KEGG   ENZYME: 2.6.1.96
Entry
EC 2.6.1.96                 Enzyme                                 
Name
4-aminobutyrate---pyruvate transaminase;
aminobutyrate aminotransferase (ambiguous);
gamma-aminobutyrate aminotransaminase (ambiguous);
gamma-aminobutyrate transaminase (ambiguous);
gamma-aminobutyric acid aminotransferase (ambiguous);
gamma-aminobutyric acid pyruvate transaminase;
gamma-aminobutyric acid transaminase (ambiguous);
gamma-aminobutyric transaminase (ambiguous);
4-aminobutyrate aminotransferase (ambiguous);
4-aminobutyric acid aminotransferase (ambiguous);
aminobutyrate transaminase (ambiguous);
GABA aminotransferase (ambiguous);
GABA transaminase (ambiguous);
GABA transferase (ambiguous);
POP2 (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
4-aminobutanoate:pyruvate aminotransferase
Reaction(IUBMB)
(1) 4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine [RN:R10178];
(2) 4-aminobutanoate + glyoxylate = succinate semialdehyde + glycine [RN:R10179]
Reaction(KEGG)
R10178 R10179
Substrate
4-aminobutanoate [CPD:C00334];
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Product
succinate semialdehyde [CPD:C00232];
L-alanine [CPD:C00041];
glycine [CPD:C00037]
Comment
Requires pyridoxal 5'-phosphate. The enzyme is found in plants that do not have the 2-oxoglutarate dependent enzyme (cf. EC 2.6.1.19). The reaction with pyruvate is reversible while the reaction with glyoxylate only takes place in the forward direction.
History
EC 2.6.1.96 created 2012
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16871  4-aminobutyrate---pyruvate transaminase
Genes
ATHAT3G22200(POP2)
ALY9321553
CRB17893100
CSAT104746666 104787216 109124790
EUSEUTSA_v10020531mg EUTSA_v10020563mg
BRP103834779 103869108 103869111
BNA106345502 106391515 106391519 106439809 111202360
BOE106294543 106314343
RSZ108806639 108833499 108836244 108860084
THJ104803008 104803009
CPAP110821608
CIT102624895
CICCICLE_v10011509mg
PVY116112175
MINC123210378 123227273
TCC18612261
GRA105793534 105803492
GHI107888213 107908328 107912667 107924570
GAB108468412 108473906
DZI111305652 111314578
EGR104425166
GMX100792355 100815181
GSJ114375970 114380371
PVUPHAVU_011G024300g
VRA106756560
VAR108340828
VUN114170004
CCAJ109798457
APRC113870019
MTR11438136
CAM101512659
LJALj3g3v3569310.1(Lj3g3v3569310.1) Lj3g3v3569310.2(Lj3g3v3569310.2)
ADU107477267
AIP107629579
AHF112737162 112789242
LANG109325764 109354047 109355542
FVE101306251 101311407
RCN112187725
PPER18781566
PMUM103329005
PAVI110768720
PDUL117620792
MDM103429193 103441440(GABA-T2)
PXB103939502 103941119
ZJU107404604 107416848 107416854 107416874
MNT21392665
CSV101211530 101219660 101220932
CMO103493051 103493054 103502504
BHJ120068092 120086780 120086830
