KEGG   ENZYME: 2.5.1.97
Entry
EC 2.5.1.97                 Enzyme                                 
Name
pseudaminic acid synthase;
PseI;
NeuB3
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose transferase (phosphate-hydrolysing, 2,7-acetylamino-transfering, 2-carboxy-2-oxoethyl-forming)
Reaction(IUBMB)
phosphoenolpyruvate + 2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose + H2O = 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid + phosphate [RN:R09841]
Reaction(KEGG)
R09841
Substrate
phosphoenolpyruvate [CPD:C00074];
2,4-bis(acetylamino)-2,4,6-trideoxy-beta-L-altropyranose;
H2O [CPD:C00001]
Product
5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid [CPD:C20082];
phosphate [CPD:C00009]
Comment
The enzyme requires a divalent metal ion, the highest activity values are observed in the presence of Mn2+ and Co2+ (10 mM).
History
EC 2.5.1.97 created 2011
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K15898  pseudaminic acid synthase
Genes
SHMShewmr7_1391
SJASJ2017_2979
IABK5X84_03460(pseI)
PXIJ5O05_14495(pseI)
PVBJ5X90_11670(pseI)
PFLICTT31_05885(pseI)
AMGAMEC673_04890
MARQMARGE09_P3486
FPZLA55_1639(pseI)
FNAOOM_1616
FNLM973_06990
FPERACH24_00845
FADCDH04_02740(pseI)
FMIF0R74_04805(pseI)
FGUSD28_06730
TMHJX580_02090(pseI)
ACAVVI35_07445(pseI)
AEAC2U39_08085(pseI)
ARVC7N77_17160(pseI)
ASIMFE240_05740(pseI)
CDIZCEDIAZO_01288(pseI)
KOAH3L93_07905(pseI)
AFFH3L97_09950(pseI)
CSTEH3L98_05395(pseI)
PSENH8B_3550
AMAHDLM_3379
CHICN8I74_00610(pseI)
BVITJIP62_12975(pseI)
HPYHP_0178
HEOC694_00885
HPJjhp_0166(neuB)
HPAHPAG1_0175
HPSHPSH_00900
HHPHPSH112_00870
HHQHPSH169_00865
HHRHPSH417_00875
HPGHPG27_163
HPPHPP12_0178
HPBHELPY_0182(neuB)
HPLHPB8_1388(neuB)
HPCHPPC_00900
HCAHPPC18_00890
HPMHPSJM_00980
HPEHPELS_05885
HPOHMPREF4655_20420(pseI)
HPIhp908_0187
HPQhp2017_0183(neuB)
HPWhp2018_0186
HPUHPCU_00850
HEFHPF16_0186(neuB)
HPFHPF30_1116(neuB)
HEQHPF32_0188(neuB)
HEXHPF57_0197(neuB)
HPTHPSAT_00865
HPZHPKB_0188
HPVHPV225_0194
HPXHMPREF0462_0233(pseI)
HENHPSNT_01075
HPHHPLT_00935
HEGHPGAM_00920
HPNHPIN_06250
HEPHPPN120_00905
HEUHPPN135_00890
HESHPSA_00905
HPYSHPSA20_0199(pseI)
HCNHPB14_00860
HPDKHP_0177(neuB)
HEYMWE_0252
HERC695_00885
HEIC730_00885
HPYAHPAKL117_00890
HPYKHPAKL86_06095
HPYOHPOK113_0186(neuB)
HPYLHPOK310_0184(neuB)
HPYBHPOKI102_01200
HPYCHPOKI112_01195
HPYDHPOKI128_00980
HPYEHPOKI154_00970
HPYFHPOKI422_01195
HPYGHPOKI673_00975
HPYHHPOKI828_00965
HPYJHPOKI898_01205
HPYRK747_09550
HPYIK750_07650
HPYUK751_06745
HPYMK749_04795
HEMK748_03215
HEBU063_0520
HEZU064_0521
HHEHH_0908
HACHac_0364
HMSHMU11700(neuB3)
HFEHFELIS_15210(neuB3)
HBIHBZC1_10970
HCEHCW_03725
HCMHCD_03040
HCPHCN_1783
