KEGG ENZYME: 2.7.1.157

ENZYME: 2.7.1.157

Entry

EC 2.7.1.157                Enzyme

Name

N-acetylgalactosamine kinase;
GALK2;
GK2;
GalNAc kinase;
N-acetylgalactosamine (GalNAc)-1-phosphate kinase;
ATP:N-acetyl-D-galactosamine 1-phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase

Reaction(IUBMB)

ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:R08967]

Reaction(KEGG)

R08967

Substrate

ATP [CPD:C00002];
N-acetyl-alpha-D-galactosamine

Product

ADP [CPD:C00008];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]

Comment

The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.

History

EC 2.7.1.157 created 2005

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K18674

N-acetylgalactosamine kinase

Genes

HSA:	2585(GALK2)

PTR:	744911(GALK2)

PPS:	100993695(GALK2)

GGO:	101128070(GALK2)

PON:	100173519(GALK2)

NLE:	100580277(GALK2)

HMH:	116482644(GALK2)

MCC:	714866(GALK2)

MCF:	102133835(GALK2)

MTHB:

126958698

MNI:	105490574(GALK2)

CSAB:

103245645(GALK2)

CATY:

105588211(GALK2)

PANU:

101018804(GALK2) 116272414

TGE:	112628039(GALK2)

MLEU:

105529996(GALK2)

RRO:	104656916(GALK2)

RBB:	108530100(GALK2)

TFN:	117070679(GALK2) 117097537

PTEH:

111552811(GALK2)

CANG:

105502194(GALK2)

CJC:	100398615(GALK2)

SBQ:	101030526(GALK2)

CIMI:

108314740(GALK2)

CSYR:

103272381(GALK2)

MMUR:

105870722(GALK2)

LCAT:

123622417(GALK2)

PCOQ:

105814473(GALK2)

OGA:	100963480(GALK2)

MMU:	69976(Galk2)

MCAL:

110289948(Galk2)

MPAH:

110317634(Galk2)

RNO:	296117(Galk2)

MCOC:

116090854(Galk2)

ANU:	117703421(Galk2)

MUN:	110560161(Galk2)

CGE:	100752083(Galk2)

MAUA:

101828441(Galk2)

PROB:

127221515(Galk2)

PLEU:

114709066(Galk2)

MORG:

121465605(Galk2)

MFOT:

126495380

AAMP:

119814350(Galk2)

NGI:	103733040(Galk2)

HGL:	101714414(Galk2)

CPOC:

100718685(Galk2)

CCAN:

109684265(Galk2)

DORD:

105980974(Galk2)

DSP:	122114690(Galk2)

NCAR:

124975956

OCU:

100349778

OPI:	101520877(GALK2)

TUP:	102477172(GALK2)

GVR:	103588671(GALK2)

CFA:	487548(GALK2)

CLUD:

112675953(GALK2)

VVP:	112920049(GALK2)

VLG:	121484244(GALK2)

AML:	100474626(GALK2)

UMR:	103676726(GALK2)

UAH:	113269599(GALK2)

UAR:	123801805(GALK2)

ELK:

111159955

LLV:

125105386

MPUF:

101691578(GALK2)

NVS:	122893728(GALK2)

ORO:	101377084(GALK2)

EJU:	114206421(GALK2)

ZCA:	113908962(GALK2)

MLX:	118003620(GALK2)

NSU:	110583826(GALK2)

LWW:	102749948(GALK2)

FCA:	101097562(GALK2)

PYU:	121041679(GALK2)

PCOO:

112855095(GALK2)

PBG:	122468665(GALK2)

LRUF:

124508602

PTG:	102956946(GALK2)

PPAD:

109263009(GALK2)

PUC:

125908851

AJU:	106967224(GALK2)

HHV:	120235044(GALK2)

BTA:	536133(GALK2)

BOM:	102285422(GALK2)

BIU:	109565141(GALK2)

BBUB:

102402043(GALK2)

BBIS:

104988254(GALK2)

CHX:	102177984(GALK2)

OAS:	101108754(GALK2)

ODA:	120852965(GALK2)

CCAD:

122443625(GALK2)

