| Entry |
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| Name |
cephalosporin-C transaminase;
cephalosporin C aminotransferase;
L-alanine:cephalosporin-C aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
cephalosporin-C:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate + D-glutamate = cephalosporin C + 2-oxoglutarate [RN: R03063]
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| Reaction(KEGG) |
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| Substrate |
(7R)-7-(5-carboxy-5-oxopentanoyl)aminocephalosporinate [CPD: C04712];
D-glutamate [CPD: C00217]
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| Product |
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| Comment |
A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.
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| History |
EC 2.6.1.74 created 1992, modified 2005
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| Pathway |
| ec00311 | Penicillin and cephalosporin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Reference |
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| Authors |
Aretz W, Sauber K. |
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| Title |
Novel D-amino acid transaminase. |
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| Journal |
Ann N Y Acad Sci 542:366-70 (1988) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.74 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.74 |
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