Entry
Name
adenosylcobinamide kinase;
CobU;
adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase;
AdoCbi kinase/AdoCbi-phosphate guanylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
RTP:adenosylcobinamide phosphotransferase
Reaction(IUBMB)
RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP [where RTP is either ATP or GTP (for symbol definitions, click here)] [RN:
R05221 R06558 ]
Reaction(KEGG)
Substrate
Product
Comment
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC
2.7.7.62 and EC
2.7.1.156 ), CobT (EC
2.4.2.21 ), CobC (EC
3.1.3.73 ) and CobS (EC
2.7.8.26 ) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC
2.7.8.26 , adenosylcobinamide-GDP ribazoletransferase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC
2.7.1.156 ) and guanylyltransferase (EC
2.7.7.62 , adenosylcobinamide-phosphate guanylyltransferase) activities. However, both activities are not required at all times. The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4].
History
EC 2.7.1.156 created 2004
Pathway
Orthology
K02231 adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase
Genes
ECOO : ECRM13514_2625(cobU)
ECOH : ECRM13516_2553(cobU)
ELR : ECO55CA74_12030(cobU)
ECW : EcE24377A_2275(cobU)
ECOA : APECO78_13760(cobU)
EDJ : ECDH1ME8569_1929(cobU)
ECOI : ECOPMV1_02116(cobU)
SEM : STMDT12_C20400(cobU)
SETC : CFSAN001921_06695(cobU)
SEEN : SE451236_16300(cobU)
SENH : CFSAN002069_21730(cobU)
SEEH : SEEH1578_19370(cobU)
SENJ : CFSAN001992_01345(cobU)
SEEC : CFSAN002050_17050(cobU)
SEEB : SEEB0189_009375(cobU)
SENC : SEET0819_17235(cobU)
REE : electrica_00894(cobU)
RTG : NCTC13098_01306(cobU)
KIE : NCTC12125_00664(cobU)
BUF : D8682_20900 D8682_24285
BFT : MNO13_05120(cobU) MNO13_08265(cobU)
BSEL : RHD99_04930(cobU) RHD99_08300(cobU)
AHN : NCTC12129_00861(cobU)
LRI : NCTC12151_01594(cobU)
XFU : XFF4834R_chr14430(cobU)
XPH : XppCFBP6546_18110(cobU)
XHD : LMG31886_11680(cobP)
DCS : ISN74_02910(cobU) ISN74_13145
VAU : VANGNB10_cI1526c(cobU)
VZI : G5S32_06045(cobU) G5S32_07885(cobU)
VPL : SA104470976_00987(cobU)
VIB : VspSTUT11_13920(cobU)
VIS : VspSTUT16_18440(cobU)
PAEB : NCGM1900_5296(cobU)
PPUD : DW66_1251 DW66_1613
PVD : CFBP1590__1589(cobP)
PPRC : PFLCHA0_c44980(cobP)
PMUD : NCTC8068_03843(cobU)
PFW : PF1751_v1c39790(cobU)
PPUU : PputUW4_03769(cobU)
PTRT : HU722_0021090(cobU)
PTW : TUM18999_41200(cobP)
PTAE : NCTC10697_01157(cobP)
MSHE : MAALD49_02260(cobU)
SSE : Ssed_2160 Ssed_2162 Ssed_3732
SLJ : EGC82_06045 EGC82_11275 EGC82_11285
