KEGG ENZYME: 2.7.1.108

ENZYME: 2.7.1.108

Entry

EC 2.7.1.108                Enzyme

Name

dolichol kinase;
dolichol phosphokinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

CTP:dolichol O-phosphotransferase

Reaction(IUBMB)

CTP + dolichol = CDP + dolichyl phosphate [RN:R01018]

Reaction(KEGG)

R01018

Substrate

CTP [CPD:C00063];
dolichol [CPD:C00381]

Product

CDP [CPD:C00112];
dolichyl phosphate [CPD:C00110]

History

EC 2.7.1.108 created 1984

Pathway

ec00510

N-Glycan biosynthesis

ec01100

Metabolic pathways

Orthology

K00902

dolichol kinase

Genes

HSA:	22845(DOLK)

PTR:	107976791(DOLK)

PPS:	100982127(DOLK)

GGO:	101138629(DOLK)

PON:	100294666(DOLK)

NLE:	100600155(DOLK)

HMH:	116475741(DOLK)

MCC:	717045(DOLK)

MCF:	101925965(DOLK)

MTHB:

126936967

MNI:	105464001(DOLK)

CSAB:

103239779(DOLK)

CATY:

105576207(DOLK)

PANU:

100137448(DOLK)

TGE:	112607574(DOLK)

MLEU:

105532866(DOLK)

RRO:	104660521(DOLK)

RBB:	108512825(DOLK)

TFN:	117072872(DOLK)

PTEH:

111545863(DOLK)

CANG:

105504037(DOLK)

CJC:	100895983(DOLK)

SBQ:	101033864(DOLK)

CIMI:

108283030(DOLK)

CSYR:

103250019(DOLK)

MMUR:

105875272(DOLK)

LCAT:

123646382(DOLK)

PCOQ:

105806607(DOLK)

OGA:	100941160(DOLK)

MMU:	227697(Dolk)

MCAL:

110288251(Dolk)

MPAH:

110318581(Dolk)

RNO:	311847(Dolk)

MCOC:

116089943(Dolk)

ANU:	117702654(Dolk)

MUN:	110555777(Dolk)

CGE:	100768385(Dolk)

MAUA:

101828147(Dolk)

PROB:

127222717(Dolk)

PLEU:

114702732(Dolk)

MORG:

121462580(Dolk)

MFOT:

126509234

AAMP:

119818994(Dolk)

NGI:	103727983(Dolk)

HGL:	101711037(Dolk)

CPOC:

100723647(Dolk)

CCAN:

109701893(Dolk)

DORD:

105989346(Dolk)

DSP:	122108941(Dolk)

NCAR:

124964180

OCU:

100344382

OPI:	101522334(DOLK)

TUP:	102490204(DOLK)

GVR:	103595918(DOLK)

CFA:	480701(DOLK)

CLUD:

112677293(DOLK)

VVP:	112927959(DOLK)

VLG:	121473424(DOLK)

AML:	100463796(DOLK)

UMR:	103670275(DOLK)

UAH:	113266489(DOLK)

UAR:	123775620(DOLK)

ELK:

111145760

LLV:

125083166

MPUF:

101675215(DOLK)

NVS:	122917185(DOLK)

ORO:	101380543(DOLK)

EJU:	114212753(DOLK)

ZCA:	113934415(DOLK)

MLX:	118017606(DOLK)

NSU:	110581424(DOLK)

LWW:	102742555(DOLK)

FCA:	101083720(DOLK)

PYU:	121035083(DOLK)

PBG:	122474851(DOLK)

LRUF:

124526996

PTG:	102969647(DOLK)

PPAD:

109250050(DOLK) 109250051

PUC:

125922212

AJU:	106966257(DOLK)

HHV:	120230150(DOLK)

BTA:	526844(DOLK)

BOM:	102265291(DOLK)

BIU:	109566530(DOLK)

BBUB:

102399274(DOLK)

BBIS:

105000804(DOLK)

CHX:	102182047(DOLK)

OAS:	101116296(DOLK)

ODA:	120852068(DOLK)

CCAD:

122442239(DOLK)

SSC:	100152320(DOLK)

CFR:	102515673(DOLK)

CBAI:

105066008(DOLK)