SSC:	100152312(GALK2)

CFR:	102518566(GALK2)

CBAI:

105077012(GALK2)

CDK:	105104776(GALK2)

VPC:	102526807(GALK2)

BACU:

103019442(GALK2)

LVE:	103086640(GALK2)

OOR:	101287500(GALK2)

DLE:	111181609(GALK2)

PCAD:

102976259(GALK2)

PSIU:

116749191(GALK2)

NASI:

112402181(GALK2)

ECB:	100070040(GALK2)

EPZ:	103551850(GALK2)

EAI:	106838512(GALK2)

MYB:	102261265(GALK2)

MYD:	102759909(GALK2)

MMYO:

118651584(GALK2)

MLF:	102428348(GALK2)

MNA:	107534872(GALK2)

PKL:	118721535(GALK2)

HAI:	109394504(GALK2)

DRO:	112311744(GALK2)

SHON:

118992603(GALK2)

AJM:	119057630(GALK2)

PDIC:

114491710(GALK2)

PHAS:

123808067(GALK2)

MMF:	118626112(GALK2)

RFQ:	117023392(GALK2)

PALE:

102887362(GALK2)

PGIG:

120623120(GALK2)

PVP:	105288812(GALK2)

RAY:	107501958(GALK2)

MJV:	108407858(GALK2)

TOD:	119238603(GALK2)

SARA:

101555556(GALK2)

LAV:	100673716(GALK2)

TMU:

101357245

ETF:	101657736(GALK2)

DNM:	101436540(GALK2)

MDO:	100025887(GALK2)

GAS:	123237950(GALK2)

SHR:	100927973(GALK2)

AFZ:

127551131

PCW:	110202044(GALK2)

OAA:	100092828(GALK2)

GGA:	415596(GALK2)

PCOC:

116225319(GALK2)

MGP:	100541570(GALK2)

CJO:	107318733(GALK2)

NMEL:

110404050(GALK2)

APLA:

101800821(GALK2)

ACYG:

106033610(GALK2)

AFUL:

116493385(GALK2)

TGU:	100220666(GALK2)

LSR:	110474248(GALK2)

SCAN:

103816023(GALK2)

PMOA:

120508925(GALK2)

OTC:	121343639(GALK2)

PRUF:

121354557(GALK2)

GFR:	102040707(GALK2)

FAB:	101809065(GALK2)

PHI:	102104028(GALK2)

PMAJ:

107209247(GALK2)

CCAE:

111934110(GALK2)

CCW:	104683987(GALK2)

CBRC:

103621263(GALK2)

ETL:	114059925(GALK2)

ZAB:	102067775(GALK2)

ACHL:

103812121(GALK2)

SVG:	106860070(GALK2)

FPG:	101914646(GALK2)

FCH:	102056200(GALK2)

CLV:	102088209(GALK2)

EGZ:	104130922(GALK2)

NNI:	104017126(GALK2)

PLET:

104620577(GALK2)

PCRI:

104025540(GALK2)

PCAO:

104044448(GALK2)

ACUN:

113484139(GALK2)

TALA:

104364644(GALK2)

PADL:

103922747(GALK2)

AFOR:

103896624(GALK2)

ACHC:

115341208(GALK2)

HALD:

104315232(GALK2)

HLE:	104834502(GALK2)

AGEN:

126043704

GCL:

127020826

CCRI:

104161319(GALK2)

CSTI:

104554247(GALK2)

CMAC:

104481169(GALK2)

MUI:	104546787(GALK2)

FGA:	104081851(GALK2)

GSTE:

104257627(GALK2)

LDI:	104343953(GALK2)

MNB:	103777518(GALK2)

OHA:	104334598(GALK2)

NNT:	104413782(GALK2)

SHAB:

115613102(GALK2)

DPUB:

104297334(GALK2)

PGUU:

104467513(GALK2)

ACAR:

104518469(GALK2)

CPEA:

104386020(GALK2)

AVIT:

104270327(GALK2)

CVF:	104287427(GALK2)

CUCA:

104055725(GALK2)

TEO:	104384173(GALK2)

BRHI:

104495036(GALK2)

AAM:	106496574(GALK2)