SCAA : TUM17387_32360(cobU)
FES : HER31_04780(cobU) HER31_04790(cobU)
TIB : THMIRHAM_09740(cobP)
TSE : THMIRHAS_14900(cobP)
TSJ : L3K52_00350(cobU) L3K52_03290(cobU)
TPUT : QJT81_01170(cobU) QJT81_03515(cobU)
TFRI : Thiofri_02323(cobP)
TNI : TVNIR_3488(cobP_[H])
GAI : IMCC3135_06220(cobP)
HEL : HELO_1818(cobU) HELO_1821
HCS : FF32_13025 FF32_13045
HAK : KO116_01848 KO116_01851
HHU : AR456_12850 AR456_12865
HCO : LOKO_03150(cobP) LOKO_03153
HALO : BWR19_06535 BWR19_06550
HHH : CLM76_13570 CLM76_13585
HBE : BEI_1062(cobP1) BEI_1064(cobP2)
HAG : BB497_14185 BB497_14200
HSV : HNO53_14375 HNO53_14390
HPRO : LMS44_13550 LMS44_13565
HQD : K1Y77_06680 K1Y77_06695
HALF : QEN58_11415 QEN58_11430
HHAO : QWG60_11885 QWG60_11900
HASO : B2G49_09475 B2G49_09490
HALW : B6N23_15605 B6N23_15620
HASH : HXW73_10550 HXW73_10565
HPIS : P1P91_09790 P1P91_09805
HAMS : NF683_14630 NF683_14645
HCAM : I4484_13975 I4484_13990
HAAH : HALA3H3_800116 HALA3H3_800119
HAXH : J4377_06880 J4377_06895
HABD : OM794_13030 OM794_13045
HQN : M0220_00810 M0220_00825
HALK : CUU95_17100 CUU95_17115
HVN : EI420_07445 EI420_07460
HOL : HORIV_40960 HORIV_41000
HPIZ : GYM47_07010 GYM47_07025
HNP : SR894_11860 SR894_11875
HTT : HZS52_14695 HZS52_14710
HMD : CTT34_07330 CTT34_07345
HAXI : HAALTHF_42450n HAALTHF_42490n
HSX : HNO51_13700 HNO51_13715
HTX : EKK97_15500 EKK97_15515
ALCA : ASALC70_01934(cobP)
BMV : BMASAVP1_A2317(cobU)
BML : BMA10229_A2970(cobU)
BPM : BURPS1710b_1199(cobU)
BPL : BURPS1106A_1044(cobU)
PLG : NCTC10937_04022(cobU)
BUO : BRPE64_ACDS06560(cobU)
CENP : M9799_00045 M9799_02010
MPT : Mpe_A2308(cobU) Mpe_B0511(cobU)
RGE : RGE_15040(cobU) RGE_44430(cobU)
RBN : RBXJA2T_12412 RBXJA2T_16407
AZA : AZKH_0611(cobU_cobP)
THAG : CKCBHOJB_03381(cobP)
FPHO : SHINM1_019320(cobU)
RBS : RHODOSMS8_03450(cobP)
SMEL : SM2011_c04305(cobP)
SFD : USDA257_c42340(cobP)
SAME : SAMCFNEI73_Ch2196(cobP)
AGR : AGROH133_06286(cobU)
ALF : CFBP5473_08375(cobU)
AVV : RvVAT039_01260(cobU)
AVF : RvVAR031_22430(cobU)
ASAL : CFBP5507_06425(cobU)
RPUS : CFBP5875_06370(cobU)
ALEG : CFBP4996_06065(cobU)
REC : RHECIAT_CH0002594(cobP)
REL : REMIM1_CH02515(cobP)
REP : IE4803_CH02541(cobP)
REI : IE4771_CH02628(cobP)
RTR : RTCIAT899_CH10625(cobP)
RGA : RGR602_CH02279(cobP)
RPHA : AMC79_CH02621(cobP)
RLW : RlegWSM1455_11945(cobU)
RBW : RLCC275e_12120(cobU)
NEN : NCHU2750_15920(cobP)
BIO : BR141012304_11389(cobU)
BSEP : HAP48_0032320(cobU)
BCAN : BcanWSM471_15505(cobU)
MAQU : Maq22A_c09395(cobU)
MMES : MMSR116_31155(cobU)
