Entry
Name
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
CDP-ME kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase
Reaction(IUBMB)
ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [RN:
R05634 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [CPD:
C11435 ]
Product
ADP [CPD:
C00008 ];
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [CPD:
C11436 ]
Comment
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
History
EC 2.7.1.148 created 2001
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00919 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Genes
CSAT : 104752589 104787046
GSJ : 114382385 114391539 114403861
LJA : Lj6g3v1008180.1(Lj6g3v1008180.1)
LANG : 109328894 109346032
CMAX : 111467031 111485475
CMOS : 111440850 111461420
MESC : 110608474 110628142
PEU : 105119635 105132979 105137824
PALZ : 118045343 118053850
CANN : 107875745 124890251
SSPL : 121748016 121751905
CSIN : 114275276 114306680
PSOM : 113307890 113322684
DOSA : Os01t0802100-01(Os01g0802100)
TAES : 123062324 123071089 123079457
PVIR : 120673866 120708375
ZOF : 121988991 121988994 121995288 121997931 122011484 122016295
SMO : SELMODRAFT_180163 SELMODRAFT_74466
CVR : CHLNCDRAFT_33454(CMK)
SMIN : v1.2.000957.t1(symbB.v1.2.000957.t1)
PTI : PHATRDRAFT_51700(CMK)
FCY : FRACYDRAFT_267640(CMK)
ECOO : ECRM13514_1575(ipk)
ECOH : ECRM13516_1535(ipk)
ELR : ECO55CA74_07210(ipk)
ECW : EcE24377A_1356(ispE)
EDJ : ECDH1ME8569_1147(ispE)
ECOI : ECOPMV1_01337(ispE)
SEEH : SEEH1578_18155(ipk)
SENJ : CFSAN001992_02575(ipk)
RTG : NCTC13098_02982(ispE)
REE : electrica_02029(ispE)
CLAP : NCTC11466_01987(ispE)
KIE : NCTC12125_01066(ispE)
METY : MRY16398_31270(ispE)
AHN : NCTC12129_03016(ispE)
PTF : PROFFT_A_06470(ispE)
PSHI : SAMEA2665130_1002(ispE)
YPG : YpAngola_A2463(ispE)
YPI : YpsIP31758_2069(ispE)
SMW : SMWW4_v1c20080(ispE)
SFJ : SAMEA4384070_2058(ispE)
SOF : NCTC11214_04045(ispE)
PAQU : DMB82_0010440(ispE)
DIC : Dpoa569_001871(ispE)
EHD : ERCIPSTX3056_404(ispE)
BAPF : BUMPF009_CDS00425(ipk)
BAPG : BUMPG002_CDS00426(ipk)
BAPU : BUMPUSDA_CDS00424(ipk)
BAPW : BUMPW106_CDS00425(ipk)
TPTY : NCTC11468_01699(ispE)
PHEI : NCTC12003_02218(ispE)
PRJ : NCTC6933_01750(ispE)
LRI : NCTC12151_02042(ispE)
HIC : NTHIC486_01482(ispE)
HPIT : NCTC13334_01519(ispE)
HHZ : NCTC10839_01255(ispE)
HAEG : NCTC8502_01392(ispE)
PDAG : 4362423_00616(ispE)
ADP : NCTC12871_00230(ipk)
ALIG : NCTC10568_00580(ipk)
ASEG : NCTC10977_01073(ispE)
AVT : NCTC3438_01082(ispE)
RPNE : NCTC8284_01768(ispE_2)
PAET : NCTC13378_00498(ispE)
XFU : XFF4834R_chr09540(ispE)
XPH : XppCFBP6546_06775(ispE)
XHD : LMG31886_33990(ispE)
VAU : VANGNB10_cI1981(ispE)
VPL : SA104470976_00642(ipk)
PVD : CFBP1590__4412(ispE)
PPRC : PFLCHA0_c51230(ispE)
PFW : PF1751_v1c07030(ispE)
PFF : PFLUOLIPICF704655(ipk)
PPUU : PputUW4_04581(ispE)
