Entry
Name
tetraacyldisaccharide 4'-kinase;
lpxK (gene name);
lipid-A 4'-kinase;
ATP:2,2',3,3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl-(1->6)-alpha-D-glucosaminyl-phosphate 4'-O-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:2-deoxy-2-{[(3R)-3-hydroxyacyl]amino}-3-O-[(3R)-3-hydroxyacyl]-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxyacyl]-2-{[(3R)-3-hydroxyacyl]amino}-1-O-phospho-alpha-D-glucopyranose 4'-O-phosphotransferase
Reaction(IUBMB)
ATP + a lipid A disaccharide = ADP + a lipid IVA [RN:
R04657 ]
Reaction(KEGG)
Substrate
Product
Comment
Involved with EC
2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC
2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria.
History
EC 2.7.1.130 created 1990, modified 2021
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K00912 tetraacyldisaccharide 4'-kinase
Genes
CSAT : 104746457 104765933 104785458
BNA : 106389901 106389903 106407327 106407608
MINC : 123207500 123214710
LJA : Lj6g3v0857760.1(Lj6g3v0857760.1)
NTA : 107773775 107800260 107821812
PSOM : 113287965 113305233
DOSA : Os07t0102000-01(Os07g0102000)
TAES : 123045162 123052991 123188790
SMO : SELMODRAFT_168973 SELMODRAFT_73554
ECOO : ECRM13514_1020(lpxK)
ECOH : ECRM13516_0955(lpxK)
ELR : ECO55CA74_05600(lpxK)
ECW : EcE24377A_1013(lpxK)
ECOA : APECO78_08555(lpxK)
EDJ : ECDH1ME8569_0866(lpxK)
ECOI : ECOPMV1_00952(lpxK)
SEM : STMDT12_C10020(lpxK)
SETC : CFSAN001921_12280(lpxK)
SEEN : SE451236_10760(lpxK)
SENH : CFSAN002069_04120(lpxK)
SEEH : SEEH1578_14125(lpxK)
SENJ : CFSAN001992_06730(lpxK)
SEEC : CFSAN002050_11270(lpxK)
SEEB : SEEB0189_014645(lpxK)
SENC : SEET0819_11840(lpxK)
RTG : NCTC13098_05034(lpxK)
REE : electrica_03369(lpxK)
CLAP : NCTC11466_03029(lpxK)
KIE : NCTC12125_02041(lpxK)
METY : MRY16398_38190(lpxK)
AHN : NCTC12129_01852(lpxK)
PTF : PROFFT_A_02610(lpxK)
PSHI : SAMEA2665130_1230(lpxK)
YPG : YpAngola_A1960(lpxK)
YPI : YpsIP31758_2576(lpxK)
SMW : SMWW4_v1c16960(lpxK)
SERS : SERRSCBI_08160(lpxK)
SFJ : SAMEA4384070_1752(lpxK)
SOF : NCTC11214_05112(lpxK)
PAQU : DMB82_0009120(lpxK)
DIC : Dpoa569_002074(lpxK)
EHD : ERCIPSTX3056_581(lpxK)
TPTY : NCTC11468_01357(lpxK_2)
PHEI : NCTC12003_02749(lpxK)
PRJ : NCTC6933_01322(lpxK)
LRI : NCTC12151_01426(lpxK)
HIC : NTHIC486_00983(lpxK)
HPIT : NCTC13334_01445(lpxK)
HHZ : NCTC10839_01032(lpxK)
HAEG : NCTC8502_01987(lpxK)
PDAG : 4362423_01054(lpxK)
ADP : NCTC12871_01363(lpxK)
ALIG : NCTC10568_01588(lpxK)
ASEG : NCTC10977_01304(lpxK)
AVT : NCTC3438_01685(lpxK)
RPNE : NCTC8284_02696(lpxK_2)
PAET : NCTC13378_00559(lpxK)
XFU : XFF4834R_chr21940(lpxK)
XPH : XppCFBP6546_02020(XppCFBP6546P_02020)
XHD : LMG31886_20450(lpxK)
LLZ : LYB30171_01277(lpxK)
VAU : VANGNB10_cI1703c(lpxK)
