Entry |
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Name |
hexokinase;
hexokinase type IV glucokinase;
hexokinase D;
hexokinase type IV;
hexokinase (phosphorylating);
ATP-dependent hexokinase;
glucose ATP phosphotransferase
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Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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Sysname |
ATP:D-hexose 6-phosphotransferase
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Reaction(IUBMB) |
ATP + D-hexose = ADP + D-hexose 6-phosphate [RN: R02848]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
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History |
EC 2.7.1.1 created 1961
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Pathway |
ec00010 | Glycolysis / Gluconeogenesis |
ec00051 | Fructose and mannose metabolism |
ec00500 | Starch and sucrose metabolism |
ec00520 | Amino sugar and nucleotide sugar metabolism |
ec00524 | Neomycin, kanamycin and gentamicin biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Bailey K, Webb EC. |
Title |
Purification of yeast hexokinase and its reaction with betabeta'-dichlorodiethyl sulphide. |
Journal |
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Reference |
|
Authors |
Berger L, Slein MW, Colowick SP, Cori CF |
Title |
ISOLATION OF HEXOKINASE FROM BAKER'S YEAST. |
Journal |
J Gen Physiol 29:379-91 (1946) |
Reference |
|
Authors |
Kunitz M, McDonald MR |
Title |
CRYSTALLINE HEXOKINASE (HETEROPHOSPHATESE) : METHOD OF ISOLATION AND PROPERTIES. |
Journal |
J Gen Physiol 29:393-412 (1946) |
Reference |
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Authors |
Pollard-Knight D, Cornish-Bowden A. |
Title |
Mechanism of liver glucokinase. |
Journal |
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Reference |
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Authors |
Ureta T, Radojkovic J, Lagos R, Guixe V, Nunez L. |
Title |
Phylogenetic and ontogenetic studies of glucose phosphorylating isozymes of vertebrates. |
Journal |
Arch Biol Med Exp (Santiago) 12:587-604 (1979) |
Reference |
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Authors |
Cardenas ML, Rabajille E, Niemeyer H. |
Title |
Fructose is a good substrate for rat liver 'glucokinase' (hexokinase D). |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.1.1 |
ExPASy - ENZYME nomenclature database: | 2.7.1.1 |
UM-BBD (Biocatalysis/Biodegradation Database): | 2.7.1.1 |
BRENDA, the Enzyme Database: | 2.7.1.1 |
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