KEGG   ENZYME: 2.7.1.151Help
Entry
EC 2.7.1.151                Enzyme                                 

Name
inositol-polyphosphate multikinase;
IpK2;
IP3/IP4 6-/3-kinase;
IP3/IP4 dual-specificity 6-/3-kinase;
IpmK;
ArgRIII;
AtIpk2alpha;
AtIpk2beta;
inositol polyphosphate 6-/3-/5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
Reaction(IUBMB)
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction) [RN:R10065];
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate [RN:R05800];
(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R05801]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:C11555]
Comment
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].
History
EC 2.7.1.151 created 2002, modified 2006
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K00915  inositol-polyphosphate multikinase
Genes
HSA: 253430(IPMK)
PTR: 450471(IPMK)
PPS: 100973083(IPMK)
GGO: 101154364(IPMK)
PON: 100462505(IPMK)
NLE: 100592716(IPMK)
MCC: 703630(IPMK)
MCF: 102143477(IPMK)
CSAB: 103216169(IPMK)
RRO: 104665616(IPMK)
RBB: 108540730(IPMK)
CJC: 100415637(IPMK)
SBQ: 101051501(IPMK)
MMU: 69718(Ipmk)
MCAL: 110303748(Ipmk)
MPAH: 110326626(Ipmk)
RNO: 171458(Ipmk)
MUN: 110559937(Ipmk)
CGE: 100772629(Ipmk)
NGI: 103730748(Ipmk)
HGL: 101700113(Ipmk)
CCAN: 109696228(Ipmk)
OCU: 100355723(IPMK)
TUP: 102483332(IPMK)
VVP: 112931055(IPMK)
AML: 100478367(IPMK)
UMR: 103667727(IPMK)
UAH: 113259062(IPMK)
ORO: 101366273(IPMK)
ELK: 111144965
FCA: 101098826(IPMK)
PTG: 102959812(IPMK)
PPAD: 109258863(IPMK)
AJU: 106973131(IPMK)
BTA: 615135(IPMK)
BOM: 102287037(IPMK)
BIU: 109553141(IPMK)
BBUB: 102400077(IPMK)
CHX: 102177585(IPMK)
OAS: 101120714(IPMK)
SSC: 100623323(IPMK)
CFR: 102520396(IPMK)
CDK: 105093838(IPMK)
BACU: 103013713(IPMK)
LVE: 103080830(IPMK)
OOR: 101280269(IPMK)
DLE: 111172551(IPMK)
PCAD: 102975028 102996268(IPMK)
ECB: 100072153(IPMK)
EPZ: 103550049(IPMK)
EAI: 106838737(IPMK)
MYB: 102254091(IPMK)
MYD: 102753565 102755711(IPMK)
MNA: 107543337(IPMK)
HAI: 109377792 109380619(IPMK)
DRO: 112305490(IPMK)
PALE: 102888012(IPMK)
RAY: 107501472(IPMK)
MJV: 108394158(IPMK)
LAV: 100665963(IPMK)
TMU: 101348316
MDO: 100024450(IPMK)
SHR: 100931610(IPMK)
PCW: 110216387(IPMK)
OAA: 100076322(IPMK)
GGA: 101751177(IPMK)
MGP: 100539865(IPMK)
CJO: 107315641(IPMK)
NMEL: 110400645(IPMK)
APLA: 101804228(IPMK)
ACYG: 106030987(IPMK)
TGU: 100225175(IPMK)
LSR: 110473330(IPMK)
SCAN: 103814222(IPMK)
GFR: 102036262(IPMK)
FAB: 101808343(IPMK)
PHI: 102102225(IPMK)
PMAJ: 107215911(IPMK)
CCAE: 111931648(IPMK)
CCW: 104695108(IPMK)
