Entry |
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Name |
trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
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Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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Sysname |
(2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units)
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Reaction(IUBMB) |
(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9--11) [RN: R09731]
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Reaction(KEGG) |
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Substrate |
(2Z,6E)-farnesyl diphosphate [CPD: C16826];
isopentenyl diphosphate [CPD: C00129]
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Product |
diphosphate [CPD: C00013];
trans,polycis-polyprenyl diphosphate [CPD: C19853]
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Comment |
Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1].
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History |
EC 2.5.1.88 created 2010
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Pathway |
ec00900 | Terpenoid backbone biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K21273 | trans,polycis-polyprenyl diphosphate synthase |
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Genes |
» show all
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Reference |
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Authors |
Ambo T, Noike M, Kurokawa H, Koyama T |
Title |
Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.5.1.88 |
ExPASy - ENZYME nomenclature database: | 2.5.1.88 |
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