KEGG ENZYME: 2.5.1.86

ENZYME: 2.5.1.86

Entry

EC 2.5.1.86                 Enzyme

Name

trans,polycis-decaprenyl diphosphate synthase;
Rv2361c;
(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units)

Reaction(IUBMB)

(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate [RN:R09244]

Reaction(KEGG)

R09244

Substrate

(2Z,6E)-farnesyl diphosphate [CPD:C16826];
isopentenyl diphosphate [CPD:C00129]

Product

diphosphate [CPD:C00013];
trans,octacis-decaprenyl diphosphate [CPD:C18321]

Comment

The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2].

History

EC 2.5.1.86 created 2010

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K14215

trans,polycis-decaprenyl diphosphate synthase

Genes

MTU:	Rv2361c(uppS)

MTV:	RVBD_2361c

MTC:	MT2430(uppS-2)

MRA:

MRA_2385

MTF:	TBFG_12387

MTB:	TBMG_01614

MTK:	TBSG_01623

MTZ:	TBXG_001599

MTG:	MRGA327_14530

MTI:	MRGA423_14675

MTE:	CCDC5079_2183

MTUR:

CFBS_2500

MTL:	CCDC5180_2155

MTO:	MTCTRI2_2404

MTD:

UDA_2361c

MTN:	ERDMAN_2594

MTJ:	J112_12670

MTUB:

MT7199_2392

MTUC:

J113_16365

MTUE:

J114_12645

MTX:	M943_12195

MTUH:

I917_16605

MTUL:

TBHG_02300

MTUT:

HKBT1_2491

MTUU:

HKBT2_2494

MTQ:	HKBS1_2498

MBO:	BQ2027_MB2382C

MBB:

BCG_2375c

MBT:

JTY_2369

MBM:	BCGMEX_2364c(uppS)

MBK:	K60_024470

MBX:

BCGT_2185

MAF:

MAF_23750

MMIC:

RN08_2617

MCE:	MCAN_23931

MCQ:	BN44_50327

MCV:	BN43_40005

MCX:	BN42_40294

MCZ:	BN45_50731

MORY:

MO_002474

MLE:

ML0634

MLB:

MLBr00634

MPA:

MAP_2141c

MAO:

MAP4_1681

MAVI:

RC58_08405

MAVU:

RE97_08405

MAV:	MAV_2034(uppS)

MAVM:

MAA44156_02368(uppS)

MIT:

OCO_20180

MIA:

OCU_20280

MID:

MIP_02839

MYO:

OEM_18010

MCHI:

AN480_10305

MIR:

OCQ_18850

MMAL:

CKJ54_08775

MLP:

MLM_2658

MMAN:

MMAN_20400(uppS)

MSER:

MTY59_36040(uppS)

MSA:	Mycsm_04084

MUL:

MUL_3614

MMI:

MMAR_3671

MMAE:

MMARE11_35790

MLI:	MULP_03919(uppS)

MPSE:

MPSD_37370(uppS_2)

MSHO:

MSHO_32770(uppS)

MMC:

Mmcs_3449

MKM:

Mkms_3512

MJL:

Mjls_3460

MMM:

W7S_09455

MKN:	MKAN_04760

MYV:	G155_19125

MYE:	AB431_19825

MHAD:

B586_09310

MDX:	BTO20_12440

MSHG:

MSG_03355(uppS)

MFJ:	MFLOJ_53690(uppS)

MSTO:

MSTO_57760(uppS)

MSIM:

MSIM_42840(uppS)

MSAK:

MSAS_15190(uppS)

MKU:	I2456_17190

MLW:	MJO58_18415

MXE:	MYXE_19080(uppS)

MNV:	MNVI_00550(uppS)

MPAG:

C0J29_20470

MNM:	MNVM_03230(uppS)

MGOR:

H0P51_18520

MCOO:

MCOO_14050(uppS)

MBAI:

MB901379_03256(uppS_1)

MSEO:

MSEO_21590(uppS)

MHEK:

JMUB5695_02017(uppS)

MGAU:

MGALJ_22030(uppS_1)

MLJ:	MLAC_24280(uppS)

MBRD:

MBRA_34710(uppS)

MSHJ:

MSHI_08440(uppS)

MMAM:

K3U93_15655

MSPG:

F6B93_14935

MOT:	LTS72_06410

MLM:

MLPF_2214

MPAA:

MKK62_09020

MMEH:

M5I08_11745

MKY:	IWGMT90018_21290(uppS)

MADI:

A7U43_12775

MWU:	PT015_07985

MYW:	BVC93_21520

MYJ:	BCA37_21310

MSM:	MSMEG_4490(uppS)

MSG:	MSMEI_4379(uppS)

