KEGG   ENZYME: 2.6.1.102
Entry
EC 2.6.1.102                Enzyme                                 

Name
GDP-perosamine synthase;
RfbE;
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase;
GDP-perosamine synthetase;
PerA;
GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate [RN:R10460]
Reaction(KEGG)
R10460
Substrate
GDP-alpha-D-perosamine [CPD:C20638];
2-oxoglutarate [CPD:C00026]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
L-glutamate [CPD:C00025]
Comment
A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis.
History
EC 2.6.1.102 created 2013
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K13010  perosamine synthetase
Genes
ECE: Z3200(per)
ECS: ECs2841
ECF: ECH74115_2970
ETW: ECSP_2791(per)
ELX: CDCO157_2621
ENF: AKI40_3665
CPOT: FOB25_20255
CEN: LH86_19220 LH86_19225
IZH: FEM41_11245
PSTS: E05_51680
YET: CH48_3099
SOF: NCTC11214_00688(btrR)
PLU: plu2404
XAX: XACM_3496
XAL: XALC_1779
SML: Smlt1417
SMT: Smal_1185
LEM: LEN_0207
RBD: ALSL_1567
VCH: VC0244
VCS: MS6_0112
VCE: Vch1786_I2528(rfbE)
VCI: O3Y_01125
VCO: VC0395_A2624(rfbE)
VCR: VC395_0276(rfbE)
VCM: VCM66_0232(rfbE)
VTA: A3045 A3046
PSOS: POS17_3025
PANR: A7J50_5567
AGU: AS4_20960 AS4_42540(arnB) AS4_42550(arnB)
PAT: Patl_3059
PSEO: OM33_07180
PSPO: PSPO_a0412(per)
CBU: CBU_0830
CBG: CbuG_1171
CBC: CbuK_0698
LOK: Loa_00041
LLG: 44548918_01764(btrR_2) 44548918_01769(yvfE) 44548918_01779(btrR_3)
MCA: MCA0215
METL: U737_04565
MMAI: sS8_5438
FPH: Fphi_1164
FPI: BF30_1409
FPX: KU46_149
FRC: KX01_1749
TCX: Tcr_1461
HMAR: HVMH_1513
NOC: Noc_1960
TEE: Tel_05565
HHA: Hhal_1567
TNI: TVNIR_0703(mosB_[H])
TBN: TBH_C0738
CVI: CV_1404(aspB) CV_1406(DegT)
LHK: LHK_00843
RPI: Rpic_4737
BPS: BPSS0422
BPSE: BDL_3649
BPSM: BBQ_5775
BPSU: BBN_3821
BPSD: BBX_5486
BPK: BBK_5627
BPSH: DR55_4931
BPSA: BBU_5626
BPSO: X996_4682
BUT: X994_4199
BTQ: BTQ_5262
BTJ: BTJ_3894
BTZ: BTL_4748
BTV: BTHA_5479
BTHE: BTN_4387
BTHM: BTRA_4654
BTHA: DR62_4436
BTHL: BG87_4720
BOK: DM82_4501
BVE: AK36_5482
BUB: BW23_864
BUK: MYA_5500
BXB: DR64_6763
PNU: Pnuc_0312
CABA: SBC2_28980(per)
AXX: ERS451415_06039(arnB_3)
PNA: Pnap_1585
AAV: Aave_4330
AAA: Acav_4233
VEI: Veis_4858
DAC: Daci_0133
CTES: O987_00730
MPT: Mpe_A2766
CFU: CFU_3306(yfbE)
OFO: BRW83_0697(per)
RGE: RGE_41280(per)
PBH: AAW51_4311(per)
MEH: M301_1779
SLT: Slit_2895
EBA: ebA5900(wecE)
DSU: Dsui_0077
SULC: CVO_05740
CJI: CJSA_1258
CJEJ: N564_01337
CJEU: N565_01376
CJEN: N755_01372
CJEI: N135_01408
CJY: QZ67_01456(epsN)
CJR: CJE1514
CFZ: CSG_17360
CCF: YSQ_02245
CCOI: YSU_02260
CCOF: VC76_06645(epsN)
CGRA: CGRAC_0736
