Entry Name GDP-perosamine synthase;
Class Transferases;BRITE hierarchy
Sysname GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB) GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate [RN:
R10460 ]
Reaction(KEGG) Substrate GDP-alpha-D-perosamine [CPD:
C20638 ];
2-oxoglutarate [CPD:
C00026 ]
Product GDP-4-dehydro-alpha-D-rhamnose [CPD:
C01222 ];
L-glutamate [CPD:
C00025 ]
Comment A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis.
History EC 2.6.1.102 created 2013
Pathway ec00520 Amino sugar and nucleotide sugar metabolism
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology Genes » show all Taxonomy Reference Authors Albermann C, Piepersberg W
Title Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
Journal Reference Authors Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG
Title Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157:H7 and synthesis of GDP-perosamine in vitro.
Journal Sequence Reference Authors Albermann C, Beuttler H
Title Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.
Journal Reference Authors Cook PD, Carney AE, Holden HM
Title Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.6.1.102
