KEGG   ENZYME: 2.6.1.106Help
Entry
EC 2.6.1.106                Enzyme                                 

Name
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase;
desV (gene name);
megDII (gene name);
eryCI (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate [RN:R06426]
Reaction(KEGG)
Substrate
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose [CPD:C11910];
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose [CPD:C11909];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.
History
EC 2.6.1.106 created 2014
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K13310  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
K16436  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Genes
GUR: Gura_4276
GBM: Gbem_3307
GEO: Geob_0430
GEM: GM21_0941
DMA: DMR_07600
NBR: O3I_007490
DPC: A6048_11425
SGR: SGR_631
SXI: SXIM_35740
SAMB: SAM23877_7111
SLE: sle_09260(sle_09260)
SRN: A4G23_02284(fdtB_3)
NDA: Ndas_4709
NAL: B005_1433
STRR: EKD16_15580(fdtB)
TCU: Tcur_2777
SEN: SACE_0734(eryCI)
AOI: AORI_1500
AJA: AJAP_32020(dnrJ)
SESP: BN6_58910(sam30)
KAL: KALB_6580(acuN1)
AHG: AHOG_05440(fdtB1)
ALO: CRK56086
SAQ: Sare_2337
MIL: ML5_4433
 » show all
Taxonomy
Reference
1  [PMID:17456741]
  Authors
Burgie ES, Thoden JB, Holden HM
  Title
Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
  Journal
Protein Sci 16:887-96 (2007)
DOI:10.1110/ps.062711007
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.106
IUBMB Enzyme Nomenclature: 2.6.1.106
ExPASy - ENZYME nomenclature database: 2.6.1.106
BRENDA, the Enzyme Database: 2.6.1.106

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