VPL : SA104470976_01590(lpxK)
PAEB : NCGM1900_3325(lpxK)
PVD : CFBP1590__3825(lpxK)
PPRC : PFLCHA0_c18150(lpxK)
PFW : PF1751_v1c31870(lpxK)
PPUU : PputUW4_04051(lpxK)
PTRT : HU722_0017710(lpxK)
PTW : TUM18999_18380(lpxK)
PTAE : NCTC10697_01225(lpxK)
PSYC : DABAL43B_1778(lpxK)
MCAT : MC25239_00827(lpxK)
MCUN : NCTC10297_01488(lpxK)
SCAA : TUM17387_15470(lpxK)
SALH : HMF8227_01159(lpxK)
CBS : COXBURSA331_A1092(lpxK)
LLG : 44548918_02045(lpxK)
LJR : NCTC11533_00717(lpxK)
LCJ : NCTC11976_01886(lpxK)
LWA : SAMEA4504053_2009(lpxK)
LSS : NCTC12082_02867(lpxK)
LADL : NCTC12735_00831(lpxK)
LANT : TUM19329_25180(lpxK)
MISZ : MishRS11D_16310(lpxK)
TIB : THMIRHAM_09700(lpxK)
TSE : THMIRHAS_14810(lpxK)
TZO : THMIRHAT_13800(lpxK)
TNI : TVNIR_0840(lpxK_[H])
GAI : IMCC3135_24715(lpxK)
THIC : TspCOW1_08420(lpxK)
HCO : LOKO_01183(lpxK_1) LOKO_01299(lpxK_2)
HAXI : HAALTHF_32840n(lpxK)
AEL : NCTC12917_02711(lpxK)
CHJ : NCTC10426_01328(lpxK)
CDIZ : CEDIAZO_01781(lpxK)
NMM : NMBM01240149_1421(lpxK)
NMS : NMBM01240355_0670(lpxK)
NMQ : NMBM04240196_1495(lpxK)
NMZ : NMBNZ0533_0718(lpxK)
NMX : NMA510612_0976(lpxK)
NWE : SAMEA3174300_1260(lpxK)
NZO : SAMEA4504057_1990(lpxK)
NCI : NCTC10296_01879(lpxK)
NCZ : NCTC10294_00304(lpxK)
NANI : NCTC12227_00659(lpxK)
ECOR : SAMEA4412678_1823(lpxK)
BMV : BMASAVP1_A0569(lpxK)
BML : BMA10229_A1046(lpxK)
BPM : BURPS1710b_1083(lpxK)
BPL : BURPS1106A_0930(lpxK)
BUE : BRPE67_ACDS21930(lpxK)
PLG : NCTC10937_01694(lpxK)
LMIR : NCTC12852_01397(lpxK)
BUO : BRPE64_ACDS22440(lpxK)
VTR : MYVALT_F_01040(lpxK)
BTRM : SAMEA390648703640(lpxK)
AXX : ERS451415_03930(lpxK)
LIM : L103DPR2_01866(lpxK)
LIH : L63ED372_01661(lpxK)
URU : DSM104443_03259(lpxK)
UPL : DSM104440_02807(lpxK)
FPHO : SHINM1_012060(lpxK)
RTT : RTTH1527_03380(lpxK)
RTB : RTB9991CWPP_03385(lpxK)
RBS : RHODOSMS8_00182(lpxK)
SMEL : SM2011_c00892(lpxK)
SFD : USDA257_c05250(lpxK)
SAME : SAMCFNEI73_Ch0848(lpxK)
AGR : AGROH133_04257(lpxK)
AVV : RvVAT039_22770(lpxK)
AVF : RvVAR031_10070(lpxK)
REC : RHECIAT_CH0000934(lpxK)
REL : REMIM1_CH00859(lpxK)
REP : IE4803_CH00856(lpxK)
REI : IE4771_CH00883(lpxK)
RTR : RTCIAT899_CH04060(lpxK)
RGA : RGR602_CH00903(lpxK)
RPHA : AMC79_CH00871(lpxK)
RLW : RlegWSM1455_02510(lpxK)
NEN : NCHU2750_04050(lpxK)
LAS : CLIBASIA_01430(lpxK)
BSW : IY71_10170 IY71_12150
BSG : IY72_09910 IY72_11690
BIO : BR141012304_20736(lpxK)
BSEP : HAP48_0022150(lpxK)
BCAN : BcanWSM471_33000(lpxK)
VGO : GJW-30_1_00373(lpxK)
BHS : BM1374165_00276(lpxK)
BBK : BARBAKC583_1203(lpxK)
BTX : BM1374166_00267(lpxK)
BEZ : NCTC12898_00157(lpxK)
MAQU : Maq22A_c25770(lpxK)
FIL : BN1229_v1_0158(lpxK)
FIY : BN1229_v1_0162(lpxK)
BVY : NCTC9239_00790(lpxK)
TSV : DSM104635_01310(lpxK)
RLI : RLO149_c042910(lpxK)
