KEGG   ENZYME: 2.6.1.7Help
Entry
EC 2.6.1.7                  Enzyme                                 

Name
kynurenine---oxoglutarate transaminase;
kynurenine transaminase (cyclizing);
kynurenine 2-oxoglutarate transaminase;
kynurenine aminotransferase;
L-kynurenine aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-kynurenine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate [RN:R01956]
Reaction(KEGG)
R01956;
(other) R04171
Show
Substrate
L-kynurenine [CPD:C00328];
2-oxoglutarate [CPD:C00026]
Product
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:C01252];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
History
EC 2.6.1.7 created 1961, modified 1983
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00816  kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
K00825  kynurenine/2-aminoadipate aminotransferase
K14264  kynurenine aminotransferase
Genes
HSA: 51166(AADAT) 56267(KYAT3) 883(KYAT1)
PTR: 456999(KYAT3) 461601(AADAT) 473069(KYAT1)
PPS: 100980672(KYAT1) 100993985(KYAT3) 100995091(AADAT)
GGO: 101128027(KYAT3) 101137144(KYAT1) 101151419(AADAT)
PON: 100435746(AADAT) 100436953(KYAT3) 100452866(KYAT1)
NLE: 100579800(KYAT3) 100584784(AADAT) 100598335(KYAT1)
MCC: 694023(KYAT3) 695264(AADAT) 717142(KYAT1)
MCF: 101925086(KYAT3) 102122792(AADAT) 102142392(KYAT1)
CSAB: 103224481(KYAT3) 103236521(AADAT) 103239781(KYAT1)
RRO: 104660517(KYAT1) 104662870(AADAT) 104664603(KYAT3)
RBB: 108512836(KYAT1) 108514569(KYAT3) 108522848(AADAT)
CJC: 100390682(KYAT1) 100392205(KYAT3) 100403876(AADAT)
SBQ: 101034905(CCBL1) 101047103(AADAT) 101049363(CCBL2)
MMU: 229905(Kyat3) 23923(Aadat) 70266(Kyat1)
RNO: 29416(Aadat) 311844(Kyat1) 541589(Kyat3)
CGE: 100769821(Kyat1) 100771070(Kyat3) 100771752
NGI: 103727134(Aadat) 103730106(Kyat3) 103742867(Kyat1)
HGL: 101701445(Kyat3) 101707012(Aadat) 101714047(Ccbl1)
CCAN: 109677660(Aadat) 109682136(Kyat3) 109697703(Kyat1)
OCU: 100351221(KYAT1) 100355602(AADAT) 100358799(KYAT3)
TUP: 102479498(AADAT) 102484200(KYAT3) 102492301(KYAT1)
CFA: 479959(KYAT3) 486059(AADAT) 491310(KYAT1)
AML: 100466080(KYAT3) 100469458(AADAT) 100484335(KYAT1)
UMR: 103658154(AADAT) 103662922(KYAT3) 103670433(KYAT1)
ORO: 101379355(CCBL2) 101379671(AADAT) 101381784(CCBL1)
FCA: 101082171(KYAT3) 101082605(KYAT1) 101091616(AADAT)
PTG: 102949681(AADAT) 102956075(KYAT1) 102960707(KYAT3)
AJU: 106966305(KYAT1) 106968046(KYAT3) 106985264(AADAT)
BTA: 104968656 508712(KYAT3) 508929(AADAT) 520638 528582(CCBL1)
BOM: 102268017(KYAT3) 102269904(AADAT) 102270370 102274277(KYAT1) 102274974
PHD: 102319020(KYAT3) 102326511 102328319(KYAT1)
