KEGG   ENZYME: 2.6.1.74Help
Entry
EC 2.6.1.74                 Enzyme                                 

Name
cephalosporin-C transaminase;
cephalosporin C aminotransferase;
L-alanine:cephalosporin-C aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
cephalosporin-C:2-oxoglutarate aminotransferase
Reaction(IUBMB)
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate [RN:R03063]
Reaction(KEGG)
Substrate
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate [CPD:C04712];
D-glutamate [CPD:C00217]
Product
cephalosporin C [CPD:C00916];
2-oxoglutarate [CPD:C00026]
Comment
A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.
History
EC 2.6.1.74 created 1992, modified 2005
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01130  Biosynthesis of antibiotics
Reference
1  [PMID:3228235]
  Authors
Aretz W, Sauber K.
  Title
Novel D-amino acid transaminase.
  Journal
Ann N Y Acad Sci 542:366-70 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.74
IUBMB Enzyme Nomenclature: 2.6.1.74
ExPASy - ENZYME nomenclature database: 2.6.1.74
BRENDA, the Enzyme Database: 2.6.1.74
CAS: 122096-91-7

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (10)   

Download RDF
DBGET integrated database retrieval system