Entry
Name
GDP-perosamine synthase;
RfbE;
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase;
GDP-perosamine synthetase;
PerA;
GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate [RN:
R10460 ]
Reaction(KEGG)
Substrate
GDP-alpha-D-perosamine [CPD:
C20638 ];
2-oxoglutarate [CPD:
C00026 ]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:
C01222 ];
L-glutamate [CPD:
C00025 ]
Comment
A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis.
History
EC 2.6.1.102 created 2013
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology
Genes
CEN : LH86_19220 LH86_19225
SOF : NCTC11214_00688(btrR)
PARI : I2D83_04605 I2D83_04610
DIC : Dpoa569_002948 Dpoa569_002950
RGL : CS053_01135 CS053_14830
DTX : ATSB10_17500 ATSB10_35930
PSYR : N018_16860 N018_16870
PCI : PCH70_19130 PCH70_19150
PVD : CFBP1590__3481 CFBP1590__3483
PLIJ : KQP88_09150 KQP88_09160
PCP : JM49_00230 JM49_00240
PCHP : C4K32_6292 C4K32_6294
PYM : AK972_0092 AK972_4161 AK972_4162
AGU : AS4_20960 AS4_42540(arnB) AS4_42550(arnB)
PVB : J5X90_03235 J5X90_03325 J5X90_11690
LLG : 44548918_01769(yvfE) 44548918_01779(btrR_3)
MEEF : JWZ97_16765 JWZ97_19425
MELL : IVG45_20330 IVG45_21940
THIO : AYJ59_04970 AYJ59_06065
TWN : L2Y54_02880 L2Y54_07655
CJAP : GWK36_01875 GWK36_14255
THIM : KFB96_06700 KFB96_06720
TNI : TVNIR_0703(mosB_[H])
HAZ : A9404_01750 A9404_06830 A9404_10310
GAI : IMCC3135_07020(rfbE) IMCC3135_24305(per)
ADH : CK627_03065 CK627_11305
THIN : CRN91_03135 CRN91_03225
CVI : CV_1404(aspB) CV_1406(DegT)
CVC : BKX93_20045 BKX93_20055
CHRI : DK842_11415 DK842_11495 DK842_14595 DK842_14605
CHRB : DK843_16850 DK843_16940 DK843_20155 DK843_20165
IFL : C1H71_05885 C1H71_05890 C1H71_16640
RIN : ACS15_0767 ACS15_0768 ACS15_5104
CTI : RALTA_A2371 RALTA_A2372
AXX : ERS451415_06039(arnB_3)
RHY : RD110_04545 RD110_21555
POS : DT070_03555 DT070_03595
POO : F7R28_05845 F7R28_05885
HSE : Hsero_2860 Hsero_4199
HSZ : ACP92_14320 ACP92_20980
MASY : DPH57_19270 DPH57_21475
MASZ : C9I28_00195 C9I28_02705
EHB : E7V67_025615 E7V67_028070
BBAG : E1O_08360 E1O_13780
SDR : SCD_n01657(rfbE) SCD_n02879 SCD_n02898
URU : DSM104443_02789(per)
AZA : AZKH_0246 AZKH_0387 AZKH_4070
AZD : CDA09_01555 CDA09_10825
FMY : HO273_11300 HO273_13145
RBS : RHODOSMS8_00393(per) RHODOSMS8_01670(per)
EMX : FKV68_30680 FKV68_31515
RLT : Rleg2_4213 Rleg2_4223
RII : FFM53_009040 FFM53_012070
RLN : J0663_09850 J0663_12600 J0663_30270
RBAN : J2J98_01175 J2J98_26930
RRG : J3P73_01470 J3P73_35435
