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Entry
EC 2.6.1.110                Enzyme                                 

Name
dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase;
SpnR;
TDP-4-keto-2,3,6-trideoxy-D-glucose 4-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate [RN:R08931]
Reaction(KEGG)
Substrate
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose [CPD:C18033];
2-oxoglutarate [CPD:C00026]
Product
dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose [CPD:C18032];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.
History
EC 2.6.1.110 created 2016
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K13329  dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase
Genes
SAMB: SAM23877_5617(srm20)
SLX: SLAV_40480(arnB2)
SFK: KY5_6527c
AAB: A4R43_01825
Taxonomy
Reference
1  [PMID:18345667]
  Authors
Hong L, Zhao Z, Melancon CE 3rd, Zhang H, Liu HW.
  Title
In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.
  Journal
J Am Chem Soc 130:4954-67 (2008)
DOI:10.1021/ja0771383
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.110
IUBMB Enzyme Nomenclature: 2.6.1.110
ExPASy - ENZYME nomenclature database: 2.6.1.110
BRENDA, the Enzyme Database: 2.6.1.110

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