MCHA111008130 111008301
CMAX111477042 111479758 111480372 111483360 111483362 111483363 111483365
CMOS111437539 111437540 111437541 111437542 111437544 111442867 111445807 111447381
CPEP111787855 111797325 111804476 111809772 111809773 111809774 111809775 111809776
RCU8264914
JCU105641156
HBR110655144 110659742
MESC110621232
POP7455851 7495636
PEU105108440 105110936
PALZ118037280 118052907
JRE109010285
QSU111983070
QLO115985540 115986531
TWL119980042
VVI100248495 100258633
VRI117911379 117911889
SLY543873(GABA-TP1) 543874(GABA-TP2) 544258(GABA-TP3)
SPEN107005469 107007340 107026604
SOT102595558 102596238 102599962
SSTN125863002 125863004 125876233
CANN107841786 107862720
NTA107759660 107759965 107784412 107802933 107812914 107821173 107832742
NSY104226521 104236859 104250096
NTO104088989 104094231 104104015
NAU109211380 109226591
INI109157385 109187554
ITR115995573 116010607
SIND105178585
OEU111379037
EGT105951954
SSPL121745393 121753609 121758910 121811009
HAN110872148 110903718
ECAD122600774 122603134
LSV111909672 111910449
CCAV112524455 112527486
DCR108200542 108204726
CSIN114281740
BVG104895371
SOE110783525 110783560
CQI110681943 110681944 110695106
NNU104599670
MING122093543
TSS122640135
PSOM113279738 113290086
NCOL116264598
OSA4328053 4336982 4336983 4344928
DOSAOs02t0112900-00(Os02g0112900) Os04t0614500-01(Os04g0614500) Os04t0614600-01(Os04g0614600) Os08t0205900-01(Os08g0205900)
OBR102701536 102702002 102702310
BDI100831754 100839166
ATS109732675 109754386
TDC119311273 119330264 119338317 119339000 119356197 119365356
TAES100682496 123054284 123156993 123161053 123165077 123190180
TUA125522203 125539467
SBI8071169 8072343 8076546
ZMA100282236 100286148 103645944
SITA101758155 101781154
SVS117860127 117865643
PVIR120641765 120679028 120682433 120682502 120711754
PHAI112897762 112898816
PDA103713189 120106801
EGU105059874
MUS103983705
DCT110109905
PEQ110020253
AOF109845251
ATR18448099
SMOSELMODRAFT_177017 SELMODRAFT_270846
PPP112284110 112285886
GTTGUITHDRAFT_164445
VNAPN96_21685
PREPCA10_49520
PFUWKF707C_14190
PPUPP_2799
PPUHB479_13880
PMOSO165_009765 O165_024215
PPJRK21_02889
PFNHZ99_03390
PMANOU5_1389
PSKU771_16045
PSECCCOS191_2907(GABA-TP1b)
PKRAYO71_16555
PPSLBJP27_05640
PSILPMA3_09585
PUMHGP31_19430
PKHJLK41_05915
PDWBV82_3290
PMAMKSS90_14235
PPHABVH74_02385
PWZJ7655_09250
PCAVD3880_00680
AWUBEN71_08205
ATNFM020_06210
CPSCPS_2025
THTE2K93_06495
OSGBST96_06695
HJABST95_14935
HALCEY643_07540
WMAWM2015_1694
WEZIC757_09990
GAIIMCC3135_15065 IMCC3135_27785
MARSA8C75_14780
NJPNEJAP_0648
AJPAMJAP_2090
CBWRR42_s1372
CCUPBKK81_02605
CUPBKK80_01950
CUUBKK79_10325
BVIBcep1808_6662
BACBamMC406_6604
BCONNL30_32710
BSEMWJ12_19180
BYIBYI23_C002220
BUEBRPE67_CCDS10000
BCAIK788_0002976
PHSC2L64_24465
