KEGG   ENZYME: 2.5.1.84
Entry
EC 2.5.1.84                 Enzyme                                 
Name
all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
SolPP synthase (ambiguous);
SPP-synthase (ambiguous);
SPP synthase (ambiguous);
solanesyl-diphosphate synthase (ambiguous);
OsSPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09250]
Reaction(KEGG)
R09250 > R07267
Substrate
geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]
Comment
(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3].
History
EC 2.5.1.84 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.84
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05356  all-trans-nonaprenyl-diphosphate synthase
Genes
AJM119058962
ATHAT1G17050(SPS2) AT1G78510(SPS1)
ALY110225373 9304798 9323808
CRB17894671 17896965
CSAT104702634 104713531 104740392 104751747 104756029 104775809
EUSEUTSA_v10007715mg EUTSA_v10018616mg
BRP103832329 103872491
BNA106346730 106354554 106354696 106365558
BOE106301071 106343305
RSZ108825091 108828623
THJ104810419 104812299 104813987 104822586
CPAP110811666
CIT102612772
CICCICLE_v10020312mg
PVY116125242
MINC123201391 123229888
TCC18594463
GRA105782627 105798922
GHI107891827 107895305 107915414 107920469
GAB108464212
DZI111298875
EGR104431592 104450052
GMX100783538 100805842
GSJ114376580 114388248
PVUPHAVU_005G064200g
VRA106762491
VAR108334430
VUN114186101
CCAJ109790225
APRC113853731
MTR25487134
CAM101502183
LJALj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
ADU107459857
AIP107613812
AHF112703489 112771865
LANG109334617 109357382
FVE101297041
RCN112202839
PPER18778932
PMUM103325805
PAVI110772576
PDUL117626647
MDM103427372 103448906
PXB103931560 103936506
ZJU107414345
MNT21403646
CSV101214140
CMO103492962
BHJ120086134
MCHA111012845
CMAX111480364 111482773
CMOS111437508 111447291
CPEP111789795 111810913
RCU8258714
JCU105641085
HBR110646978 110661949
MESC110601874
POP7459128
PEU105140437
PALZ118063542
JRE108994345
QSU111989322
QLO115955302
TWL119986060
VVI100246988
VRI117908989
SLY101253007(SppS)
SPEN107026209
SOT102593674
SSTN125876287
CANN107878554
NTA107765960 107832641
NSY104243529
NTO104101158
NAU109243898
INI109150506 109155754
ITR115997059 116029890
SIND105165488 105176904
OEU111368875 111374720 111389251
EGT105957125 105970397
SSPL121783697 121787504 121803081 121807016
HAN110885948 110895200
ECAD122596409
LSV111904475
CCAV112516899
DCR108220839 108224138
CSIN114274488 114289614
BVG104899063
SOE110783766
CQI110702759 110737893
NNU104585964 104610500
MING122059732
TSS122651288
PSOM113287425 113295653
NCOL116249055 116264365
OSA107276142 4351957
DOSAOs05t0582300-01(Os05g0582300)
OBR102703542 102721369
BDI100826224 100835146
ATS109748254
TDC119293764
TAES123069734 123183265
TUA125531192
SBI8155346
ZMA100191875 100282721 103653367
SITA101761340 101780515
SVS117848120
PVIR120665997 120699238
PHAI112883879 112884053
PDA103712684
EGU105047202 105048867
MUS103989203
DCT110112294
PEQ110032238
AOF109842749
ATR18430924
SMOSELMODRAFT_177791 SELMODRAFT_446259
PPP112278371 112293520
CRECHLRE_13g565650v5
VCNVOLCADRAFT_57046
MNGMNEG_8646 MNEG_9373
CSLCOCSUDRAFT_15266
CVRCHLNCDRAFT_49140
APROF751_0189
OLUOSTLU_51700(clpR2)
OTAOT_ostta17g01400
BPGBathy06g03500
MISMICPUN_58850
MPPMICPUCDRAFT_23095
SMINv1.2.008416.t1(symbB.v1.2.008416.t1)
BSTOC0V70_09165
DEDDHBDCA_p976
DECDCF50_p1034
DRSDEHRE_09350
SYNslr0611(sds)
SYZMYO_110(sds)
SYYSYNGTS_0001(sds)
SYTSYNGTI_0001(sds)
SYSSYNPCCN_0001(sds)
SYQSYNPCCP_0001(sds)
SYJD082_04480(sds)
SYOC7I86_00005(sds)
SYCsyc1741_c(sds)
SYUM744_04455
SYFSynpcc7942_2362
SYDSyncc9605_1137
SYESyncc9902_1320
SYGsync_1551
SYRSynRCC307_1159(preA)
SYXSynWH7803_1038(preA)
SYPSYNPCC7002_A0580(sdsA)
CYACYA_2276(sds)
CYBCYB_0451(sds)
SYNESyn6312_1736
SYNPSyn7502_02664
