KEGG   ENZYME: 2.6.1.117
Entry
EC 2.6.1.117                Enzyme                                 

Name
L-glutamine---4-(methylsulfanyl)-2-oxobutanoate aminotransferase;
mtnE (gene name);
Solyc11g013170.1 (locus name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-glutamine:4-(methylsulfanyl)-2-oxobutanoate aminotransferase
Reaction(IUBMB)
L-glutamine + 4-(methylsulfanyl)-2-oxobutanoate = 2-oxoglutaramate + L-methionine [RN:R12507]
Reaction(KEGG)
R12507
Substrate
L-glutamine [CPD:C00064];
4-(methylsulfanyl)-2-oxobutanoate [CPD:C01180]
Product
2-oxoglutaramate [CPD:C00940];
L-methionine [CPD:C00073]
Comment
A pyridoxal-phosphate protein. The enzyme, found in both prokaryotes and eukaryotes, catalyses the last reaction in a methionine salvage pathway. In mammals this activity is catalysed by the multifunctional glutamine transaminase K (cf. EC 2.6.1.64, glutamine---phenylpyruvate transaminase).
History
EC 2.6.1.117 created 2019
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K08969  L-glutamine---4-(methylsulfanyl)-2-oxobutanoate aminotransferase
K23977  L-glutamine---4-(methylsulfanyl)-2-oxobutanoate aminotransferase
Genes
ATH: AT1G77670
ALY: 9325216
CRB: 17896472
CSAT: 104702549 104713438 104751661
EUS: EUTSA_v10018556mg
BRP: 103830559
BNA: 106353476 106368943
BOE: 106300688
RSZ: 108818209
THJ: 104810152
CPAP: 110816703
CIT: 102621176
TCC: 18592299
GRA: 105797179
GHI: 107951450
GAB: 108460253
EGR: 104450489
CAM: 101511886
LJA: Lj0g3v0135259.1(Lj0g3v0135259.1) Lj1g3v0785940.1(Lj1g3v0785940.1) Lj1g3v0786110.1(Lj1g3v0786110.1)
ADU: 107460784
AIP: 107606079
FVE: 101298764
RCN: 112172636
PPER: 18793089
PMUM: 103319942
PAVI: 110753440
ZJU: 107403249
MCHA: 111011191
CMAX: 111476876
CPEP: 111797729
RCU: 8274095
JCU: 105638909
HBR: 110638924
QSU: 112033148
VVI: 104882468
SLY: 101251438
SPEN: 107004877
CANN: 107867990
OEU: 111397468
HAN: 110917231
LSV: 111877416
CCAV: 112510385
DCR: 108221896
BVG: 104893637
SOE: 110795038
NNU: 104608496
OSA: 4347242
DOSA: Os09t0453800-01(Os09g0453800)
OBR: 102709592
BDI: 100842390
ATS: 109767646
SBI: 8062774
ZMA: 100276369
SITA: 101752642
PDA: 103712523
EGU: 105058225
MUS: 103984039
DCT: 110115339
PEQ: 110021338
AOF: 109851579
ATR: 18435834
KPN: KPN_01361
KPU: KP1_2435(mtnE)
KPP: A79E_2804
KPJ: N559_2895
KPX: PMK1_03755(dapL)
KPNU: LI86_14440
KPNK: BN49_2492
KVA: Kvar_2940
KPE: KPK_3045
EBI: EbC_28130
BSU: BSU13580(ykrV)
BSR: I33_1529
BSL: A7A1_1502
BSH: BSU6051_13580(mtnE)
BSUT: BSUB_01478(mtnE)
BSUL: BSUA_01478(mtnE)
BSUS: Q433_07765
BSS: BSUW23_06975(mtnE)
BST: GYO_1685
BSO: BSNT_07849(ykrV)
