| Entry |
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| Name |
GDP-perosamine synthase;
RfbE;
GDP-4-keto-6-deoxy-D-mannose-4-aminotransferase;
GDP-perosamine synthetase;
PerA;
GDP-4-amino-4,6-dideoxy-alpha-D-mannose:2-oxoglutarate aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
GDP-alpha-D-perosamine:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate [RN: R10460]
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| Reaction(KEGG) |
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| Substrate |
GDP-alpha-D-perosamine [CPD: C20638];
2-oxoglutarate [CPD: C00026]
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| Product |
GDP-4-dehydro-alpha-D-rhamnose [CPD: C01222];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis.
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| History |
EC 2.6.1.102 created 2013
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Albermann C, Piepersberg W |
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| Title |
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine. |
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| Journal |
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| Reference |
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| Authors |
Zhao G, Liu J, Liu X, Chen M, Zhang H, Wang PG |
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| Title |
Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157:H7 and synthesis of GDP-perosamine in vitro. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Albermann C, Beuttler H |
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| Title |
Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7. |
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| Journal |
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| Reference |
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| Authors |
Cook PD, Carney AE, Holden HM |
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| Title |
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.6.1.102 |
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