KEGG ENZYME: 2.7.1.157

ENZYME: 2.7.1.157

Entry

EC 2.7.1.157 Enzyme

Name

N-acetylgalactosamine kinase;
GALK2;
GK2;
GalNAc kinase;
N-acetylgalactosamine (GalNAc)-1-phosphate kinase;
ATP:N-acetyl-D-galactosamine 1-phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase

Reaction(IUBMB)

ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:R08967]

Reaction(KEGG)

R08967

Substrate

ATP [CPD:C00002];
N-acetyl-alpha-D-galactosamine

Product

ADP [CPD:C00008];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]

Comment

The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.

History

EC 2.7.1.157 created 2005

Orthology

K18674

N-acetylgalactosamine kinase

Genes

HSA:	2585(GALK2)

PTR:	744911(GALK2)

PPS:	100993695(GALK2)

GGO:	101128070(GALK2)

PON:	100173519(GALK2)

NLE:	100580277(GALK2)

MCC:	714866(GALK2)

MCF:	102133835(GALK2)

CSAB:

103245645(GALK2)

RRO:	104656916(GALK2)

RBB:	108530100(GALK2)

CJC:	100398615(GALK2)

SBQ:	101030526(GALK2)

MMU:	69976(Galk2)

MCAL:

110289948(Galk2)

MPAH:

110317634(Galk2)

RNO:	296117(Galk2)

MUN:	110560161(Galk2)

CGE:	100752083(Galk2)

NGI:	103733040(Galk2)

HGL:	101714414(Galk2)

CCAN:

109684265(Galk2)

OCU:	100349778(GALK2)

TUP:	102477172(GALK2)

CFA:	487548(GALK2)

VVP:	112920049(GALK2)

AML:	100474626(GALK2)

UMR:	103676726(GALK2)

UAH:	113269599(GALK2)

ORO:	101377084(GALK2)

ELK:

111159955

FCA:	101097562(GALK2)

PTG:	102956946(GALK2)

PPAD:

109263009(GALK2)

AJU:	106967224(GALK2)

BTA:	536133(GALK2)

BOM:	102285422(GALK2)

BIU:	109565141(GALK2)

BBUB:

102402043(GALK2)

CHX:	102177984(GALK2)

OAS:	101108754(GALK2)

SSC:	100152312(GALK2)

CFR:	102518566(GALK2)

CDK:	105104776(GALK2)

BACU:

103019442(GALK2)

LVE:	103086640(GALK2)

OOR:	101287500(GALK2)

DLE:	111181609(GALK2)

PCAD:

102976259(GALK2)

ECB:	100070040(GALK2)

EPZ:	103551850(GALK2)

EAI:	106838512(GALK2)

MYB:	102261265(GALK2)

MYD:	102759909(GALK2)

MNA:	107534872(GALK2)

HAI:	109394504(GALK2)

DRO:	112311744(GALK2)

PALE:

102887362(GALK2)

RAY:	107501958(GALK2)

MJV:	108407858(GALK2)

LAV:	100673716(GALK2)

TMU:

101357245

MDO:	100025887(GALK2)

SHR:	100927973(GALK2)

PCW:	110202044(GALK2)

OAA:	100092828(GALK2)

GGA:	415596(GALK2)

MGP:	100541570(GALK2)

CJO:	107318733(GALK2)

NMEL:

110404050(GALK2)

APLA:

101800821(GALK2)

ACYG:

106033610(GALK2)

TGU:	100220666(GALK2)

LSR:	110474248(GALK2)

SCAN:

103816023(GALK2)

GFR:	102040707(GALK2)

FAB:	101809065(GALK2)

PHI:	102104028(GALK2)

PMAJ:

107209247(GALK2)

CCAE:

111934110(GALK2)

CCW:	104683987(GALK2)

ETL:	114059925(GALK2)

FPG:	101914646(GALK2)

FCH:	102056200(GALK2)

CLV:	102088209(GALK2)

EGZ:	104130922(GALK2)

NNI:	104017126(GALK2)

ACUN:

113484139(GALK2)

PADL:

103922747(GALK2)

AAM:	106496574(GALK2)

ASN:	102386197(GALK2)

AMJ:	102566502(GALK2)

PSS:	102462792(GALK2)

CMY:	102935480(GALK2)

CPIC:

101943695(GALK2)

ACS:	100560349(galk2)

