| Entry |
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| Name |
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase;
PseC;
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine:2-oxoglutarate aminotransferase;
UDP-beta-L-threo-pentapyranos-4-ulose transaminase;
UDP-4-dehydro-6-deoxy-D-glucose transaminase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine:2-oxoglutarate transaminase
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| Reaction(IUBMB) |
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate [RN: R09825]
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| Reaction(KEGG) |
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| Substrate |
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine [CPD: C19961];
2-oxoglutarate [CPD: C00026]
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| Product |
UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose [CPD: C19823];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal 5'-phosphate protein. The enzyme transfers the primary amino group of L-glutamate to C-4'' of UDP-4-dehydro sugars, forming a C-N bond in a stereo configuration opposite to that of UDP. The enzyme from the bacterium Bacillus cereus has been shown to act on UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose, UDP-beta-L-threo-pentapyranos-4-ulose, UDP-4-dehydro-6-deoxy-D-glucose, and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose. cf. EC 2.6.1.34, UDP-N-acetylbacillosamine transaminase, which catalyses a similar reaction, but forms the C-N bond in the same stereo configuration as that of UDP.
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| History |
EC 2.6.1.92 created 2011, modified 2018
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K15895 | UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine transaminase |
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| Genes |
» show all
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| Reference |
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| Authors |
Schoenhofen IC, McNally DJ, Vinogradov E, Whitfield D, Young NM, Dick S, Wakarchuk WW, Brisson JR, Logan SM |
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| Title |
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Schoenhofen IC, Lunin VV, Julien JP, Li Y, Ajamian E, Matte A, Cygler M, Brisson JR, Aubry A, Logan SM, Bhatia S, Wakarchuk WW, Young NM |
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| Title |
Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Mostafavi AZ, Troutman JM |
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| Title |
Biosynthetic assembly of the Bacteroides fragilis capsular polysaccharide A precursor bactoprenyl diphosphate-linked acetamido-4-amino-6-deoxygalactopyranose. |
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| Journal |
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| Reference |
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| Authors |
Hwang S, Li Z, Bar-Peled Y, Aronov A, Ericson J, Bar-Peled M |
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| Title |
The biosynthesis of UDP-d-FucNAc-4N-(2)-oxoglutarate (UDP-Yelosamine) in Bacillus cereus ATCC 14579: Pat and Pyl, an aminotransferase and an ATP-dependent Grasp protein that ligates 2-oxoglutarate to UDP-4-amino-sugars. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.92 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.92 |
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