KEGG ENZYME: 2.6.1.36

ENZYME: 2.6.1.36

Entry

EC 2.6.1.36                 Enzyme

Name

L-lysine 6-transaminase;
lysine 6-aminotransferase;
lysine epsilon-aminotransferase;
lysine epsilon-transaminase;
lysine:2-ketoglutarate 6-aminotransferase;
L-lysine-alpha-ketoglutarate aminotransferase;
L-lysine-alpha-ketoglutarate 6-aminotransferase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

L-lysine:2-oxoglutarate 6-aminotransferase

Reaction(IUBMB)

L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate [RN:R00457]

Reaction(KEGG)

R00457

Substrate

L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026]

Product

(S)-2-amino-6-oxohexanoate [CPD:C04076];
L-glutamate [CPD:C00025]

Comment

A pyridoxal-phosphate protein. The product (L-allysine) is converted into the intramolecularly dehydrated form, (S)-2,3,4,5-tetrahydropyridine-2-carboxylate.

History

EC 2.6.1.36 created 1972, modified 2011

Orthology

K03918

L-lysine 6-transaminase

Genes

PCA:

Pcar_2442

PACE:

A6070_03115

PEF:	A7E78_13695

DPS:

DP2333

DBK:	DGMP_09540

LLU:	AKJ09_00862 AKJ09_07223

AEX:	Astex_2700

MTU:	Rv3290c(lat)

MTV:	RVBD_3290c

MTC:	MT3389(lat)

MRA:	MRA_3331(lat)

MTF:	TBFG_13319

MTB:	TBMG_03338

MTK:	TBSG_03361

MTZ:	TBXG_003318

MTG:	MRGA327_20240

MTE:	CCDC5079_3037

MTUR:

CFBS_3481(lat)

MTL:	CCDC5180_2999

MTO:	MTCTRI2_3357(lat)

MTD:	UDA_3290c(lat)

MTN:	ERDMAN_3606(lat)

MTJ:	J112_17680

MTUB:

MT7199_3332

MTUC:

J113_22960

MTUE:

J114_17640

MTX:	M943_17000

MTUH:

I917_23125

MTUL:

TBHG_03226

MTUT:

HKBT1_3468(lat)

MTUU:

HKBT2_3475(lat)

MTQ:	HKBS1_3478(lat)

MBO:	BQ2027_MB3318C(lat)

MBB:	BCG_3319c(lat)

MBT:	JTY_3315(lat)

MBM:	BCGMEX_3317c(lat)

MBK:	K60_034200

MAF:	MAF_33010(lat)

MMIC:

RN08_3630

MCE:	MCAN_33131(lat)

MCQ:	BN44_70081(lat)

MCV:	BN43_60305(lat)

MCX:	BN42_41348(lat)

MCZ:	BN45_60328(lat)

MPA:	MAP_3410c(lat)

MAO:

MAP4_0371

MAVI:

RC58_01770

MAVU:

RE97_01780

MAV:

MAV_4262

MIT:

OCO_41280

MIA:

OCU_41200

MID:

MIP_06217

MYO:

OEM_41540

MCHI:

AN480_21665

MIR:

OCQ_42550

MMAL:

CKJ54_19700

MLP:

MLM_3421

MMAN:

MMAN_29310(lat)

MSA:	Mycsm_01310

MUL:	MUL_2644(lat)

MMC:

Mmcs_1272

MKM:

Mkms_1289

MJL:

Mjls_1301

MMI:	MMAR_1243(lat)

MMAE:

MMARE11_12110(lat)

MMM:

W7S_20600

MLI:	MULP_01403(lat)

MKN:	MKAN_20985

MYV:	G155_09025

MYE:	AB431_07605

MGO:	AFA91_30200

MHAD:

B586_17690

MDX:	BTO20_26550

MFJ:	MFLOJ_22420(lat)

MSTO:

MSTO_26210(lat)

MGRO:

FZ046_12915

MXE:	MYXE_37520(lat)

MNV:	MNVI_27780(lat)

MBAI:

MB901379_01139(lat)

MPSE:

MPSD_14200(lat)

MSHO:

MSHO_60720(lat)

MHEK:

JMUB5695_03701(lat)

MGAU:

MGALJ_57380

MLJ:	MLAC_32540(lat)

MBRD:

MBRA_04060(lat)

MSHJ:

MSHI_25380(lat)

MDF:	K0O62_07670(lat)

MMAM:

K3U93_05435(lat)

MHOL:

K3U96_19800(lat)

MSEN:

K3U95_20830(lat)

MPAE:

K0O64_07235(lat)

MSPG:

F6B93_05340

MOT:	LTS72_19175(lat)

MRF:	MJO55_06905(lat)

MCRO:

MI149_08090(lat)