PCAFDSC91_006868
PDIOPDMSB3_2401.1(spuC)
BPEBP2305
BPCBPTD_2264
BPERBN118_0763
BPETB1917_2213
BPEUQ425_16060
BPARBN117_1750
BPABPP2424
BBHBN112_1642
BBRBB1873
BBMBN115_3162
BBXBBS798_1774
BPTBpet3097
BAVBAV2206
BHOD560_0023
BHMD558_0026
BHZACR54_02963(tpa)
BTRMSAMEA390648703040(tpa_2) SAMEA390648703251(bioA_2)
BBROBAU06_16795
BFZBAU07_09390
BPDZBBN53_07200
BOHAKI39_16090
BGMCAL15_15385
PUTPT7_1614
AKATKWG_24240
AMIMMIM_c39140
CDNBN940_12961 BN940_13021
RHYRD110_24415
POLBpro_0421
VEIVeis_3196
VAPVapar_5230 Vapar_5629
VPEVarpa_0605
VPDVAPA_1c54400
VAMC4F17_01295 C4F17_28545
SIMPC6571_15770
MPTMpe_A0371
METPC1M51_11040
HSEHsero_1123
HSZACP92_05630
HRBHrubri_0930
XYKGT347_03105 GT347_10445
MLNA9174_13570
MCIMesci_5413
MAMOA6B35_00165
MESWA9K65_029540
MESMEJ066_28995
MESPC1M53_19140 C1M53_23500
MHUAMCHK_0321
MJREB229_13695
MESRFGU64_09905
MOHIHQ72_14360
MESOBSQ44_07585 BSQ44_21920
MESMeso_4250
AAKAA2016_0584
AMIHCO731_00574(tpa)
PHTBLM14_13005 BLM14_29360
PHYLHB779_10295
NKIKW403_04425
PLAPlav_0797
PMOBHG718_09685
KMNHW532_04695
RBSRHODOSMS8_00357
SMESM_b20379
SMKSinme_3799
SMQSinmeB_4295
SMXSM11_pD1234
SMIBN406_04030(GABA-TP3) BN406_06293(GABA-TP3)
SMEGC770_GR4pD1223
SMELSM2011_b20379
SMERDU99_31405
SMDSmed_3738
SIXBSY16_4291
EADOV14_a1582
EAHFA04_33600
ESJSJ05684_b52390
EAKEKH55_3456
ATUAtu3300
ARAArad_9339(bioA)
ATAAWN88_03400
AGRAGROH133_11145 AGROH133_14247
ATFAch5_31520
AVIAvi_9130
AROB0909_22270
AGTEYD00_21305
ALFCFBP5473_22735
ARUIG6M88_16660 G6M88_20890
AVQHRR99_17045
RETRHE_CH02145
RECRHECIAT_CH0002203
RELREMIM1_CH02155
REPIE4803_CH02157
REIIE4771_CH02244
RLURLEG12_01060
RTRRTCIAT899_PC06530
RIRBN877_II1544
RPUSCFBP5875_21535
RHNAMJ98_CH02196
RPHAAMC79_CH02276
RHXAMK02_CH02207
RHVBA939_18440
RHKKim5_CH02254
REZAMJ99_CH02274
ROYG3A56_18235
RBQJ2J99_25440 J2J99_25790
RLSHB780_06425
NGLRG1141_CH37570
NGGRG540_CH38220
NEOCYG48_14250
NENNCHU2750_32320 NCHU2750_35590 NCHU2750_54570
RHTNT26_3623
RFVRFYW14_03515 RFYW14_04180
SHZshn_02765 shn_26215
BMEBMEI1757
BMELDK63_1728
BMIBMEA_A0199
BMZBM28_A0203
BMGBM590_A0200
BMWBMNI_I0189
BMEEDK62_1223
BMFBAB1_0191
BMBBruAb1_0186
BMCBAbS19_I01810
BAABAA13334_I00160
BABODK55_205
BABRDO74_1677
BABTDK49_2054
BABBDK48_1921
BABUDK53_200
BABSDK51_1262
BABCDO78_117
BMSBR0191
BSIBS1330_I0191
BSFBSS2_I0188
BSUIBSSP1_I0189
BSUPBSPT1_I0191
BSUVBSPT2_I0192
BSUCBSSP2_I0189
BMTBSUIS_A0192
BSZDK67_10
BSVBSVBI22_A0191
BSWIY71_01070
BSGIY72_00795
BOVBOV_0184
BCSBCAN_A0196
BSKBCA52141_I1382
BOLBCOUA_I0191
BCARDK60_292
BCASDA85_00925
BMRBMI_I194
BPPBPI_I192 BPI_II550
BPVDK65_1179
BCETV910_101783
BCEEV568_102003
BVLBF3285c1_0492
BRUBFS01_00885
BRJBKD03_09885
OINIAR37_03680
BIOBR141012304_10379
OANOant_0199
OAHDR92_48
BPSNNIK97_10330
OCHCES85_3010 CES85_3433
OCRHGK82_00350
