Entry
Name
N-acetylgalactosamine kinase;
GALK2;
GK2;
GalNAc kinase;
N-acetylgalactosamine (GalNAc)-1-phosphate kinase;
ATP:N-acetyl-D-galactosamine 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase
Reaction(IUBMB)
ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:
R08967 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
N-acetyl-alpha-D-galactosamine
Product
ADP [CPD:
C00008 ];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:
C18060 ]
Comment
The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.
History
EC 2.7.1.157 created 2005
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
K18674 N-acetylgalactosamine kinase
Genes
PANU : 101018804(GALK2) 116272414
TFN : 117070679(GALK2) 117097537
DMER : 138804122 138815881
TACU : 119928750 119931547(GALK2)
SRX : 107712518(galk2) 107739099
SANH : 107662478 107688931
CCAR : 109050785(galk2) 109058485
SALP : 111971804 112071115(galk2)
ARUT : 117428098 117429482
DSI : Dsimw501_GD12949(Dsim_GD12949)
ACOZ : 120951450 120951540
AARA : 120896951 120897195
AMER : 121593099 121593100
ASTE : 118509695 118509696
AMAP : 126560793 126560794
AFUN : 125767848 125767849
AMOU : 128303421 128304129
AMRS : 128712189 128713116
PPYR : 116174372 116174380
SLIU : 111353018 111353019
CFEL : 113363059 113363887
AFRA : 136043837 136043841
CEL : CELE_M01D7.4(tag-96)
CBR : CBG_22217(Cbr-tag-96)
NAI : NECAME_00216 NECAME_11071
TSP : Tsp_09390 Tsp_11575 Tsp_11823
PMAX : 117334057 117334414
AIRR : 138332910 138333059
DPOL : 127855377 127855768
SHX : MS3_00003309(GALK2_1)
CSAT : 104725032 104744827 104764353
BNA : 106352899 106401687 106439085 106452993 125593860 125599754
CIC : CICLE_v10004814mg CICLE_v10004815mg
MINC : 123210226 123220204
GHI : 107931507 107935097 107936088 121213728
HSYR : 120159048 120176062 120202534
GSJ : 114393733 114419948 114424258
APRC : 113846676 113852764 113861828
LANG : 109329383 109338402 109362134
PCIN : 129298842 129309170 129320477
QSA : O6P43_003695 O6P43_021884
MSYL : 126597293 126608486
PCOX : 137731590 137736828
CSAV : 115710566 115717222 115723314
CMAX : 111470682 111479371
CMOS : 111443458 111457755
CPEP : 111791010 111800913
MESC : 110602178 110610320
PALZ : 118045989 118062441
CILL : 122300346 122317793
NTA : 107771316 107806963 107813265
SIND : 105156834 105178872
OEU : 111371523 111381334 111388285
SSPL : 121767278 121769918
SHIS : 125200845 125207924
APAN : 127250302 127266427
HPUM : 140874484 140879086
PHUA : 140967021 140981046 140985067
PEBU : 140814248 140827519 140830800
CCAV : 112522162 112527306
CSIN : 114308382 114310686 114313049
MING : 122071960 122090614
PSOM : 113326912 113328397 113333343 113342593 113342616 113346944
TDC : 119283917 119287582 119312655
TAES : 123084150 123087796 123114130 123123618
MFLO : 136480788 136481479
PVIR : 120649205 120691849
ZOF : 121977857 121979263 121983911 122036820
ACAK : 137956249 137958902
SMO : SELMODRAFT_144964 SELMODRAFT_268487
ACAN : ACA1_074450 ACA1_107480
TET : TTHERM_00145260 TTHERM_00703700
PTM : GSPATT00007558001 GSPATT00015163001
FCY : FRACYDRAFT_264529(GALK2_1)
TVA : 4757550(TVAGG3_0871730) 4763737(TVAGG3_0356730) 4766419(TVAGG3_0980690)
SSAO : 94294990(SS50377_20967) 94300556(SS50377_26533)
» show all
Taxonomy
Reference
Authors
Pastuszak I, Drake R, Elbein AD.
Title
Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.
Journal
Reference
Authors
Pastuszak I, O'Donnell J, Elbein AD.
Title
Identification of the GalNAc kinase amino acid sequence.
Journal
Sequence
Reference
Authors
Thoden JB, Holden HM
Title
The molecular architecture of human N-acetylgalactosamine kinase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.157