KEGG   ENZYME: 2.6.1.102
Entry
EC 2.6.1.102                Enzyme                                 
Name
GDP-perosamine synthase;
RfbE;
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase;
GDP-perosamine synthetase;
PerA;
GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate [RN:R10460]
Reaction(KEGG)
R10460
Substrate
GDP-alpha-D-perosamine [CPD:C20638];
2-oxoglutarate [CPD:C00026]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
L-glutamate [CPD:C00025]
Comment
A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis.
History
EC 2.6.1.102 created 2013
Pathway
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
Orthology
K13010  perosamine synthetase
Genes
ECE: Z3200(per)
ECS: ECs_2841(arnB)
ECF: ECH74115_2970
ETW: ECSP_2791(per)
ELX: CDCO157_2621
CPOT: FOB25_20255
YEP: YE105_C1505
YET: CH48_3099
XAX: XACM_3496
SFOE: K5L94_02485
STEQ: ICJ04_02470
LYT: DWG18_00890
THEH: G7079_12150
DTX: ATSB10_35930
DYE: EO087_14145
VCH: VC_0244
VCF: IR04_06145
VCS: MS6_0112
VCE: Vch1786_I2528(rfbE)
VCQ: EN18_18115
VCJ: VCD_001373
VCI: O3Y_01125
VCO: VC0395_A2624(rfbE)
VCR: VC395_0276(rfbE)
VCM: VCM66_0232(rfbE)
VCL: VCLMA_A0215
VQI: CCZ37_12430
PMOE: HV782_020725
PIZ: LAB08_R15100
PSDT: NH234_21535
PAGB: AWM79_20520
ASP: AOR13_2482
ASQ: AVL57_11085
AAW: AVL56_10225
ALE: AV939_10105
ALZ: AV940_09875
SALM: D0Y50_04655
PMAW: MACH26_32720
LLG: 44548918_01769(yvfE)
MEEF: JWZ97_16765
MMT: Metme_1187
MELL: IVG45_21940
MRP: NM686_017165
MAH: MEALZ_0739
THIS: HZT40_22615
TLO: J9253_14080
TSB: HMY34_08605
TWN: L2Y54_02880 L2Y54_07655
TLC: RCF98_06685
TSJ: L3K52_03730
TPUT: QJT81_20055
THIP: N838_20425
CJAP: GWK36_01875
MARL: HH196_10930
AHA: AHA_2901
AHD: AI20_20260
ADH: CK627_11305
SLIM: SCL_1222
CHRI: DK842_11495
CHRB: DK843_16940
BUB: BW23_864
BURT: BTHE68_52510
BUZ: AYM40_03395
PNU: Pnuc_0312
POLY: PSHI2_02850(perA)
POLN: PSHI8_02850(perA)
CABA: SBC2_28980(per)
CABK: NK8_80540
RHOB: HTY51_14345
ACIV: EXV95_21555
CBX: Cenrod_2070
MPT: Mpe_A2766
METP: C1M51_03365
RGE: RGE_41280(per)
HFR: G5S34_02325
SDR: SCD_n02879
URU: DSM104443_02789(per)
DDEN: KI615_14775
AZA: AZKH_0246
RBT: NOVO_09405(arnB_2)
MESR: FGU64_22500
CHEA: PVE73_19995
RPUS: CFBP5875_22110
RLT: Rleg2_4223
RPHA: AMC79_CH00807
RII: FFM53_009040
RLN: J0663_12600
RBW: RLCC275e_02210
RHIZ: QMO80_002346
NGL: RG1141_PA05570
BME: BMEI1414
BMEL: DK63_2074
BMI: BMEA_A0559
BMZ: BM28_A0535
BMG: BM590_A0537
BMW: BMNI_I0529
BMEE: DK62_880
BMF: BAB1_0544
BMB: BruAb1_0544
BMC: BAbS19_I05100
BAA: BAA13334_I03105
BABO: DK55_551
BABR: DO74_1335
BABT: DK49_315
BABB: DK48_1574
BABU: DK53_541
BABS: DK51_919
BABC: DO78_458
BMS: BR0521
BSI: BS1330_I0520
BSF: BSS2_I0508
BSUI: BSSP1_I1185(rbmB)
BSUP: BSPT1_I1196(rbmB)
BSUV: BSPT2_I1181(rbmB)
BSUC: BSSP2_I0534(rbmB)
BMT: BSUIS_A0552(rbmB)
BSZ: DK67_1450
BSV: BSVBI22_A0520
BSW: IY71_02655
BSG: IY72_02380
BOV: BOV_0525
BCS: BCAN_A0533(rbmB)
BSK: BCA52141_I0861
BOL: BCOUA_I0521
BCAR: DK60_604
