KEGG   ENZYME: 2.6.1.36
Entry
EC 2.6.1.36                 Enzyme                                 
Name
L-lysine 6-transaminase;
lysine 6-aminotransferase;
lysine epsilon-aminotransferase;
lysine epsilon-transaminase;
lysine:2-ketoglutarate 6-aminotransferase;
L-lysine-alpha-ketoglutarate aminotransferase;
L-lysine-alpha-ketoglutarate 6-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-lysine:2-oxoglutarate 6-aminotransferase
Reaction(IUBMB)
L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate [RN:R00457]
Reaction(KEGG)
R00457
Substrate
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The product (L-allysine) is converted into the intramolecularly dehydrated form, (S)-2,3,4,5-tetrahydropyridine-2-carboxylate.
History
EC 2.6.1.36 created 1972, modified 2011
Orthology
K03918  L-lysine 6-transaminase
Genes
PCAPcar_2442
PACEA6070_03115
PEFA7E78_13695
DPSDP2333
DBKDGMP_09540
LLUAKJ09_00862 AKJ09_07223
AEXAstex_2700
MTURv3290c(lat)
MTVRVBD_3290c
MTCMT3389(lat)
MRAMRA_3331(lat)
MTFTBFG_13319
MTBTBMG_03338
MTKTBSG_03361
MTZTBXG_003318
MTGMRGA327_20240
MTECCDC5079_3037
MTURCFBS_3481(lat)
MTLCCDC5180_2999
MTOMTCTRI2_3357(lat)
MTDUDA_3290c(lat)
MTNERDMAN_3606(lat)
MTJJ112_17680
MTUBMT7199_3332
MTUCJ113_22960
MTUEJ114_17640
MTXM943_17000
MTUHI917_23125
MTULTBHG_03226
MTUTHKBT1_3468(lat)
MTUUHKBT2_3475(lat)
MTQHKBS1_3478(lat)
MBOBQ2027_MB3318C(lat)
MBBBCG_3319c(lat)
MBTJTY_3315(lat)
MBMBCGMEX_3317c(lat)
MBKK60_034200
MAFMAF_33010(lat)
MMICRN08_3630
MCEMCAN_33131(lat)
MCQBN44_70081(lat)
MCVBN43_60305(lat)
MCXBN42_41348(lat)
MCZBN45_60328(lat)
MPAMAP_3410c(lat)
MAOMAP4_0371
MAVIRC58_01770
MAVURE97_01780
MAVMAV_4262
MITOCO_41280
MIAOCU_41200
MIDMIP_06217
MYOOEM_41540
MCHIAN480_21665
MIROCQ_42550
MMALCKJ54_19700
MLPMLM_3421
MMANMMAN_29310(lat)
MSAMycsm_01310
MULMUL_2644(lat)
MMCMmcs_1272
MKMMkms_1289
MJLMjls_1301
MMIMMAR_1243(lat)
MMAEMMARE11_12110(lat)
MMMW7S_20600
MLIMULP_01403(lat)
MKNMKAN_20985
MYVG155_09025
MYEAB431_07605
MGOAFA91_30200
MHADB586_17690
MDXBTO20_26550
MFJMFLOJ_22420(lat)
MSTOMSTO_26210(lat)
MGROFZ046_12915
MXEMYXE_37520(lat)
MNVMNVI_27780(lat)
MBAIMB901379_01139(lat)
MPSEMPSD_14200(lat)
MSHOMSHO_60720(lat)
MHEKJMUB5695_03701(lat)
MGAUMGALJ_57380
MLJMLAC_32540(lat)
MBRDMBRA_04060(lat)
MSHJMSHI_25380(lat)
MDFK0O62_07670(lat)
MMAMK3U93_05435(lat)
MHOLK3U96_19800(lat)
MSENK3U95_20830(lat)
MPAEK0O64_07235(lat)
