Entry Name adenosylmethionine---8-amino-7-oxononanoate transaminase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase
Reaction(IUBMB) S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate [RN:
R03231 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
8-amino-7-oxononanoate [CPD:
C01092 ]
Product S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate [CPD:
C04425 ];
7,8-diaminononanoate [CPD:
C01037 ]
Comment A pyridoxal 5'-phosphate enzyme. S-adenosylhomocysteine can also act as donor.
History EC 2.6.1.62 created 1983
Pathway Orthology K00833 adenosylmethionine---8-amino-7-oxononanoate aminotransferase
K19562 bifunctional dethiobiotin synthetase / adenosylmethionine---8-amino-7-oxononanoate aminotransferase
Genes » show all Taxonomy Reference 1
Authors Izumi, Y., Sato, K., Tani, Y. and Ogata, K.
Title Purification of 7-keto-8-aminopelargonic acid-7,8-diaminopelargonic acid aminotransferase, an enzyme involved in biotin synthesis, from Brevibacterium divaricatum.
Journal Agric Biol Chem 37:2683-2684 (1973)
Reference 2
Authors Izumi, Y., Sato, K., Tani, Y. and Ogata, K.
Title 7,8-Diaminopelargonic acid aminotransferase, an enzyme involved in biotin synthesis by microorganisms.
Journal Agric Biol Chem 39:175-181 (1975)
Reference Authors Stoner GL, Eisenberg MA
Title Purification and properties of 7, 8-diaminopelargonic acid aminotransferase.
Journal J Biol Chem 250:4029-36 (1975)
Sequence Other DBs ExplorEnz - The Enzyme Database: 2.6.1.62
ExPASy - ENZYME nomenclature database: 2.6.1.62