BCAS: DA85_02495
BMR: BMI_I523
BPP: BPI_I552
BPV: DK65_838
BCET: V910_101439
BCEE: V568_101612
BVL: BF3285c1_0236
BRU: BFS01_02580
BRS: S23_22630
BRC: BCCGELA001_25605
BOT: CIT37_24205
BRQ: CIT40_22035
BGQ: X265_13660
BSYM: CIT39_21325
BBET: F8237_26375
BDG: LPJ38_32040
BBAN: J4G43_054615
BCOU: IC761_11620
BXN: I3J27_26015
VGO: GJW-30_1_00095(epsN)
SNO: Snov_1137
MET: M446_4033
MNO: Mnod_0874 Mnod_3171
MTAD: M6G65_08220
MFLG: ABS361_22430
CCR: CC_1012
CCS: CCNA_01064
CSE: Cseg_3262
CFH: C1707_06545
CAUF: CSW63_17525
CAUB: AMEJIAPC_02974(per)
RLI: RLO149_c044340(arnB)
MALG: MALG_02566
SULI: C1J05_06600
SPHX: E5675_10130
SSED: H9L14_04905
SSIN: G7078_00710
SAAP: E2E30_14540
SJP: SJA_C1-30260
PARJ: J4G78_11420
ACR: Acry_0289
AMV: ACMV_03170 ACMV_03190
AZS: E6C72_14655
AZP: E6C67_03600 E6C67_03990
ADJ: ACIU1J_32045
FER: FNB15_14465
DVN: HQ394_19015
TXI: TH3_00070
APM: HIMB5_00011240
HCP: HCN_1201
HCB: HCBAA847_0764
CCOC: CCON33237_0130
AVP: AVENP_2927
AIE: LXN10_05525
GEM: GM21_2600
GEV: GSVR_42670
GLO: Glov_3378 Glov_3402
GBM: Gbem_2570 Gbem_2577(rfbE)
GER: KP004_07835
DFI: AXF13_07150 AXF13_10745
BWS: WCP94_001737
DAK: DaAHT2_0376
DTO: TOL2_C35360
DEK: DSLASN_21140
SAT: SYN_00827
DTI: Desti_4858
ADE: Adeh_3061
ANK: AnaeK_3157
MRM: A7982_07503
SAMY: DB32_000370
PIR: VN12_04535(epsN_1)
MFF: MFFC18_22050(epsN_1)
AHEL: Q31a_17810(epsN_2)
PND: Pla175_39230(epsN)
GAW: V144x_30100(epsN_1)
SVP: Pan189_03410(epsN)
KST: KSMBR1_1989(rfbE_3)
PHM: PSMK_25250
LPRO: PQO03_09610
LIOW: AB3N60_09990
LGOR: AB3N59_07295 AB3N59_07345
GET: QOZ81_001481
GGR: HKW67_13460
BEG: INE88_02802(per)
FLA: SY85_05415
PGO: FSB84_04810
FEI: K9M53_00750 K9M53_08810
PROE: H9L23_02680
PMUO: LOK61_10495 LOK61_16380
PEV: KYH19_01690
PSN: Pedsa_3202
MGIK: GO620_005095
SBX: CA265_01760
FUA: LVD17_22365
RSR: T7867_07390
GFO: GFO_0550
GRL: LPB144_06685
FPLU: NLG42_01580
FBC: FB2170_05785
POLA: BXQ17_13940
AUE: C5O00_09655
PMX: PERMA_1629
DIN: Selin_2473
CNI: Calni_1964
PJD: Pjdr2_3523
PMS: KNP414_03319
PMQ: PM3016_3539
PMW: B2K_18255
PLUT: EI981_25865
PPRT: ET464_03280
PALO: E6C60_3794
PTHI: NDS46_22785
PDY: QJQ58_29455
PMAE: LMZ02_02060
PELG: ACJ7K1_23260
CNO: NT01CX_1789
CBL: CLK_2097
CBB: CLD_1860
CBN: CbC4_1001
CBF: CLI_2769
CBM: CBF_2761
CEU: A7L45_09460 A7L45_12105
CFM: BJL90_06925
CTAG: LL095_12310
CALE: FDN13_00860
CRS: FQB35_02455
CPRF: K7H06_14785
OCW: OW730_17295
DRM: Dred_3134
TJR: TherJR_2782
CLE: Clole_3813
TIT: Thit_0479
TXY: Thexy_1880
TSH: Tsac_2670
MTA: Moth_0752
MTHO: MOTHE_c06960(epsN)
MTHZ: MOTHA_c07900(epsN)
MHUI: MHLNE_07400(per_2)
HALS: D7D81_05120
AFT: BBF96_11110
SGBI: P3F81_10845
CCHA: ELD05_07905
MOT: LTS72_07930
SALB: XNR_5866
SBH: SBI_01977
STRE: GZL_00795 GZL_09215
SLD: T261_7945
SKY: D0C37_31585
SNR: SNOUR_03780 SNOUR_41430
SALU: DC74_1397 DC74_7922
SALL: SAZ_07520 SAZ_40905
SGV: B1H19_05045
SALJ: SMD11_6577(per)
SGD: ELQ87_34025
SQZ: FQU76_30665
SAST: CD934_00665