MTUN : MTUNDRAET4_2397(cobP)
FIL : BN1229_v1_1435(cobP)
FIY : BN1229_v1_1436(cobP)
BVY : NCTC9239_00630(cobP)
RLI : RLO149_c035830(cobP)
PHP : PhaeoP97_02610(cobP)
PPIC : PhaeoP14_02412(cobP)
RED : roselon_00399 roselon_02147
SINL : DSM14862_02906(cobP)
SPSE : SULPSESMR1_00058(cobP)
RMM : ROSMUCSMR3_01236(cobP)
ROH : FIU89_17295(cobP1) FIU89_18440(cobP2)
AHT : ANTHELSMS3_02533(cobP)
LVS : LOKVESSMR4R_02757(cobP)
AALK : LGT41_0004870(cobU)
NOR : FA702_01500(cobU) FA702_20575(cobU)
SHAN : PPZ50_01295(cobU) PPZ50_08565(cobU)
SJP : SJA_C2-03290(cobU_cobP)
SBD : ATN00_04765 ATN00_06855
SPPH : KFK14_02830(cobU) KFK14_09790(cobU)
SPAG : sphantq_04021(cobP)
ASZ : ASN_2613(cobU) ASN_878(cobU)
GEC : GEO60473_24330(cobU)
GBN : GEOBRER4_37050(cobU)
BIF : N288_01305 N288_01325
BWH : A9C19_10035 A9C19_10050
BBAD : K7T73_03015 K7T73_03035
BACQ : DOE78_21330 DOE78_21335
BACA : FAY30_10690 FAY30_10710
BASB : M662_03700 M662_03715
BHK : B4U37_11515 B4U37_11530
BCIR : C2I06_20915 C2I06_20935
BMQ : BMQ_1997(cobU) BMQ_2000
BMD : BMD_1953(cobU) BMD_1956
BMH : BMWSH_3280 BMWSH_3283(cobU)
BMEG : BG04_4298 BG04_4301
PKS : IE339_16025 IE339_16040
BKW : BkAM31D_10685(cobU_1) BkAM31D_10700(cobU_2)
BPF : BpOF4_15115(cobU) BpOF4_15135
BON : A361_01310 A361_01330
BKO : CKF48_08005 CKF48_08025
CFIR : NAF01_01235 NAF01_01255
CSPG : LS684_01395 LS684_01410 LS684_23175
BDA : FSZ17_03055 FSZ17_03075
GTE : GTCCBUS3UF5_25450 GTCCBUS3UF5_25480
GTK : GT3570_10755 GT3570_10770
GTM : GT3921_08215 GT3921_08230
GLI : GLN3_04195 GLN3_04210
BCAL : CWI35_17110 CWI35_17125
GTN : GTNG_2191 GTNG_2194(cobU)
GWC : GWCH70_2204 GWCH70_2207
GYC : GYMC61_0421 GYMC61_0424
GYA : GYMC52_2238 GYMC52_2241
GCT : GC56T3_1243 GC56T3_1246
GMC : GY4MC1_1293 GY4MC1_1296
GGH : GHH_c23460 GHH_c23490
GJF : M493_11645 M493_11660
GEA : GARCT_02230 GARCT_02233(cobP)
GEL : IB49_03060 IB49_03075
GSE : GT50_15855 GT50_15870
GSR : GS3922_04750 GS3922_04765
GEJ : A0V43_09255 A0V43_09270
GZA : IC807_07435 IC807_07450
GTH : Geoth_1403 Geoth_1406
PTL : AOT13_15860 AOT13_15875
PTB : DER53_15850 DER53_15865
PARG : PspKH34_12450(cobU) PspKH34_12480
AGN : AFK25_09170 AFK25_09185
AAMY : GFC30_2460 GFC30_2463
ANL : GFC29_1533 GFC29_1536
AND : GRQ40_12075 GRQ40_12090
ACAI : ISX45_09310 ISX45_09325
AAYD : B379_13115 B379_13130
LSP : Bsph_2445(cobP) Bsph_2449
LGY : T479_13080 T479_13095
LFU : HR49_14045 HR49_14060
LYS : LBYS11_09305 LBYS11_09320
LYB : C3943_18575 C3943_18590
LYZ : DCE79_05255 DCE79_05270
LYG : C1N55_12225 C1N55_12240
