Entry
Name
trans,polycis-decaprenyl diphosphate synthase;
Rv2361c;
(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate [RN:
R09244 ]
Reaction(KEGG)
Substrate
(2Z,6E)-farnesyl diphosphate [CPD:
C16826 ];
isopentenyl diphosphate [CPD:
C00129 ]
Product
diphosphate [CPD:
C00013 ];
trans,octacis-decaprenyl diphosphate [CPD:
C18321 ]
Comment
The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2].
History
EC 2.5.1.86 created 2010
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K14215 trans,polycis-decaprenyl diphosphate synthase
Genes
MBAI : MB901379_03256(uppS_1)
MHEK : JMUB5695_02017(uppS)
MGAU : MGALJ_22030(uppS_1)
MPHL : MPHLCCUG_03461(uppS_1)
MTHN : 4412656_02789(uppS)
MCHT : MCHIJ_31760(uppS_2)
MAUU : NCTC10437_03626(uppS_2)
MPSC : MPSYJ_29460(uppS_2)
MMAT : MMAGJ_75300(uppS_2)
MSEI : MSEDJ_48030(uppS_1)
MFLV : NCTC10271_01784(uppS_2)
MSAL : DSM43276_01538(uppS_2)
MTER : 4434518_01468(uppS_2)
» show all
Taxonomy
Reference
Authors
Kaur D, Brennan PJ, Crick DC
Title
Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.
Journal
Sequence
Reference
Authors
Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH
Title
The structural basis of chain length control in Rv1086.
Journal
Sequence
Reference
Authors
Crick DC, Schulbach MC, Zink EE, Macchia M, Barontini S, Besra GS, Brennan PJ
Title
Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.86
ExPASy - ENZYME nomenclature database: 2.5.1.86