HCBHCBAA847_2066
HHMBN341_3140
HTYBN2458_PEG0381
HBLXJ32_01420
HADCDV25_07195(pseI)
HETBBW65_06570
HCLNCTC13205_00368(spsE_1)
HWIA0Z60_02455(pseI)
HSHNHP194022_15540(neuB)
HPULNCTC13154_00281(spsE)
HAILASB7_09380(pseI)
WSUWS2109
SUASaut_0136
SKUSulku_0155
SULRB649_00690
CJECj1317(pseI)
CJBBN148_1317(pseI)
CJJCJJ81176_1334(neuB)
CJUC8J_1251(neuB)
CJNICDCCJ07001_1263
CJICJSA_1255(pseI)
CJMCJM1_1290(pseI)
CJSCJS3_1417
CJPA911_06405
CJEJN564_01335
CJEUN565_01374
CJENN755_01370
CJEIN135_01406
CJERH730_07535
CJVMTVDSCj20_1313(pseI)
CJYQZ67_01452(pseI)
CJQUC78_1266(pseI)
CJLPJ17_06975
CJWPJ18_06780
CJRCJE1512(neuB)
CJDJJD26997_0397
CJZM635_02275
CJXBN867_13060
CFFCFF8240_1556
CFTCFF04554_1565(pseI)
CFVCFVI03293_1587(pseI)
CFXCFV97608_1689(pseI)
CFZCSG_16920
CAMPCFT03427_1513(pseI)
CFPCR44_07675
CCVCCV52592_0565(pseI)
CLACLA_0169(pseI)
CLRUPTC16701_0178(pseI)
CLMUPTC16712_0176(pseI)
CLQUPTC4110_0170(pseI)
CLNUPTC3659_0189(pseI)
CLLCONCH_0164(pseI)
CCOLBN865_08190c
CCCG157_02210
CCQN149_1280(pseI)
CCFYSQ_02260
CCYYSS_07155
CCOIYSU_02275
CCOFVC76_06635(pseI)
CCOOATE51_00930(pseI)
CAJCIG1485E_1505(pseI)
CISCINS_0157(pseI)
CVOCVOL_0160(pseI)
CPELCPEL_0174(pseI)
CAMRCAQ16704_0169(pseI)
CSMCSUB8521_0179(pseI)
CSFCSUB8523_0173(pseI)
CHYOCHH_1600(pseI)
CHVCHELV3228_0385(pseI)
CPINCPIN18020_0127(pseI)
CCUNCCUN_1340(pseI)
CLXCLAN_1240(pseI)
CAVICAV_1218(pseI)
CHWA2J15_000480(pseI)
CAMZCVIC12175_0323(pseI)
CAMYCSUIS_1327(pseI)
COJCORN_0174(pseI)
CUXCUP3940_1257(pseI)
CRXCRECT_0228(pseI)
CARMCARM_0135(pseI)
CMUCCMCT_1057(pseI)
CSHOCSHOW_1837(pseI)
CINFCINF_1035(pseI)
CNVCNZW441b_1300(pseI)
CVUCVULP_0373(pseI)
SDLSdel_2213
SBASulba_2447
SMULSMUL_3176(pseI)
SHALSHALO_2912
SULSSdiek1_2901
SULJSJPD1_2797
ABUAbu_2246(neuB)
ABTABED_2056
ABLA7H1H_2193(pseI)
ACREACRYA_0127(pseI)
ALANALANTH_2129(pseI)
APOCAPORC_1981(pseI)
AFCAFAEC_0081(pseI)
ATHRATH_1859(pseI)
ANTArnit_2950
AAQIAAQM_2371(pseI)
AVPAVENP_2942(pseI)
AMARAMRN_2660(pseI)
ACAAACAN_2663(pseI)
AMOLAMOL_2612(pseI)
HYONNO_0332
SINUIMZ28_03850(pseI)
NAMNAMH_1595
NAPC3L23_08285(pseI)
CMEDFE773_01415(pseI)
CPAFC6V80_09010(pseI)
HMRHipma_1649
PSYFN1030_14460(pseI)
PPORJCM14722_05450(spsE)
DSFUWK_02421
DALDalk_0632
DATHRM2_36740(neuB)
DAODesac_1882
DTIDesti_1710
TIDThein_0449
LLUAKJ09_07809
BSHILGQ02_19515(pseI)
EXMU719_13415
JEOJMA_28170
AVSAWM76_07140
JEPBW721_08310
CACCA_C2187(spsE)
CAESMB_G2220
CAYCEA_G2201(spsE)
CTETBN906_01852
CNONT01CX_1891
CBOCBO2720
CBACLB_2661
CBHCLC_2594
CBYCLM_3086(pseI)
CBLCLK_2105
CBKCLL_A0832
CBICLJ_B2947
CBTCLH_0798
CBJH04402_02802
CBECbei_4278
CBZCbs_4278
CBEILF65_04801
CLJCLJU_c05510
CSRCspa_c45320(pseI)
CSBCLSA_c39500(pseI)
CAHCAETHG_2633(pseI)
CLTCM240_1654(pseI)