CHYO: CHH_1599
CHV: CHELV3228_1647(legC)
CAVI: CAV_1221(legC)
ABU: Abu_0667
AMYT: AMYT_0895
ATP: ATR_1815
AELL: AELL_2685
HBV: ABIV_2492
HEBR: AEBR_2857
ARC: ABLL_0807
GME: Gmet_2016
GEO: Geob_2974
GEM: GM21_2600
DEU: DBW_1491
DDS: Ddes_2212
DMA: DMR_40520
DTR: RSDT_0946
DFL: DFE_2605
DAS: Daes_1984
PPRF: DPRO_1453
DBA: Dbac_2215
DALK: DSCA_12190 DSCA_18220(wecE)
ADE: Adeh_3061
MXA: MXAN_3232
CCX: COCOR_02989(tbmB)
HOH: Hoch_0297
SAT: SYN_00827
RBT: NOVO_09405(arnB_2)
MES: Meso_3973
SMD: Smed_4809
RLE: RL0240
RHT: NT26_3139
BME: BMEI1414
BMEL: DK63_2074
BMEE: DK62_880
BMF: BAB1_0544
BABO: DK55_551
BABR: DO74_1335
BABT: DK49_315
BABB: DK48_1574
BABU: DK53_541
BABS: DK51_919
BABC: DO78_458
BMS: BR0521
BSUI: BSSP1_I1185(rbmB)
BSUP: BSPT1_I1196(rbmB)
BSUV: BSPT2_I1181(rbmB)
BSUC: BSSP2_I0534(rbmB)
BMT: BSUIS_A0552(rbmB)
BSZ: DK67_1450
BOV: BOV_0525
BCS: BCAN_A0533(rbmB)
BCAR: DK60_604
BCAS: DA85_02495
BMR: BMI_I523
BPP: BPI_I552
BPV: DK65_838
AOL: S58_22950
BRAD: BF49_5656
NWI: Nwi_2405
NHA: Nham_3035
VGO: GJW-30_1_00095(epsN)
XAU: Xaut_0120
SNO: Snov_1137
MCH: Mchl_3986
MET: M446_4033
BID: Bind_0406
MSL: Msil_3637
MSC: BN69_2648
RBM: TEF_11390
CCR: CC_1012
CAK: Caul_4930
CSE: Cseg_3262
MALG: MALG_02566
SWI: Swit_2644
SPHD: HY78_12295
SPHI: TS85_14405
ADO: A6F68_00414(wbpE)
ACR: Acry_0289
AZL: AZL_022560(pmrH)
TXI: TH3_00070
MAGQ: MGMAQ_1151(arnB) MGMAQ_3542
MGM: Mmc1_0563
MAI: MICA_1007
MAN: A11S_970
BBA: Bd1679
BMX: BMS_3122
HAX: BALOs_0811(per)
AFR: AFE_1540
BSX: C663_3264
BLI: BL03104
BLD: BLi00802
BAQ: BACAU_3147(rfbE)
BAMP: B938_15990
BAML: BAM5036_3035(degT)
BAMA: RBAU_3256
BAMN: BASU_3037
BAMT: AJ82_17635
BAMY: V529_33820
BAO: BAMF_3247(RBAM_031210)
BQL: LL3_03530
BAMI: KSO_003525
BAMC: U471_32380
BAMF: U722_16755
BTM: MC28_G039
BMYO: BG05_5627(pseC)
BMYC: DJ92_3827(pseC)
BACP: SB24_13145
GKA: GK3127
GEA: GARCT_03165(arnB)
PTB: DER53_12255(pseC)
LSP: Bsph_1161
SAUC: CA347_97
LSG: lse_1138
PPOY: RE92_14245
PSWU: SY83_08905
BTS: Btus_0884
CARC: NY10_963
CTC: CTC_01707
CBL: CLK_2097
CBB: CLD_1860
CBN: CbC4_1001
CBT: CLH_1450
CBF: CLI_2769
CBM: CBF_2761
CBE: Cbei_4711
CBZ: Cbs_4711
CKL: CKL_2468
CKR: CKR_2182
CSEP: CP523_10895(pseC)
HSC: HVS_01500(arnB1) HVS_04515(arnB2) HVS_10000(epsN)
BPB: bpr_I0425
BHU: bhn_I0401
CEW: EKH84_21390(pseC)
SLP: Slip_0030
PTH: PTH_0393(WecE) PTH_1115(WecE)
ELM: ELI_2684
OVA: OBV_05420
CTHM: CFE_2536
CBAR: PATL70BA_2640(perA)
TTE: TTE0667(WecE2)
TIT: Thit_0479
MTA: Moth_0752
MTHO: MOTHE_c06960(epsN)
MTHZ: MOTHA_c07900(epsN)
TSH: Tsac_2670
MANA: MAMMFC1_02384(epsN_2)
PFAC: PFJ30894_01731(fdtB)
MIT: OCO_31080