MSM:	MSMEG_1764

MSG:	MSMEI_1721(lat)

MSB:	LJ00_08800

MSN:	LI99_08800

MSH:	LI98_08800

MVA:

Mvan_1652

MGI:

Mflv_4796

MSP:	Mspyr1_42060

MCB:	Mycch_1253

MNE:	D174_08145

MYN:	MyAD_08005

MFT:	XA26_18090

MPHL:

MPHLCCUG_01571(lat)

MVQ:

MYVA_1409

MLL:	B1R94_21520

MRH:	MycrhN_0460

MHAS:

MHAS_00472(lat)

MCHT:

MCHIJ_50490

MDR:	MDOR_08610

MAUU:

NCTC10437_01354(lat)

MMAG:

MMAD_14260

MMOR:

MMOR_51570

MAIC:

MAIC_12720

MALV:

MALV_20190

MTY:	MTOK_34750

MPSC:

MPSYJ_50730

MARZ:

MARA_24850

MGAD:

MGAD_25610

MHEV:

MHEL_35780

MSAR:

MSAR_04540

MANY:

MANY_52260

MAUB:

MAUB_17660

MPOF:

MPOR_18930

MPHU:

MPHO_53670

MMUC:

C1S78_020750

MMAT:

MMAGJ_46610

MBOK:

MBOE_56650

MFG:	K6L26_23640(lat)

MSEI:

MSEDJ_26930

MAB:

MAB_3646c

MMV:	MYCMA_2002

MABB:

MASS_3658

MABL:

MMASJCM_3646

MCHE:

BB28_18635

MIZ:	BAB75_20855

MSTE:

MSTE_03793

MSAO:

MYCSP_16795

MSAL:

DSM43276_03441(lat)

ASD:

AS9A_4565

NFA:

NFA_9840

NFR:	ERS450000_03131(lat)

NCY:	NOCYR_1048(lat)

NBR:	O3I_005745

NNO:	NONO_c11440

NSL:	BOX37_04830

NSR:	NS506_07306

NTP:	CRH09_06510

NOZ:	DMB37_26665(lat)

NOD:	FOH10_25500

NAH:	F5544_06740

NAD:	NCTC11293_01835(lat)

NWL:	NWFMUON74_60610

NIE:	KV110_06320(lat)

NTC:	KHQ06_00595(lat)

NHU:	H0264_07080

NYA:	LTV02_25870(lat)

NGP:	LTT66_06545(lat)

RHA:	RHA1_ro06277(lat)

RER:	RER_21100(lat)

REY:

O5Y_10070

REB:	XU06_10295

RQI:	C1M55_10735

ROP:	ROP_63400(lat)

ROA:	Pd630_LPD02936

REQ:

REQ_33980

RPY:	Y013_07840

RBY:	CEJ39_18760

RHB:

NY08_3760

RAV:	AAT18_17415

RFA:	A3L23_01897(lat)

RHS:	A3Q41_01468(lat)

RHW:	BFN03_04310

RRZ:	CS378_06955

RHU:	A3Q40_03707(lat)

RHQ:	IM25_22155

RHOD:

AOT96_20915

RRT:	4535765_03390(lat)

RCR:	NCTC10994_03875(lat)

RTM:	G4H71_17580

RKO:	JWS14_34160

RGO:	KYT97_08005(lat)

ROZ:	CBI38_19365

SRT:

Srot_1934

SCT:	SCAT_5685(lat)

SCY:	SCATT_56850

SALL:

SAZ_00190 SAZ_42615

SCLF:

BB341_07785

STRD:

NI25_03825

SLAU:

SLA_6893

SCYA:

EJ357_40940

STIR:

DDW44_23100

SFEU:

IM697_27840

IVA:	Isova_2511

ORN:	DV701_13495

MPH:	MLP_13250(lat)

MIK:	FOE78_06905

MICG:

GJV80_22800

PRV:	G7070_06360

BRT:	J4N02_12690

SRO:

Sros_7678

NOA:	BKM31_54810

NOW:	GBF35_41665

NCX:	Nocox_34080(lat)

NGN:	LCN96_46675(lat)

TBI:

Tbis_2682

FRA:	Francci3_2873

FRE:	Franean1_2373

FRI:	FraEuI1c_2435

FAL:	FRAAL4414(lat)

FSY:	FsymDg_2929

SEN:	SACE_0784(lat)

SACG:

FDZ84_15560

AAB:	A4R43_03215

AMYY:

YIM_39190(lat)

PHH:	AFB00_06515

PBRO:

HOP40_17080

AHM:	TL08_10590

ACTI:

UA75_11255

ACAD:

UA74_11170

AHG:	AHOG_10515(lat)

SACE:

GIY23_03070

AEY:	CDG81_03545

EUZ:	DVS28_a2843

STI:

Sthe_2786

TTR:

Tter_1717

ROO:	G5S37_22895

PCOR:

KS4_05960(lat)

THYD:

TTHT_1021(lat)

TAI:

Taci_1141

TLI:

Tlie_0683

AMO:	Anamo_0517

CPOR:

BED41_05255

PPN:	Palpr_0480

SRU:

SRU_0799

SRM:	SRM_00977(argD)

RMR:

Rmar_2194

RMG:	Rhom172_0680

RBAR:

AWN76_017990

PHE:

Phep_1211

PEP:	AQ505_21630

PCM:	AY601_3271

PSTY:

BFS30_04170

PGS:	CPT03_00465

PEJ:	FYC62_02210

PEK:	FFJ24_014700

PROE:

H9L23_15555

PEX:	IZT61_21755

PMUO:

LOK61_11690(lat)

SHG:	Sph21_3678

SHT:	KO02_02845

SPHN:

BV902_04485

SMIZ:

4412673_03435(lat)

SPSC:

E2P86_15290

SPHZ:

E3D81_14520

SPHE:

GFH32_15640

SPDR:

G6053_03270

SDJ:	NCTC13534_04868(lat_2)

STHA:

NCTC11429_00947(lat)

SSPI:

I6J01_06200

SMUI:

I6J00_19965

SSIY:

JVX97_00015

SCN:	Solca_2439

MUP:	A0256_21580

MUC:

MuYL_1402

MGOT:

MgSA37_01318(lat)

MUH:	HYN43_017530

MGIN:

FRZ54_21220

MGK:	FSB76_06255

MRUB:

DEO27_018215

MGOS:

DIU38_001245

MMAB:

HQ865_04970

MGIK:

GO620_009590

AGD:	FRZ59_15880

OLI:	FKG96_15635

SBX:	CA265_14455

FBA:

FIC_01043

WVI:	Weevi_0195

EAO:

BD94_2101

EMN:	M876_07540

EEN:	BBD30_16390

ELB:	VO54_00617(lat)

EMG:	BBD33_12285

EGO:	BBD34_18730

EGM:	AYC65_07775

ELZ:	FCS00_00515

ELT:	FGE20_10275

CHZ:	CHSO_2425(lat)

CGN:	OK18_17935

CIH:	ATE47_06935

CHH:	A0O34_19660

CIO:	CEQ15_05780

CHRY:

CEY12_02800

CPIP:

CJF12_05130

CHRS:

EAG08_21240

CHRZ:

CO230_06725

CARH:

EGY05_07965

CSHA:

EG350_10380

CNK:	EG343_00715

CJT:	EG359_02185

CIL:	EG358_11900

CCAU:

EG346_20155

CBEN:

EG339_17410

CGLE:

NCTC11432_00461(lat)

CTAI:

NCTC12078_00689(lat)

CLAC:

EG342_17065

CTAK:

4412677_00654(lat)

CSAL:

NBC122_02910(lat)

CBP:	EB354_07975

CNP:	M0D58_02615(lat)

CCAO:

H5J24_10650

CFAE:

LL667_12045(lat)

CJG:	NCTC13459_00450(lat)

CCAS:

EIB73_04350

CANT:

NCTC13489_00432(lat)

KDA:	EIB71_08980

KHI:	EG338_10125

KBE:	J4771_01670

KFA:	Q73A0000_01685

EVA:	EIB75_05340

EZE:	KI430_07935(lat)

CNR:	EB819_05965

EBV:	F0358_11795

EFAL:

FH779_10445

ESTE:

HNV03_06610

FBO:	J9309_13230(lat)

IAL:	IALB_1476(lat)

MRO:

MROS_2755

CPRV:

CYPRO_2662

ABI:

Aboo_0464

ACF:	AciM339_0584

» show all

Reference

1 [PMID:5722275]

Authors

Soda K, Misono H, Yamamoto T.

Title

L-Lysine:alpha-ketoglutarate aminotransferase. I. Identification of a product, delta-1-piperideine-6-carboxylic acid.

Journal

Biochemistry 7:4102-9 (1968)
DOI:10.1021/bi00851a045

Reference

2 [PMID:5722276]

Authors

Soda K, Misono H.

Title

L-Lysine:alpha-ketoglutarate aminotransferase. II. Purification, crystallization, and properties.

Journal

Biochemistry 7:4110-9 (1968)
DOI:10.1021/bi00851a046

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.36

IUBMB Enzyme Nomenclature:

2.6.1.36

ExPASy - ENZYME nomenclature database:

2.6.1.36

BRENDA, the Enzyme Database:

2.6.1.36

CAS:

9054-68-6

DBGET integrated database retrieval system