MSPGF6B93_05340
MOTLTS72_19175(lat)
MRFMJO55_06905(lat)
MCROMI149_08090(lat)
MSMMSMEG_1764
MSGMSMEI_1721(lat)
MSBLJ00_08800
MSNLI99_08800
MSHLI98_08800
MVAMvan_1652
MGIMflv_4796
MSPMspyr1_42060
MCBMycch_1253
MNED174_08145
MYNMyAD_08005
MFTXA26_18090
MPHLMPHLCCUG_01571(lat)
MVQMYVA_1409
MLLB1R94_21520
MRHMycrhN_0460
MHASMHAS_00472(lat)
MCHTMCHIJ_50490
MDRMDOR_08610
MAUUNCTC10437_01354(lat)
MMAGMMAD_14260
MMORMMOR_51570
MAICMAIC_12720
MALVMALV_20190
MTYMTOK_34750
MPSCMPSYJ_50730
MARZMARA_24850
MGADMGAD_25610
MHEVMHEL_35780
MSARMSAR_04540
MANYMANY_52260
MAUBMAUB_17660
MPOFMPOR_18930
MPHUMPHO_53670
MMUCC1S78_020750
MMATMMAGJ_46610
MBOKMBOE_56650
MFGK6L26_23640(lat)
MSEIMSEDJ_26930
MABMAB_3646c
MMVMYCMA_2002
MABBMASS_3658
MABLMMASJCM_3646
MCHEBB28_18635
MIZBAB75_20855
MSTEMSTE_03793
MSAOMYCSP_16795
MSALDSM43276_03441(lat)
ASDAS9A_4565
NFANFA_9840
NFRERS450000_03131(lat)
NCYNOCYR_1048(lat)
NBRO3I_005745
NNONONO_c11440
NSLBOX37_04830
NSRNS506_07306
NTPCRH09_06510
NOZDMB37_26665(lat)
NODFOH10_25500
NAHF5544_06740
NADNCTC11293_01835(lat)
NWLNWFMUON74_60610
NIEKV110_06320(lat)
NTCKHQ06_00595(lat)
NHUH0264_07080
NYALTV02_25870(lat)
NGPLTT66_06545(lat)
RHARHA1_ro06277(lat)
RERRER_21100(lat)
REYO5Y_10070
REBXU06_10295
RQIC1M55_10735
ROPROP_63400(lat)
ROAPd630_LPD02936
REQREQ_33980
RPYY013_07840
RBYCEJ39_18760
RHBNY08_3760
RAVAAT18_17415
RFAA3L23_01897(lat)
RHSA3Q41_01468(lat)
RHWBFN03_04310
RRZCS378_06955
RHUA3Q40_03707(lat)
RHQIM25_22155
RHODAOT96_20915
RRT4535765_03390(lat)
RCRNCTC10994_03875(lat)
RTMG4H71_17580
RKOJWS14_34160
RGOKYT97_08005(lat)
ROZCBI38_19365
SRTSrot_1934
SCTSCAT_5685(lat)
SCYSCATT_56850
SALLSAZ_00190 SAZ_42615
SCLFBB341_07785
STRDNI25_03825
SLAUSLA_6893
SCYAEJ357_40940
STIRDDW44_23100
SFEUIM697_27840
IVAIsova_2511
ORNDV701_13495
MPHMLP_13250(lat)
MIKFOE78_06905
MICGGJV80_22800
PRVG7070_06360
BRTJ4N02_12690
SROSros_7678
NOABKM31_54810
NOWGBF35_41665
NCXNocox_34080(lat)
NGNLCN96_46675(lat)
TBITbis_2682
FRAFrancci3_2873
FREFranean1_2373
FRIFraEuI1c_2435
FALFRAAL4414(lat)
FSYFsymDg_2929
SENSACE_0784(lat)
SACGFDZ84_15560
AABA4R43_03215
AMYYYIM_39190(lat)
PHHAFB00_06515
PBROHOP40_17080
AHMTL08_10590
ACTIUA75_11255
ACADUA74_11170
AHGAHOG_10515(lat)
SACEGIY23_03070
AEYCDG81_03545
EUZDVS28_a2843
STISthe_2786
TTRTter_1717
ROOG5S37_22895
PCORKS4_05960(lat)
THYDTTHT_1021(lat)
TAITaci_1141
TLITlie_0683
AMOAnamo_0517
CPORBED41_05255
