KEGG   ENZYME: 2.6.1.96
Entry
EC 2.6.1.96                 Enzyme                                 

Name
4-aminobutyrate---pyruvate transaminase;
aminobutyrate aminotransferase (ambiguous);
gamma-aminobutyrate aminotransaminase (ambiguous);
gamma-aminobutyrate transaminase (ambiguous);
gamma-aminobutyric acid aminotransferase (ambiguous);
gamma-aminobutyric acid pyruvate transaminase;
gamma-aminobutyric acid transaminase (ambiguous);
gamma-aminobutyric transaminase (ambiguous);
4-aminobutyrate aminotransferase (ambiguous);
4-aminobutyric acid aminotransferase (ambiguous);
aminobutyrate transaminase (ambiguous);
GABA aminotransferase (ambiguous);
GABA transaminase (ambiguous);
GABA transferase (ambiguous);
POP2 (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
4-aminobutanoate:pyruvate aminotransferase
Reaction(IUBMB)
(1) 4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine [RN:R10178];
(2) 4-aminobutanoate + glyoxylate = succinate semialdehyde + glycine [RN:R10179]
Reaction(KEGG)
R10178 R10179
Substrate
4-aminobutanoate [CPD:C00334];
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Product
succinate semialdehyde [CPD:C00232];
L-alanine [CPD:C00041];
glycine [CPD:C00037]
Comment
Requires pyridoxal 5'-phosphate. The enzyme is found in plants that do not have the 2-oxoglutarate dependent enzyme (cf. EC 2.6.1.19). The reaction with pyruvate is reversible while the reaction with glyoxylate only takes place in the forward direction.
History
EC 2.6.1.96 created 2012
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16871  4-aminobutyrate---pyruvate transaminase
Genes
AQU: 100637930
ATH: AT3G22200(POP2)
ALY: 9321553
CRB: 17893100
CSAT: 104746666 104787216 109124790
EUS: EUTSA_v10020531mg EUTSA_v10020563mg
BRP: 103834779 103869108 103869111
BNA: 106345502 106391515 106391519 106439809 111202360
BOE: 106294543 106314343
RSZ: 108806639 108833499 108836244 108860084
CPAP: 110821608
CIT: 102624895
PVY: 116112175
TCC: 18612261
EGR: 104425166
VRA: 106756560
VAR: 108340828
VUN: 114170004
CCAJ: 109798457
APRC: 113870019
CAM: 101512659
LJA: Lj3g3v3569310.1(Lj3g3v3569310.1) Lj3g3v3569310.2(Lj3g3v3569310.2)
ADU: 107477267
AIP: 107629579
RCN: 112187725
PPER: 18781566
PMUM: 103329005
PAVI: 110768720
PDUL: 117620792
MDM: 103429193 103441440(GABA-T2)
MNT: 21392665
RCU: 8264914
JCU: 105641156
MESC: 110621232
JRE: 109010285
QSU: 111983070
TWL: 119980042
SLY: 543873(GABA-TP1) 543874(GABA-TP2) 544258(GABA-TP3)
SIND: 105178585
OEU: 111379037
EGT: 105951954
CSIN: 114281740
BVG: 104895371
NNU: 104599670
MING: 122093543
NCOL: 116264598
DOSA: Os02t0112900-00(Os02g0112900) Os04t0614500-01(Os04g0614500) Os04t0614600-01(Os04g0614600) Os08t0205900-01(Os08g0205900)
EGU: 105059874
MUS: 103983705
DCT: 110109905
PEQ: 110020253
AOF: 109845251
ATR: 18448099
PPU: PP_2799
PPUH: B479_13880
PMAN: OU5_1389
PSEC: CCOS191_2907(GABA-TP1b)
PSIL: PMA3_09585
PDW: BV82_3290
CPS: CPS_2025
BCON: NL30_32710
BSEM: WJ12_19180
BPE: BP2305
BPC: BPTD_2264
BPER: BN118_0763
BPET: B1917_2213
BPEU: Q425_16060
