KEGG ENZYME: 2.7.1.146

ENZYME: 2.7.1.146

Entry

EC 2.7.1.146                Enzyme

Name

ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase;
ADP-dependent phosphofructokinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ADP:D-fructose-6-phosphate 1-phosphotransferase

Reaction(IUBMB)

ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]

Reaction(KEGG)

R05805 > R09084

Substrate

ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]

Product

AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]

Comment

ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.

History

EC 2.7.1.146 created 2001

Pathway

ec00010

Glycolysis / Gluconeogenesis

ec00030

Pentose phosphate pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K00918

ADP-dependent phosphofructokinase/glucokinase

Genes

GRC:	GI584_20260

TCO:	Theco_1176

CSCI:

HDCHBGLK_00653

CSH:	Closa_0608

QDO:	H9Q78_06885

HALS:

D7D81_07845

LPIL:

LIP_1249

MBAS:

ALGA_3097

ASAC:

ATHSA_0704

MJA:

MJ_1604

MFE:	Mefer_1517

MVU:	Metvu_0786

MFS:	MFS40622_0160

MIF:	Metin_0227

MJH:	JH146_0031

MESG:

MLAUSG7_0561(pfkC)

MESA:

MLASG1_0234(pfkC)

MIG:	Metig_1734

MMP:	MMP1296(pfkC)

MMQ:	MmarC5_0297

MMX:	MmarC6_1378

MMZ:	MmarC7_0541

MMD:

GYY_07315

MMAK:

MMKA1_15210(pfkC)

MMAO:

MMOS7_14030(pfkC)

MMAD:

MMJJ_15470

MAE:

Maeo_0005

MVN:	Mevan_0606

MVO:	Mvol_0050 Mvol_0110

MOK:	Metok_1190

METF:

CFE53_04560

PFU:	PF0312 PF1784

PFI:	PFC_00640 PFC_09670

PHO:	PH0589(PH0589) PH1645(PH1645)

PAB:	PAB0967 PAB2013

PYN:	PNA2_0229 PNA2_1204

PYA:	PYCH_02450 PYCH_10910

PYS:	Py04_0618 Py04_1537

PYC:	TQ32_02010 TQ32_08590

TKO:	TK0376 TK1110

TON:	TON_0246 TON_1012

TGA:	TGAM_0818(glkA) TGAM_1465(pfkC)

TSI:	TSIB_0252 TSIB_1220

TBA:	TERMP_00004 TERMP_01160

THE:	GQS_04080 GQS_10400

THA:	TAM4_1728 TAM4_738

THM:	CL1_0470 CL1_1657

TLT:	OCC_01044 OCC_09701

THS:	TES1_0130 TES1_1218

TNU:	BD01_0151 BD01_1045

TEU:	TEU_06460 TEU_11110

TGY:	X802_00245 X802_07910

THV:	ADU37_CDS01920 ADU37_CDS09450

TCH:	CHITON_1323 CHITON_1878

TPEP:

A0127_02440 A0127_09685

TGG:	A3K92_05080 A3K92_05775

TCE:	A3L02_00520 A3L02_03710

TBS:	A3L01_01790 A3L01_05875

THH:	CDI07_01765 CDI07_05830(pfkC)

TSL:	A3L11_05625 A3L11_10255

TTD:	A3L14_03240 A3L14_08235

TPRF:

A3L09_05575 A3L09_08760

TRL:	A3L10_00730 A3L10_04695

TPAF:

A3L08_05185 A3L08_09265

THY:	A3L12_01825 A3L12_06865

TIC:	FH039_03970 FH039_09365(pfkC)

TCQ:	TIRI35C_0588(glkA) TIRI35C_1487(pfkC)

THEM:

FPV09_00340(pfkC) FPV09_05320

THEI:

K1720_04385 K1720_09185(pfkC)

PPAC:

PAP_01430 PAP_04875

MBA:	Mbar_A2004 Mbar_A2005

MBY:	MSBRM_2497 MSBRM_2498

MBW:	MSBRW_2730 MSBRW_2731

MBAR:

MSBR2_2474 MSBR2_2475

MBAK:

MSBR3_2515 MSBR3_2516

MAC:	MA_3562(glkA) MA_3563(pfk)

MMA:	MM_0472 MM_0473

MMJ:	MSMAS_0831 MSMAS_0832

MMAC:

MSMAC_0811 MSMAC_0812

MVC:	MSVAZ_2547 MSVAZ_2548

MEK:	MSKOL_2555 MSKOL_2556

MLS:	MSLAZ_2352 MSLAZ_2353

METM:

MSMTP_2385 MSMTP_2386

MEF:	MSWH1_2360 MSWH1_2361

MEQ:	MSWHS_2732 MSWHS_2733

MSJ:	MSSAC_3156 MSSAC_3157

MSZ:	MSSIH_0989 MSSIH_0990

MSW:	MSSIT_1026 MSSIT_1027

MTHR:

MSTHT_1057 MSTHT_1058

MTHE:

MSTHC_2246 MSTHC_2247

MHOR:

MSHOH_0977 MSHOH_0978

MFZ:	AOB57_011160 AOB57_011165(pfkC)

MBU:	Mbur_1338 Mbur_1339

MMET:

MCMEM_1827 MCMEM_1828

MELO:

J7W08_08075 J7W08_08080(pfkC)

MMH:	Mmah_1645 Mmah_1646

MHAZ:

BHR79_05490 BHR79_05495

MEV:	Metev_0816 Metev_0817

MZH:	Mzhil_0819 Mzhil_0820

MPY:	Mpsy_1159 Mpsy_1160

MZI:	HWN40_02795 HWN40_02800

MHZ:	Metho_2034 Metho_2035

MTP:

Mthe_1214

MCJ:	MCON_0234(pfkC)

MBN:

Mboo_1525

HSN:	DV733_07550

SRUB:

C2R22_19410

HALU:

HUG12_09055

NMG:

Nmag_3826

NGE:	Natgr_2898

HRU:	Halru_0715 Halru_2961

HLC:	CHINAEXTREME19235

NAJ:	B1756_05745

NAG:	AArcMg_1072

NAN:	AArc1_2551

NBG:	DV706_17425

NAS:	GCU68_12220

SAWL:

NGM29_19280

NAC:	AQV86_01495

FLT:	Sv326_0933

NCON:

LC1Nh_0114

» show all

Reference

1 [PMID:10409652]

Authors

Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.

Title

Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.

Journal

J Biol Chem 274:21023-8 (1999)
DOI:10.1074/jbc.274.30.21023

Sequence

[pfu:PF1784]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.146

IUBMB Enzyme Nomenclature:

2.7.1.146

ExPASy - ENZYME nomenclature database:

2.7.1.146

BRENDA, the Enzyme Database:

2.7.1.146

CAS:	237739-62-7

DBGET integrated database retrieval system