PTRT : HU722_0004860(ispE)
PTW : TUM18999_51550(ispE)
PTAE : NCTC10697_03685(ispE)
ACUM : C9E88_015735(ispE) C9E88_17250(ispE)
MCAT : MC25239_00215(ispE)
MCUN : NCTC10297_00309(ispE)
SCAA : TUM17387_10150(ispE)
SALH : HMF8227_01009(ispE)
MISZ : MishRS11D_36860(ispE)
TNI : TVNIR_2674(ispE_[H])
GAI : IMCC3135_10690(ispE)
THIC : TspCOW1_29610(ispE)
HSV : HNO53_12955 HNO53_14120(ispE)
CDIZ : CEDIAZO_01438(ispE)
NMM : NMBM01240149_1220(ispE)
NMS : NMBM01240355_0868(ispE)
NMQ : NMBM04240196_1290(ispE)
NMZ : NMBNZ0533_0918(ispE)
NWE : SAMEA3174300_0290(ipk)
NZO : SAMEA4504057_2009(ipk)
NCI : NCTC10296_00259(ipk)
NCZ : NCTC10294_00920(ipk)
NANI : NCTC12227_01409(ipk)
ECOR : SAMEA4412678_1083(ispE)
REH : H16_A0374(h16_A0374)
BMV : BMASAVP1_A0086(ispE)
BML : BMA10229_A1504(ispE)
BPM : BURPS1710b_0755(ispE)
BPL : BURPS1106A_0587(ispE)
BUE : BRPE67_ACDS02370(ispE)
PLG : NCTC10937_04399(ipk)
BUO : BRPE64_ACDS02430(ispE)
VTR : MYVALT_G_01130(ispE)
BTRM : SAMEA390648701827(ipk)
AXX : ERS451415_05365(ispE)
LIM : L103DPR2_00891(ispE)
LIH : L63ED372_02350(ispE)
URU : DSM104443_00374(ispE)
UPL : DSM104440_00423(ispE)
FPHO : SHINM1_000430(ispE)
ERU : Erum3340(probable_ispE)
ERW : ERWE_CDS_03410(ispE)
ERG : ERGA_CDS_03370(ispE)
RBS : RHODOSMS8_00262(ispE)
SMEL : SM2011_c00862(ispE)
SFD : USDA257_c05540(ispE)
SAME : SAMCFNEI73_Ch0880(ispE)
AVV : RvVAT039_23070(ispE)
AVF : RvVAR031_10370(ispE)
REC : RHECIAT_CH0000963(ispE)
REL : REMIM1_CH00887(ispE)
REP : IE4803_CH00885(ispE)
REI : IE4771_CH00913(ispE)
RTR : RTCIAT899_CH04200(ispE)
RGA : RGR602_CH00934(ispE)
RPHA : AMC79_CH00901(ispE)
BIO : BR141012304_10164(ispE)
VGO : GJW-30_1_01583(ispE)
BHS : BM1374165_00400(ispE)
BBK : BARBAKC583_0387(ispE)
BTX : BM1374166_00593(ispE)
BEZ : NCTC12898_00274(ispE)
MAQU : Maq22A_1p34295(ispE)
MTUN : MTUNDRAET4_0701(ispE)
FIL : BN1229_v1_3914(ispE)
FIY : BN1229_v1_3902(ispE)
BVY : NCTC9239_00660(ispE)
TSV : DSM104635_02655(ispE)
RLI : RLO149_c027580(ispE)
SINL : DSM14862_00643(ispE)
SPSE : SULPSESMR1_02446(ispE)
RMM : ROSMUCSMR3_01866(ispE)
AHT : ANTHELSMS3_00461(ispE)
LVS : LOKVESSMR4R_02940(ispE)
SBIN : SBA_ch1_25070(ispE)
SFLA : SPHFLASMR4Y_00842(ispE)
HGN : E6W36_12745 E6W36_12750
HPO : HMPREF4655_20038(ispE)
HPX : HMPREF0462_1423(ispE)
HCL : NCTC13205_00042(ispE)
HSH : NHP194022_06860(ispE)
SMAS : HUE87_02000 HUE87_03520
CJV : MTVDSCj20_1108(ispE)
CFV : CFVI03293_0680(ispE)
CAMP : CFT03427_0703(ispE)
CCOC : CCON33237_0709(ispE)
CLR : UPTC16701_1028(ispE)
CLM : UPTC16712_1058(ispE)
CAMR : CAQ16704_1046(ispE)
CHV : CHELV3228_1146(ispE)
CPIN : CPIN18020_0673(ispE)
CAMZ : CVIC12175_0787(ispE)
GBN : GEOBRER4_14530(ispE)
BSON : S101395_00060(ispE)
BFD : NCTC4823_04168(ispE)
PARG : PspKH34_00420(ispE)
BLEN : NCTC4824_00056(ispE)
SUQ : HMPREF0772_10025(ispE)
SUF : SARLGA251_04290(ispE)