ETL: 114060290(IPMK) 114071299
FPG: 101922653(IPMK)
FCH: 102053151(IPMK)
CLV: 102098297(IPMK)
EGZ: 104128403(IPMK)
NNI: 104013568(IPMK)
ACUN: 113481828(IPMK)
PADL: 103916492(IPMK)
AAM: 106498578(IPMK)
ASN: 102379224(IPMK)
AMJ: 102574742(IPMK)
PSS: 102448749(IPMK)
CMY: 102934554(IPMK)
CPIC: 101949940(IPMK)
ACS: 100560539(ipmk)
PVT: 110073675(IPMK)
PBI: 103050503(IPMK)
PMUR: 107285107(IPMK)
TSR: 106550724(IPMK)
PMUA: 114597267(IPMK)
GJA: 107124655(IPMK)
XLA: 108697359(ipmk.S) 447535(ipmk.L)
XTR: 100485175(ipmk)
NPR: 108788857(IPMK)
DRE: 100151036(ipmka) 790916(ipmkb)
IPU: 108263300 108274002(ipmk)
PHYP: 113527504(ipmk) 113541013
AMEX: 103031896 103035921(ipmk)
EEE: 113576897 113577017(ipmk)
TRU: 101068659(ipmk)
LCO: 104938069(ipmk)
NCC: 104954473(ipmk)
MZE: 101484766(ipmk)
ONL: 100697543(ipmk)
OLA: 101168158(ipmk)
XMA: 102236019(ipmk)
XCO: 114150691(ipmk)
PRET: 103482182(ipmk)
CVG: 107087638(ipmk)
NFU: 107396954(ipmk)
AOCE: 111588282(ipmk)
CSEM: 103381652(ipmk)
POV: 109627029(ipmk)
LCF: 108876813(ipmk)
SDU: 111237040(ipmk)
SLAL: 111664336(ipmk)
HCQ: 109529284(ipmk)
BPEC: 110154216(ipmk)
MALB: 109966674(ipmk)
ELS: 105006191(ipmk)
SFM: 108932688 108939714(ipmk)
PKI: 111853742(ipmk)
LCM: 102351435(IPMK)
CMK: 103180913(ipmk)
RTP: 109929881(ipmk)
CIN: 100181124
SPU: 576026
APLC: 110988184
DME: Dmel_CG13688(Ipk2)
DER: 6542207
DSI: Dsimw501_GD22857(Dsim_GD22857)
DSR: 110178181
DPE: 6589590
DMN: 108162765
DWI: 6644172
DAZ: 108611529
DNV: 115561995
DHE: 111599180
MDE: 101890959
LCQ: 111680509
AAG: 5576218
AALB: 115260379
AME: 724909
BIM: 100741069
BTER: 100647372
CCAL: 108626431
OBB: 114875638
SOC: 105194884
MPHA: 105829000
AEC: 105153183
ACEP: 105621350
PBAR: 105427938
VEM: 105570074
HST: 105184462
DQU: 106743474
CFO: 105253694
LHU: 105671661
PGC: 109861092
OBO: 105277647
PCF: 106789901
NVI: 100121919
CSOL: 105367488
MDL: 103576872
TCA: 661775
DPA: 109544545
ATD: 109608507
NVL: 108558778
BMOR: 101740910
BMAN: 114250148
PMAC: 106713113
PRAP: 110999112
HAW: 110380263
TNL: 113503788
API: 100166192
AGS: 114122779
RMD: 113553182
BTAB: 109033460
CLEC: 106674014
ZNE: 110831036
FCD: 110853922
TUT: 107360338
DPTE: 113799174
PTEP: 107444393
CEL: CELE_ZK795.1(ipmk-1)
CBR: CBG13522
BMY: Bm1_39650
TSP: Tsp_05937
PCAN: 112556725
CRG: 105329464
MYI: 110449876
OBI: 106870575
LAK: 106156040
ADF: 107358834
AMIL: 114972815
PDAM: 113678722
SPIS: 111328026
DGT: 114528564
HMG: 101241397
ATH: AT5G07370(IPK2a) AT5G61760(IPK2BETA)
THJ: 104818295
CPAP: 110820479
CIT: 102615927
TCC: 18605232
DZI: 111291280
GMX: 100127407(IPK2)
