KEGG   ENZYME: 2.7.1.147Help
Entry
EC 2.7.1.147                Enzyme                                 

Name
ADP-specific glucokinase;
ADP-dependent glucokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ADP:D-glucose 6-phosphotransferase
Reaction(IUBMB)
ADP + D-glucose = AMP + D-glucose 6-phosphate [RN:R05804]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-glucose [CPD:C00031]
Product
AMP [CPD:C00020];
D-glucose 6-phosphate [CPD:C00092]
Comment
Requires Mg2+. The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
History
EC 2.7.1.147 created 2001
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase
K08074  ADP-dependent glucokinase
Genes
HSA: 83440(ADPGK)
PTR: 748791(ADPGK)
PPS: 100988588(ADPGK)
GGO: 101140731(ADPGK)
PON: 100173850(ADPGK)
NLE: 100596634(ADPGK)
MCC: 699257(ADPGK)
MCF: 101866506(ADPGK)
CSAB: 103245364(ADPGK)
RRO: 104673839(ADPGK)
CJC: 100385481(ADPGK)
SBQ: 101050870(ADPGK)
MMU: 72141(Adpgk)
RNO: 315722(Adpgk)
CGE: 100754978(Adpgk)
NGI: 103736851(Adpgk)
HGL: 101717458(Adpgk)
CCAN: 109687654(Adpgk)
OCU: 100347024(ADPGK)
TUP: 102498911(ADPGK)
CFA: 478360(ADPGK)
AML: 100473629(ADPGK)
UMR: 103679135(ADPGK)
ORO: 101378614(ADPGK)
FCA: 101088581(ADPGK)
PTG: 102961110(ADPGK)
AJU: 106974196(ADPGK)
BTA: 518158(ADPGK)
BOM: 102286604(ADPGK)
BIU: 109564750(ADPGK)
PHD: 102330752(ADPGK)
CHX: 102181503(ADPGK)
OAS: 101116836(ADPGK)
SSC: 100623786(ADPGK)
CFR: 102523920(ADPGK)
CDK: 105087286(ADPGK)
BACU: 103021058(ADPGK)
LVE: 103082058(ADPGK)
OOR: 101278987(ADPGK)
ECB: 100052166(ADPGK)
EPZ: 103555465(ADPGK)
EAI: 106836645(ADPGK)
MYB: 102260287(ADPGK)
MYD: 102775076(ADPGK)
HAI: 109391764(ADPGK)
RSS: 109449588(ADPGK)
PALE: 102897483(ADPGK)
LAV: 100662497(ADPGK)
TMU: 101353805
MDO: 100016323(ADPGK)
SHR: 100921460(ADPGK)
OAA: 100077123(ADPGK)
GGA: 415317(ADPGK)
MGP: 100544507(ADPGK)
CJO: 107318502(ADPGK)
APLA: 101797470(ADPGK)
ACYG: 106044200(ADPGK)
TGU: 100230242(ADPGK)
GFR: 102040116(ADPGK)
FAB: 101814955(ADPGK)
PHI: 102108989(ADPGK)
PMAJ: 107209369(ADPGK)
CCW: 104697511(ADPGK)
FPG: 101912436(ADPGK)
FCH: 102052366(ADPGK)
CLV: 102093047(ADPGK)
EGZ: 104130704(ADPGK)
AAM: 106486110(ADPGK)
ASN: 102369271(ADPGK)
AMJ: 102576175(ADPGK)
PSS: 102444452(ADPGK)
CMY: 102945709(ADPGK)
CPIC: 101937495(ADPGK)
ACS: 100567625(adpgk)
PVT: 110084388(ADPGK)
PBI: 103059020(ADPGK)
GJA: 107116940(ADPGK)
NPR: 108784070(ADPGK) 108792739
DRE: 557919(adpgk) 566398(adpgk2)
IPU: 108269756 108275069(adpgk)
AMEX: 103040241 103047422(adpgk)
TRU: 101076196(adpgk) 101076203
LCO: 104920148 104929546(adpgk)
OLA: 101160066(adpgk) 101160396
XMA: 102225042(adpgk) 102232621
PRET: 103461108(adpgk) 103462836
NFU: 107381177 107395420(adpgk)
CSEM: 103379410(adpgk) 103379918
LCF: 108877019 108883016(adpgk)
BPEC: 110169162(adpgk) 110172923
ELS: 105016080 105018670(adpgk)
LCM: 102354033 102364267(ADPGK)
CMK: 103178909 103188726(adpgk)
DSI: Dsimw501_GD14473(Dsim_GD14473)
MDE: 101896047
AAG: 110676244
AME: 413336
BIM: 100749517
BTER: 100652288
SOC: 105205417
AEC: 105145579
ACEP: 105620980
PBAR: 105429499
HST: 105183903
CFO: 105249194
LHU: 105674879
PGC: 109855885
NVI: 100118248
BMOR: 101746527
PMAC: 106711958
PRAP: 111001851
ZNE: 110841380
TUT: 107361191
CEL: CELE_C50D2.7(C50D2.7)
CBR: CBG06989
BMY: Bm1_43195
TSP: Tsp_05422
EPA: 110250152
ADF: 107332063
HMG: 100213786
DDI: DDB_G0287631(glk)
DFA: DFA_06097(cmfA)
SPAR: SPRG_15821
TPYO: X956_09010
MBAS: ALGA_3097
MJA: MJ_1604
MMP: MMP1296(pfkC)
MMD: GYY_07315
MAE: Maeo_0005
MAC: MA_3562(glkA) MA_3563(pfk)
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
NMG: Nmag_3826
PHO: PH0589(PH0589) PH1645(PH1645)
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
 » show all
Taxonomy
Reference
1  [PMID:8530474]
  Authors
Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM.
  Title
Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 270:30453-7 (1995)
DOI:10.1074/jbc.270.51.30453
  Sequence
[pfu:PF0312]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.147
IUBMB Enzyme Nomenclature: 2.7.1.147
ExPASy - ENZYME nomenclature database: 2.7.1.147
BRENDA, the Enzyme Database: 2.7.1.147
CAS: 173585-07-4

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