CHX: 102180605(KYAT1) 102182368(KYAT3) 102190411(AADAT)
OAS: 101117485(CCBL1) 101119265(CCBL2) 101121661(AADAT)
SSC: 100152011(AADAT) 100157176(KYAT3) 100515071(KYAT1)
CFR: 102514713(KYAT1) 102515842(AADAT) 102522240(KYAT3)
CDK: 105084526(KYAT3) 105092558(KYAT1) 105101723(AADAT)
BACU: 103001193(KYAT3) 103002075(AADAT) 103002354 103010164(KYAT1)
LVE: 103071573 103073927(KYAT1) 103077196(AADAT) 103090268(KYAT3)
ECB: 100052141(KYAT3) 100067095(AADAT) 100070151(KYAT1)
EPZ: 103550870(KYAT1) 103554076(AADAT) 103557170(KYAT3)
EAI: 106831581(KYAT3) 106843200(AADAT) 106845422(KYAT1)
MYB: 102246710(KYAT1) 102246937(KYAT3) 102255657(AADAT)
MYD: 102764566(AADAT) 102770113(KYAT1) 102774189(KYAT3)
RSS: 109436541(AADAT) 109445910(KYAT1) 109458284(KYAT3)
PALE: 102885606(KYAT3) 102886879(AADAT) 102890346(KYAT1)
LAV: 100653952(AADAT) 100674418(KYAT1) 100676040(KYAT3)
MDO: 100013642(KYAT1) 100027687(KYAT3) 100031005
SHR: 100913887(AADAT) 100925132(KYAT1) 100928200(KYAT3)
OAA: 100074153(CCBL1) 100074828(KYAT3) 100076580(AADAT)
GGA: 417202(CCBL1) 424517(KYAT3) 428728(AADAT)
MGP: 100539859(AADAT) 100545698(KYAT1) 100546759(KYAT3)
CJO: 107313054(AADAT) 107317420(KYAT3) 107321728(KYAT1)
APLA: 101796959(KYAT3) 101797673(AADAT) 101804188(KYAT1)
ACYG: 106032348(AADAT) 106034104(CCBL2) 106047313(CCBL1)
TGU: 100223564(KYAT3) 100226378(KYAT1) 100228964(AADAT)
GFR: 102038773(AADAT) 102043066(KYAT3) 102045568(KYAT1)
FAB: 101809203(KYAT1) 101816765(KYAT3) 101817402(AADAT)
PHI: 102108384(KYAT3) 102109435(KYAT1) 102114032(AADAT)
PMAJ: 107203407(AADAT) 107207980(KYAT3) 107212063(KYAT1)
CCW: 104688281(KYAT1) 104690544(AADAT) 104695321(KYAT3)
FPG: 101916601(AADAT) 101923826(KYAT3) 101924602(KYAT1)
FCH: 102052592(KYAT1) 102055107(KYAT3) 102059338(AADAT)
CLV: 102087961(AADAT) 102092812(KYAT3) 102097970(KYAT1)
EGZ: 104122512(CCBL1) 104122910(CCBL2) 104123112(AADAT)
AAM: 106484015(AADAT) 106490298(KYAT1) 106499802(KYAT3)
AMJ: 102564187(KYAT1) 102573373(AADAT) 102574637(KYAT3)
PSS: 102443615 102446036(KYAT1) 102459761(KYAT3) 102463594(AADAT)
CMY: 102931085(KYAT1) 102933210(AADAT) 102947846(KYAT3)
CPIC: 101933473(AADAT) 101948590(KYAT3) 101949101 101949140(KYAT1)
PVT: 110079452(KYAT3) 110079688(KYAT1) 110085380(AADAT) 110085384
PBI: 103050097(AADAT) 103054557(KYAT3) 103058068(KYAT1)
GJA: 107107125(AADAT) 107107127 107115481(KYAT1) 107126241(KYAT3)
XLA: 108715667(kyat3.S) 380432(kyat3.L) 398787(aadat.L) 432067(aadat.S) 734936(kyat1.L)
XTR: 496662(aadat) 496736(kyat1)
NPR: 108789894(AADAT) 108791027(KYAT3) 108794311(KYAT1)
DRE: 393315(ccbl2) 557979(aadat) 791592(kyat1)
