| Entry |
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| Name |
6-phosphofructokinase;
phosphohexokinase;
phosphofructokinase I;
phosphofructokinase (phosphorylating);
6-phosphofructose 1-kinase;
ATP-dependent phosphofructokinase;
D-fructose-6-phosphate 1-phosphotransferase;
fructose 6-phosphate kinase;
fructose 6-phosphokinase;
nucleotide triphosphate-dependent phosphofructokinase;
phospho-1,6-fructokinase;
PFK
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:D-fructose-6-phosphate 1-phosphotransferase
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| Reaction(IUBMB) |
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate [RN: R00756]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 2.7.1.105 6-phosphofructo-2-kinase.
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| History |
EC 2.7.1.11 created 1961
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| Pathway |
| ec00010 | Glycolysis / Gluconeogenesis |
| ec00051 | Fructose and mannose metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K00850 | 6-phosphofructokinase 1 |
| K16370 | 6-phosphofructokinase 2 |
| K21071 | ATP-dependent phosphofructokinase / diphosphate-dependent phosphofructokinase |
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| Genes |
» show all
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| Reference |
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| Authors |
AXELROD B, SALTMAN P, BANDURSKI RS, BAKER RS. |
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| Title |
Phosphonexokinase in higher plants. |
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| Journal |
J Biol Chem 197:89-96 (1952) |
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| Reference |
2 |
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| Authors |
Ling, K.H., Pastkau, V., Marcus, F. and Lardy, H.A. |
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| Title |
Phosphofructokinase. I. Skeletal muscle. |
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| Journal |
Methods Enzymol 9:425-429 (1966) |
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| Reference |
3 |
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| Authors |
Mansour, T.E. |
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| Title |
Phosphofructokinase. II. Heart muscle. |
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| Journal |
Methods Enzymol 9:430-436 (1966) |
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| Reference |
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| Authors |
Odeide R, Guilloton M, Dupuis B, Ravon D, Rosenberg AJ. |
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| Title |
[Study of an enzyme allosteric to 2 substrates: phosphofructokinase of rat muscle. I. Preparation and crystallization of the enzyme] |
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| Journal |
Bull Soc Chim Biol (Paris) 50:2023-33 (1968) |
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| Reference |
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| Authors |
Parmeggiani A, Luft JH, Love DS, Krebs EG. |
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| Title |
Crystallization and properties of rabbit skeletal muscle phosphofructokinase. |
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| Journal |
J Biol Chem 241:4625-37 (1966) |
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| Reference |
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| Authors |
RACKER E |
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| Title |
Spectrophotometric measurement of hexokinase and phosphohexokinase activity. |
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| Journal |
J Biol Chem 167:843-54 (1947) |
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| Reference |
7 |
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| Authors |
Sols, A. and Salas, M.L. |
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| Title |
Phosphofructokinase. III. Yeast. |
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| Journal |
Methods Enzymol 9:436-442 (1966) |
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| Reference |
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| Authors |
Uyeda K, Kurooka S. |
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| Title |
Crystallization and properties of phosphofructokinase from Clostridium pasteurianum. |
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| Journal |
J Biol Chem 245:3315-24 (1970) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.1.11 |
| ExPASy - ENZYME nomenclature database: | 2.7.1.11 |
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