| Entry |
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| Name |
adenosylmethionine---8-amino-7-oxononanoate transaminase;
7,8-diaminonanoate transaminase;
7,8-diaminononanoate transaminase;
DAPA transaminase (ambiguous);
7,8-diaminopelargonic acid aminotransferase;
DAPA aminotransferase (ambiguous);
7-keto-8-aminopelargonic acid;
diaminopelargonate synthase;
7-keto-8-aminopelargonic acid aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate [RN: R03231]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
8-amino-7-oxononanoate [CPD: C01092]
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| Product |
S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate [CPD: C04425];
7,8-diaminononanoate [CPD: C01037]
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| Comment |
A pyridoxal 5'-phosphate enzyme. S-adenosylhomocysteine can also act as donor.
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| History |
EC 2.6.1.62 created 1983
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| Pathway |
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| Orthology |
| K00833 | adenosylmethionine---8-amino-7-oxononanoate aminotransferase |
| K19562 | bifunctional dethiobiotin synthetase / adenosylmethionine---8-amino-7-oxononanoate aminotransferase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Izumi, Y., Sato, K., Tani, Y. and Ogata, K. |
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| Title |
Purification of 7-keto-8-aminopelargonic acid-7,8-diaminopelargonic acid aminotransferase, an enzyme involved in biotin synthesis, from Brevibacterium divaricatum. |
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| Journal |
Agric Biol Chem 37:2683-2684 (1973) |
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| Reference |
2 |
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| Authors |
Izumi, Y., Sato, K., Tani, Y. and Ogata, K. |
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| Title |
7,8-Diaminopelargonic acid aminotransferase, an enzyme involved in biotin synthesis by microorganisms. |
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| Journal |
Agric Biol Chem 39:175-181 (1975) |
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| Reference |
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| Authors |
Stoner GL, Eisenberg MA. |
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| Title |
Purification and properties of 7, 8-diaminopelargonic acid aminotransferase. |
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| Journal |
J Biol Chem 250:4029-36 (1975) |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.62 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.62 |
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