KEGG   ENZYME: 2.6.1.102Help
Entry
EC 2.6.1.102                Enzyme                                 

Name
GDP-perosamine synthase;
RfbE;
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase;
GDP-perosamine synthetase;
PerA;
GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate [RN:R10460]
Reaction(KEGG)
Substrate
GDP-alpha-D-perosamine [CPD:C20638];
2-oxoglutarate [CPD:C00026]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
L-glutamate [CPD:C00025]
Comment
A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis.
History
EC 2.6.1.102 created 2013
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K13010  perosamine synthetase
Genes
ECE: Z3200(per)
ECS: ECs2841
ECF: ECH74115_2970
ETW: ECSP_2791(per)
ELX: CDCO157_2621
YEP: YE105_C1505
YET: CH48_3099
XAX: XACM_3496
LYT: DWG18_00890
DTX: ATSB10_35930
VCH: VC0244
VCS: MS6_0112
VCE: Vch1786_I2528(rfbE)
VCI: O3Y_01125
VCO: VC0395_A2624(rfbE)
VCR: VC395_0276(rfbE)
VCM: VCM66_0232(rfbE)
PAT: Patl_3059
LLG: 44548918_01769(yvfE)
FPH: Fphi_1164
SLIM: SCL_1222
RPI: Rpic_4737
BPS: BPSS0422
BPSE: BDL_3649
BPSM: BBQ_5775
BPSU: BBN_3821
BPSD: BBX_5486
BPK: BBK_5627
BPSH: DR55_4931
BPSA: BBU_5626
BPSO: X996_4682
BUT: X994_4199
BUB: BW23_864
PNU: Pnuc_0312
VEI: Veis_4858
MPT: Mpe_A2766
RGE: RGE_41280(per)
SLT: Slit_2895
AZA: AZKH_0246
HCP: HCN_1201
GSK: KN400_2961(rfbE)
GUR: Gura_4084
GLO: Glov_3402
GBM: Gbem_2577(rfbE)
GEM: GM21_2600
ADE: Adeh_3061
SAT: SYN_00827
RBT: NOVO_09405(arnB_2)
RLE: RL0240
RLG: Rleg_4504
BME: BMEI1414
BMEL: DK63_2074
BMEE: DK62_880
BMF: BAB1_0544
BABO: DK55_551
BABR: DO74_1335
BABT: DK49_315
BABB: DK48_1574
BABU: DK53_541
BABS: DK51_919
BABC: DO78_458
BMS: BR0521
BSUI: BSSP1_I1185(rbmB)
BSUP: BSPT1_I1196(rbmB)
BSUV: BSPT2_I1181(rbmB)
BSUC: BSSP2_I0534(rbmB)
BMT: BSUIS_A0552(rbmB)
BSZ: DK67_1450
BOV: BOV_0525
BCS: BCAN_A0533(rbmB)
BCAR: DK60_604
BCAS: DA85_02495
BMR: BMI_I523
BPP: BPI_I552
BPV: DK65_838
BRS: S23_22630
NWI: Nwi_2405
VGO: GJW-30_1_00095(epsN)
AZC: AZC_3470
SNO: Snov_1137
MET: M446_4033
CCR: CC_1012
CSE: Cseg_3262
RLI: RLO149_c044340(arnB)
ACR: Acry_0289
MAG: amb0054
BTI: BTG_07620
GKA: GK3127
LSP: Bsph_1161
PMW: B2K_18255
BTS: Btus_0884
CBL: CLK_2097
CBB: CLD_1860
CBN: CbC4_1001
CBT: CLH_1450
CBF: CLI_2769
CBM: CBF_2761
DRM: Dred_3134
PTH: PTH_1115(WecE)
TIT: Thit_0479
MTA: Moth_0752
TSH: Tsac_2670
MIT: OCO_31080
MIA: OCU_30960
MIR: OCQ_31700
SALU: DC74_7922
SALL: SAZ_40905
KSK: KSE_46570
PDX: Psed_1887
SYN: slr1615(rfbE) slr2114(spsC)
SYZ: MYO_114890(spsC) MYO_13370(rfbE)
SYY: SYNGTS_0333(rfbE) SYNGTS_1475(spsC)
SYT: SYNGTI_0333(rfbE) SYNGTI_1475(spsC)
SYS: SYNPCCN_0333(rfbE) SYNPCCN_1474(spsC)
SYQ: SYNPCCP_0333(rfbE) SYNPCCP_1474(spsC)
SYC: syc1444_d(rfbE)
MAR: MAE_20080
CYT: cce_1406
CTHE: Chro_4829
PIR: VN12_04535(epsN_1)
KST: KSMBR1_1989(rfbE_3)
SRU: SRU_0601
GFO: GFO_0550
TNP: Tnap_0420
MARN: LN42_06755
DTU: Dtur_0594
MMP: MMP0351(aspB-like1)
MAE: Maeo_0427
MVO: Mvol_0929
MTH: MTH_334
FPL: Ferp_2376
PAB: PAB0774(aspB-like1)
PFU: PF0767
PFI: PFC_02990
TGA: TGAM_2150(degT)
TSI: TSIB_2028
TLT: OCC_01394
MBU: Mbur_1589
MTP: Mthe_1460
MCJ: MCON_2573
MHU: Mhun_2126
MBN: Mboo_1834
IAG: Igag_1197
KCR: Kcr_1162
 » show all
Taxonomy
Reference
1  [PMID:11479276]
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Reference
2  [PMID:17888872]
  Authors
Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG
  Title
Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia  coli O157:H7 and synthesis of GDP-perosamine in vitro.
  Journal
Biochem Biophys Res Commun 363:525-30 (2007)
DOI:10.1016/j.bbrc.2007.08.184
  Sequence
[ece:Z3200]
Reference
3  [PMID:18201574]
  Authors
Albermann C, Beuttler H
  Title
Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.
  Journal
FEBS Lett 582:479-84 (2008)
DOI:10.1016/j.febslet.2008.01.005
Reference
4  [PMID:18795799]
  Authors
Cook PD, Carney AE, Holden HM
  Title
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
  Journal
Biochemistry 47:10685-93 (2008)
DOI:10.1021/bi801309q
  Sequence
[ccr:CC_1012]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.102
IUBMB Enzyme Nomenclature: 2.6.1.102
ExPASy - ENZYME nomenclature database: 2.6.1.102
BRENDA, the Enzyme Database: 2.6.1.102

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