Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy

N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase

N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate [RN:R04217]

R04217
Reaction

N2-succinyl-L-ornithine [CPD:C03415];
2-oxoglutarate [CPD:C00026]

A pyridoxal-phosphate protein. Also acts on N2-acetyl-L-ornithine and L-ornithine, but more slowly [3]. In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC 2.6.1.11) and ornithine aminotransferase (EC 2.6.1.13) activities are catalysed by the same enzyme, but this is not the case in all species [5]. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].

EC 2.6.1.81 created 2006

1  [PMID:2865249]

2  [PMID:9696779]

3  [PMID:3534538]

4  [PMID:9393691]

5  [PMID:3129535]