BPAR: BN117_1750
BPA: BPP2424
BBR: BB1873
BPT: Bpet3097
BAV: BAV2206
BHO: D560_0023
BHM: D558_0026
BHZ: ACR54_02963(tpa)
BTRM: SAMEA390648703040(tpa_2) SAMEA390648703251(bioA_2)
PUT: PT7_1614
AMIM: MIM_c39140
POL: Bpro_0421
VEI: Veis_3196
MPT: Mpe_A0371
MHUA: MCHK_0321
MES: Meso_4250
AMIH: CO731_00574(tpa)
PLA: Plav_0797
SME: SM_b20379
SMI: BN406_04030(GABA-TP3) BN406_06293(GABA-TP3)
SMER: DU99_31405
SMD: Smed_3738
ATU: Atu3300
ARA: Arad_9339(bioA)
AVI: Avi_9130
RHT: NT26_3623
BME: BMEI1757
BMEL: DK63_1728
BMEE: DK62_1223
BMF: BAB1_0191
BABO: DK55_205
BABR: DO74_1677
BABT: DK49_2054
BABB: DK48_1921
BABU: DK53_200
BABS: DK51_1262
BABC: DO78_117
BMS: BR0191
BSZ: DK67_10
BOV: BOV_0184
BCAR: DK60_292
BCAS: DA85_00925
BMR: BMI_I194
BPV: DK65_1179
OAN: Oant_0199
OAH: DR92_48
BJA: blr4134(blr4134)
BBT: BBta_1928
BRS: S23_41280
BRAD: BF49_0928
BARH: WN72_22355
RPB: RPB_1491
MDI: METDI3676
MEX: Mext_2908
MCH: Mchl_3134
MPO: Mpop_3032
MET: M446_3814
MNO: Mnod_5513
MOR: MOC_1061
META: Y590_14055
MAQU: Maq22A_1p33760(bioA) Maq22A_2p42700(bioA)
MIND: mvi_00110
BVR: BVIR_1905
BLAG: BLTE_04450
HDI: HDIA_1218(bioA_2)
MMED: Mame_01968(bioK_1)
RBM: TEF_07805
LABT: FIU93_01860(tpa2)
SIL: SPO1166
JAN: Jann_1121
RDE: RD1_2337
KVL: KVU_0413
KVU: EIO_0885
PGD: Gal_02556
LAQU: R2C4_05700
CID: P73_3746
SPSE: SULPSESMR1_02511(tpa)
RID: RIdsm_04416(tpa_4)
ROH: FIU89_15075(tpa5)
RSP: RSP_3261(bioA)
PDE: Pden_3052
PMAU: CP157_02551(spuC_2)
RSU: NHU_01302
RHC: RGUI_3802
PALW: PSAL_000240(spuC_1)
KEU: S101446_00109(spuC)
KSC: CD178_00086(bioK)
RRU: Rru_A2041
RRF: F11_10495
RCE: RC1_0997
MAG: amb1684
MGRY: MSR1_19010(bioA_2)
MAGX: XM1_2248(GABA-TP)
MAGN: WV31_18875
TMO: TMO_0276
TXI: TH3_06800
MAGQ: MGMAQ_1311
SRN: A4G23_04201(bioK_3)
SFK: KY5_0302
SRJ: SRO_1590
SGF: HEP81_01776(argD)
MRB: Mrub_2631
 » show all
Reference
1
  Authors
Van Cauwenberghe, O.R. and Shelp, B.J.
  Title
Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum.
  Journal
Phytochemistry 52:575-581 (1999)
Reference
2  [PMID:12859897]
  Authors
Palanivelu R, Brass L, Edlund AF, Preuss D
  Title
Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels.
  Journal
Cell 114:47-59 (2003)
DOI:10.1016/S0092-8674(03)00479-3
  Sequence
[ath:AT3G22200]
Reference
3  [PMID:19264755]
  Authors
Clark SM, Di Leo R, Dhanoa PK, Van Cauwenberghe OR, Mullen RT, Shelp BJ
  Title
Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate.
  Journal
J Exp Bot 60:1743-57 (2009)
DOI:10.1093/jxb/erp044
  Sequence
[ath:AT3G22200]
Reference
4  [PMID:19470656]
  Authors
Clark SM, Di Leo R, Van Cauwenberghe OR, Mullen RT, Shelp BJ
  Title
Subcellular localization and expression of multiple tomato gamma-aminobutyrate transaminases that utilize both pyruvate and glyoxylate.
  Journal
J Exp Bot 60:3255-67 (2009)
DOI:10.1093/jxb/erp161
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.96
IUBMB Enzyme Nomenclature: 2.6.1.96
ExPASy - ENZYME nomenclature database: 2.6.1.96
BRENDA, the Enzyme Database: 2.6.1.96

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