KEGG   ENZYME: 2.7.1.119
Entry
EC 2.7.1.119                Enzyme                                 

Name
hygromycin-B 7''-O-kinase;
hygromycin B phosphotransferase;
hygromycin-B kinase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:hygromycin-B 7''-O-phosphotransferase
Reaction(IUBMB)
ATP + hygromycin B = ADP + 7''-O-phosphohygromycin B [RN:R03770]
Reaction(KEGG)
R03770
Substrate
ATP [CPD:C00002];
hygromycin B [CPD:C01925]
Product
ADP [CPD:C00008];
7''-O-phosphohygromycin B
Comment
Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring.
History
EC 2.7.1.119 created 1989, modified 2009, modified 2011
Orthology
K17880  hygromycin-B 7''-O-kinase
Genes
XHY: FZ025_02925
SDN: Sden_2943
SSE: Ssed_4380
SPL: Spea_2805
SVO: SVI_4227
SPSW: Sps_05479
LSD: EMK97_14005
PSPO: PSPO_a1848(hyg)
CUU: BKK79_15750
ADK: Alide2_1935
SHZ: shn_08510
BJA: blr1035
BRA: BRADO6829
BRS: S23_67720
AOL: S58_06400
BRAD: BF49_7151
PPY: PPE_01320
PPOL: X809_07440
SCO: SCO3277(SCE39.27c)
SVE: SVEN_5979
SLD: T261_3533
SRW: TUE45_pSRc_0512(TUE45_pSRTUE45c_0512)
SLAU: SLA_6338
SALF: SMD44_02510(hyg)
SFK: KY5_2295c
KFL: Kfla_0215
KRA: Krad_2754
AOI: AORI_1717
AMYY: YIM_40145
AMI: Amir_2164
SESP: BN6_18860
KAL: KALB_4352
ACTI: UA75_06520
ACAD: UA74_06520
AFS: AFR_32445
 » show all
Reference
1  [PMID:3026811]
  Authors
Zalacain M, Pardo JM, Jimenez A.
  Title
Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.
  Journal
Eur J Biochem 162:419-22 (1987)
DOI:10.1111/j.1432-1033.1987.tb10618.x
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.119
IUBMB Enzyme Nomenclature: 2.7.1.119
ExPASy - ENZYME nomenclature database: 2.7.1.119
BRENDA, the Enzyme Database: 2.7.1.119
CAS: 88361-67-5

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