KEGG ENZYME: 2.7.1.157

ENZYME: 2.7.1.157

Entry

EC 2.7.1.157 Enzyme

Name

N-acetylgalactosamine kinase;
GALK2;
GK2;
GalNAc kinase;
N-acetylgalactosamine (GalNAc)-1-phosphate kinase;
ATP:N-acetyl-D-galactosamine 1-phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase

Reaction(IUBMB)

ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:R08967]

Reaction(KEGG)

R08967

Substrate

ATP [CPD:C00002];
N-acetyl-alpha-D-galactosamine

Product

ADP [CPD:C00008];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]

Comment

The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.

History

EC 2.7.1.157 created 2005

Orthology

K18674

N-acetylgalactosamine kinase

Genes

HSA:	2585(GALK2)

PTR:	744911(GALK2)

PPS:	100993695(GALK2)

GGO:	101128070(GALK2)

PON:	100173519(GALK2)

NLE:	100580277(GALK2)

MCC:	714866(GALK2)

MCF:	102133835(GALK2)

CSAB:

103245645(GALK2)

RRO:	104656916(GALK2)

RBB:	108530100(GALK2)

CJC:	100398615(GALK2) 103789124(GALK2)

SBQ:	101030526(GALK2)

MMU:	69976(Galk2)

RNO:	296117(Galk2)

CGE:	100752083(Galk2)

NGI:	103733040(Galk2)

HGL:	101714414(Galk2)

CCAN:

109684254 109684265(Galk2)

OCU:	100349778(GALK2)

TUP:	102477172(GALK2)

CFA:	487548(GALK2)

AML:	100474626(GALK2)

UMR:	103676726(GALK2)

ORO:	101377084(GALK2)

FCA:	101097562(GALK2)

PTG:	102956946(GALK2)

AJU:	106967224(GALK2)

BTA:	536133(GALK2)

BOM:	102285422(GALK2)

BIU:	109565141(GALK2)

PHD:	102324705(GALK2)

CHX:	102177984(GALK2)

OAS:	101108754(GALK2)

SSC:	100152312(GALK2)

CFR:	102518566(GALK2)

CDK:	105104776(GALK2)

BACU:

103019442(GALK2)

LVE:	103086640(GALK2)

OOR:	101287500(GALK2)

ECB:	100070040(GALK2)

EPZ:	103551850(GALK2)

EAI:	106838512(GALK2)

MYB:	102261265(GALK2)

MYD:	102759909(GALK2)

HAI:	109394504(GALK2)

RSS:	109441111 109446871(GALK2)

PALE:

102887362(GALK2)

LAV:	100673716(GALK2) 104846861

TMU:

101357245

MDO:	100025887(GALK2)

SHR:	100927973(GALK2)

OAA:

100092828

GGA:	415596(GALK2)

MGP:	100541570(GALK2)

CJO:	107318733(GALK2)

APLA:

101800821(GALK2)

ACYG:

106033610(GALK2)

TGU:	100220666(GALK2)

GFR:	102040707(GALK2)

FAB:	101809065(GALK2)

PHI:	102104028(GALK2)

PMAJ:

107209247(GALK2)

CCW:	104683987(GALK2)

FPG:	101914646(GALK2)

FCH:	102056200(GALK2)

CLV:	102088209(GALK2)

EGZ:	104130922(GALK2)

AAM:	106496574(GALK2)

ASN:	102386197(GALK2)

AMJ:	102566502(GALK2)

PSS:	102462792(GALK2)

CMY:	102935480(GALK2)

CPIC:

101943695(GALK2)

ACS:	100560349(galk2)

PVT:	110077234(GALK2)

PBI:	103054405(GALK2)

GJA:	107124464(GALK2)

XLA:	380379(galk2.L)

XTR:	448280(galk2)

NPR:	108792192(GALK2)

DRE:	792268(galk2)

SRX:	107712518(galk2) 107739099

SANH:

107662478 107688931

SGH:	107557993 107589326

CCAR:

