KEGG   ENZYME: 2.6.1.105
Entry
EC 2.6.1.105                Enzyme                                 

Name
lysine---8-amino-7-oxononanoate transaminase;
DAPA aminotransferase (ambiguous);
bioA (gene name) (ambiguous);
bioK (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-lysine:8-amino-7-oxononanoate aminotransferase
Reaction(IUBMB)
L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate [RN:R10699]
Reaction(KEGG)
R10699
Substrate
L-lysine [CPD:C00047];
8-amino-7-oxononanoate [CPD:C01092]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
7,8-diaminononanoate [CPD:C01037]
Comment
A pyridoxal 5'-phosphate enzyme [2]. Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase).
History
EC 2.6.1.105 created 2014
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K19563  lysine---8-amino-7-oxononanoate aminotransferase
Genes
AFR: AFE_1924(bioA)
AFJ: AFERRID_28900
BSU: BSU30230(bioA)
BSR: I33_3077(bioA)
BSL: A7A1_1653
BSH: BSU6051_30230(bioK)
BSY: I653_14470
BSUT: BSUB_03212(bioK)
BSUL: BSUA_03212(bioK)
BSUS: Q433_16395
BSS: BSUW23_14645(bioK)
BST: GYO_3271(bioA)
BSO: BSNT_09443(bioA)
BSQ: B657_30230(bioK)
BSX: C663_2868(bioK)
BLI: BL00953(bioA)
BLD: BLi00767(bioA)
BLH: BaLi_c08650(bioA)
BAY: RBAM_018280(bioA)
BAQ: BACAU_1786(bioA)
BYA: BANAU_1953(bioA)
BAMP: B938_09455
BAML: BAM5036_1765(bioK)
BAMA: RBAU_1803(bioK)
BAMN: BASU_1783(bioK)
BAMB: BAPNAU_1916(bioA)
BAMT: AJ82_10385
BAMY: V529_17980(bioA)
BMP: NG74_01904(bioK)
BAO: BAMF_1923(bioK)
BAZ: BAMTA208_07890(bioK)
BQL: LL3_02013(bioK)
BXH: BAXH7_01607(bioA)
BQY: MUS_2182(bioA)
BAMI: KSO_010225
BAMC: U471_18830
BAMF: U722_09670
BSON: S101395_00962(bioA)
BAH: BAMEG_4381(bioA)
BAI: BAA_4363(bioA)
BANT: A16_43400
BANR: A16R_43950
BANS: BAPAT_4166
BANV: DJ46_3031(bioA)
BCA: BCE_4189(bioA)
BCZ: BCE33L3875(bioA)
BCR: BCAH187_A4253(bioA)
BCB: BCB4264_A4230(bioA)
BCU: BCAH820_4143(bioA)
BCG: BCG9842_B1007(bioA)
BCQ: BCQ_3909(bioA)
BCX: BCA_4232(bioA)
BAL: BACI_c40910(bioA2)
BNC: BCN_4035
BCF: bcf_20495
BCER: BCK_14595
BTL: BALH_3735(bioA)
BTB: BMB171_C3785(bioA)
BTT: HD73_4421
BTHI: BTK_21760
BTC: CT43_CH4127(bioA)
BTM: MC28_3412
BTG: BTB_c42560(bioA)
BTI: BTG_28805
BTW: BF38_5293(bioA)
BWW: bwei_0829(bioA)
BMYO: BG05_1901(bioA)
BMYC: DJ92_1219(bioA)
BTRO: FJR70_14360(bioA)
BJS: MY9_3023
BMET: BMMGA3_08100(bioK)
BACP: SB24_00515
BACB: OY17_12275
BACO: OXB_3534
BACY: QF06_13305
BACL: BS34A_32870(bioA)
BALM: BsLM_3007
BEO: BEH_11235
BGY: BGLY_0781(bioK)
BPF: BpOF4_04195(bioA)
BKW: BkAM31D_02745(bioK)
AFL: Aflv_1071(bioA)
VPN: A21D_01032(bioK_1)
BBE: BBR47_54640(bioA)
BRW: GOP56_16000(bioA)
PBK: Back11_03850(bioA)
COHN: KCTCHS21_53510(bioA)
AAC: Aaci_2857
BTS: Btus_2598
SPAE: E2C16_12250(bioA)
LKI: LKI_05230
 » show all
Reference
1  [PMID:15880481]
  Authors
Van Arsdell SW, Perkins JB, Yocum RR, Luan L, Howitt CL, Chatterjee NP, Pero JG
  Title
Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction.
  Journal
Biotechnol Bioeng 91:75-83 (2005)
DOI:10.1002/bit.20488
  Sequence
[bsu:BSU30230]
Reference
2  [PMID:20565114]
  Authors
Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC
  Title
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
  Journal
Biochemistry 49:6746-60 (2010)
DOI:10.1021/bi902097j
  Sequence
[bsu:BSU30230]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.105
IUBMB Enzyme Nomenclature: 2.6.1.105
ExPASy - ENZYME nomenclature database: 2.6.1.105
BRENDA, the Enzyme Database: 2.6.1.105

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