KEGG   ENZYME: 2.7.1.119Help
Entry
EC 2.7.1.119                Enzyme                                 

Name
hygromycin-B 7''-O-kinase;
hygromycin B phosphotransferase;
hygromycin-B kinase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:hygromycin-B 7''-O-phosphotransferase
Reaction(IUBMB)
ATP + hygromycin B = ADP + 7''-O-phosphohygromycin B [RN:R03770]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
hygromycin B [CPD:C01925]
Product
ADP [CPD:C00008];
7''-O-phosphohygromycin B
Comment
Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring.
History
EC 2.7.1.119 created 1989, modified 2009, modified 2011
Orthology
K17880  hygromycin-B 7''-O-kinase
Genes
SDN: Sden_2943
SSE: Ssed_4380
SPL: Spea_2805
SVO: SVI_4227
SCU: SCE1572_39530
BJA: blr1035
BJU: BJ6T_10600
BJP: RN69_05170
BRA: BRADO6829
BBT: BBta_0715
BRS: S23_67720
AOL: S58_06400
SCO: SCO3277(SCE39.27c)
SVE: SVEN_5979
KRA: Krad_2754
AOI: AORI_1717
AMI: Amir_2164
SESP: BN6_18860
KAL: KALB_4352
AFS: AFR_32445
 » show all
Taxonomy
Reference
1  [PMID:3026811]
  Authors
Zalacain M, Pardo JM, Jimenez A.
  Title
Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.
  Journal
Eur J Biochem 162:419-22 (1987)
DOI:10.1111/j.1432-1033.1987.tb10618.x
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.119
IUBMB Enzyme Nomenclature: 2.7.1.119
ExPASy - ENZYME nomenclature database: 2.7.1.119
BRENDA, the Enzyme Database: 2.7.1.119
CAS: 88361-67-5

DBGET integrated database retrieval system