KEGG ENZYME: 2.5.1.83

ENZYME: 2.5.1.83

Entry

EC 2.5.1.83                 Enzyme

Name

hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific];
HexPS (ambiguous);
hexaprenyl pyrophosphate synthetase (ambiguous);
hexaprenyl diphosphate synthase (ambiguous);
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

(2E,6E)-farnesyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate farnesyltranstransferase (adding 3 units of 3-methylbut-3-en-1-yl)

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09245]

Reaction(KEGG)

R09245

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129]

Product

diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]

Comment

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate [1].

History

EC 2.5.1.83 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.83

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K05355

hexaprenyl diphosphate synthase

K21274

hexaprenyl diphosphate synthase small subunit

K21275

hexaprenyl diphosphate synthase large subunit

Genes

CME:	CYME_CMJ246C

SCE:	YBR003W(COQ1)

SEUB:

DI49_0184

SPAO:

SPAR_B01070

AGO:	AGOS_AER004W

ERC:

Ecym_5300

KLA:	KLLA0_E17183g

KMX:	KLMA_60114(COQ1)

LTH:	KLTH0G16368g

VPO:	Kpol_1036p41

ZRO:	ZYRO0A04620g

CGR:	2886824(GVI51_C04037)

NCS:	NCAS_0I01970(NCAS0I01970)

NDI:	NDAI_0A06570(NDAI0A06570)

TPF:	TPHA_0A04460(TPHA0A04460)

TBL:	TBLA_0F00560(TBLA0F00560)

TGB:	HG536_0G03050

TDL:	TDEL_0D04200(TDEL0D04200)

KAF:	KAFR_0F02550(KAFR0F02550)

KNG:	KNAG_0J01180(KNAG0J01180)

ZMK:	HG535_0C02340

PPA:	PAS_chr4_0819

DHA:	DEHA2B02640g

PIC:	PICST_86778(COQ1)

PGU:	PGUG_02562

SPAA:

SPAPADRAFT_59987

LEL:	PVL30_000484(COQ1)

CAL:	CAALFM_CR00570WA(CaO19.7478)

CTP:	CTRG_01016

COT:	CORT_0A03790

CDU:	CD36_25670

CTEN:

18246326(COQ1)

YLI:	2909963(YALI2_B00439g)

CLU:	CLUG_04350

CLUS:

A9F13_04g01595

CAUR:

CJI96_0003402

SLB:	AWJ20_394(COQ1)

PKZ:	C5L36_0D01990

BNN:	FOA43_001379

BBRX:

BRETT_002538

OPA:	HPODL_03901

SLUD:

SCDLUD_002533

NCR:

NCU02305

NTE:	NEUTE1DRAFT124027(NEUTE1DRAFT_124027)

SMP:	SMAC_08723

PAN:	PODANSg1807

PBEL:

QC761_509670(COQ1)

PPSD:

QC762_509670(COQ1)

PPSP:

QC763_509670(COQ1)

PPSA:

QC764_509670(COQ1)

TTT:	THITE_2117141

MTM:	MYCTH_2308814

CTHR:

CTHT_0016730

MGR:

MGG_03343

PPEI:

PpBr36_06486

PGRI:

PgNI_00709

SSCK:

SPSK_04068

FGR:	FGSG_10933

FPU:	FPSE_06046

FPOA:

FPOAC1_009679

FVN:	FVRRES_10316

FVR:	FVEG_11617

FOX:	FOXG_12870

NHE:	NECHADRAFT_93238

FFC:	NCS54_00645700

FKR:	NCS57_00686000

FMU:	J7337_010022

TRE:	TRIREDRAFT_68728

TRR:	M419DRAFT_38563

TATV:

25779678(TrAtP1_008741)

MAJ:

MAA_03330

MBRN:

26246070(G6M90_00g085240)

PCHM:

VFPPC_04198

CMT:

CCM_00496

AMUS:

LMH87_000769

PLJ:	28884193(PLICBS_005461)

PTKZ:

JDV02_003904(COQ1)

VAL:	VDBG_03289

VDA:	VDAG_02194

CFJ:	CFIO01_07326

CLUP:

CLUP02_12999

CHIG:

CH63R_12248

SAPO:

SAPIO_CDS3842

ELA:	UCREL1_11765

PFY:	PFICI_14449

SSL:	SS1G_11088

BFU:	BCIN_02g05540(Bccoq1)

MBE:

MBM_07123

PSCO:

LY89DRAFT_649566

GLZ:	GLAREA_07665

ANI:	ANIA_10340

AFM:	AFUA_3G06120

ACT:	ACLA_034080

NFI:	NFIA_071130

AOR:	AO090020000085

ANG:	An11g10370

AFV:	AFLA_010570

ALUC:

AKAW2_80893A(COQ1)