MIA: OCU_30960
MIR: OCQ_31700
CAQU: CAQU_12175
REY: O5Y_01240
ROP: ROP_39650
RFA: A3L23_02053(per)
SALB: XNR_5866
SGB: WQO_10765
SFA: Sfla_4281
SBH: SBI_01977
STRP: F750_2428
SFI: SFUL_2170
SLD: T261_7945
STRM: M444_35975
SRN: A4G23_00420(arnB) A4G23_01676(fdtB_2)
SALJ: SMD11_6577(per)
SRJ: SRO_7372
KSK: KSE_46570
MALK: MalAC0309_2271(stsC)
ART: Arth_4050
ARM: ART_1663
ACIT: HPK19_05670(pseC)
AAU: AAur_2678
LMOI: VV02_09910
SERJ: SGUI_0551
DCO: SAMEA4475696_1942(arnB_1)
PAC: PPA0135
PAW: PAZ_c01470(degT)
PACC: PAC1_00735
PACH: PAGK_0140
CACN: RN83_01130
CGRN: 4412665_00509(arnB)
PPC: HMPREF9154_2726(degT)
ACIJ: JS278_02849(per)
MPH: MLP_25760
NCA: Noca_4210
NDK: I601_1770(fdtB)
PSIM: KR76_03355
SRO: Sros_2363
FAL: FRAAL0507
AMN: RAM_01055
AMM: AMES_0204
AMZ: B737_0205
AOI: AORI_0212
AMYY: YIM_01060(arnB1) YIM_01105(arnB2) YIM_21480(arnB4) YIM_39545(epsN)
PDX: Psed_1887
PSEA: WY02_00365
PAUT: Pdca_01380
AMI: Amir_1734
AHG: AHOG_18370(stsC)
SAQ: Sare_1683
MIL: ML5_2192
ASE: ACPL_7491
ACTS: ACWT_7361
PSUU: Psuf_011620(per)
TPYO: X956_02575
TBW: NCTC13354_00627(arnB)
AHW: NCTC11636_02345(arnB)
EYY: EGYY_09100(WecE)
SYN: slr1615(rfbE) slr2114(spsC)
SYZ: MYO_114890(spsC) MYO_13370(rfbE)
SYY: SYNGTS_0333(rfbE) SYNGTS_1475(spsC)
SYT: SYNGTI_0333(rfbE) SYNGTI_1475(spsC)
SYS: SYNPCCN_0333(rfbE) SYNPCCN_1474(spsC)
SYQ: SYNPCCP_0333(rfbE) SYNPCCP_1474(spsC)
SYC: syc1444_d(rfbE)
SYW: SYNW0446
PRM: EW15_2178
MAR: MAE_20080
CYT: cce_1406
TER: Tery_4955
CALH: IJ00_24095
DOU: BMF77_03745(rfbE_3)
DFO: Dform_01818(per|rfbE)
ATM: ANT_08450
PCU: pc0792
PNL: PNK_1445
OTE: Oter_2890
MIN: Minf_0469(wecE)
MKC: kam1_456
PSL: Psta_1436
PIR: VN12_04535(epsN_1) VN12_07015(epsN_2) VN12_10480(btrR)
RUL: UC8_06060(arnB)
MFF: MFFC18_22050(epsN_1)
TTF: THTE_2311
PLS: VT03_07240(epsN) VT03_22770(btrR_1) VT03_30290(btrR_2)
PLH: VT85_09880(arnB)
FMR: Fuma_05218(btrR_2)
GMR: GmarT_17220(epsN)
BVO: Pan97_10750(btrR)
AGV: OJF2_08750(stsC_1)
KST: KSMBR1_1989(rfbE_3) KSMBR1_2319(arnB_3)
PBU: L21SP3_00620(arnB) L21SP3_00948(epsN) L21SP3_00949(wbpE_2)
PBP: STSP1_00337(arnB)
PBAS: SMSP2_00901(fdtB_1) SMSP2_01654(arnB)
ALUS: STSP2_01769(arnB)
VBL: L21SP4_00616(arnB)
TPED: TPE_0191
LIE: LIF_A0439(wecE) LIF_A1294(wecE)
LIS: LIL_13138(wecE6)
LBJ: LBJ_1121
LBL: LBL_1175
LST: LSS_16451
BRM: Bmur_0748
BPW: WESB_0845
BIP: Bint_0971
ABAS: ACPOL_0482
EPO: Epro_0455(degT)
PGN: PGN_1073
PDI: BDI_0127
TFO: BFO_1073
BLQ: L21SP5_00553(epsN) L21SP5_02125(arnB_2) L21SP5_02127(arnB_3)
SRU: SRU_0601
SRM: SRM_00695(wecE)
SDJ: NCTC13534_05288(arnB_2)
DFE: Dfer_4492
SLI: Slin_0603
GFO: GFO_0550