SAUT : SAI1T1_2003680(ispE)
SAUJ : SAI2T2_1003680(ispE)
SAUK : SAI3T3_1003680(ispE)
SAUQ : SAI4T8_1003680(ispE)
SAUV : SAI7S6_1003670(ispE)
SAUW : SAI5S5_1003660(ispE)
SAUX : SAI6T6_1003670(ispE)
SAUY : SAI8T7_1003670(ispE)
SDP : NCTC12225_02520(ispE)
SPIC : SAMEA4384060_2395(ispE)
SSH : NCTC13712_00427(ispE)
SSIM : SAMEA4384339_0421(ispE)
SSTE : SAMEA4384403_2382(ispE)
LMOC : LMOSLCC5850_0184(ispE)
LMW : LMOSLCC2755_0189(ispE)
LMX : LMOSLCC2372_0191(ispE)
LMZ : LMOSLCC2482_0190(ispE)
LMON : LMOSLCC2376_0161(ispE)
LMOS : LMOSLCC7179_0184(ispE)
LMOO : LMOSLCC2378_0203(ispE)
LMOY : LMOSLCC2479_0190(ispE)
LMOT : LMOSLCC2540_0193(ispE)
LMOA : LMOATCC19117_0199(ispE)
LGZ : NCTC10812_00155(ispE)
PPQ : PPSQR21_000340(ispE)
COHN : KCTCHS21_00410(ispE)
SPOR : SporoP33_09570(ipk)
SURE : SporoP32a_09885(ipk)
SGG : SGGBAA2069_c00970(ipk)
SFER : NCTC12278_00292(ipk)
SCAI : NCTC12191_00445(ipk)
SPSU : NCTC13786_01075(ipk)
SPOC : NCTC10925_00131(ipk)
SURN : NCTC13766_02141(ispE)
LRU : HMPREF0538_21392(ispE)
EFAU : EFAU085_02723(ispE)
EFU : HMPREF0351_12585(ispE)
ECEC : NCTC12421_02305(ispE)
AUR : HMPREF9243_1679(ispE)
CCOH : SAMEA4530647_0141(ipk)
CGEL : psyc5s11_05520(ispE)
SMAN : C12CBH8_10970(ispE)
PFAA : MM59RIKEN_33810(ispE)
VFA : MM35RIKEN_05550(ispE)
VCOP : MM50RIKEN_07370(ispE)
BPRO : PMF13cell1_00088(ispE)
CSCI : HDCHBGLK_01441(ispE)
ACEL : acsn021_00700(ispE)
ACHT : bsdcttw_48320(ispE)
PDF : CD630DERM_35660(ispE)
FAA : HMPREF0389_00533(ispE)
PHX : KGNDJEFE_00011(ispE)
CBAR : PATL70BA_2216(ispE)
ABUT : Ami103574_01825(ispE)
ETM : CE91St48_02780(ispE)
CDIA : CaldiYA01_09730(ispE)
PHAR : NCTC13077_00353(ispE)
PIV : NCTC13079_01065(ispE)
VRM : 44547418_01648(ispE)
VDN : NCTC11831_01674(ispE)
MANA : MAMMFC1_00956(ispE)
PFAC : PFJ30894_00794(ispE)
AARG : Aargi30884_19720(ispE)
ABSI : A9CBEGH2_17660(ispE)
FIT : Fi14EGH31_00320(ispE)
SDI : SDIMI_v3c08410(ispE)
STAI : STAIW_v1c10920(ispE)
SAPI : SAPIS_v1c09860(ispE)
SCQ : SCULI_v1c10570(ispE)
SSAB : SSABA_v1c09180(ispE)
SATR : SATRI_v1c12490(ispE)
SERI : SERIO_v1c12190(ispE)
STUR : STURON_001072(ispE)
SLL : SLITO_v1c10980(ispE)
SCJ : SCANT_v1c10040(ispE)
SHJ : SHELI_v1c11400(ispE)
SFZ : SFLOR_v1c11250(ispE)
SCOU : SCORR_v1c09920(ispE)
STAB : STABA_v1c11040(ispE)
SMOO : SMONO_v1c08020(ispE)
SALX : SALLE_v1c11250(ispE)
SGQ : SGLAD_v1c10110(ispE)
SCHI : SCHIN_v1c12130(ispE)
MGN : HFMG06NCA_0063(ispE)
MGS : HFMG95NCA_0063(ispE)
MGT : HFMG01NYA_0063(ispE)
MGV : HFMG94VAA_0063(ispE)
MGW : HFMG01WIA_0063(ispE)
MGAC : HFMG06CAA_0063(ispE)
MGAN : HFMG08NCA_0063(ispE)
MGNC : HFMG96NCA_0063(ispE)
MPE : MYPE10380(MYPE10380)
MMAE : MMARE11_42910(ispE)
MBAI : MB901379_03927(ispE)
MHEK : JMUB5695_01239(ispE)
MPHL : MPHLCCUG_04376(ispE)
MTHN : 4412656_03645(ispE)
MAUU : NCTC10437_04519(ispE)
MFLV : NCTC10271_00959(ispE)