KEGG   ENZYME: 2.6.1.23
Entry
EC 2.6.1.23                 Enzyme                                 

Name
4-hydroxyglutamate transaminase;
4-hydroxyglutamate aminotransferase;
4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate [RN:R05052]
Reaction(KEGG)
R05052;
(other) R03266
Substrate
erythro-4-hydroxy-L-glutamate [CPD:C05947];
2-oxoglutarate [CPD:C00026]
Product
(4R)-4-hydroxy-2-oxoglutarate [CPD:C05946];
L-glutamate [CPD:C00025]
Comment
The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.
History
EC 2.6.1.23 created 1972, modified 1982, modified 2020
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13948827]
  Authors
GOLDSTONE A, ADAMS E.
  Title
Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
  Journal
J Biol Chem 237:3476-85 (1962)
Reference
2  [PMID:14089443]
  Authors
KURATOMI K, FUKUNAGA K, KOBAYASHI Y.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT  LIVER. II. A TRANSAMINASE CONCERNED IN GAMMA-HYDROXYGLUTAMATE METABOLISM.
  Journal
Biochim Biophys Acta 78:629-36 (1963)
DOI:10.1016/0006-3002(63)91028-X
Reference
3  [PMID:14170323]
  Authors
MAITRA U, DEEKKER E
  Title
PURIFICATION OF RAT-LIVER GAMMA-HYDROXYGLUTAMATE TRANSAMINASE AND ITS PROBABLE IDENTITY WITH GLUTAMATE-ASPARTATE TRANSAMINASE.
  Journal
Biochim Biophys Acta 81:517-32 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.23
IUBMB Enzyme Nomenclature: 2.6.1.23
ExPASy - ENZYME nomenclature database: 2.6.1.23
BRENDA, the Enzyme Database: 2.6.1.23
CAS: 37277-86-4

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