RHIZ : QMO80_002346 QMO80_002355
BRC : BCCGELA001_25475 BCCGELA001_25605
BOT : CIT37_24205 CIT37_24340
BRQ : CIT40_00985 CIT40_21900 CIT40_22035
BGQ : X265_13660 X265_13715
BSYM : CIT39_21190 CIT39_21325
BDG : LPJ38_31910 LPJ38_32040
BQB : J4P68_0006775 J4P68_0024600
BAUT : QA635_15565 QA635_34635
BGK : IC762_09785 IC762_24945
BPAH : QA639_29500 QA639_34745
VGO : GJW-30_1_00095(epsN)
BVV : BHK69_00520 BHK69_07810
MEDK : QEV83_02285 QEV83_10815
MHEY : H2LOC_005800 H2LOC_019955
RLI : RLO149_c044260 RLO149_c044340(arnB)
SSIN : G7078_00710 G7078_06220
AMV : ACMV_03170 ACMV_03190
ALI : AZOLI_2320 AZOLI_p60092
AZZ : DEW08_11480 DEW08_30005
AARE : D3093_13700 D3093_30980
AZS : E6C72_01190 E6C72_14655
NAO : Y958_05520 Y958_27295
MGY : MGMSRv2__3403 MGMSRv2__3407
MAGN : WV31_13130 WV31_15785
DVN : HQ394_05625 HQ394_19015
MAG : amb0054 amb0078 amb3808
MAGQ : MGMAQ_1151(arnB) MGMAQ_3542
PUB : SAR11_0534 SAR11_0553
ECOG : FIV45_02180 FIV45_06895
HCB : HCBAA847_0764 HCBAA847_0813 HCBAA847_0841
HAD : CDV25_00590 CDV25_01125
TDN : Suden_0190 Suden_0593 Suden_0852
SKU : Sulku_0158 Sulku_1579
SULR : B649_00675 B649_04220
CCO : CCC13826_0537 CCC13826_2049 CCC13826_2305
CCOC : CCON33237_0130 CCON33237_1286 CCON33237_1628
CHV : CHELV3228_1647(legC)
ACIB : ACBT_0330 ACBT_0336
AVP : AVENP_1996 AVENP_2927
AMAR : AMRN_0884 AMRN_2656
ACAA : ACAN_0877 ACAN_2659
AMOL : AMOL_0786 AMOL_2608
GSK : KN400_1997 KN400_2961(rfbE)
GAO : A2G06_06995 A2G06_14210
GBM : Gbem_2570 Gbem_2577(rfbE) Gbem_3734
GER : KP004_00160 KP004_07835
PEF : A7E78_01510 A7E78_05565
DFI : AXF13_07150 AXF13_10745 AXF13_15065
DDN : DND132_0779 DND132_2434
DSX : GD604_13330 GD604_13385
DTO : TOL2_C23120 TOL2_C35360
DLI : dnl_17360(per) dnl_56590
DTI : Desti_4306 Desti_4858
AVM : JQX13_12550 JQX13_45480
MBD : MEBOL_000374 MEBOL_000376 MEBOL_006112
BSTO : C0V70_01685 C0V70_17800 C0V70_17810 C0V70_17815
BAO : BAMF_3247(RBAM_031210)
BTEQ : G4P54_17390 G4P54_18815(pseC)
BCG : BCG9842_B1720(pseC) BCG9842_B2853
BTN : BTF1_09720 BTF1_14880
PSYH : D0S48_03995 D0S48_07155(pseC)
PLUT : EI981_02295 EI981_25865
PPRT : ET464_03250 ET464_03280
PLYC : GXP70_28065 GXP70_28120
PALO : E6C60_0677 E6C60_3794
CBEI : LF65_04806 LF65_05249
CSB : CLSA_c39580(spsC) CLSA_c41680
CEU : A7L45_09460 A7L45_12105
CFM : BJL90_06925 BJL90_07045 BJL90_21240
CTX : Clo1313_0233 Clo1313_2894
CCL : Clocl_1021 Clocl_1022
HSC : HVS_01500(arnB1) HVS_04515(arnB2) HVS_10000(epsN)
RHER : EHE19_000780(pseC) EHE19_015260