LPAK : GDS87_10525 GDS87_10540
LAGR : FJQ98_11520 FJQ98_11535
HMN : HM131_17685 HM131_17705
VHL : BME96_05420 BME96_05440
VNE : CFK40_06495 CFK40_06515
LAO : AOX59_07990 AOX59_08010
FAR : ABE41_016175 ABE41_016190
BTHV : CQJ30_15215 CQJ30_15225
PSYH : D0S48_09140 D0S48_09155
PSYO : PB01_03200 PB01_03220
NMK : CHR53_11220 CHR53_11240
NTM : BTDUT50_10655 BTDUT50_10670
NCM : QNK12_11690 QNK12_11710
NNV : QNH39_14530 QNH39_14545
MEKU : HUW50_24245 HUW50_24260
MSEM : GMB29_13225 GMB29_13240
MDG : K8L98_12510 K8L98_12525
AIA : AWH56_025205 AWH56_025225
BVQ : FHE72_12615 FHE72_12630
BOU : I5818_21025 I5818_21045
ALKL : MM271_14225 MM271_14245
DOM : RRU94_22420 RRU94_22440
LMOC : LMOSLCC5850_1136(cobU)
LMW : LMOSLCC2755_1139(cobU)
LMX : LMOSLCC2372_1142(cobU)
LMZ : LMOSLCC2482_1185(cobU)
LMON : LMOSLCC2376_1098(cobU)
LMOS : LMOSLCC7179_1114(cobU)
LMOO : LMOSLCC2378_1150(cobU)
LMOY : LMOSLCC2479_1143(cobU)
LMOT : LMOSLCC2540_1125(cobU)
LMOA : LMOATCC19117_1146(cobU)
BBE : BBR47_12410(cobU) BBR47_39350
BFM : BP422_01445 BP422_14985
BAGR : BA6348_11385 BA6348_22665
BCHS : JNE38_06590(cobU) JNE38_19980(cobU)
BCOP : JD108_11575(cobU) JD108_17370(cobU)
BPAB : PSE45_06185(cobU) PSE45_18270(cobU)
BAYD : BSPP4475_06660(cobU) BSPP4475_15740
BBOR : RFB14_13720(cobU) RFB14_19925(cobU)
BRUM : NDK47_14270(cobU) NDK47_20685(cobU)
BREH : HP435_06300(cobU) HP435_18780(cobU)
PPQ : PPSQR21_013600(cobU)
PXL : BS614_11245 BS614_12845
PBAC : HUB98_23925(cobU) HUB98_25350
PUI : PUW25_06290(cobU) PUW25_07640
PMAH : PTQ21_12640(cobU) PTQ21_14265
PDY : QJQ58_28180(cobU) QJQ58_29910
PPOG : QPK24_05725(cobU) QPK24_07210
PPAB : KET34_07860(cobU) KET34_09615
PEZZ : HW560_29210 HW560_31070(cobU)
CCHL : FPL14_21540 FPL14_25265
COHL : J4772_08045 J4772_09650
AFX : JZ786_00030(cobU) JZ786_07535(cobU)
ACUR : JZ785_03260(cobU) JZ785_03410(cobU)
SSIL : SOLI23_04460 SOLI23_04475
SOB : CSE16_05390 CSE16_05405
PLN : Plano_2432 Plano_2436
PRT : AUC31_13930 AUC31_13945
PLL : I858_010605 I858_010625
PANA : BBH88_06745 BBH88_06765
PDG : BCM40_03015 BCM40_03035
PHC : BBI08_09405 BBI08_09425
PMAR : B0X71_15190 B0X71_15210
PPLA : BBI15_08370 BBI15_08385
PLX : CW734_14420 CW734_14435
PMAT : BBI11_13985 BBI11_14000
PDEC : H1Q58_13295 H1Q58_13310
PLAY : DNR44_007505 DNR44_007520
KZO : NCTC404_00494 NCTC404_00497(cobP)
SPSY : AZE41_19650 AZE41_19670
SPOR : SporoP33_11295 SporoP33_11315
SPOP : SporoP37_11710 SporoP37_11730
SURE : SporoP32a_11985 SporoP32a_12000
SPOS : DV702_15960 DV702_15980
SPAE : E2C16_11700 E2C16_11720