GSJ: 114378283
VRA: 106756308
CAM: 101499122
LJA: Lj3g3v0463560.1(Lj3g3v0463560.1)
ADU: 107463105
AIP: 107612848
FVE: 101314526
RCN: 112178712
PPER: 18776852
PMUM: 103337905
PAVI: 110757800
ZJU: 107423333
CSV: 101222676
CMO: 103494615
MCHA: 111015224
CMAX: 111479614
CMOS: 111457968
CPEP: 111790999
RCU: 8275463
JCU: 105648688
HBR: 110659725
JRE: 108999223
VVI: 100250912(IPK2)
SOT: 102577543(IPMK) 102599548
INI: 109183005
SIND: 105158271
OSA: 4329509
DOSA: Os02t0523800-01(Os02g0523800)
OBR: 102703374
BDI: 100838319
ATS: 109732235(LOC109732235)
SBI: 8059604
SITA: 101764096
MUS: 103971160
DCT: 110100476
PEQ: 110032183
ATR: 18434574
PPP: 112287121
MNG: MNEG_1909
APRO: F751_5641
SCE: YDR173C(ARG82)
ERC: Ecym_4203
KMX: KLMA_50536(ARG82)
NCS: NCAS_0B03200(NCAS0B03200)
NDI: NDAI_0A01200(NDAI0A01200)
TPF: TPHA_0C02470(TPHA0C02470)
TBL: TBLA_0H01030(TBLA0H01030)
TDL: TDEL_0F04950(TDEL0F04950)
KAF: KAFR_0B06020(KAFR0B06020)
CAL: CAALFM_C209730CA(IPK2)
SLB: AWJ20_3593(ARG82)
NCR: NCU06315
NTE: NEUTE1DRAFT60460(NEUTE1DRAFT_60460)
MGR: MGG_14150
SSCK: SPSK_09096
CMT: CCM_08832
MBE: MBM_03256
ANI: AN0156.2
ANG: ANI_1_1358164(An18g04520)
ABE: ARB_03060
TVE: TRV_06092
PTE: PTT_17736
CNE: CNN02250
CNB: CNBN2290
ABP: AGABI1DRAFT121474(AGABI1DRAFT_121474)
ABV: AGABI2DRAFT209575(AGABI2DRAFT_209575)
MGL: MGL_0277
MRT: MRET_1034
SPAR: SPRG_07163
 » show all
Taxonomy
Reference
1  [PMID:10574768]
  Authors
Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH.
  Title
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
  Journal
Curr Biol 9:1323-6 (1999)
DOI:10.1016/S0960-9822(00)80055-X
  Sequence
[sce:YDR173C]
Reference
2  [PMID:10720331]
  Authors
Odom AR, Stahlberg A, Wente SR, York JD.
  Title
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
  Journal
Science 287:2026-9 (2000)
DOI:10.1126/science.287.5460.2026
Reference
3  [PMID:12226109]
  Authors
Stevenson-Paulik J, Odom AR, York JD.
  Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
  Journal
J Biol Chem 277:42711-8 (2002)
DOI:10.1074/jbc.M209112200
  Sequence
Reference
4  [PMID:15531582]
  Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW.
  Title
The pathway for the production of inositol hexakisphosphate in human cells.
  Journal
J Biol Chem 280:1911-20 (2005)
DOI:10.1074/jbc.M411528200
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.151
IUBMB Enzyme Nomenclature: 2.7.1.151
ExPASy - ENZYME nomenclature database: 2.7.1.151
BRENDA, the Enzyme Database: 2.7.1.151
CAS: 9077-69-4

DBGET integrated database retrieval system