SNQ: CP978_03015
SGZ: C0216_12715
SPAD: DVK44_34005
SRIM: CP984_01730
SCYG: S1361_34295(arnB)
SRUG: F0345_01345
SVIO: HWN34_29660
SYUN: MOV08_03295 MOV08_42795
SOV: QZH56_02540
KAU: B6264_25290
KCH: O1G21_33995
XYL: ET495_09130 ET495_09170
CCHE: NP064_12140
AWS: ACN3XK_74020
AAB: A4R43_07640 A4R43_38475
AMYY: YIM_21480(arnB4) YIM_39545(epsN)
APRT: MUY14_02725 MUY14_20870
ARHD: VSH64_12445
PSEA: WY02_00365
PSEQ: AD006_18030
PECQ: AD017_25870
LED: BBK82_47100
CROS: N8J89_26355
MICH: FJK98_09900
MCRA: ID554_03075
VER: HUT12_10065
MENO: Jiend_08670(per)
MPRN: Q3V37_27885
PLAB: C6361_29165
PLAT: C6W10_06275
PSUU: Psuf_011620(per)
NHI: B1s21160_05750
SYN: slr2114(spsC)
SYZ: MYO_114890(spsC)
SYY: SYNGTS_1475(spsC)
SYT: SYNGTI_1475(spsC)
SYS: SYNPCCN_1474(spsC)
SYQ: SYNPCCP_1474(spsC)
SYO: C7I86_07645
SYNS: OLK001_14380
TSZ: OOK60_03910
LEPT: JVX88_17920
MAR: MAE_20080
MVZ: myaer102_53190
CYT: cce_1406
CWA: CwatDRAFT_5107
CYP: PCC8801_0082
CYH: Cyan8802_0080
NCW: NIES2107_28530
ANB: ANA_C12624
CALO: Cal7507_3846 Cal7507_5899
MDP: NIES3275_05490
AFLO: HEQ12_06705
SKV: NIES73_36680
SCYT: SAMD_39060 SAMD_55280
SCYS: NIES4073_34690 NIES4073_47040
BSEN: DP114_00155
BOX: DP113_00155
NCN: BZZ01_23915
CTHE: Chro_4829
PLP: Ple7327_1391
LEK: hrd7_23740(perA)
CAP: CLDAP_10910 CLDAP_21470
TNP: Tnap_0420
FRR: IB67_01505
FGW: QO060_09705
MPZ: Marpi_1257
MARN: LN42_06755
MINF: MESINF_0673
PRF: PeribacterA2_0882
MIB: UY43_C0001G0726
MTH: MTH_334
MTEE: MTTB_13420
MRID: FGU46_00790
MHU: Mhun_2126
FAC: FACI_IFERC01G1903
SIS: LS215_0628
 » show all
Reference
1  [PMID:11479276]
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Reference
2  [PMID:17888872]
  Authors
Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG
  Title
Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia  coli O157:H7 and synthesis of GDP-perosamine in vitro.
  Journal
Biochem Biophys Res Commun 363:525-30 (2007)
DOI:10.1016/j.bbrc.2007.08.184
  Sequence
[ece:Z3200]
Reference
3  [PMID:18201574]
  Authors
Albermann C, Beuttler H
  Title
Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.
  Journal
FEBS Lett 582:479-84 (2008)
DOI:10.1016/j.febslet.2008.01.005
Reference
4  [PMID:18795799]
  Authors
Cook PD, Carney AE, Holden HM
  Title
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
  Journal
Biochemistry 47:10685-93 (2008)
DOI:10.1021/bi801309q
  Sequence
[ccr:CC_1012]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.102
IUBMB Enzyme Nomenclature: 2.6.1.102
ExPASy - ENZYME nomenclature database: 2.6.1.102
BRENDA, the Enzyme Database: 2.6.1.102

  All links  
Gene (39694)   
   MGENES (35672)   
   RefGene (4022)   
Protein sequence (3120)   
   UniProt (3089)   
   SWISS-PROT (3)   
   RefSeq(pep) (28)   
DNA sequence (2277)   
   RefSeq(nuc) (1606)   
   GenBank (336)   
   EMBL (335)   
Protein domain (4)   
   InterPro (4)   
All databases (45095)   

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