SURL : BI350_15780 BI350_15800
RST : ATY39_16665 ATY39_16680
PANC : E2636_13650 E2636_13670
VIJ : JNUCC6_17410 JNUCC6_17425
SMEN : SAMEA4412692_0378(cobU)
AUR : HMPREF9243_1750(cobU)
CBEI : LF65_01396 LF65_01398
CSR : Cspa_c14640(cobU1) Cspa_c14660(cobU2)
CSB : CLSA_c32010(cobU) CLSA_c32030
CLT : CM240_1150 CM240_1152
CBUT : ATN24_00845 ATN24_00855
CTAE : BGI42_11190 BGI42_11200
CDY : F3K33_06770 F3K33_06780
CCOH : SAMEA4530647_0601(cobU)
CGAS : J1C67_15605 J1C67_15615
CGEL : psyc5s11_37650(cobU)
FPLA : A4U99_04095 A4U99_04105
FPRA : CG447_11845 CG447_11855
FDU : GXM22_12110 GXM22_12120
IBU : IB211_01512 IB211_01514
EUU : ADJ67_00890 ADJ67_00900
RHO : RHOM_09045 RHOM_09055
CCOM : I6K69_14920 I6K69_14925
BYL : A4V09_05565 A4V09_05575
BHAN : CGC63_07855 CGC63_07865
BLAU : DQQ01_09590 DQQ01_09600
BPRO : PMF13cell1_04258(cobU_1) PMF13cell1_04260(cobU_2)
BLAB : EYS05_14430 EYS05_14440
BLIQ : INP51_06575 INP51_08490
BLUI : Blut17040_19780(cobU)
BCOC : BLCOC_32860 BLCOC_32880(cobU)
LACY : A4V08_33980 A4V08_33990
CSCI : HDCHBGLK_00114(cobU_1) HDCHBGLK_00116(cobU_2)
CSH : Closa_2383 Closa_2409
ARF : AR1Y2_1900 AR1Y2_1902
ACAC : EYQ97_08935 EYQ97_08945
PXV : FXF36_13590 FXF36_13600
ANR : Ana3638_11120 Ana3638_11130
ACEL : acsn021_39600 acsn021_39620(cobU)
EEL : EUBELI_20177 EUBELI_20179
RGN : RGna_05500 RGna_05505
QDO : H9Q78_00335 H9Q78_00345
ERE : EUBREC_1922 EUBREC_1924
CBAR : PATL70BA_0698(cobU)
AMIC : Ami3637_10395 Ami3637_10400
ETM : CE91St48_39100(cobU)
PDF : CD630DERM_34380(cobU)
PHX : KGNDJEFE_02265(cobU)
EAC : EAL2_808p00940(cobU)
PIV : NCTC13079_00696(cobU)
VRM : 44547418_00922(cobU)
VDN : NCTC11831_01041(cobP)
DHO : Dia5BBH33_09530(cobU)
MANA : MAMMFC1_03998(cobU)
PFAC : PFJ30894_01712(cobP)
TSG : HLK68_07615 HLK68_07625
SHI : Shel_21090 Shel_21110
CBAC : JI75_05420 JI75_05430
BWA : HLV38_01075 HLV38_01085
MBO : BQ2027_MB0260C(cobU)
MMAE : MMARE11_31530(cobU)
MKN : MKAN_02945 MKAN_20435
MBAI : MB901379_02759(cobU)
MHEK : JMUB5695_02148(cobU)
MOT : LTS72_08360 LTS72_19775
MKY : IWGMT90018_24790(cobU)
MPHL : MPHLCCUG_03338(cobU)
MTHN : 4412656_00541(cobU_1) 4412656_01831(cobU_2)
MAUU : NCTC10437_00334(cobU)
MALV : MALV_02830(cobU) MALV_28420
MFLV : NCTC10271_01984(cobU)
MSAL : DSM43276_01748(cobP)
MTER : 4434518_00431(cobU)
CDIP : ERS451417_01657(cobU)
CUN : Cul210932_1618(cobU)
CUQ : Cul210931_1504(cobU)
CUJ : CUL131002_1542(cobU)
NFR : ERS450000_02413(cobU)
NAD : NCTC11293_02745(cobU)
RER : RER_36080(cobP) RER_53580
REB : XU06_16765 XU06_25785