PHP : PhaeoP97_03261(lpxK)
PPIC : PhaeoP14_03149(lpxK)
SINL : DSM14862_00385(lpxK)
SPSE : SULPSESMR1_02987(lpxK)
RMM : ROSMUCSMR3_02996(lpxK)
AHT : ANTHELSMS3_02008(lpxK)
LVS : LOKVESSMR4R_03752(lpxK)
AALK : LGT41_0002295(lpxK)
MAES : Ga0123461_0667 Ga0123461_1370
HPO : HMPREF4655_20571(lpxK)
HPX : HMPREF0462_0386(lpxK)
HPYA : HPAKL117_01625(lpxK)
HPYK : HPAKL86_03505(lpxK)
HCL : NCTC13205_00785(lpxK)
HSH : NHP194022_09920(lpxK)
HPUL : NCTC13154_01267(lpxK)
CJV : MTVDSCj20_0820(lpxK)
CFV : CFVI03293_1034(lpxK)
CAMP : CFT03427_1059(lpxK)
CCOC : CCON33237_1285(lpxK)
CLR : UPTC16701_0866(lpxK)
CLM : UPTC16712_0896(lpxK)
CAMR : CAQ16704_0884(lpxK)
CHV : CHELV3228_1429(lpxK)
CPIN : CPIN18020_0648(lpxK)
CAMZ : CVIC12175_0741(lpxK)
GBN : GEOBRER4_32830(lpxK)
PPOR : JCM14722_11890(lpxK)
SBF : JCM31447_28800(lpxK)
VRM : 44547418_00562(lpxK)
VDN : NCTC11831_01400(lpxK)
DHO : Dia5BBH33_02590(lpxK)
MANA : MAMMFC1_02256(lpxK)
CTJT : CTJTET1_02105(lpxK)
CTFS : CTRC342_02125(lpxK)
CTHF : CTRC852_02140(lpxK)
CTCJ : CTRC943_02085(lpxK)
CTHJ : CTRC953_02085(lpxK)
CTMJ : CTRC966_02100(lpxK)
CTTJ : CTRC971_02090(lpxK)
CTJS : CTRC122_02120(lpxK)
OBG : Verru16b_02866(lpxK)
ABIW : Abiwalacus_06560(lpxK)
LCRE : Pla8534_40000(lpxK)
BTHO : Btheta7330_01132(lpxK)
BCEL : BcellWH2_01481(lpxK)
BFC : BacF7301_24305(lpxK)
PCRE : NCTC12858_01062(lpxK)
PCAG : NCTC12856_01732(lpxK)
PSOE : CE91St14_12560(lpxK)
PMZ : HMPREF0659_A5844(lpxK)
PDN : HMPREF9137_1195(lpxK)
POC : NCTC13071_01950(lpxK)
PHER : prwr041_19640(lpxK)
ACOU : A5CBH24_26430(lpxK)
ADA : A5CPEGH6_18680(lpxK)
SMIZ : 4412673_00003(lpxK)
SDJ : NCTC13534_00003(lpxK)
STHA : NCTC11429_01570(lpxK)
PSEZ : HME7025_01173(lpxK)
SPON : HME9304_02401(lpxK)
AALG : AREALGSMS7_00097(lpxK)
KOS : KORDIASMS9_02236(lpxK)
KAN : IMCC3317_39900(lpxK)
CGLE : NCTC11432_02696(lpxK)
CTAI : NCTC12078_02698(lpxK)
CTAK : 4412677_01144(lpxK)
CHRJ : CHRYMOREF3P_2275(lpxK)
CJG : NCTC13459_01519(lpxK)
CANT : NCTC13489_02642(lpxK)
KFA : Q73A0000_14830(lpxK)
PTAN : CRYO30217_00534(lpxK)
PROC : Ptc2401_00506(lpxK)
» show all
Taxonomy
Reference
Authors
Ray BL, Raetz CR.
Title
The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A.
Journal
J Biol Chem 262:1122-8 (1987)
Reference
Authors
Emptage RP, Daughtry KD, Pemble CW 4th, Raetz CR.
Title
Crystal structure of LpxK, the 4'-kinase of lipid A biosynthesis and atypical P-loop kinase functioning at the membrane interface.
Journal
Sequence
Reference
Authors
Emptage RP, Pemble CW 4th, York JD, Raetz CR, Zhou P.
Title
Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis.
Journal
Sequence
Reference
Authors
Emptage RP, Tonthat NK, York JD, Schumacher MA, Zhou P.
Title
Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.130