KEGG   ENZYME: 2.7.1.146
Entry
EC 2.7.1.146                Enzyme                                 
Name
ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase;
ADP-dependent phosphofructokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ADP:D-fructose-6-phosphate 1-phosphotransferase
Reaction(IUBMB)
ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
Reaction(KEGG)
R05805 > R09084
Substrate
ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]
Product
AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.
History
EC 2.7.1.146 created 2001
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00030  Pentose phosphate pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase
Genes
GRCGI584_20260
TCOTheco_1176
CSCIHDCHBGLK_00653
CSHClosa_0608
QDOH9Q78_06885
HALSD7D81_07845
LPILLIP_1249
MBASALGA_3097
ASACATHSA_0704
MJAMJ_1604
MFEMefer_1517
MVUMetvu_0786
MFSMFS40622_0160
MIFMetin_0227
MJHJH146_0031
MESGMLAUSG7_0561(pfkC)
MESAMLASG1_0234(pfkC)
MIGMetig_1734
MMPMMP1296(pfkC)
MMQMmarC5_0297
MMXMmarC6_1378
MMZMmarC7_0541
MMDGYY_07315
MMAKMMKA1_15210(pfkC)
MMAOMMOS7_14030(pfkC)
MMADMMJJ_15470
MAEMaeo_0005
MVNMevan_0606
MVOMvol_0050 Mvol_0110
MOKMetok_1190
METFCFE53_04560
PFUPF0312 PF1784
PFIPFC_00640 PFC_09670
PHOPH0589(PH0589) PH1645(PH1645)
PABPAB0967 PAB2013
PYNPNA2_0229 PNA2_1204
PYAPYCH_02450 PYCH_10910
PYSPy04_0618 Py04_1537
PYCTQ32_02010 TQ32_08590
TKOTK0376 TK1110
TONTON_0246 TON_1012
TGATGAM_0818(glkA) TGAM_1465(pfkC)
TSITSIB_0252 TSIB_1220
TBATERMP_00004 TERMP_01160
THEGQS_04080 GQS_10400
THATAM4_1728 TAM4_738
THMCL1_0470 CL1_1657
TLTOCC_01044 OCC_09701
THSTES1_0130 TES1_1218
TNUBD01_0151 BD01_1045
TEUTEU_06460 TEU_11110
TGYX802_00245 X802_07910
THVADU37_CDS01920 ADU37_CDS09450
TCHCHITON_1323 CHITON_1878
TPEPA0127_02440 A0127_09685
TGGA3K92_05080 A3K92_05775
TCEA3L02_00520 A3L02_03710
TBSA3L01_01790 A3L01_05875
THHCDI07_01765 CDI07_05830(pfkC)
TSLA3L11_05625 A3L11_10255
TTDA3L14_03240 A3L14_08235
TPRFA3L09_05575 A3L09_08760
TRLA3L10_00730 A3L10_04695
TPAFA3L08_05185 A3L08_09265
THYA3L12_01825 A3L12_06865
TICFH039_03970 FH039_09365(pfkC)
TCQTIRI35C_0588(glkA) TIRI35C_1487(pfkC)
THEMFPV09_00340(pfkC) FPV09_05320
THEIK1720_04385 K1720_09185(pfkC)
PPACPAP_01430 PAP_04875
MBAMbar_A2004 Mbar_A2005
MBYMSBRM_2497 MSBRM_2498
MBWMSBRW_2730 MSBRW_2731
MBARMSBR2_2474 MSBR2_2475
MBAKMSBR3_2515 MSBR3_2516
MACMA_3562(glkA) MA_3563(pfk)
MMAMM_0472 MM_0473
MMJMSMAS_0831 MSMAS_0832
MMACMSMAC_0811 MSMAC_0812
MVCMSVAZ_2547 MSVAZ_2548
MEKMSKOL_2555 MSKOL_2556
MLSMSLAZ_2352 MSLAZ_2353
METMMSMTP_2385 MSMTP_2386
MEFMSWH1_2360 MSWH1_2361
MEQMSWHS_2732 MSWHS_2733
MSJMSSAC_3156 MSSAC_3157
MSZMSSIH_0989 MSSIH_0990
MSWMSSIT_1026 MSSIT_1027
MTHRMSTHT_1057 MSTHT_1058
MTHEMSTHC_2246 MSTHC_2247
MHORMSHOH_0977 MSHOH_0978
MFZAOB57_011160 AOB57_011165(pfkC)
MBUMbur_1338 Mbur_1339
MMETMCMEM_1827 MCMEM_1828
MELOJ7W08_08075 J7W08_08080(pfkC)
MMHMmah_1645 Mmah_1646
MHAZBHR79_05490 BHR79_05495
MEVMetev_0816 Metev_0817
MZHMzhil_0819 Mzhil_0820
MPYMpsy_1159 Mpsy_1160
MZIHWN40_02795 HWN40_02800
MHZMetho_2034 Metho_2035
MTPMthe_1214
MCJMCON_0234(pfkC)
MBNMboo_1525
HSNDV733_07550
SRUBC2R22_19410
HALUHUG12_09055
NMGNmag_3826
NGENatgr_2898
HRUHalru_0715 Halru_2961
HLCCHINAEXTREME19235
NAJB1756_05745
NAGAArcMg_1072
NANAArc1_2551
NBGDV706_17425
NASGCU68_12220
SAWLNGM29_19280
NACAQV86_01495
FLTSv326_0933
NCONLC1Nh_0114
 » show all
Reference
1  [PMID:10409652]
  Authors
Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.
  Title
Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 274:21023-8 (1999)
DOI:10.1074/jbc.274.30.21023
  Sequence
[pfu:PF1784]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.146
IUBMB Enzyme Nomenclature: 2.7.1.146
ExPASy - ENZYME nomenclature database: 2.7.1.146
BRENDA, the Enzyme Database: 2.7.1.146
CAS: 237739-62-7

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