DFG : B0537_06785 B0537_12495
FWA : DCMF_13740 DCMF_20655
ACEL : acsn021_17390 acsn021_24270
CLE : Clole_3584 Clole_3813
CBAR : PATL70BA_2640(perA)
VPY : HZI73_16800 HZI73_23140
CST : CLOST_0364 CLOST_2341
HAS : Halsa_0063 Halsa_0577
HALS : D7D81_05120 D7D81_17950
SELO : AXE86_07125 AXE86_08935
STIM : H1B31_00580 H1B31_05890
MANA : MAMMFC1_02384(epsN_2)
PFAC : PFJ30894_01731(fdtB)
RPSK : JWS13_15890 JWS13_22550
SMAL : SMALA_6000 SMALA_6649
STRE : GZL_00795 GZL_09215 GZL_p00136 GZL_p00204
SPRI : SPRI_0310 SPRI_3644 SPRI_7043
SNR : SNOUR_03780 SNOUR_28965 SNOUR_41430
SALU : DC74_1397 DC74_416 DC74_7922
SALL : SAZ_02565 SAZ_07520 SAZ_40905
SPAD : DVK44_04525 DVK44_27710 DVK44_34005
SCAL : I6J39_32545 I6J39_32550
SYUN : MOV08_03295 MOV08_29400 MOV08_42795
KAU : B6264_24450 B6264_25290 B6264_29170
KCH : O1G21_33995 O1G21_36765
BCV : Bcav_1180 Bcav_1184 Bcav_3346
XYL : ET495_09130 ET495_09170
NOW : GBF35_30360 GBF35_36370
SACG : FDZ84_24470 FDZ84_29460
AMQ : AMETH_0233 AMETH_6141(rifK)
AAB : A4R43_07640 A4R43_28250 A4R43_38475
AMYY : YIM_01105(arnB2) YIM_21480(arnB4) YIM_39545(epsN)
APRT : MUY14_02725 MUY14_20870 MUY14_35605
ARHD : VSH64_12445 VSH64_38135
SESP : BN6_01560 BN6_25280 BN6_47650
KPHY : AOZ06_00875 AOZ06_00905
ACTA : C1701_00900 C1701_10135 C1701_10170
PMAD : BAY61_00810 BAY61_22950
UME : RM788_11495 RM788_25895
MCAB : HXZ27_10785 HXZ27_10835
MCRA : ID554_03075 ID554_14290 ID554_21230
CATI : CS0771_67980 CS0771_68080
SYN : slr1615(rfbE) slr2114(spsC)
SYZ : MYO_114890(spsC) MYO_13370(rfbE)
SYY : SYNGTS_0333(rfbE) SYNGTS_1475(spsC)
SYT : SYNGTI_0333(rfbE) SYNGTI_1475(spsC)
SYS : SYNPCCN_0333(rfbE) SYNPCCN_1474(spsC)
SYQ : SYNPCCP_0333(rfbE) SYNPCCP_1474(spsC)
SYO : C7I86_01735 C7I86_07645
PSER : ABRG53_0471 ABRG53_0475
CWA : CwatDRAFT_3907 CwatDRAFT_5107
CYP : PCC8801_0082 PCC8801_3899
CYH : Cyan8802_0080 Cyan8802_3949
LFS : HFV01_27475 HFV01_27495
NOS : Nos7107_0142 Nos7107_0806 Nos7107_0810
NCW : NIES2107_28530 NIES2107_34030
ACY : Anacy_1440 Anacy_6111
AWA : AA650_08260 AA650_20070
CALO : Cal7507_3846 Cal7507_5899
MDP : NIES3275_05490 NIES3275_67890
DOZ : HEP80_10475 HEP80_24025
SKV : NIES73_36680 NIES73_46380
SCYT : SAMD_39060 SAMD_55280
SCYS : NIES4073_34690 NIES4073_47040 NIES4073_57120
CTHE : Chro_0800 Chro_4816 Chro_4829
PLP : Ple7327_1391 Ple7327_4337
ABAO : BEQ56_04255 BEQ56_13070
CAP : CLDAP_10910 CLDAP_21470
PIR : VN12_04535(epsN_1) VN12_07015(epsN_2)
MFF : MFFC18_22050(epsN_1)