CDK:	105092555(DOLK)

VPC:	102536094(DOLK)

BACU:

103008709(DOLK)

LVE:	103075157(DOLK)

OOR:	101288979(DOLK)

DLE:	111177143(DOLK)

PCAD:

102974368(DOLK)

PSIU:

116755650(DOLK)

ECB:	100070129(DOLK) 100146151

EPZ:	103550872(DOLK)

EAI:	106845417(DOLK)

MYB:	102249695(DOLK)

MYD:	102769036(DOLK)

MMYO:

118666984(DOLK) 118679018

MLF:	102431835(DOLK)

MNA:	107524700(DOLK)

PKL:	118706694(DOLK)

HAI:	109380386(DOLK)

DRO:	112306231(DOLK)

SHON:

118980261(DOLK)

AJM:	119050796(DOLK)

PDIC:

114502800(DOLK)

PHAS:

123823343(DOLK)

MMF:	118629695(DOLK)

RFQ:	117031618(DOLK)

PALE:

102891632(DOLK)

PGIG:

120601678(DOLK)

PVP:	105294797(DOLK)

RAY:	107504523(DOLK)

MJV:	108389781(DOLK)

TOD:	119231157(DOLK)

SARA:

101557892(DOLK)

LAV:	100662271(DOLK)

TMU:

101357368

ETF:	101664169(DOLK)

DNM:	101439584(DOLK)

MDO:	100013804(DOLK)

GAS:	123235234(DOLK)

SHR:	100925391(DOLK)

AFZ:

127550869

PCW:	110193764(DOLK)

OAA:	100088250(DOLK)

GGA:	417199(DOLK)

PCOC:

116234229(DOLK)

MGP:	100549792(DOLK)

CJO:	107321749(DOLK)

NMEL:

110407084(DOLK)

APLA:

101803615(DOLK)

ACYG:

106047317(DOLK)

AFUL:

116497087(DOLK)

TGU:	100217598(DOLK)

LSR:	110482291(DOLK)

SCAN:

103819015(DOLK)

PMOA:

120507486(DOLK)

OTC:	121337124(DOLK)

PRUF:

121357658(DOLK)

GFR:	102044852(DOLK)

FAB:	101810760(DOLK)

PHI:	102110090(DOLK)

PMAJ:

109022351(DOLK)

CCAE:

111936981(DOLK)

CCW:	104688284(DOLK)

CBRC:

103623172(DOLK)

ETL:	114054519(DOLK)

ZAB:	102072897(DOLK)

ACHL:

103801898(DOLK)

SVG:	106851402(DOLK)

FPG:	101910463(DOLK)

FCH:	102052937(DOLK)

CLV:	102098864(DOLK)

EGZ:	104122476(DOLK)

NNI:	104023151(DOLK)

PLET:

104615668(DOLK)

PCRI:

104036755(DOLK)

PCAO:

104040513(DOLK)

ACUN:

113486377(DOLK)

TALA:

104356503(DOLK)

PADL:

103915300(DOLK)

AFOR:

103905292(DOLK)

ACHC:

115334797(DOLK)

HALD:

104316036(DOLK)

HLE:	104833926(DOLK)

AGEN:

126052315

GCL:

127023548

CCRI:

104165172(DOLK)

CSTI:

104554821(DOLK)

EHS:	104504836(DOLK)

CMAC:

104482000(DOLK)

MUI:	104545758(DOLK)

FGA:	104075535(DOLK)

GSTE:

104252527(DOLK)

LDI:	104344538(DOLK)

MNB:	103773057(DOLK)

OHA:	104329333(DOLK)

NNT:	104404314(DOLK)

SHAB:

115616965(DOLK)

DPUB:

104296386(DOLK)

PGUU:

104470593(DOLK)

ACAR:

104526556(DOLK)

CPEA:

104389854(DOLK)

AVIT:

104269211(DOLK)

CVF:	104289117(DOLK)

CUCA:

104066793(DOLK)

TEO:	104374805(DOLK)

BRHI:

104497399(DOLK)

AAM:	106490300(DOLK)

AROW:

112962985(DOLK)

NPD:	112956087(DOLK)

TGT:	104581174(DOLK)

DNE:	112989569(DOLK)

