| Entry |
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| Name |
alanine transaminase;
glutamic-pyruvic transaminase;
glutamic-alanine transaminase;
GPT (ambiguous);
alanine aminotransferase;
alanine-alpha-ketoglutarate aminotransferase;
alanine-pyruvate aminotransferase;
ALT;
glutamic acid-pyruvic acid transaminase;
glutamic-pyruvic aminotransferase;
L-alanine aminotransferase;
L-alanine transaminase;
L-alanine-alpha-ketoglutarate aminotransferase;
pyruvate transaminase;
pyruvate-alanine aminotransferase;
pyruvate-glutamate transaminase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
L-alanine:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate [RN: R00258]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
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| History |
EC 2.6.1.2 created 1961
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| Pathway |
| ec00250 | Alanine, aspartate and glutamate metabolism |
| ec00710 | Carbon fixation in photosynthetic organisms |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K14260 | alanine-synthesizing transaminase |
| K14272 | glutamate--glyoxylate aminotransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Dumitru IF, Iordachescu D, Niculescu S. |
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| Title |
Chromatographic purification, crystallization and study of vegetable L-alanine: 2-oxoglutarate-aminotransferase properties. |
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| Journal |
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| Reference |
2 |
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| Authors |
Dumitru, I.F., Iordachescu, D. and Niculescu, S. |
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| Title |
L-Alanine: 2-oxoglutarate-aminotransferase chromatographic purification and crystallization of the enzyme from seeds of Glycine hispida var Cheepeura. |
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| Journal |
Rev Roum Biochim 7:31-44 (1970) |
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| Reference |
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| Authors |
GREEN DE, LELOIR LF, NOCITO V |
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| Title |
Transaminases. |
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| Journal |
J Biol Chem 161:559-82 (1945) |
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| Reference |
4 |
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| Authors |
Iordachescu, D., Dumitru, I.F. and Corniciuc, M.-T. |
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| Title |
Comparative biochemical studies concerning L-alanine: 2-oxoglutarate-aminotransferase from the liver and the bile of swines. |
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| Journal |
Rev Roum Biochim 20:173-179 (1983) |
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| Reference |
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| Authors |
WILSON DG, KING KW, BURRIS RH. |
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| Title |
Transamination reactions in plants. |
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| Journal |
J Biol Chem 208:863-74 (1954) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.2 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.2 |
| BRENDA, the Enzyme Database: | 2.6.1.2 |
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