BSQ: B657_13580(mtnE)
BSX: C663_1399(mtnE)
BLI: BL03539(mtnV)
BLD: BLi01514(mtnE)
BLH: BaLi_c15930(mtnE)
BAQ: BACAU_1313(mtnE)
BYA: BANAU_1272(mtnE)
BAMP: B938_06950
BAML: BAM5036_1272(mtnE)
BAMA: RBAU_1314(mtnE)
BAMN: BASU_1293(mtnE)
BAMB: BAPNAU_2427(mtnE)
BAMT: AJ82_07675
BAMY: V529_12880(mtnE)
BMP: NG74_01391(dapL_1)
BAO: BAMF_1440(mtnE)
BAZ: BAMTA208_10345(mtnE)
BQL: LL3_01460(mtnE)
BXH: BAXH7_02115(mtnE)
BQY: MUS_1439(mtnE)
BAMI: KSO_012685
BAMC: U471_13590
BAMF: U722_07140
BSON: S101395_03401(mtnE)
BHA: BH1060
BAN: BA_4254
BAR: GBAA_4254
BAT: BAS3945
BAI: BAA_4276
BANT: A16_42550
BANR: A16R_43090
BANS: BAPAT_4079
BANV: DJ46_2946
BCE: BC4035
BCA: BCE_4102
BCQ: BCQ_3824
BCX: BCA_4147
BNC: BCN_3947
BCF: bcf_20070
BCER: BCK_15025
BTL: BALH_3652
BTT: HD73_4334
BTHI: BTK_21335
BTM: MC28_3327
BTG: BTB_c41700(mtnE)
BTI: BTG_29245
BTW: BF38_5208
BWW: bwei_0916(mtnE)
BMYO: BG05_1987
BMYC: DJ92_1130
BCL: ABC1492(mtnV)
BPU: BPUM_1251
BPUM: BW16_07060
BPUS: UP12_06565
BMQ: BMQ_1249(mtnE)
BMD: BMD_1233(mtnE)
BMH: BMWSH_3987(ykrV)
BMEG: BG04_3548
BJS: MY9_1487
BMET: BMMGA3_05040(mtnE)
BACW: QR42_06420
BACP: SB24_03035
BACB: OY17_09775
BACO: OXB_3392
BACY: QF06_05800
BACL: BS34A_15080(ykrV)
BALM: BsLM_1439
BEO: BEH_04810
BGY: BGLY_1451(mtnV)
BKW: BkAM31D_04210(dapL_1)
OIH: OB0420
GKA: GK0952
GTN: GTNG_0840
GGH: GHH_c08890(mtnE)
GEA: GARCT_00964(dapL_2)
AFL: Aflv_1998
AAMY: GFC30_1261
ANL: GFC29_147
LSP: Bsph_0917
HLI: HLI_09840
PSYO: PB01_07995
SAU: SA2347
SAW: SAHV_2544
SAE: NWMN_2460
SAD: SAAV_2626
SUZ: MS7_2567
SUG: SAPIG2611
SAUA: SAAG_00381
SAUS: SA40_2314
SAUU: SA957_2398
SAUG: SA268_2476
SAUF: X998_2543
SAB: SAB2433c
SAUB: C248_2618
SAUC: CA347_2635
SAUR: SABB_01124
SAUI: AZ30_13415
SAUD: CH52_06200
SAMS: NI36_12810
SEPP: SEB_02127
SEPS: DP17_1062
SCA: SCA_0010
SDT: SPSE_0561
SPAS: STP1_1062
SCAP: AYP1020_1731(dapL)
SSCH: LH95_02925
SSCZ: RN70_03200
SAGQ: EP23_06985
SDP: NCTC12225_00640(dapL)
MCL: MCCL_0180
MCAK: MCCS_03030(dapL)
LMO: lmo0286
LMOD: LMON_0288
LMOW: AX10_09970
LMOQ: LM6179_0591(mtnE)
LMR: LMR479A_0305(mtnE)
LMOM: IJ09_08825
LMOG: BN389_03100(mtnE)
LMP: MUO_01625
LMOX: AX24_14205
LMQ: LMM7_0319
LMS: LMLG_0764
LMOK: CQ02_01620
LIN: lin0314
LWE: lwe0260
LSG: lse_0269
LIV: LIV_0263
LGZ: NCTC10812_00338(dapL)
ESI: Exig_2539
EAN: Eab7_2381
GMO: NCTC11323_00544(dapL)
GHA: NCTC10459_01206(dapL)
BBE: BBR47_41850(mtnE)
PPM: PPSC2_14305(ykrV1) PPSC2_18090(ykrV3)
PPO: PPM_2877(ykrV1) PPM_3640(ykrV3)
PPOL: X809_34175
PMS: KNP414_04020(mtnE)
PMW: B2K_27845
PRI: PRIO_0678(mtnE1) PRIO_1504(mtnE3)
PSWU: SY83_18295
ASOC: CB4_02874(dapL_2)
