| Entry |
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| Name |
trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units)
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| Reaction(IUBMB) |
(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9--11) [RN: R09731]
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| Reaction(KEGG) |
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| Substrate |
(2Z,6E)-farnesyl diphosphate [CPD: C16826];
isopentenyl diphosphate [CPD: C00129]
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| Product |
diphosphate [CPD: C00013];
trans,polycis-polyprenyl diphosphate [CPD: C19853]
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| Comment |
Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1].
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| History |
EC 2.5.1.88 created 2010
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K21273 | trans,polycis-polyprenyl diphosphate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Ambo T, Noike M, Kurokawa H, Koyama T |
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| Title |
Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.88 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.88 |
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