (2005)
DOI:10.1128/JB.187.23.8137-8148.2005
  Sequence
[sso:SSO2345]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.82
IUBMB Enzyme Nomenclature: 2.5.1.82
ExPASy - ENZYME nomenclature database: 2.5.1.82
BRENDA, the Enzyme Database: 2.5.1.82

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