OCLGTN27_01015
PSCQKHQ08_01055
BJAblr4134(blr4134)
BJUBJ6T_56750 BJ6T_81330
BJPRN69_27505 RN69_39500
BBTBBta_1928
BRSS23_41280
BRCBCCGELA001_17235
BRADBF49_0928
BOTCIT37_05140 CIT37_33355
BRQCIT40_13380
BGQX265_17230
BGZXH91_20135
BSYMCIT39_12555
BBETF8237_00995
BARHWN72_22355
BVZBRAD3257_4876
BDGLPJ38_22695
RPBRPB_1491
BOPAXW83_05045 AXW83_05070 AXW83_12715
BOSBSY19_3995
BVVBHK69_00045 BHK69_27605
BOIBLM15_17705 BLM15_24705
BOFFQV39_26240 FQV39_29880
XDIEZH22_01165 EZH22_15955
SNOSnov_0274 Snov_1569
STARG3545_16940
ANCGBB76_16235
APRAG3A50_08585
APOLK9D25_11270 K9D25_18425
MEAMex_1p3113
MDIMETDI3676
MEXMext_2908
MCHMchl_3134
MPOMpop_3032
MZAB2G69_22105
MRDMrad2831_0848 Mrad2831_3217
METM446_3814
MNOMnod_5513
MORMOC_1061
METAY590_14055
MAQUMaq22A_1p33760(bioA) Maq22A_2p42700(bioA)
MPHYMCBMB27_00445
MEEDA075_15375
METDC0214_16170
METXA3862_26315
METSDK389_01470
METIDK427_24940
MMESMMSR116_22040
MTEADK419_04175
MINDmvi_00110
MOGMMB17_24085
MTADM6G65_12605
RHJHZY79_15435
BBARRHAL1_03786
RHZRHPLAN_18600
METGHT051_12825
BVRBVIR_1905
BLAGBLTE_04450
CMETK6K41_00070
HDIHDIA_1218(bioA_2)
MAADAZF01_02625
MMEDMame_01968(bioK_1)
AUAM673_19005 M673_21240 M673_22855
AALAIGS74_17480
AALMLUX29_19545
AUZSa4125_32180
AUBLXB15_13495
BRND1F64_18625
NOHG5V57_09890 G5V57_15790 G5V57_22410
RBMTEF_07805
LAPACP90_24025
LABRCHH27_24600
LABPFJ695_27495
LABTFIU93_01860(tpa2)
LAGGB0E33_07480
PHRC6569_00440
PSTGE8M01_03660 E8M01_07960 E8M01_14570 E8M01_17225
LIZLGH83_15400
ACUTMRB58_04470
SILSPO1166
SITTM1040_2031
JANJann_1121
RDERD1_2337
RLIRLO149_c021610
KVLKVU_0413
KVUEIO_0885
KROBVG79_00677
PGAPGA1_c09350
PGLPGA2_c09240
PGDGal_02556
PHPPhaeoP97_00901 PhaeoP97_03853
PPICPhaeoP14_00855
PHQD1820_00440
LMDMETH_12640
LEJETW24_13310
LAQUR2C4_05700
LCAEK3721_11655
REDroselon_00220
CIDP73_3746
YPACCEW88_05875
YANAYJ57_12825
TPROGa0080559_TMP3230
PABYGa0080574_TMP1142 Ga0080574_TMP1876
SULDB5M07_18130
SINLDSM14862_04268(spuC_3) DSM14862_04320(spuC_4)
SPSESULPSESMR1_02511(tpa)
RIDRIdsm_04416(tpa_4)
ROHFIU89_15075(tpa5)
OCDFHY55_05550 FHY55_15670
TGLHFZ77_07890 HFZ77_08120
PALXGQA70_05145
RSPRSP_3261(bioA)
RSHRsph17029_3993
RSQRsph17025_3280
RSKRSKD131_3436
CAZTLV780_15100
PDEPden_3052
PAMIJCM7686_1171 JCM7686_1757 JCM7686_2098
PYEA6J80_17840
PCONB0A89_12060
PZHCX676_00775 CX676_08755
PAROCUV01_11655
PARUCYR75_06990
PAMNJCM7685_1687
PMUTDPM13_16815
PARSDRW48_14385
PARREOJ32_05075
PAAKFIU66_01330
PKDF8A10_04675
PPANESD82_02875
PLIAE4191_13530 E4191_16990
PSANHGN31_01200
PMAUCP157_02551(spuC_2)
PTPRCA23_c27850
RSUNHU_01302
RHMB5V46_12200
RHCRGUI_3802
RMBK529_003700 K529_016625
DAAAKL17_0232 AKL17_1456
THWBMG03_07170
TECAKL02_006070
GFUKM031_17770
SEDIEBB79_06050
HMLHmaOT1_08250 HmaOT1_09540
BOOE2K80_01635
PPRUFDP22_08670 FDP22_11040