AROW:

112963500(GALK2)

NPD:	112952810(GALK2)

TGT:	104569522(GALK2)

DNE:	112981436(GALK2)

SCAM:

104148254(GALK2)

ASN:	102386197(GALK2)

AMJ:	102566502(GALK2)

CPOO:

109309046(GALK2)

GGN:	109288586(GALK2)

PSS:	102462792(GALK2)

CMY:	102935480(GALK2)

CPIC:

101943695(GALK2)

TST:	117870614 117870615

CABI:

116815033(GALK2)

MRV:	120372903(GALK2)

ACS:	100560349(galk2)

PVT:	110077234(GALK2)

SUND:

121934374(GALK2)

PBI:	103054405(GALK2)

PMUR:

107287684(GALK2)

CTIG:

120315066(GALK2)

TSR:	106552931(GALK2)

PGUT:

117675736(GALK2)

VKO:	123027618(GALK2)

PMUA:

114584994(GALK2)

ZVI:	118092993(GALK2)

HCG:	128335149(GALK2)

GJA:	107124464(GALK2)

STOW:

125424504(GALK2)

XLA:	380379(galk2.L)

XTR:	448280(galk2)

NPR:	108792192(GALK2)

RTEM:

120931319(GALK2)

BBUF:

120985837(GALK2)

BGAR:

122927618(GALK2)

DRE:	792268(galk2)

SRX:	107712518(galk2) 107739099

SANH:

107662478 107688931

SGH:	107557993 107589326

CCAR:

109050785(galk2) 109058485

CAUA:

113067040(galk2)

CGIB:

127947047

PPRM:

120495526

MAMB:

125246772(galk2)

CIDE:

127507596

MASI:

127437420

IPU:	108275233(galk2)

PHYP:

113529543(galk2)

SMEO:

124392279(galk2)

TFD:	113659996(galk2)

AMEX:

103026995(galk2)

EEE:	113581772(galk2)

TRU:	101066943(galk2)

TNG:	GSTEN00025596G001

LCO:	104940594(galk2)

NCC:	104960092(galk2)

CGOB:

115009484(galk2)

ELY:	117261859(galk2)

EFO:	125887919(galk2)

PLEP:

121950267(galk2)

SLUC:

116038611(galk2)

ECRA:

117949648(galk2)

ESP:	116693880(galk2)

PFLV:

114560168(galk2)

GAT:	120808893(galk2)

PPUG:

119196710(galk2)

MSAM:

119893799(galk2)

CUD:	121514988(galk2)

ALAT:

119025054(galk2)

MZE:	101474367(galk2)

ONL:	100694499(galk2)

OAU:	116332650(galk2)

OLA:	101171825(galk2)

OML:	112152155(galk2)

XMA:	102218065(galk2)

XCO:	114136950(galk2)

XHE:	116731878(galk2)

PRET:

103466438(galk2)

PFOR:

103131462(galk2)

PLAI:

106935791(galk2)

PMEI:

106932641(galk2)

GAF:	122835901(galk2)

CVG:	107087412(galk2)

CTUL:

119787377(galk2)

GMU:	124884767(galk2)

KMR:	108230033(galk2)

ALIM:

106526835(galk2)

NWH:	119416370(galk2)

AOCE:

111577706(galk2)

MCEP:

125014347(galk2)

CSEM:

103380462(galk2)

POV:	109624422(galk2)

SSEN:

122775507(galk2)

HHIP:

117763560(galk2)

HSP:	118110070(galk2)

LCF:

108876666

SDU:	111229735(galk2)

SLAL:

111658545(galk2)

XGL:	120793693(galk2)

HCQ:	109507570(galk2)

SSCV:

125970797

BPEC:

110169595(galk2)

MALB:

109972807(galk2)

BSPL:

114857086(galk2)

SASA:

100194982(galk2)

STRU:

115196586

OTW:	112227451(galk2)

OMY:	110500811(galk2)

OGO:	124031836(galk2)

ONE:	115123517(galk2)

SALP:

111971804 112071115(galk2)

SNH:	120066439(galk2)

CCLU:

121531564(galk2)