RQI : C1M55_17765 C1M55_27020
RPY : Y013_10255 Y013_14375
RHOD : AOT96_06980 AOT96_28025
RCR : NCTC10994_03404(cobU)
RGO : KYT97_06740(cobU) KYT97_16900(cobU)
RHOO : RA302_17255(cobU) RA302_26035(cobU)
REQ : REQ_28350(cobU) REQ_39280
SLE : sle_49660(sle_49660)
SXT : KPP03845_102415(cobU)
ALX : LVQ62_02075 LVQ62_10370
SERJ : SGUI_0840 SGUI_2137
ORN : DV701_05280 DV701_11630
ORZ : FNH13_05475 FNH13_08490
ORD : L0A91_06035 L0A91_12070
OCP : NF557_03980 NF557_06375
OFA : NF556_04910 NF556_08320
DCO : SAMEA4475696_1828(cobU)
CGRN : 4412665_00800(cobU)
PAUS : NCTC13651_01039(cobU)
PPC : HMPREF9154_1119(cobU)
TEZ : BKM78_01610 BKM78_10395
TLA : TLA_TLA_00326(cobU_1) TLA_TLA_02095(cobU_2)
NPI : G7071_10140 G7071_14480(cobU)
NAQU : ENKNEFLB_00266(cobU_1) ENKNEFLB_01616(cobU_2)
BLAP : MVA48_06555 MVA48_06970(cobU)
SYR : SynRCC307_1234(cobU)
SYX : SynWH7803_1122(cobU)
SYH : Syncc8109_1334(cobU_cobP)
TVN : NIES2134_106360(cobP)
LET : O77CONTIG1_02591(cobP)
CHON : NIES4102_05380(cobP)
SYP : SYNPCC7002_A1561(cobU)
SYNN : NIES970_04530(cobU)
MVZ : myaer102_11820(cobP)
PAGH : NIES204_00710(cobU)
PRUN : PCC7821_04316(cobP)
CALS : NIES3974_41290(cobU)
NSPH : BDGGKGIB_03225(cobP)
DET : DET0660(cobU-1) DET0694(cobU-2)
DFO : Dform_00895(cobP|cobU) Dform_00922(cobP|cobU)
DEIN : DAAJ005_11455(cobU)
ABIW : Abiwalacus_00640(cobU)
FPOL : ERS445057_01314(cobU)
PPIO : CE91St28_02660 CE91St28_20750
PYY : RAH42_11070 RAH42_12575
BCEL : BcellWH2_00326(cobP)
PCRE : NCTC12858_01876(cobP)
PCAG : NCTC12856_00649(cobP)
POC : NCTC13071_01280(cobP)
PROC : Ptc2401_01256(cobP)
NMV : NITMOv2_1607(cobP) NITMOv2_1836(cobU)
» show all
Taxonomy
Reference
Authors
O'Toole GA, Escalante-Semerena JC.
Title
Purification and characterization of the bifunctional CobU enzyme of Salmonella typhimurium LT2. Evidence for a CobU-GMP intermediate.
Journal
Reference
Authors
Thompson TB, Thomas MG, Escalante-Semerena JC, Rayment I.
Title
Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution,.
Journal
Sequence
Reference
Authors
Thompson TB, Thomas MG, Escalante-Semerena JC, Rayment I.
Title
Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site.
Journal
Sequence
Reference
Authors
Thomas MG, Thompson TB, Rayment I, Escalante-Semerena JC.
Title
Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation.
Journal
Reference
Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title
The biosynthesis of adenosylcobalamin (vitamin B12).
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.156