KEGG   ENZYME: 2.6.1.80
Entry
EC 2.6.1.80                 Enzyme                                 

Name
nicotianamine aminotransferase;
NAAT;
NAAT-I;
NAAT-II;
NAAT-III;
nicotianamine transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
nicotianamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate [RN:R07277]
Reaction(KEGG)
R07277
Substrate
nicotianamine [CPD:C05324];
2-oxoglutarate [CPD:C00026]
Product
3''-deamino-3''-oxonicotianamine [CPD:C15486];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. This enzyme is produced by grasses. They secrete both the nicotianamine and the transaminated product into the soil around them. Both compounds chelate iron(II) and iron(III); these chelators, called mugineic acid family phytosiderophores, are taken up by the grass, which is thereby supplied with iron.
History
EC 2.6.1.80 created 2005
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14271  nicotianamine aminotransferase
Genes
OSA: 9267778
DOSA: Os02t0306401-00(Os02g0306401)
OBR: 102711499
BDI: 100831451
ATS: 109747034 109747035
TDC: 119283036 119283052 119348169 119348182
TAES: 123059564 123093828 123136500 123154591 123182310 123182311
SBI: 110433086 8081150
ZMA: 100191283 100193424
SITA: 101775023
PHAI: 112878152
 » show all
Reference
1
  Authors
Kanazawa, K., Higuchi, K., Nishizawa, N.-K., Fushiya, S., Chino, M. and Mori, S.
  Title
Nicotianamine aminotransferase activities are correlated with the phytosiderophore secretions under Fe-deficient conditions in Gramineae.
  Journal
J Exp Bot 45:1903-1906 (1994)
Reference
2  [PMID:10557244]
  Authors
Takahashi M, Yamaguchi H, Nakanishi H, Shioiri T, Nishizawa NK, Mori S
  Title
Cloning two genes for nicotianamine aminotransferase, a critical enzyme in iron acquisition (Strategy II) in graminaceous plants.
  Journal
Plant Physiol 121:947-56 (1999)
DOI:10.1104/pp.121.3.947
  Sequence
Reference
3  [PMID:14699112]
  Authors
Schaaf G, Ludewig U, Erenoglu BE, Mori S, Kitahara T, von Wiren N.
  Title
ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals.
  Journal
J Biol Chem 279:9091-6 (2004)
DOI:10.1074/jbc.M311799200
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.80
IUBMB Enzyme Nomenclature: 2.6.1.80
ExPASy - ENZYME nomenclature database: 2.6.1.80
BRENDA, the Enzyme Database: 2.6.1.80
CAS: 154907-64-9

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