ELS:	105018363(galk2)

SFM:	108942064(galk2)

PKI:	111846659(galk2)

AANG:

118227960(galk2)

LOC:	102690729(galk2)

PSPA:

121294622

ARUT:

117428098 117429482

PSEX:

120541344(galk2)

LCM:	102351584(GALK2)

CMK:	103186962(galk2)

RTP:

109916355

CPLA:

122540998(galk2)

BFO:

118410032

BBEL:

109466995

CIN:

100178740

SCLV:

120334709

SPU:

591788

APLC:

110984721

AJC:

117123369

SKO:

100376157

DME:	Dmel_CG5288(Galk)

DER:

6544979

DSE:

6604968

DSI:	Dsimw501_GD12949(Dsim_GD12949)

DYA:	Dyak_GE21269

DAN:

6493010

DSR:

110190643

DPO:

4814010

DPE:

6603000

DMN:

108151574

DWI:

6646317

DGR:

6558013

DMO:	Dmoj_GI11486

DNV:

108652455

DHE:

111599786

DVI:

6623682

CCAT:

101457008

BOD:

106625028

RZE:

108373683

MDE:

101899814

SCAC:

106094565

LCQ:

111686521

LSQ:

119606329

HIS:

119648782

AGA:	AgaP_AGAP005012 AgaP_AGAP005013 AgaP_AGAP012568

ACOZ:

120951450 120951540

AARA:

120896951 120897195

AMER:

121593099 121593100

ASTE:

118509695 118509696

AAG:

5565716

AALB:

109416487

CQU:	CpipJ_CPIJ000128

CNS:

116337741

BCOO:

119080722

AME:

551581

ACER:

108002576

ALAB:

122712794

BIM:

100749831

BBIF:

117204365

BVK:

117235041

BVAN:

117153357

BTER:

100648022

BPYO:

122569090

CCAL:

108628447

OBB:

114872389

MGEN:

117221445

NMEA:

116424950

CGIG:

122394976

SOC:

105202170

MPHA:

105836697

AEC:

105145674

ACEP:

105627945

PBAR:

105426814

VEM:

105565086

HST:

105192639

DQU:

106742033

CFO:

105248693

FEX:

115239031

LHU:

105677111

PGC:

109854402

OBO:	105286760 113562013

PCF:

106792561

PFUC:

122519779

VPS:

122631785

NVI:

100116833

CSOL:

105359829

TPRE:

106649597

MDL:

103575647

CGLO:

123266711

FAS:

105273317

DAM:

107040458

AGIF:

122856815

CINS:

118074236

LHT:

122507529

CCIN:

107271008

TCA:

660592

DPA:

109539373

SOY:

115878980

ATD:

109599412

CSET:

123322552

AGB:

108913117

LDC:

111515137

NVL:

108565645

APLN:

108743357

PPYR:

116174372 116174380

OTU:

111424620

BMOR:

101745110

BMAN:

114244077

MSEX:

115450125

BANY:

112051246

NIQ:

126769111

PMAC:

106716876

PPOT:

106111923

PXU:

106124873

PRAP:

111000806

PBX:

123714578

PNAP:

125059614

ZCE:

119829714

CCRC:

123694463

HAW:

110380006

HZE:

124631625

TNL:

113496781

SLIU:

111353018 111353019

OFU:

114357140

PXY:

105393024

CFEL:

113363059 113363887

API:

100168735

DNX:

107165780

AGS:

114126911

RMD:

113551579

BTAB:

109035554

DCI:

103518459

CLEC:

106673886

HHAL:

106686188

NLU:

111056561

PHU:	Phum_PHUM424860

FOC:

113204934

TPAL:

117653437

ZNE:

110841302

CSEC:

111874212

SGRE:

126365895

FCD:

110858073

DPX:	DAPPUDRAFT_305622

DMK:

123474750

DPZ:

124315318

PVM:

113800813

PJA:

122265572

PCHN:

125031071

PMOO:

119581550

HAME:

121874255

PCLA:

123762092

PTRU:

123510812

ESN:

127006603

HAZT:

108675693

EAF:

111707425

LSM:

121114733

PPOI:

119092815

ISC:	IscW_ISCW005368

DSV:

119449703

RSAN:

119382921

RMP:

119169983

VDE:

111249141

VJA:

111270487

TUT:

107362724

DPTE:

113799192

DFR:

124494870

CSCU:

111638589

PTEP:

107440195

SDM:

118180396

CEL:	CELE_M01D7.4(tag-96)

CBR:	CBG_22217(Cbr-tag-96)

BMY:	BM_BM12010(Bm12010)

LOA:	LOAG_04522

NAI:	NECAME_00216 NECAME_11071

TSP:	Tsp_09390 Tsp_11575 Tsp_11823

HRO:	HELRODRAFT_171000

LGI:	LOTGIDRAFT_206567

PCAN:

112553882

BGT:

106065030

GAE:

121376914

HRF:

124136668

HRJ:

124284593

CRG:

105327634

MYI:	110451194 110461518

PMAX:

117334057 117334414

MCAF:

127734136

MMER:

123522914

DPOL:

127855377 127855768

OBI:

106875465

OSN:	115209292 115232262

LAK:

106158489

SMM:	Smp_078400

SHX:	MS3_00003309(GALK2_1)

OVI:	T265_10833

EGL:

EGR_07667

NVE:

5521063

EPA:

110238219

ATEN:

116295842

ADF:

107331877

AMIL:

114947527

PDAM:

113671760

SPIS:

111339158

DGT:

114537520

XEN:

124457487

HMG:

100201282

TAD:	TRIADDRAFT_51952

AQU:

100635641

ATH:	AT3G06580(GALK)

ALY:

9320659

CRB:

17891124

CSAT:

104725032 104744827 104764353

EUS:	EUTSA_v10020583mg

BRP:	103849843 103870735

BNA:	106351102 106352899 106401687 106452993

BOE:	106296154 106328312

RSZ:	108805417 108809455

THJ:

104818876

CPAP:

110821277

CIT:	102609053 102612610

CIC:	CICLE_v10004814mg CICLE_v10004815mg

PVY:	116110893 116124295

MINC:

123210226 123220204

TCC:

18603687

GRA:	105775397 105800770

GHI:	107931507 107935097 107936088 121213728

GAB:	108454150 108480623

DZI:

111280004

EGR:

104415246

GMX:	100796793 100803230

GSJ:	114393733 114419948 114424258

PVU:	PHAVU_003G116700g PHAVU_010G104600g

VRA:	106764922 106766523

VAR:	108329962 108329967

VUN:

114177171

CCAJ:

109811004

APRC:

113846676 113852764 113861828

MTR:

11418335

CAM:

101496906

PSAT:

127073163

LJA:	Lj0g3v0357339.1(Lj0g3v0357339.1) Lj4g3v2263880.1(Lj4g3v2263880.1)

ADU:

107462750

AIP:

107639344

AHF:	112703094 112723190

LANG:

109329383 109338402 109362134

FVE:

101301951

RCN:

112201004

PPER:

18790144

PMUM:

103323208

PAVI:

110752320

MDM:	103403520 103452662

PXB:

103961282

ZJU:	107404688 107407078 107407090 107407595 107407602 107408564 107408869 107408871 107408935

MNT:

21388072

CSV:

101222674

CMO:

103483903

BHJ:

120088820

MCHA:

111009231

CMAX:

111470682 111479371

CMOS:

111443458 111457755

CPEP:

111791010 111800913

RCU:

8258843

JCU:

105643566

HBR:	110669400 110672942

MESC:

110602178 110610320

POP:	7485841 7485886

PEU:	105115525 105122254

PALZ:

118045989 118062441

JRE:	108994829 109010775

CILL:

122300346 122317793

QSU:

111983133

QLO:

115995390

TWL:	120012333 120015657

VVI:

100244839

VRI:

117914862

SLY:

101267552

SPEN:

107008513

SOT:

102597452

SSTN:

125860846

CANN:

107878649

NTA:	107771316 107806963 107813265

NSY:

104236621

NTO:	104100681 104110994

NAU:	109207994 109217520

INI:

109176233

ITR:

116002744

SIND:

105156834 105178872

OEU:	111371523 111381334 111388285

EGT:

105960638

SSPL:

121767278 121769918

APAN:

127250302 127266427

HAN:

110940986

ECAD:

122579179

LSV:

111914177

CCAV:

112522162 112527306

DCR:	108196702 108199458

CSIN:

114308382 114310686 114313049

BVG:

104887933

SOE:	110787295 110798325

CQI:	110697308 110738208

NNU:

104598734

MING:

122071960 122090614

TSS:	122660528 122671844

PSOM:

113326912 113328397 113333343 113342593 113342616 113346944

OSA:

4334679

DOSA:

Os03t0832600-01(Os03g0832600)

OBR:

102720420

OGL:

127768454

BDI:

100824538

ATS:

109744798

TDC:	119283917 119287582 119312655

TAES:

123084150 123087796 123114130 123123618

TUA:

125552979

LPER:

127291952

SBI:

8079681

ZMA:

100284953

SITA:

101761856

SVS:

117840869

PVIR:

120649205 120691849

PHAI:

112877055

PDA:	103712675 103721022

EGU:

105039960

MUS:

103976564

ZOF:	121977857 121979263 121983911 122036820

DCT:

110106124

PEQ:

110021877

AOF:	109819882 109847232

NCOL:

116254706

ATR:

18431449

SMO:	SELMODRAFT_144964 SELMODRAFT_268487

PPP:	112287070 112296002

CRE:	CHLRE_17g732300v5

VCN:	VOLCADRAFT_98854

MNG:	MNEG_10228

CSL:	COCSUDRAFT_25096

CVR:	CHLNCDRAFT_57327

APRO:

F751_4029

OLU:	OSTLU_31076

OTA:	OT_ostta04g01480

BPG:	Bathy01g01320

MIS:	MICPUN_60667

MPP:	MICPUCDRAFT_26260

CCP:	CHC_T00007304001

LBC:	LACBIDRAFT_251636

MPR:	MPER_03299

CPUT:

CONPUDRAFT_50823

SRE:	PTSG_06504

DDI:	DDB_G0292112(galK)

DPP:	DICPUDRAFT_147991

DFA:	DFA_05675(galK)

ACAN:

ACA1_074450 ACA1_107480

TGO:	TGME49_229780

TET:	TTHERM_00145260 TTHERM_00703700

PTM:	GSPATT00007558001 GSPATT00015163001

FCY:	FRACYDRAFT_264529(GALK2_1)

PIF:	PITG_10010

PSOJ:

PHYSODRAFT_492612

GTT:	GUITHDRAFT_160545

TVA:	TVAG_2v0356730 TVAG_2v0871730 TVAG_2v0980690

BRV:	CFK39_06660

BGG:	CFK41_02270

BRZ:	CFK38_04455

BSAU:

DWV08_11750

AOS:	AXE84_07315

AVC:	NCTC10951_01629(galK_2)

TBH:	Tbon_09120

SACI:

Sinac_5476

PCOR:

KS4_25140(galK_2)

PBAS:

SMSP2_01028(galK_1)

» show all

Reference

1 [PMID:8702831]

Authors

Pastuszak I, Drake R, Elbein AD.

Title

Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.

Journal

J Biol Chem 271:20776-82 (1996)
DOI:10.1074/jbc.271.34.20776

Reference

2 [PMID:8798585]

Authors

Pastuszak I, O'Donnell J, Elbein AD.

Title

Identification of the GalNAc kinase amino acid sequence.

Journal

J Biol Chem 271:23653-6 (1996)
DOI:10.1074/jbc.271.39.23653

Sequence

[hsa:2585]

Reference

3 [PMID:16006554]

Authors

Thoden JB, Holden HM

Title

The molecular architecture of human N-acetylgalactosamine kinase.

Journal

J Biol Chem 280:32784-91 (2005)
DOI:10.1074/jbc.M505730200

Sequence

[hsa:2585]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.157

IUBMB Enzyme Nomenclature:

2.7.1.157

ExPASy - ENZYME nomenclature database:

2.7.1.157

BRENDA, the Enzyme Database:

2.7.1.157

DBGET integrated database retrieval system