PVT:	110077234(GALK2)

PBI:	103054405(GALK2)

PMUR:

107287684(GALK2)

TSR:	106552931(GALK2)

PMUA:

114584994(GALK2)

GJA:	107124464(GALK2)

XLA:	380379(galk2.L)

XTR:	448280(galk2)

NPR:	108792192(GALK2)

DRE:	792268(galk2)

SRX:	107712518(galk2) 107739099

SANH:

107662478 107688931

SGH:	107557993 107589326

CCAR:

109050785(galk2) 109058485

IPU:	108275233(galk2)

PHYP:

113529543(galk2)

AMEX:

103026995(galk2)

EEE:	113581772(galk2)

TRU:	101066943(galk2)

TNG:	GSTEN00025596G001

LCO:	104940594(galk2)

NCC:	104960092(galk2)

MZE:	101474367(galk2)

ONL:	100694499(galk2)

OLA:	101171825(galk2)

XMA:	102218065(galk2)

XCO:	114136950(galk2)

PRET:

103466438(galk2)

CVG:	107087412(galk2)

KMR:	108230033(galk2)

ALIM:

106526835(galk2)

AOCE:

111577706(galk2)

CSEM:

103380462(galk2)

POV:	109624422(galk2)

LCF:	108876666(galk2)

SDU:	111229735(galk2)

SLAL:

111658545(galk2)

HCQ:	109507570(galk2)

BPEC:

110169595(galk2)

MALB:

109972807(galk2)

SASA:

100194982(galk2)

OTW:

112227451

SALP:

111971804 112071115(galk2)

ELS:	105018363(galk2)

SFM:	108942064(galk2)

PKI:	111846659(galk2)

LCM:	102351584(GALK2)

CMK:	103186962(galk2)

RTP:

BFO:

CIN:

SPU:

APLC:

SKO:

DME:	Dmel_CG5288(Galk)

DER:

6544979

DSE:

6604968

DSI:	Dsimw501_GD12949(Dsim_GD12949)

DYA:	Dyak_GE21269

DAN:

6493010

DSR:

110190643

DPO:	Dpse_GA18788

DPE:

6603000

DMN:

108151574

DWI:

6646317

DGR:	Dgri_GH14960

DMO:	Dmoj_GI11486

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP005012 AgaP_AGAP005013 AgaP_AGAP012568

AAG:

5565716

AALB:

109416487

CQU:	CpipJ_CPIJ000128

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:	105286760 113562013

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

PMAC:

PRAP:

HAW:

TNL:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM424860

ZNE:

110841302

FCD:

110858073

DPX:	DAPPUDRAFT_305622

PVM:

113800813

ISC:	IscW_ISCW005368

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_M01D7.4(tag-96)

CBR:	CBG22217(Cbr-tag-96)

BMY:

Bm1_16455

LOA:	LOAG_04522

NAI:	NECAME_00216 NECAME_11071

TSP:	Tsp_09390 Tsp_11575 Tsp_11823

HRO:	HELRODRAFT_171000

LGI:	LOTGIDRAFT_206567

PCAN:

112553882

CRG:

105327634

MYI:	110451194 110461518

OBI:

106875465

LAK:

106158489

SMM:	Smp_078400

SHX:

MS3_04825

OVI:	T265_10833

EGL:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:	100197100 100201282

TAD:	TRIADDRAFT_51952

AQU:

100635641

ATH:	AT3G06580(GALK)

ALY:

9320659

CRB:

17891124

CSAT:

104725032 104744827 104764353

EUS:	EUTSA_v10020583mg

BRP:	103849843 103870735

BNA:	106351102 106352899 106401687 106452993

BOE:	106296154 106328312

RSZ:	108805417 108809455

THJ:

104818876

CPAP:

110821277

CIT:	102609053 102612610

CIC:	CICLE_v10004814mg CICLE_v10004815mg

TCC:

18603687

GRA:	105775397 105800770

GHI:	107931507 107936088

GAB:	108454150 108480623

DZI:

111280004

EGR:

104415246

GMX:	100796793 100803230

GSJ:	114393733 114419948 114424258

PVU:	PHAVU_003G116700g PHAVU_010G104600g

VRA:	106764922 106766523

VAR:	108329962 108329967

VUN:

114177171

CCAJ:

109811004

MTR:	MTR_4g122670

CAM:

101496906

LJA:	Lj0g3v0357339.1(Lj0g3v0357339.1) Lj4g3v2263880.1(Lj4g3v2263880.1)

ADU:

107462750

AIP:

107639344

LANG:

109329383 109338402 109362134

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:	103403520 103452662

PXB:

103961282

ZJU:	107404688 107407078 107407090 107407595 107407602 107408564 107408869 107408871 107408935

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110669400 110672942

MESC:

110602178 110610320

POP:	7485841 7485886

PEU:	105115525 105122254

JRE:	108994829 109010775

QSU:

VVI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107771316 107806963 107813265

NSY:

104236621

NTO:	104100681 104110994

NAU:	109207994 109217520

INI:

109176233

SIND:

105156834 105178872

OEU:	111371523 111381334 111388285

HAN:

110940986

LSV:

111914177

CCAV:

112522162 112527306

DCR:	108196702 108199458

BVG:

104887933

SOE:	110787295 110798325

CQI:	110697308 110738208

NNU:

104598734

PSOM:

113326912 113328397 113333343 113342593 113342616 113346944

OSA:

4334679

DOSA:

Os03t0832600-01(Os03g0832600)

OBR:

102720420

BDI:

100824538

ATS:	109744798(LOC109744798)

SBI:

8079681

ZMA:	100284953(pco060326)

SITA:

101761856

PDA:	103712675 103721022

EGU:

MUS:

DCT:

PEQ:

AOF:	109819882 109847232

ATR:

18431449

SMO:	SELMODRAFT_144964 SELMODRAFT_268487

PPP:	112287070 112296002

CRE:	CHLREDRAFT_122621(GAL1)

VCN:	VOLCADRAFT_98854

MNG:	MNEG_10228

CSL:	COCSUDRAFT_25096

CVR:	CHLNCDRAFT_57327

APRO:

F751_4029

OLU:	OSTLU_31076

OTA:	OT_ostta04g01480

BPG:	Bathy01g01320

MIS:	MICPUN_60667

MPP:	MICPUCDRAFT_26260

CCP:	CHC_T00007304001

LBC:	LACBIDRAFT_251636

MPR:	MPER_03299

CPUT:

CONPUDRAFT_50823

SRE:	PTSG_06504

DDI:	DDB_G0292112(galK)

DPP:	DICPUDRAFT_147991

DFA:	DFA_05675(galK)

ACAN:

ACA1_074450 ACA1_107480

TGO:	TGME49_229780

TET:	TTHERM_00145260 TTHERM_00703700

PTM:	GSPATT00007558001 GSPATT00015163001

FCY:	FRACYDRAFT_264529(GALK2_1)

PIF:	PITG_10010

PSOJ:

PHYSODRAFT_492612

GTT:	GUITHDRAFT_160545

TVA:	TVAG_284490 TVAG_472220 TVAG_472380 TVAG_484130 TVAG_487340

BRV:	CFK39_06660

BGG:	CFK41_02270

BRZ:	CFK38_04455

BSAU:

DWV08_11750

AOS:	AXE84_07315

ANE:	AN27039_1643

AVC:	NCTC10951_01629(galK_2)

TBH:	Tbon_09120

SACI:

Sinac_5476

PBAS:

SMSP2_01028(galK_1)

» show all

Reference

1 [PMID:8702831]

Authors

Pastuszak I, Drake R, Elbein AD.

Title

Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.

Journal

J Biol Chem 271:20776-82 (1996)
DOI:10.1074/jbc.271.34.20776

Reference

2 [PMID:8798585]

Authors

Pastuszak I, O'Donnell J, Elbein AD.

Title

Identification of the GalNAc kinase amino acid sequence.

Journal

J Biol Chem 271:23653-6 (1996)
DOI:10.1074/jbc.271.39.23653

Sequence

[hsa:2585]

Reference

3 [PMID:16006554]

Authors

Thoden JB, Holden HM.

Title

The molecular architecture of human N-acetylgalactosamine kinase.

Journal

J Biol Chem 280:32784-91 (2005)
DOI:10.1074/jbc.M505730200

Sequence

[hsa:2585]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.157

IUBMB Enzyme Nomenclature:

2.7.1.157

ExPASy - ENZYME nomenclature database:

2.7.1.157

BRENDA, the Enzyme Database:

2.7.1.157

DBGET integrated database retrieval system