MSB:	LJ00_22215

MSN:	LI99_22220

MSH:	LI98_22225

MVA:

Mvan_3822

MGI:

Mflv_2714

MSP:	Mspyr1_21510

MCB:	Mycch_3349

MNE:	D174_18705

MYN:	MyAD_18345

MFT:	XA26_39030

MPHL:

MPHLCCUG_03461(uppS_1)

MVQ:

MYVA_3646

MRH:	MycrhN_4345

MTHN:

4412656_02789(uppS)

MHAS:

MHAS_01373(uppS_1)

MDU:	MDUV_07360(uppS)

MCHT:

MCHIJ_31760(uppS_2)

MDR:	MDOR_25540(uppS_1)

MAUU:

NCTC10437_03626(uppS_2)

MMAG:

MMAD_36380(uppS)

MMOR:

MMOR_27760(uppS_2)

MFX:	MFAL_14320(uppS_1)

MAIC:

MAIC_35240(uppS_1)

MIJ:	MINS_32970(uppS)

MALV:

MALV_00980(uppS_1)

MTY:	MTOK_58870(uppS)

MPSC:

MPSYJ_29460(uppS_2)

MARZ:

MARA_60590(uppS_2)

MGAD:

MGAD_01790(uppS)

MHEV:

MHEL_00920(uppS)

MSAR:

MSAR_45800(uppS)

MANY:

MANY_19810(uppS_1)

MAUB:

MAUB_49910(uppS_2)

MPOF:

MPOR_40120(uppS_2)

MPHU:

MPHO_19560(uppS_1)

MMUC:

C1S78_008610

MMAT:

MMAGJ_75300(uppS_2)

MBOK:

MBOE_34810(uppS_2)

MFG:	K6L26_12630

MSEI:

MSEDJ_48030(uppS_1)

MFLV:

NCTC10271_01784(uppS_2)

MCEE:

MCEL_02590(uppS_1)

MBRM:

L2Z93_001262

MMON:

EWR22_17845

MGO:	AFA91_18000

MHOL:

K3U96_10045

MSEN:

K3U95_16515

MPAE:

K0O64_19145

MRF:	MJO55_17350

MDF:	K0O62_18795

MCRO:

MI149_20015

MGRO:

FZ046_23020

MAUS:

JN090_17305

MFRE:

EXE63_26100

MBUG:

MU0053_001777

MKR:	MKOR_04020(uppS_1)

MPAK:

MIU77_06305

MAB:

MAB_1676

MMV:	MYCMA_0917

MABB:

MASS_1769

MABL:

MMASJCM_1699

MCHE:

BB28_09115

MIZ:	BAB75_09060

MSTE:

MSTE_01676

MSAO:

MYCSP_07620

MSAL:

DSM43276_01538(uppS_2)

MJD:	JDM601_1566

MTER:

4434518_01468(uppS_2)

MMIN:

MMIN_31680(uppS)

MHIB:

MHIB_10160(uppS)

MHER:

K3U94_08615

MVM:	MJO54_08670

MKK:	MU0083_001392

SMAL:

SMALA_6898

SSOI:

I1A49_38270(uppS)

SAUO:

BV401_38125

SANT:

QR300_06735(uppS)

ACTI:

UA75_19165

ACAD:

UA74_18675

» show all

Reference

1 [PMID:15516568]

Authors

Kaur D, Brennan PJ, Crick DC

Title

Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis.

Journal

J Bacteriol 186:7564-70 (2004)
DOI:10.1128/JB.186.22.7564-7570.2004

Sequence

[mtu:Rv2361c]

Reference

2 [PMID:18597781]

Authors

Wang W, Dong C, McNeil M, Kaur D, Mahapatra S, Crick DC, Naismith JH

Title

The structural basis of chain length control in Rv1086.

Journal

J Mol Biol 381:129-40 (2008)
DOI:10.1016/j.jmb.2008.05.060

Sequence

[mtu:Rv2361c]

Reference

3 [PMID:11004176]

Authors

Crick DC, Schulbach MC, Zink EE, Macchia M, Barontini S, Besra GS, Brennan PJ

Title

Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.

Journal

J Bacteriol 182:5771-8 (2000)
DOI:10.1128/JB.182.20.5771-5778.2000

Sequence

[mtu:Rv2361c] [msm:MSMEG_4490]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.86

IUBMB Enzyme Nomenclature:

2.5.1.86

ExPASy - ENZYME nomenclature database:

2.5.1.86

BRENDA, the Enzyme Database:

2.5.1.86

All links

Protein sequence (16)   
   UniProt (9)   
   SWISS-PROT (5)   
   PDBSTR (2)   
DNA sequence (71)   
   GenBank (36)   
   EMBL (35)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   InterPro (3)   
All databases (91)   

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