NDO: DDD_3556
PPH: Ppha_0525
TTK: TST_1471
TMW: THMA_0586
TMQ: THMB_0586
TMX: THMC_0586
TPT: Tpet_0346
TRQ: TRQ2_0364
TNA: CTN_0093
TLE: Tlet_1087
TME: Tmel_1881
TAF: THA_178
THER: Y592_00965
FNO: Fnod_0665
PMO: Pmob_1802
DTN: DTL3_0050
KOL: Kole_1760
CABY: Cabys_1640
DTU: Dtur_0594
NJA: NSJP_4034
LFC: LFE_2409
SAAL: L336_0182
MMP: MMP0351(aspB-like1)
MAE: Maeo_0427
MVO: Mvol_0929
MTH: MTH_334
METC: MTCT_1081
MWO: MWSIV6_1580(degT)
METE: tca_01144(per)
MST: Msp_0290
MRU: mru_1959
MSI: Msm_1030
MEB: Abm4_1542
MMIL: sm9_2042
MEYE: TL18_09395
MOL: YLM1_1406
METH: MBMB1_1707
MFC: BRM9_0959
MCUB: MCBB_2005(degT)
MFV: Mfer_1047
MKA: MK0156
FPL: Ferp_2376
GAH: GAH_01472
PFU: PF0767
PFI: PFC_02990
PAB: PAB0774(aspB-like1)
TON: TON_1700
TGA: TGAM_2150(degT)
TSI: TSIB_2028
THM: CL1_0825
TLT: OCC_01394
MBAR: MSBR2_3375
MMA: MM_1152
MTHR: MSTHT_1687
MTHE: MSTHC_1602
MHOR: MSHOH_0209
MPY: Mpsy_0708
MTP: Mthe_1460
MCJ: MCON_2573
MEMA: MMAB1_2324(pseC) MMAB1_2689(degT) MMAB1_3053
MPI: Mpet_1392
MBN: Mboo_1834
MPL: Mpal_0812
RCI: RCIX1921
HHI: HAH_0359
HALL: LC1Hm_1363
HME: HFX_6150(wecE) HFX_6228(wecE)
NAT: NJ7G_1380
SALI: L593_11285
IAG: Igag_1197
HBU: Hbut_1412
PIS: Pisl_1846
PCL: Pcal_0404
PAS: Pars_2093
PYR: P186_0279
POG: Pogu_0031
TNE: Tneu_1274
TTN: TTX_1722
TUZ: TUZN_1781
VDI: Vdis_1728
VMO: VMUT_0177
TPE: Tpen_0110
NCT: NMSP_0143 NMSP_1667(aspC_3)
NEV: NTE_03161
TAA: NMY3_00753(fdtB)
NFN: NFRAN_1759(fdtB)
KCR: Kcr_1162
BARC: AOA65_1192(aspC_2)
BARB: AOA66_1484
CCAI: NAS2_0537
 » show all
Reference
1  [PMID:11479276]
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Reference
2  [PMID:17888872]
  Authors
Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG
  Title
Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia  coli O157:H7 and synthesis of GDP-perosamine in vitro.
  Journal
Biochem Biophys Res Commun 363:525-30 (2007)
DOI:10.1016/j.bbrc.2007.08.184
  Sequence
[ece:Z3200]
Reference
3  [PMID:18201574]
  Authors
Albermann C, Beuttler H
  Title
Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.
  Journal
FEBS Lett 582:479-84 (2008)
DOI:10.1016/j.febslet.2008.01.005
Reference
4  [PMID:18795799]
  Authors
Cook PD, Carney AE, Holden HM
  Title
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
  Journal
Biochemistry 47:10685-93 (2008)
DOI:10.1021/bi801309q
  Sequence
[ccr:CC_1012]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.102
IUBMB Enzyme Nomenclature: 2.6.1.102
ExPASy - ENZYME nomenclature database: 2.6.1.102
BRENDA, the Enzyme Database: 2.6.1.102

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