ACHE:

ACHE_70473A(COQ1)

APUU:

APUU_31174S(COQ1)

PCS:	N7525_009212

PDP:	PDIP_00870

POU:	POX_g09019

TMF:	EYB26_009001

TRG:	TRUGW13939_11219

CIM:	CIMG_00484

CPW:	CPC735_057400

URE:	UREG_00522

PBL:	PAAG_05961

ABE:

ARB_07252

TVE:

TRV_03960

AJE:	HCAG_01245

BGH:	BDBG_06739

PNO:	SNOG_03045

PTE:

PTT_13690

PTRR:

6338962(PtrM4_028830)

BZE:	COCCADRAFT_107085

BSC:	COCSADRAFT_169302

BOR:	COCMIDRAFT_22591

AALT:

CC77DRAFT_951220

ARAB:

EKO05_0000542

ZTR:	MYCGRDRAFT_73426(COQ1)

PFJ:	MYCFIDRAFT_72669

FFU:	CLAFUR5_09538

CBET:

CB0940_10267

BCOM:

BAUCODRAFT_34812

NPA:	UCRNP2_7312

TML:	GSTUM_00003780001

SPO:	2541402(dps1)

SOM:	SOMG_02290(dps1)

CNE:

CNI01740

CNB:

CNBH1650

CNG:	CNAG_04375

CGI:	CGB_H2490W

CDEU:

CNBG_2676

TMS:	TREMEDRAFT_15595

CCAC:

CcaHIS019_0305350(COQ1)

PPL:	POSPLDRAFT_90841

TVS:	TRAVEDRAFT_157916

DSQ:	DICSQDRAFT_173926 DICSQDRAFT_176811

PCO:	PHACADRAFT_168921

SHS:	STEHIDRAFT_71092

HIR:	HETIRDRAFT_308186

PSQ:	PUNSTDRAFT_25993

ADL:	AURDEDRAFT_110102

FME:	FOMMEDRAFT_136957

GTR:	GLOTRDRAFT_67486

LBC:	LACBIDRAFT_251291 LACBIDRAFT_335947

CCI:	CC1G_00492 CC1G_05865

ABP:	AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)

ABV:	AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)

PCUB:

JR316_0011391

MPR:	MPER_08383

MRR:	Moror_7207 Moror_8053

E1B28_001638 E1B28_004206

SCM:	SCHCO_02488796(SCHCODRAFT_02488796) SCHCO_02492233(SCHCODRAFT_02492233) SCHCO_02641733(SCHCODRAFT_02641733) SCHCO_02697952(SCHCODRAFT_02697952)

CPUT:

CONPUDRAFT_116134

SLA:	SERLADRAFT_444711

WSE:	WALSEDRAFT_59360

WIC:	J056_004047

UMA:	UMAG_11674

PFP:	PFL1_02050

SGRA:

EX895_004282

MGL:

MGL_1241

MRT:

MRET_2902

MSYM:

MSY001_0654

PGR:	PGTG_00683

PTRC:

PtA15_13A363 PtA15_1A555 PtA15_1A569

PSTR:

Pst134EA_000298 Pst134EA_000303

MLR:	MELLADRAFT_102532

DFA:	DFA_03641(coq1)

PYO:	PY17X_0301300

PCB:	PCHAS_0303000

PBE:	PBANKA_0300800

PKN:	PKNH_0418400

PVX:	PVX_003575

PCY:	PCYB_042740

FCY:	FRACYDRAFT_275453

PSOJ:

PHYSODRAFT_336262

MACR:

BHM04_03485 BHM04_03495

MARY:

LAU42_05990 LAU42_06000

MBRU:

MGG13_06470 MGG13_06480

MEPI:

KFV12_07710 KFV12_07720

MEQU:

KFV11_06170

MBOC:

QSV55_06085 QSV55_06095

MCL:	MCCL_1121(hepB2) MCCL_1123(hepB1)

MCAK:

MCCS_13080(hexs-b) MCCS_13100(hexs-a)

MBOE:

HT586_07190 HT586_07200

» show all

Reference

1 [PMID:7174655]

Authors

Fujii H, Koyama T, Ogura K.

Title

Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components.

Journal

J Biol Chem 257:14610-2 (1982)

Sequence

[ag:BAA25266 BAA25268]

Reference

2 [PMID:9515931]

Authors

Shimizu N, Koyama T, Ogura K

Title

Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.

Journal

J Bacteriol 180:1578-81 (1998)
DOI:10.1128/JB.180.6.1578-1581.1998

Sequence

[ag:BAA25266 BAA25268]

Reference

3 [PMID:11514159]

Authors

Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T

Title

Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases.

Journal

Bioorg Med Chem Lett 11:2157-9 (2001)
DOI:10.1016/S0960-894X(01)00391-2