PPNPalpr_0480
SRUSRU_0799
SRMSRM_00977(argD)
RMRRmar_2194
RMGRhom172_0680
RBARAWN76_017990
PHEPhep_1211
PEPAQ505_21630
PCMAY601_3271
PSTYBFS30_04170
PGSCPT03_00465
PEJFYC62_02210
PEKFFJ24_014700
PROEH9L23_15555
PEXIZT61_21755
PMUOLOK61_11690(lat)
SHGSph21_3678
SHTKO02_02845
SPHNBV902_04485
SMIZ4412673_03435(lat)
SPSCE2P86_15290
SPHZE3D81_14520
SPHEGFH32_15640
SPDRG6053_03270
SDJNCTC13534_04868(lat_2)
STHANCTC11429_00947(lat)
SSPII6J01_06200
SMUII6J00_19965
SSIYJVX97_00015
SCNSolca_2439
MUPA0256_21580
MUCMuYL_1402
MGOTMgSA37_01318(lat)
MUHHYN43_017530
MGINFRZ54_21220
MGKFSB76_06255
MRUBDEO27_018215
MGOSDIU38_001245
MMABHQ865_04970
MGIKGO620_009590
AGDFRZ59_15880
OLIFKG96_15635
SBXCA265_14455
FBAFIC_01043
WVIWeevi_0195
EAOBD94_2101
EMNM876_07540
EENBBD30_16390
ELBVO54_00617(lat)
EMGBBD33_12285
EGOBBD34_18730
EGMAYC65_07775
ELZFCS00_00515
ELTFGE20_10275
CHZCHSO_2425(lat)
CGNOK18_17935
CIHATE47_06935
CHHA0O34_19660
CIOCEQ15_05780
CHRYCEY12_02800
CPIPCJF12_05130
CHRSEAG08_21240
CHRZCO230_06725
CARHEGY05_07965
CSHAEG350_10380
CNKEG343_00715
CJTEG359_02185
CILEG358_11900
CCAUEG346_20155
CBENEG339_17410
CGLENCTC11432_00461(lat)
CTAINCTC12078_00689(lat)
CLACEG342_17065
CTAK4412677_00654(lat)
CSALNBC122_02910(lat)
CBPEB354_07975
CNPM0D58_02615(lat)
CCAOH5J24_10650
CFAELL667_12045(lat)
CJGNCTC13459_00450(lat)
CCASEIB73_04350
CANTNCTC13489_00432(lat)
KDAEIB71_08980
KHIEG338_10125
KBEJ4771_01670
KFAQ73A0000_01685
EVAEIB75_05340
EZEKI430_07935(lat)
CNREB819_05965
EBVF0358_11795
EFALFH779_10445
ESTEHNV03_06610
FBOJ9309_13230(lat)
IALIALB_1476(lat)
MROMROS_2755
CPRVCYPRO_2662
ABIAboo_0464
ACFAciM339_0584
 » show all
Reference
1  [PMID:5722275]
  Authors
Soda K, Misono H, Yamamoto T.
  Title
L-Lysine:alpha-ketoglutarate aminotransferase. I. Identification of a product, delta-1-piperideine-6-carboxylic acid.
  Journal
Biochemistry 7:4102-9 (1968)
DOI:10.1021/bi00851a045
Reference
2  [PMID:5722276]
  Authors
Soda K, Misono H.
  Title
L-Lysine:alpha-ketoglutarate aminotransferase. II. Purification, crystallization, and properties.
  Journal
Biochemistry 7:4110-9 (1968)
DOI:10.1021/bi00851a046
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.36
IUBMB Enzyme Nomenclature: 2.6.1.36
ExPASy - ENZYME nomenclature database: 2.6.1.36
BRENDA, the Enzyme Database: 2.6.1.36
CAS: 9054-68-6

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