SCAM:

104150656(DOLK)

ASN:	102382311(DOLK)

AMJ:	102575563(DOLK)

CPOO:

109313916(DOLK)

GGN:	109292936(DOLK)

PSS:	102447166(DOLK)

CMY:	102930129(DOLK)

CPIC:

101947859(DOLK)

TST:	117889381(DOLK)

CABI:

116835198(DOLK)

MRV:	120386866(DOLK)

ACS:	100567828(dolk)

PVT:	110079686(DOLK)

SUND:

121936600(DOLK)

PBI:	103059753(DOLK)

PMUR:

107296251(DOLK)

CTIG:

120308684(DOLK)

TSR:	106542064(DOLK)

PGUT:

117676581(DOLK)

VKO:	123035171(DOLK)

PMUA:

114589290(DOLK)

ZVI:	118083931(DOLK)

GJA:	107115666(DOLK)

STOW:

125441818(DOLK)

XLA:	108699959 444437(dolk.S)

XTR:	100380159(dolk)

NPR:	108801835(DOLK)

RTEM:

120914170(DOLK)

BBUF:

120977850(DOLK)

BGAR:

122946272(DOLK)

DRE:	799960(dolk)

SRX:	107705981 107737192

SANH:

107661635 107675814

SGH:	107585683 107599364

CCAR:

109058815 109064360

CAUA:

113039019 113039024 113064432(dolk)

CGIB:

127941669 127986196

PPRM:

120471239(dolk)

MAMB:

125252520(dolk)

CIDE:

127504366

MASI:

127428736 127431174

IPU:	108279170(dolk)

PHYP:

113535436(dolk)

SMEO:

124397561(dolk)

TFD:	113633949(dolk)

AMEX:

103031654(dolk)

EEE:	113590035(dolk)

TRU:	101063422(dolk)

TNG:	GSTEN00034715G001

LCO:	104926521(dolk)

NCC:	104953533(dolk)

CGOB:

115016736(dolk)

ELY:	117269665(dolk)

EFO:	125905995(dolk)

PLEP:

121959569(dolk)

SLUC:

116062933(dolk)

ECRA:

117959859(dolk)

ESP:	116704335(dolk)

PFLV:

114570938(dolk)

GAT:	120832318(dolk)

PPUG:

119226729(dolk)

MSAM:

119893970 119914605(dolk)

CUD:	121524786(dolk)

ALAT:

119030423(dolk)

MZE:	101485623(dolk)

ONL:	100702743(dolk)

OAU:	116331796(dolk)

OLA:	101166482(dolk)

OML:	112163228(dolk)

XMA:	102234603(dolk)

XCO:	114150225(dolk)

XHE:	116725021(dolk)

PRET:

103473432(dolk)

PFOR:

103151460(dolk)

PLAI:

106954265(dolk)

PMEI:

106923843(dolk)

GAF:	122846794(dolk)

CVG:	107089745(dolk)

CTUL:

119776576(dolk)

GMU:	124872431(dolk)

NFU:	107374768(dolk)

KMR:	108231005(dolk)

ALIM:

106516281(dolk)

NWH:	119424436(dolk)

AOCE:

111564096(dolk)

MCEP:

124996378(dolk)

CSEM:

103390100(dolk)

POV:	109626397(dolk)

SSEN:

122758404(dolk)

HHIP:

117771714(dolk)

HSP:	118125904(dolk)

LCF:

108873985

SDU:	111236179(dolk)

SLAL:

111652420(dolk)

XGL:	120806171(dolk)

HCQ:	109517157(dolk)

SSCV:

125979933

BPEC:

110157295(dolk)

MALB:

109972299(dolk)

BSPL:

114866435(dolk)

SASA:

106570126(dolk)

STRU:

115159961(dolk)

OTW:	112220263(dolk)

OMY:	110523279(dolk)

OGO:	123989388(dolk)

ONE:	115115536(dolk)

SALP:

111961883(dolk)

SNH:	120025912(dolk)

CCLU:

121583202(dolk)

ELS:	105028402(dolk)

SFM:	108934365(dolk)

PKI:	111841830(dolk)

AANG:

118212423(dolk)

LOC:	102692240(dolk)

PSPA:

121309750(dolk)

ARUT:

117396947 117422467

PSEX:

120535059(dolk)

LCM:	102349892(DOLK)

CMK:	103184631(dolk)

RTP:	109935629(dolk)

BFO:

118432113

BBEL:

109480764

CIN:

104266616

SCLV:

120327881

SPU:

100890843

APLC:

110988305

SKO:

102805898

DME:	Dmel_CG8311(Dolk)

DER:

6548542

DSE:

6609467

DSI:	Dsimw501_GD25530(Dsim_GD25530)

DYA:	Dyak_GE14052

DSR:

110186573

DPO:

4803570

DPE:

6591165

DMN:

108158558

DWI:

6639725

DGR:

6559244

DMO:	Dmoj_GI19069

DAZ:

108615633

DNV:

108653597

DHE:

111593566

CCAT:

101454740

BOD:

106621430

RZE:

108379648

MDE:

101892672

SCAC:

106086674

LCQ:

111675366

LSQ:

119603041

HIS:

119653387

AGA:	AgaP_AGAP002683

ACOZ:

120952776

AARA:

120893892

ASTE:

118505004

AAG:

5568847

AALB:

109404504 115261509

CQU:	CpipJ_CPIJ002894

CNS:

116342588

BCOO:

119084404

AME:

724234

ACER:

107994846

ALAB:

122712795

BIM:

100742063

BBIF:

117213609

BVK:

117234303

BVAN:

117166226

BTER:

100643573

BPYO:

122568569

CCAL:

108622046

OBB:

114880449

MGEN:

117218374

NMEA:

116429815

CGIG:

122404872

SOC:	105200707 113003668

MPHA:

105832732

AEC:

105144110

ACEP:

105624543

PBAR:

105433305

VEM:

105557182

HST:

105183541

DQU:

106745609

CFO:

105257357

FEX:

115233676

LHU:

105674181

PGC:

109856864

OBO:

105285988

PCF:

106790634

PFUC:

122513436

VPS:

122637120

NVI:

100115154

CSOL:

105367259

TPRE:

106652253

MDL:

103577373

CGLO:

123260156

FAS:

105267826

DAM:

107041885

AGIF:

122858348

CCIN:

107270718

TCA:

658408

DPA:

109543951

SOY:

115884600

ATD:

109605975

CSET:

123314777

AGB:

108907694

LDC:

111508484

NVL:

108569721

APLN:

108736321

PPYR:

116164145

OTU:

111420319

BMOR:

101745247

BMAN:

114251113

MSEX:

115451174

DPL:	KGM_205409

BANY:

112046375

PMAC:

106709977

PPOT:

106104869

PXU:

106119465

PRAP:

111003183

ZCE:

119839578

HAW:

110384280

HZE:

124636985

TNL:

113503574

SLIU:

111355130

OFU:

114354198

PXY:

105382800

API:

103310394

AGS:

114122137

RMD:

113558166

BTAB:

109043212

DCI:

103519479

CLEC:

106666485 106666526

HHAL:

106677599

NLU:

111058006

PHU:	Phum_PHUM244120

FOC:

113216302

TPAL:

117648463

ZNE:

110840357

CSEC:

111874992

FCD:

110858165

DMK:

123472368

PVM:

113806422

PJA:	122259758 122265879

PCHN:

125041936

HAME:

121863302

PCLA:

123759285

PTRU:

123520044

HAZT:

108677543

EAF:

111705114

LSM:

121130211

ISC:	IscW_ISCW002709

DSV:

119450331

RSAN:

119383427

RMP:

119170389

VDE:

111242994

VJA:

111267874

TUT:

107370863

DPTE:

113795058

DFR:

124492919

PTEP:

107443123

SDM:

118189865

CEL:	CELE_Y56A3A.36(dolk-1)

CBR:

CBG_13324

BMY:	BM_BM6885(Bm6885)

LOA:	LOAG_12687

TSP:

Tsp_05654

HRO:	HELRODRAFT_76716

PCAN:

112553698

GAE:

121385318

HRF:

124135713

CRG:

105326269

MYI:

110460194

PMAX:

117334665

MMER:

123566359

OBI:

106870889

OSN:

115223836

LAK:

106159756

SMM:	Smp_048540

SHX:	MS3_00002570

OVI:	T265_08673

EGL:

EGR_04642

NVE:

5503032

EPA:

110242919

ATEN:

116301067

ADF:

107339574

AMIL:

114953809

PDAM:

113682294

SPIS:

111323501

DGT:

114522662

XEN:

124452113

HMG:

105844027

TAD:	TRIADDRAFT_54357

AQU:

100640451

ATH:

AT3G45040

ALY:

9311777

CRB:

17885790

CSAT:

104710973 104774124 104790755

EUS:	EUTSA_v10002461mg

BRP:	103867627 103873203

BNA:	106380579 106381912 106393000 106427781 106451303 106451304

BOE:	106322993 106337391

RSZ:	108806131 108836728

THJ:

104799516

CPAP:

110823963

CIT:

102611244

CIC:	CICLE_v10028099mg

PVY:

116145070

MINC:

123203286

TCC:

18590943

GRA:	105784019 105788978

GHI:	107891661 107927146 107963907

GAB:	108483714 108484565

DZI:	111285607 111301475

EGR:

104432906

GMX:	100793756 100799242

GSJ:	114377416 114380091

PVU:	PHAVU_005G1319000

VRA:

106759486

VAR:

108333405

VUN:

114185301

CCAJ:

109811593

APRC:

113854667

MTR:

25487856

CAM:

101501533

PSAT:

127087086

LJA:	Lj3g3v1102870.1(Lj3g3v1102870.1)

ADU:

107476504

AIP:

107629256

AHF:	112736458 112785548

LANG:

109351665

FVE:

101301615

RCN:

112188699

PPER:

18773176

PMUM:

103325872

PAVI:

110755445

PDUL:

117631569

MDM:

103447915

PXB:

103947697

ZJU:

107411475

MNT:

21403493

CSV:

101218949

CMO:

103501385

BHJ:

120083213

MCHA:

111020455

CMAX:

111469273

CMOS:

111464874

CPEP:

111782845

RCU:

8275212

JCU:

105628038

HBR:

110646828

MESC:

110613837

POP:

7491163

PEU:

105111193

PALZ:

118034789

JRE:

109010582

CILL:

122292017

QSU:

112028031

QLO:

115980838

TWL:	120002420 120004937

VVI:

100261999

VRI:

117916614

SLY:

101266730

SPEN:

107021187

SOT:

102589990

SSTN:

125874401

CANN:

107875605

NTA:	107815285 107817055

NSY:

104234691

NTO:

104090678

NAU:

109237376

INI:

109192994

ITR:

116017312

SIND:

105170815

OEU:	111378173 111382426

EGT:

105958720

SSPL:

121741649 121742015 121745586

APAN:

127244008

HAN:

110890969

ECAD:

122581369

LSV:

111886062

CCAV:

112519481

DCR:

108210107

CSIN:

114265766

BVG:

104902881

SOE:

110792880

CQI:	110691721 110730924

NNU:

104595088

MING:

122061811

TSS:

122653736

PSOM:

113296971 113313122 113313496 113338896

OSA:

4328285

OGL:

127764288

BDI:

100821329

ATS:

109781234

TDC:	119315225 119323532

TAES:

123132228 123136265 123143770

TUA:	125514146 125516589

LPER:

127293921 127308944

SBI:

8073376

ZMA:

103626608

PVIR:

120648580 120654637

PHAI:

112885865

PDA:	103707005 103714879

EGU:	105055568 105059113

MUS:

103990639

ZOF:	122000639 122004925

DCT:

110095483

PEQ:

110039309

AOF:

109848376

NCOL:

116253640

ATR:

18426471

PPP:

112290520

MNG:	MNEG_12402

CSL:	COCSUDRAFT_56338

CVR:	CHLNCDRAFT_138551

APRO:

F751_0234

OLU:	OSTLU_32849

OTA:	OT_ostta07g04510

MIS:	MICPUN_98922

MPP:	MICPUCDRAFT_67543

CME:	CYME_CMR461C

GSL:	Gasu_48960

SCE:	YMR013C(SEC59)

SEUB:

DI49_4100

SPAO:

SPAR_M01370

AGO:	AGOS_ABR051C

ERC:

Ecym_4587

KLA:	KLLA0_D11198g

KMX:	KLMA_60419(SEC59)

LTH:	KLTH0D07634g

VPO:	Kpol_1056p11

ZRO:	ZYRO0E06006g

CGR:	CAGL0M07700g

NCS:	NCAS_0A12680(NCAS0A12680)

NDI:	NDAI_0B01580(NDAI0B01580)

TPF:	TPHA_0I02410(TPHA0I02410)

TBL:	TBLA_0I01580(TBLA0I01580)

TGB:	HG536_0G01270

TDL:	TDEL_0B06490(TDEL0B06490)

KAF:	KAFR_0A02090(KAFR0A02090)

KNG:	KNAG_0M02080(KNAG0M02080)

ZMK:	HG535_0G03580

PPA:	PAS_chr2-1_0498

DHA:	DEHA2G01452g

PIC:	PICST_58284(SEC59)

PGU:	PGUG_04656

SPAA:

SPAPADRAFT_62074

LEL:	LELG_02123

CAL:	CAALFM_C302690CA(CaO19.261)

CTP:	CTRG_02548

COT:	CORT_0B03400

CDU:	CD36_82700

CTEN:

CANTEDRAFT_117362

YLI:	YALI0E18942g

CLU:	CLUG_02394

CLUS:

A9F13_24g00143

CAUR:

CJI97_000415

PKZ:	C5L36_0A10180

BNN:	FOA43_001454

BBRX:

BRETT_002619

OPA:	HPODL_04275

SPO:	SPCC63.10c(sec59)

TMS:	TREMEDRAFT_74797

TVS:	TRAVEDRAFT_21010

DSQ:	DICSQDRAFT_133331

SHS:	STEHIDRAFT_72672

PSQ:	PUNSTDRAFT_139242

FME:	FOMMEDRAFT_117686

CCI:	CC1G_14421

MRR:	Moror_4620

SCM:	SCHCO_02503590(SCHCODRAFT_02503590)

CPUT:

CONPUDRAFT_119896

PFP:	PFL1_04321

MGL:

MGL_1869

MRT:

MRET_1940

EIN:	Eint_040610

MBR:	MONBRDRAFT_22886

SRE:	PTSG_09670

DDI:	DDB_G0285689

DPP:	DICPUDRAFT_29220

DFA:

DFA_01668

EHI:	EHI_049520(65.t00002)

EDI:	EDI_167810 EDI_336470

EIV:	EIN_410930

ACAN:

ACA1_072860

PCB:	PCHAS_0202150

PBE:	PBANKA_0203750

PVX:	PVX_081295

TAN:

TA14655

TPV:

TP02_0702

TOT:	TOT_020000682

BEQ:	BEWA_025260

BBO:	BBOV_II007580

BBIG:

BBBOND_0102690

CPV:

cgd2_1560

CHO:	Chro.20170

TGO:	TGME49_271170

PTM:	GSPATT00002992001

SMIN:

v1.2.033976.t3(symbB.v1.2.033976.t3)

PTI:	PHATRDRAFT_48523

TPS:	THAPSDRAFT_263701

PIF:	PITG_01187

PSOJ:

PHYSODRAFT_501611 PHYSODRAFT_504686

SPAR:

SPRG_06315

EHX:	EMIHUDRAFT_122165 EMIHUDRAFT_97251

NGR:	NAEGRDRAFT_63868

TVA:	TVAG_2v0529490

» show all

Reference

1 [PMID:457672]

Authors

Burton WA, Scher MG, Waechter CJ.

Title

Enzymatic phosphorylation of dolichol in central nervous tissue.

Journal

J Biol Chem 254:7129-36 (1979)

Reference

2 [PMID:6257336]

Authors

Rip JW, Carroll KK.

Title

Properties of a dolichol phosphokinase activity associated with rat liver microsomes.

Journal

Can J Biochem 58:1051-6 (1980)
DOI:10.1139/o80-142

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.108

IUBMB Enzyme Nomenclature:

2.7.1.108

ExPASy - ENZYME nomenclature database:

2.7.1.108

BRENDA, the Enzyme Database:

2.7.1.108

CAS:	71768-07-5

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