AMEX: 103027162(kyat3) 103040807(aadat) 103046817(kyat1)
TRU: 101064758(kyat1) 101066451(kyat3) 101078353(aadat)
LCO: 104931917(kyat3) 104938006(aadat) 104939087(kyat1)
NCC: 104946129(ccbl1) 104951126(aadat) 104955761(ccbl2)
MZE: 101466800(kyat1) 101486988(kyat3) 101487147(aadat)
OLA: 101156284(aadat) 101164171(kyat1) 101173380
XMA: 102233774(aadat) 102235261(kyat3) 102237088(kyat1)
PRET: 103463971(kyat3) 103473416(kyat1) 103475938(aadat)
NFU: 107374788(ccbl1) 107377046(aadat) 107397216(ccbl2)
CSEM: 103376809(kyat3) 103388590(aadat) 103390101(kyat1)
LCF: 108874059 108874060(kyat1) 108878962(kyat3) 108903085(aadat)
HCQ: 109508374(aadat) 109517170(kyat1) 109529744(kyat3)
BPEC: 110154758 110154910 110157436(kyat1) 110170749(aadat)
SASA: 100195431(kat3) 106569847 106608880(aadat)
ELS: 105015286(kyat1) 105026755(aadat) 105030533(kyat3)
SFM: 108921052(aadat) 108921915
LCM: 102348380(KYAT1) 102363875(AADAT) 102366870(KYAT3)
CMK: 103171755(kyat1) 103174679(kyat3) 103180238(aadat)
SKO: 102808740
DSI: Dsimw501_GD20629(Dsim_GD20629)
MDE: 101891461
AAG: 5564787
AME: 724239(GB10285) 724811(GB15834) 725529(GB19755)
ZNE: 110837661
CEL: CELE_F28H6.3(nkat-1) CELE_R03A10.4(nkat-3)
CBR: CBG07704(Cbr-nkat-3) CBG10259
BMY: Bm1_10490
SHX: MS3_06559
EPA: 110244036
AQU: 100641141
APRO: F751_0981
SCE: YJL060W(BNA3)
KMX: KLMA_50067(BNA3)
NCS: NCAS_0A09200(NCAS0A09200)
NDI: NDAI_0G05760(NDAI0G05760)
TPF: TPHA_0O01450(TPHA0O01450)
TDL: TDEL_0D01900(TDEL0D01900)
KAF: KAFR_0A01710(KAFR0A01710)
CAUR: QG37_00211
SLB: AWJ20_1268(BNA3)
NCR: NCU03347(nic-4)
NTE: NEUTE1DRAFT84478(NEUTE1DRAFT_84478)
MGR: MGG_03264
MAW: MAC_05770
MAJ: MAA_01732
CMT: CCM_08981
MBE: MBM_06522
ANI: AN5616.2
ANG: ANI_1_908184(An04g05490)
ABE: ARB_02285
TVE: TRV_04968
PTE: PTT_12703
CNE: CNA00190
CNB: CNBA0180
ABP: AGABI1DRAFT38406(AGABI1DRAFT_38406)
ABV: AGABI2DRAFT67810(AGABI2DRAFT_67810)
MGL: MGL_1970
DFA: DFA_03567 DFA_11928(ccbl)
SMIN: v1.2.018754.t1(symbB.v1.2.018754.t1)
NGD: NGA_0728200(CCBL) NGA_2018300(AADAT)
 » show all
Taxonomy
Reference
1  [PMID:13357462]
  Authors
BONNER DM, JAKOBY WB.
  Title
Kynurenine transaminase from neurospora.
  Journal
J Biol Chem 221:689-95 (1956)
Reference
2  [PMID:13449053]
  Authors
MASON M.
  Title
Kynurenine transaminase of rat kidney; a study of coenzyme dissociation.
  Journal
J Biol Chem 227:61-8 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.7
IUBMB Enzyme Nomenclature: 2.6.1.7
ExPASy - ENZYME nomenclature database: 2.6.1.7
BRENDA, the Enzyme Database: 2.6.1.7
CAS: 9030-38-0

DBGET integrated database retrieval system