PAEDG5B38_10845 G5B38_12415
PSHQF3W81_10865
POZI0K15_03600
PALWPSAL_000240(spuC_1)
PPAFI8N54_05730
PGVSL003B_3287
CACTHZ995_11370
THASC6Y53_15655
HDHG5B40_10695 G5B40_16810
CMAGCBW24_12200
FAPGR316_12570
GCEKYE46_14985
AMAQGO499_01875
SANDH3309_12335
KNAB0W47_15385 B0W47_15750
KEUS101446_00109(spuC)
KSCCD178_00086(bioK)
KREGWK63_04705
AOYEOV40_011170
RGIRGI145_10140
ROSCTJ15_07200
RMUCFOB66_03025 FOB66_12000
RMTIAI58_02400
KHAIFJ82_11150
SRFLHU95_07355 LHU95_09880
RAPRHOA_5919(spuC) RHOA_6165(spuC)
SHUMSTHU_04430 STHU_26150 STHU_28620 STHU_38920
SVCSTVA_05980 STVA_18280 STVA_27680 STVA_32590
STELSTAQ_14060 STAQ_26950 STAQ_39730
AZLAZL_b03720
ALIAZOLI_2849
ABSAZOBR_40214
ABQABAZ39_01730
ABFAMK58_12110
ATIAL072_03730
AHUA6A40_11375
AZTTSH58p_13270
AZMDM194_10945
AZZDEW08_09030
AOZHUE56_10985 HUE56_28285
NCBC0V82_01300 C0V82_03020
SKTIGS68_07675
SMUCJL100_019940
SROEJL101_018685
RRURru_A2041
RRFF11_10495
RCERC1_0997
RPMRSPPHO_01272
MAGamb1684
MGYMGMSRv2__0300
MGRYMSR1_19010(bioA_2)
MAGXXM1_2248(GABA-TP)
MAGNWV31_18875
TMOTMO_0276
HJOAY555_10380
FERFNB15_10320
HTQFRZ44_19070 FRZ44_39080
HADHFRZ61_37560
DEXHWD60_14845
DVNHQ394_16020
TXITH3_06800
THACCSC3H3_06585
TIIDY252_00205
THAIIT893_00025
MAGQMGMAQ_1311
ELIOKO353_03520 KO353_13825
NACINUH88_15175
APCHIMB59_00002820
SNEANBZ79_07080
SSXSACTE_6541
SRNA4G23_04201(bioK_3)
SALWCP975_33665
SCADDN051_36185
SLSSLINC_6421
SALFSMD44_00395
SFKKY5_0302
SRJSRO_1590
SKACP970_41345
SGFHEP81_01776(argD)
SFBCP974_22650
MRBMrub_2631
MTAIMtai_v1c22370
 » show all
Reference
1
  Authors
Van Cauwenberghe, O.R. and Shelp, B.J.
  Title
Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum.
  Journal
Phytochemistry 52:575-581 (1999)
Reference
2  [PMID:12859897]
  Authors
Palanivelu R, Brass L, Edlund AF, Preuss D
  Title
Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels.
  Journal
Cell 114:47-59 (2003)
DOI:10.1016/S0092-8674(03)00479-3
  Sequence
[ath:AT3G22200]
Reference
3  [PMID:19264755]
  Authors
Clark SM, Di Leo R, Dhanoa PK, Van Cauwenberghe OR, Mullen RT, Shelp BJ
  Title
Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate.
  Journal
J Exp Bot 60:1743-57 (2009)
DOI:10.1093/jxb/erp044
  Sequence
[ath:AT3G22200]
Reference
4  [PMID:19470656]
  Authors
Clark SM, Di Leo R, Van Cauwenberghe OR, Mullen RT, Shelp BJ
  Title
Subcellular localization and expression of multiple tomato gamma-aminobutyrate transaminases that utilize both pyruvate and glyoxylate.
  Journal
J Exp Bot 60:3255-67 (2009)
DOI:10.1093/jxb/erp161
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.96
IUBMB Enzyme Nomenclature: 2.6.1.96
ExPASy - ENZYME nomenclature database: 2.6.1.96
BRENDA, the Enzyme Database: 2.6.1.96

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