AHEL : Q31a_17810(epsN_2) Q31a_30460(epsN_3) Q31a_45130(epsN_4)
AMOB : HG15A2_22920(fdtB_1)
PLS : VT03_07240(epsN) VT03_30290(btrR_2)
GIM : F1728_06170 F1728_24335 F1728_25540
SDYN : Mal52_04160(epsN) Mal52_28790(btrR)
CCOS : Pan44_29740(btrR_2)
LRS : PX52LOC_02215 PX52LOC_02219
SACI : Sinac_0668 Sinac_6925
KST : KSMBR1_1989(rfbE_3) KSMBR1_2319(arnB_3)
PHM : PSMK_18740 PSMK_25250
PBU : L21SP3_00948(epsN) L21SP3_00949(wbpE_2)
PBAS : SMSP2_00901(fdtB_1)
LIE : LIF_A0439(wecE) LIF_A1294(wecE)
LBI : LEPBI_I0696 LEPBI_I2024
LAJ : A0128_07365 A0128_17245
LMAY : DPV73_04035 DPV73_15980
BHD : BHYOB78_11570 BHYOB78_13440
PET : PEIBARAKI_4990 PEIBARAKI_4992
PROJ : KDN43_01425 KDN43_05935
BLQ : L21SP5_00553(epsN) L21SP5_02127(arnB_3)
FLA : SY85_00780 SY85_05415
FEI : K9M53_00750 K9M53_08810
PMUO : LOK61_10495 LOK61_16380
SDJ : NCTC13534_05288(arnB_2)
AGD : FRZ59_07145 FRZ59_07510
CMR : Cycma_0152 Cycma_2923
CAMU : CA2015_0124 CA2015_2885
RHOZ : GXP67_20395 GXP67_27950
RUN : DR864_18370 DR864_23710
RUP : DTQ70_02880 DTQ70_03725 DTQ70_24995
FKI : FK004_02440 FK004_02455
CJG : NCTC13459_02713(arnB_4)
CANT : NCTC13489_01543(arnB_2)
PMX : PERMA_0060 PERMA_1629
CNI : Calni_1798 Calni_1964
MIB : UY43_C0001G0701 UY43_C0001G0726
MSJ : MSSAC_0542 MSSAC_4180
HHSR : HSR6_0632 HSR6_0646
NHO : HWV23_15825 HWV23_15890
HALI : BV210_17880 BV210_19390
HME : HFX_6150(wecE) HFX_6228(wecE)
HGI : ABY42_18120 ABY42_18450
HALG : HUG10_18415 HUG10_19250
HALU : HUG12_00935 HUG12_20285
NVR : FEJ81_06160 FEJ81_07040
HRU : Halru_1006 Halru_1608
NOU : Natoc_2262 Natoc_3372
NKR : NKOR_00360 NKOR_00530 NKOR_09285
NID : NPIRD3C_0064 NPIRD3C_0198
NIN : NADRNF5_0122 NADRNF5_2116
NCL : C5F47_00795 C5F47_09025
NOX : C5F49_00780 C5F49_08920
NUE : C5F50_00690 C5F50_12360
NCT : NMSP_0143 NMSP_1667(aspC_3)
NIC : DSQ20_00725 DSQ20_09910
NDV : NDEV_0137(spsC2) NDEV_0208(spsC3) NDEV_0228 NDEV_2078
NBV : T478_0150 T478_0169 T478_0191
TAH : SU86_005995 SU86_007125
» show all
Taxonomy
Reference
Authors
Albermann C, Piepersberg W
Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
Journal
Reference
Authors
Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG
Title
Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157:H7 and synthesis of GDP-perosamine in vitro.
Journal
Sequence
Reference
Authors
Albermann C, Beuttler H
Title
Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.
Journal
Reference
Authors
Cook PD, Carney AE, Holden HM
Title
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.6.1.102