CSQCSCA_3176
CLDCLSPO_c27820(pseI)
CEUA7L45_14325
CTAEBGI42_03935(pseI)
CFMBJL90_07025
CARGRSJ17_12835
CDRKB9W14_04045
CDYF3K33_21895(pseI)
CCOHSAMEA4530647_1491(spsE)
CFERD4Z93_09240(pseI)
CLOSDMR38_02440(pseI)
CRWCROST_020420(pseI)
CFBCLFE_020370(pseI)
CAUNCLAUR_009480(pseI)
CNNCNEO_3840(pseI)
AOEClos_2510
GFEGferi_06945
PBIFKXZ80_05435(pseI)
OCWOW730_17355(pseI) OW730_21380(pseI)
CTHCthe_2229
CTXClo1313_2902
CCLClocl_4082
HSCHVS_01475(pseI1) HVS_04485(pseI2)
RHEREHE19_000755(pseI)
BPBbpr_I2559(neuB2)
BHUbhn_I2423
RHORHOM_00785
SSUNH9Q77_13780(pseI)
AHBbsdtb5_38070
EREEUBREC_3247
CEWEKH84_21385(pseI)
TEMJW646_12045(pseI)
TGCL0P85_15665(pseI)
DORDesor_4905
DAUDaud_1772
ACAEHYG86_00790(pseI)
TMTTmath_0718
KMEH0A61_02803(pseI)
KPARJL105_08005(pseI)
CAZOG3A45_09455(pseI)
SRISELR_23720
ELEElen_2425
EYYEGYY_09060
RCARcas_0774
OPROcepr_2165
MFFMFFC18_01580(pseI)
ROLCA51_18000(pseI)
FCII6I83_02445(pseI)
AMOAnamo_0538
ARAMKAR29_08815
BFGBF638R_3762
BHLBache_1948
BHFC3V43_13585(pseI)
BEGINE88_04056(pseI)
BHUMJXR92_011985(pseI)
BSALK6V25_09565(pseI)
PETPEIBARAKI_4457
PSACPSM36_1392(pseI)
PARCCI960_11570(pseI)
OSPOdosp_0125
PGSCPT03_16765(pseI)
SPHNBV902_02100
SPDRG6053_00975(pseI)
SSIYJVX97_02420(pseI)
ESTDN752_19920(pseI)
PSEZHME7025_02498(pseI)
AANHG9X63_04255(pseI)
DYCNFI80_14160(pseI)
PACTCA264_07975
FLMMY04_2866(pseI)
GFOGFO_2016(NeuB)
FINKQS_04780(neuB)
FFAFFWV33_16665
FPALHYN49_00315(pseI)
FMGHYN48_00290(pseI)
FFLHYN86_01685(pseI)
CATCA2559_13043
DODDCS32_13465(pseI)
NOMAAT17_01915
PHALH9I45_06435(pseI)
PLITK8354_12850(pseI)
WINWPG_0822
WIJBWZ20_09290
TMARMARIT_1555(pseI)
TPACPG913_04905(pseI)
FORFORMB_12950
FOHFORMA_12200
TAJC1A40_06900(pseI)
ANPFK178_01775(pseI)
BIAGMA17_12820(pseI)
FBMMQE35_08980(pseI)
SAHNJRG66_01025(pseI)
FBUUJ101_00315(neuB)
FTEFluta_0224
FLUCHH17_13955(pseI)
CRMK6119_04505(pseI)
MROMROS_1160
HTHHTH_1538(neuB)
HTEHydth_1526
DAPDacet_0631
GTLEP073_12670(pseI)
CNICalni_0723
MSCHN508_001046(pseI_1) N508_001414(pseI_2)
PRFPeribacterA2_0964
BBGWUT28_C0001G0399
METFCFE53_01720(pseI)
MSIMsm_1539
METVK4897_08545(pseI)
MCUBMCBB_1285(pseI)
MEQMSWHS_1969
MPYMpsy_2359
PSYTDSAG12_01856
 » show all
Reference
1  [PMID:16120604]
  Authors
Chou WK, Dick S, Wakarchuk WW, Tanner ME
  Title
Identification and characterization of NeuB3 from Campylobacter jejuni as a pseudaminic acid synthase.
  Journal
J Biol Chem 280:35922-8 (2005)
DOI:10.1074/jbc.M507483200
  Sequence
[cje:Cj1317]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.97
IUBMB Enzyme Nomenclature: 2.5.1.97
ExPASy - ENZYME nomenclature database: 2.5.1.97
BRENDA, the Enzyme Database: 2.5.1.97

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