COHN: KCTCHS21_26560(mtnE)
AAC: Aaci_1035
AAD: TC41_1069(mtnE)
BTS: Btus_2743
SIV: SSIL_3467
JEO: JMA_14740
KZO: NCTC404_00555(dapL_1)
STC: str0463(aspC3) str1350
STL: stu0463(aspC3)
STE: STER_0499
STN: STND_0460
STU: STH8232_0574(dapL)
STW: Y1U_C0445
STHE: T303_03420
SGG: SGGBAA2069_c06310(avtA)
SGT: SGGB_0659(mtnE)
STB: SGPB_0559(mtnE)
SSR: SALIVB_0485(mtnE)
STF: Ssal_01700(mtnE)
STJ: SALIVA_0445(mtnE)
SSAH: HSISS4_00383(aspC3)
SMN: SMA_0640(mtnE)
SIF: Sinf_0565
SIK: K710_0641
SLU: KE3_0636
LPL: lp_0339(dapC)
LPJ: JDM1_0306
LPT: zj316_0532(dapC)
LPZ: Lp16_0304
LSL: LSL_1927(avtA)
LSI: HN6_01655(avtA)
LSJ: LSJ_2181c
LRE: Lreu_0348
LRF: LAR_0337
LRU: HMPREF0538_21555(dapL)
LRT: LRI_1591
LHE: lhv_0567
LHV: lhe_0638
LHD: HUO_09300
LFE: LAF_0342
LFR: LC40_0239
LFF: LBFF_0362
LRH: LGG_02924(dapL)
LRG: LRHM_2816
LRL: LC705_02892(dapL)
LRA: LRHK_3012
LBH: Lbuc_0783
LRM: LRC_16980
LSN: LSA_01240(mtnE)
LME: LEUM_0018
LMM: MI1_00090
LMK: LMES_0018
LCI: LCK_01694
LKI: LKI_02980
LGS: LEGAS_1893(mtnE)
CRN: CAR_c14730(mtnE2)
CARC: NY10_1530
CPAS: Clopa_4777
CSQ: CSCA_0271
CTYK: CTK_C08150
CCT: CC1_07820
CPY: Cphy_1235
CPRO: CPRO_10300(ybdL)
OVA: OBV_09620
SAY: TPY_2543(mtnE)
BPRS: CK3_29680
FMA: FMG_0214
MHG: MHY_29160
PFT: JBW_03460
MANA: MAMMFC1_00241(ybdL)
STED: SPTER_07920(dapC) SPTER_42040(ybdL_1) SPTER_45950(ybdL_2)
STRM: M444_35565
PFR: PFREUD_23330(aspC)
PFRE: RM25_2233
BLA: BLA_0847
BBB: BIF_00727
BBC: BLC1_1231
BLV: BalV_1233
BLW: W7Y_1274
BLS: W91_1303
BANI: Bl12_1193
BANL: BLAC_06405
BANM: EN10_06450
BDE: BDP_0696
BDN: BBDE_0666
BBI: BBIF_1150
BKS: BBKW_0535
BCAT: BBCT_0501
BANG: BBAG_0382
BPSC: BBPC_0551
BSCA: BBSC_0086
TTR: Tter_0434
GES: VT84_18825(ybdL)
FSC: FSU_2981
GAU: GAU_3126
MPL: Mpal_1153
NMG: Nmag_1783(aspC5)
 » show all
Reference
1  [PMID:12670965]
  Authors
Berger BJ, English S, Chan G, Knodel MH
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
  Sequence
[bsu:BSU13580]
Reference
2  [PMID:24837359]
  Authors
Ellens KW, Richardson LG, Frelin O, Collins J, Ribeiro CL, Hsieh YF, Mullen RT, Hanson AD
  Title
Evidence that glutamine transaminase and omega-amidase potentially act in tandem  to close the methionine salvage cycle in bacteria and plants.
  Journal
Phytochemistry 113:160-9 (2015)
DOI:10.1016/j.phytochem.2014.04.012
  Sequence
[sly:101251438] [zma:100276369] [bsu:BSU13580]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.117
IUBMB Enzyme Nomenclature: 2.6.1.117
ExPASy - ENZYME nomenclature database: 2.6.1.117
BRENDA, the Enzyme Database: 2.6.1.117

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