109050785(galk2) 109058485

IPU:	108275233(galk2)

AMEX:

103026995(galk2)

TRU:	101066943(galk2)

TNG:	GSTEN00025596G001

LCO:	104940594(galk2)

NCC:	104960092(galk2)

MZE:	101474367(galk2)

OLA:	101171825(galk2)

XMA:	102218065(galk2)

PRET:

103466438(galk2)

CSEM:

103380462(galk2)

LCF:	108876666(galk2)

HCQ:	109507570(galk2)

BPEC:

110169595(galk2)

SASA:

100194982(galk2)

ELS:	105018363(galk2)

SFM:	108942064(galk2)

LCM:	102351584(GALK2)

CMK:	103186962(galk2)

BFO:	BRAFLDRAFT_124366

CIN:

SPU:

APLC:

SKO:

DME:	Dmel_CG5288(Galk)

DPO:	Dpse_GA18788

DAN:	Dana_GF10135

DER:	Dere_GG15045

DPE:	Dper_GL15042

DSE:	Dsec_GM24899

DSI:	Dsimw501_GD12949(Dsim_GD12949)

DWI:	Dwil_GK12284

DYA:	Dyak_GE21269

DGR:	Dgri_GH14960

DMO:	Dmoj_GI11486

DVI:	Dvir_GJ13681

MDE:

101899814

AGA:	AgaP_AGAP005012 AgaP_AGAP005013 AgaP_AGAP012568

AAG:

5565716

CQU:	CpipJ_CPIJ000128

AME:

BIM:

BTER:

SOC:

AEC:

ACEP:

PBAR:

HST:

CFO:

LHU:

PGC:

NVI:

TCA:

DPA:

NVL:	108563052 108565645

BMOR:

101745110

DPL:	KGM_201541

PMAC:

PRAP:

PXY:

API:

DNX:

PHU:	Phum_PHUM424860

ZNE:

110841302

FCD:

110858073

DPX:	DAPPUDRAFT_305622

ISC:	IscW_ISCW005368

TUT:

107362724

CEL:	CELE_M01D7.4(tag-96)

CBR:	CBG22217(Cbr-tag-96)

NAI:	NECAME_00216 NECAME_11071

BMY:

Bm1_16455

LOA:	LOAG_04522

TSP:	Tsp_09390 Tsp_11575 Tsp_11823

HRO:	HELRODRAFT_171000

LGI:	LOTGIDRAFT_149048 LOTGIDRAFT_206567

CRG:

105327634

MYI:	110451194 110461518

OBI:

106875465

LAK:	106158489 106174692

SMM:	Smp_078400

SHX:

MS3_04825

OVI:	T265_10833

NVE:	NEMVE_v1g197607

EPA:

110238219

ADF:

107331877

HMG:	100197100 100201282

TAD:	TRIADDRAFT_51952

AQU:

100635641

ATH:	AT3G06580(GALK)

ALY:	ARALYDRAFT_896791

CRB:

17891124

CSAT:

104725032 104744827 104764353

EUS:	EUTSA_v10020583mg

BRP:	103849843 103870735

BNA:	106351102 106352899 106401687 106452993

BOE:	106296154 106328312

THJ:

104818876

CPAP:

110821277

CIT:	102609053 102612610

CIC:	CICLE_v10004814mg CICLE_v10004815mg

TCC:

18603687

GRA:	105775397 105800770

GHI:	107931507 107936088

DZI:

111280004

EGR:

104415246

GMX:	100796793 100803230

PVU:	PHAVU_003G116700g PHAVU_010G104600g

VRA:	106764922 106766523

VAR:	108329962 108329967

CCAJ:

109789052 109811004

MTR:	MTR_4g122670

CAM:

101496906

LJA:	Lj0g3v0357339.1(Lj0g3v0357339.1) Lj4g3v2263880.1(Lj4g3v2263880.1)

ADU:

107462750

AIP:

107639344

LANG:

109329383 109338402 109362134

FVE:

PPER:

PMUM:

PAVI:

MDM:	103403520 103452662

PXB:

103961282

ZJU:	107404688 107407078 107407090 107407595 107407602 107408564 107408869 107408871 107408935 107409149

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110669400 110672942

POP:	7485841 7485886

JRE:	108994829 109010775

VVI:

SLY:

SPEN:

SOT:

CANN:

NTA:	107771316 107806963 107813265

NSY:

104236621

NTO:	104100681 104110994

INI:

109176233

SIND:

105156834 105178872

OEU:	111371523 111381334 111388285

HAN:

110940986

LSV:	111902588 111907950 111908922 111914177

DCR:	108196702 108199458

BVG:

104887933

SOE:	110787295 110798325

NNU:

104598734

OSA:

4334679

DOSA:

Os03t0832600-01(Os03g0832600)

OBR:

102720420

BDI:

100824538

ATS:	109744798(LOC109744798)

SBI:

8079681

ZMA:	100284953(pco060326)

SITA:

101761856

PDA:	103712675 103719305 103721022

EGU:

105039960

MUS:

103976564

DCT:

110106124

AOF:	109819882 109846176 109847232 109847816 109850161

ATR:

18431449

SMO:	SELMODRAFT_144964 SELMODRAFT_268487

PPP:	112287070 112296002

CRE:	CHLREDRAFT_122621(GAL1)

VCN:	VOLCADRAFT_98854

MNG:	MNEG_10228

OLU:	OSTLU_31076

OTA:	OT_ostta04g01480

BPG:	Bathy01g01320

MIS:	MICPUN_60667

MPP:	MICPUCDRAFT_26260

CSL:	COCSUDRAFT_25096

CVR:	CHLNCDRAFT_57327

APRO:

F751_4029

CCP:	CHC_T00007304001

LBC:	LACBIDRAFT_251636

SRE:	PTSG_06504

DDI:	DDB_G0292112(galK)

DPP:	DICPUDRAFT_147991

DFA:	DFA_05675(galK)

ACAN:

ACA1_074450 ACA1_107480

TGO:	TGME49_229780

TET:	TTHERM_00145260 TTHERM_00703700

PTM:	GSPATT00007558001 GSPATT00015163001

FCY:	FRACYDRAFT_264529(GALK2_1)

PIF:	PITG_10010

PSOJ:

PHYSODRAFT_492612

GTT:	GUITHDRAFT_160545

TVA:	TVAG_484130

SACI:

Sinac_5476

PBAS:

SMSP2_01028(galK_1)

» show all

Reference

1 [PMID:8702831]

Authors

Pastuszak I, Drake R, Elbein AD.

Title

Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.

Journal

J Biol Chem 271:20776-82 (1996)
DOI:10.1074/jbc.271.34.20776

Reference

2 [PMID:8798585]

Authors

Pastuszak I, O'Donnell J, Elbein AD.

Title

Identification of the GalNAc kinase amino acid sequence.

Journal

J Biol Chem 271:23653-6 (1996)
DOI:10.1074/jbc.271.39.23653

Sequence

[hsa:2585]

Reference

3 [PMID:16006554]

Authors

Thoden JB, Holden HM.

Title

The molecular architecture of human N-acetyl galactosamine kinase.

Journal

J Biol Chem (2005)
DOI:10.1074/jbc.M505730200

Sequence

[hsa:2585]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.157

IUBMB Enzyme Nomenclature:

2.7.1.157

ExPASy - ENZYME nomenclature database:

2.7.1.157

BRENDA, the Enzyme Database:

2.7.1.157

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2149)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (357)   
   KEGG MGENES (360)   
   RefGene (1431)   
Protein sequence (59)   
   UniProt (34)   
   SWISS-PROT (4)   
   RefSeq(pep) (21)   
DNA sequence (34)   
   RefSeq(nuc) (26)   
   GenBank (8)   
All databases (2249)   

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