SYNKKR100_08045
SYNRKR49_03240
SYNDKR52_10950
SYHSyncc8109_1551
SYNWSynWH8103_01143(sds)
SYVAWQ23_03060
SYLAWQ21_03035
SYNCCB0101_03630(sds)
SYNYBM449_13485
DSLDacsa_0433
SYWSYNW1011(sds)
CGCCyagr_0415
CYICBM981_0715(preA)
PMAPro_1042(crtE)
PMMPMM0618(sds)
PMTPMT_0392
PMNPMN2A_0055
PMIPMT9312_0618
PMBA9601_06741(sds)
PMCP9515_06831(sds)
PMFP9303_18951(sds)
PMGP9301_06441(sds)
PMHP9215_07001(sds)
PMJP9211_10311(sds)
PMENATL1_06761(sds)
PRCEW14_0663
PRMEW15_0718
CMPCha6605_4130
AMRAM1_4909(sds)
WNAKA717_06355(sds)
TVNNIES2134_116780(sds)
SLWBRW62_02200
TELtlr1757(sds)
THNNK55_05445(sdsA)
THECFFX45_07305(sds)
LEPLepto7376_2404
LENLEP3755_01010
LETO77CONTIG1_01361(hepT)
LBOLBWT_24310
KOVK9N68_31025(sds)
LSCKIK02_08660(sds)
LSKJ5X98_09000(sds)
HHGXM38_031750(preA)
PSEUPse7367_3398
PSERABRG53_3209
THEUHPC62_12685(sds)
GLPGlo7428_0843
GENGM3709_1768
GEEGM3708_375
CHONNIES4102_32230
MARMAE_00010(sds)
MPKVL20_2046
MIQB5D77_22100
MVZmyaer102_35090(sds)
CANCyan10605_2007
CSNCyast_2152
CYLAA637_04100(sds)
HAOPCC7418_0987
ENNFRE64_00290(sds)
CYUUCYN_02260
CYTcce_2465(sds)
CWACwatDRAFT_5051
CYPPCC8801_0374
CYHCyan8802_0383
CYCPCC7424_1227
CYJCyan7822_0065
CYNCyan7425_4840
TERTery_0157
ARPNIES39_N00440(sds)
PAGHNIES204_34370(sds)
PPSUNO713_05023(preA)
OXYHCG48_21390(sds)
MVAGD0A34_10925(sds)
LFSHFV01_14595(sds)
MICMic7113_1628
GEIGEI7407_0914
OACOscil6304_4151
ONIOsc7112_4458
MPROBJP34_21265
PHORJWS08_00220(sds)
PYHNEA10_10040(sds)
CEPCri9333_3322
GVIgll0753(sds)
GLJGKIL_2127(sds)
GMLISF26_05410(sds)
ANAalr0096(sds)
NPUNpun_R1834
NOSNos7107_1547
NOPNos7524_1387
NONNOS3756_52910
NFLCOO91_05413
NOECLI64_12930(sds)
NSHGXM_01052
NEDHUN01_21495(sds)
AVAAva_1469
NAZAazo_0858
ANBANA_C12807(sds)
ACYAnacy_0566
AWAAA650_07700
ANNEH233_05145(sds)
CSGCylst_4885
RSINB6N60_02420
CALOCal7507_0890
CALTCal6303_4786
CALHIJ00_17620
CALNNIES2098_47760
RIVRiv7116_1590
FISFIS3754_14160
NSPBMF81_03890(hepT)
NSPHBDGGKGIB_00348(hepT)
DOUBMF77_03530(hepT)
DFSHGD76_22675(sds)
DHTNG743_19045(sds)
CCURIAR63_04880(sds)
CRKL3I90_06785(sds)
AFLOHEQ12_11890(sds)
TOQHCG51_11960(sds)
NCNBZZ01_30115
CTHEChro_0646
PLPPle7327_0833
SCSSta7437_0631
STANSTA3757_20020
CEOETSB_0422(sds)
CERRGRSB_0382(sds)
 » show all
Reference
1  [PMID:911777]
  Authors
Sagami H, Ogura K, Seto S
  Title
Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus.
  Journal
Biochemistry 16:4616-22 (1977)
DOI:10.1021/bi00640a014
Reference
2  [PMID:7447947]
  Authors
Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM.
  Title
Variable product specificity of solanesyl pyrophosphate synthetase.
  Journal
Biochem Biophys Res Commun 96:1648-53 (1980)
DOI:10.1016/0006-291X(80)91363-7
Reference
3  [PMID:20421194]
  Authors
Ohara K, Sasaki K, Yazaki K
  Title
Two solanesyl diphosphate synthases with different subcellular localizations and  their respective physiological roles in Oryza sativa.
  Journal
J Exp Bot 61:2683-92 (2010)
DOI:10.1093/jxb/erq103
  Sequence
[osa:4341844]
Reference
4  [PMID:1748647]
  Authors
Ohnuma S, Koyama T, Ogura K
  Title
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.
  Journal
J Biol Chem 266:23706-13 (1991)
Reference
5  [PMID:1429508]
  Authors
Gotoh T, Koyama T, Ogura K
  Title
Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase.
  Journal
J Biochem 112:20-7 (1992)
DOI:10.1093/oxfordjournals.jbchem.a123859
Reference
6  [PMID:8226825]
  Authors
Teclebrhan H, Olsson J, Swiezewska E, Dallner G
  Title
Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.
  Journal
J Biol Chem 268:23081-6 (1993)
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.84
IUBMB Enzyme Nomenclature: 2.5.1.84
ExPASy - ENZYME nomenclature database: 2.5.1.84
BRENDA, the Enzyme Database: 2.5.1.84

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