KEGG   ENZYME: 2.6.1.118
Entry
EC 2.6.1.118                Enzyme                                 

Name
[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase;
lysJ (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
2-oxoglutarate:[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate aminotransferase
Reaction(IUBMB)
an [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate = an [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate [RN:R09778]
Reaction(KEGG)
R09778
Substrate
[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate;
2-oxoglutarate [CPD:C00026]
Product
[amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine;
L-glutamate [CPD:C00025]
Comment
The enzyme participates in an L-lysine biosynthesis pathway in certain species of archaea and bacteria.
History
EC 2.6.1.118 created 2019
Pathway
ec00300  Lysine biosynthesis
Orthology
K05830  LysW-gamma-L-lysine/LysW-L-ornithine aminotransferase
Genes
RRS: RoseRS_2722
RCA: Rcas_3460
CAU: Caur_3656
CHL: Chy400_3943
CAG: Cagg_0221
HAU: Haur_3309
TRO: trd_1515
STI: Sthe_0219
ATM: ANT_12380(argD)
PSUB: Pelsub_P1477
CAP: CLDAP_41060(argD)
DRA: DR_0794
DGE: Dgeo_1416
DDR: Deide_16910(argD)
DFC: DFI_08425
DGA: DEGR_15170(argD_1)
TRA: Trad_1401
TTH: TT_C1393
TTJ: TTHA1755
TSC: TSC_c03550(rocD)
TAQ: TO73_0260
TTR: Tter_0321
TAI: Taci_0450
TLI: Tlie_1472
MRO: MROS_0161
CABY: Cabys_1935 Cabys_3152(argD)
PTO: PTO1470
FAI: FAD_0507(lysJ)
CDIV: CPM_0546
PFU: PF1685
PFI: PFC_10180(argD)
PHO: PH1716(PH1716)
PAB: PAB2440(argD)
PYN: PNA2_0326
PYS: Py04_1633
TKO: TK0275
THS: TES1_0510
HHB: Hhub_3651(argD)
HALH: HTSR_0667(argD)
HHSR: HSR6_0693(argD)
HSU: HLASF_2140(argD)
HSF: HLASA_2174(argD)
HMA: rrnAC2675(argD)
HHI: HAH_3080(argD)
NPH: NP_5264A(argD)
NMO: Nmlp_1240(argD)
HUT: Huta_1499
HTI: HTIA_1542
HMU: Hmuk_0775
HALL: LC1Hm_3291(argD)
HWA: HQ_3717A(argD)
HWC: Hqrw_4132(argD)
HVO: HVO_0043(argD)
HME: HFX_0043(argD)
HLA: Hlac_2613
HDF: AArcSl_0040(argD)
HTU: Htur_0325
NMG: Nmag_1758(argD)
NAT: NJ7G_0260
SALI: L593_07900
APE: APE_1464(lysJ)
ACJ: ACAM_0924(lysJ)
IHO: Igni_0944
IIS: EYM_01870
IAG: Igag_1751
STO: STK_01910(argD_lysJ)
SSO: SSO0160(argD)
SOL: Ssol_1138
SSOA: SULA_1174
SSOL: SULB_1175
SSOF: SULC_1173
SAI: Saci_0755(argD)
SID: M164_1985
SII: LD85_2240
SIH: SiH_1923
SIR: SiRe_1850
SIC: SiL_1832
MSE: Msed_0169
MCN: Mcup_1904
AHO: Ahos_0888
STEP: IC006_1907
PAI: PAE2515
PIS: Pisl_1923
PCL: Pcal_0283
PAS: Pars_1404
PYR: P186_1106
POG: Pogu_0801
TNE: Tneu_1167
CMA: Cmaq_0767
TTN: TTX_0623(lysJ_argD)
TUZ: TUZN_0263
VDI: Vdis_0197
NMR: Nmar_1291
NID: NPIRD3C_0833(argD)
NIN: NADRNF5_0665(argD)
NCT: NMSP_0397(hemL_1)
NGA: Ngar_c29940(argD2)
NVN: NVIE_016480(argD1)
NEV: NTE_00736
TAA: NMY3_02224(argD)
NFN: NFRAN_2986(argD)
NCV: NCAV_1249(argD)
NBV: T478_1046(argD)
NDV: NDEV_1626(argD)
KCR: Kcr_0813
BARB: AOA66_0022(hemL_1)
CCAI: NAS2_0269
 » show all
Reference
1  [PMID:11489859]
  Authors
Miyazaki J, Kobashi N, Nishiyama M, Yamane H
  Title
Functional and evolutionary relationship between arginine biosynthesis and prokaryotic lysine biosynthesis through alpha-aminoadipate.
  Journal
J Bacteriol 183:5067-73 (2001)
DOI:10.1128/JB.183.17.5067-5073.2001
  Sequence
[tth:TT_C1393]
Reference
2  [PMID:19620981]
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M.
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
  Sequence
[tth:TT_C1393]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.118
IUBMB Enzyme Nomenclature: 2.6.1.118
ExPASy - ENZYME nomenclature database: 2.6.1.118
BRENDA, the Enzyme Database: 2.6.1.118

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