| Entry |
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| Name |
inositol-pentakisphosphate 2-kinase;
IP5 2-kinase;
Gsl1p;
Ipk1p;
inositol polyphosphate kinase;
inositol 1,3,4,5,6-pentakisphosphate 2-kinase;
Ins(1,3,4,5,6)P5 2-kinase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase
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| Reaction(IUBMB) |
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate [RN: R05202]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD: C01284]
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| Product |
ADP [CPD: C00008];
1D-myo-inositol hexakisphosphate [CPD: C01204]
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| Comment |
The enzyme can also use Ins(1,4,5,6)P4 [2] and Ins(1,4,5)P3 [3] as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment [5].
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| History |
EC 2.7.1.158 created 2006
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| Pathway |
| ec00562 | Inositol phosphate metabolism |
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| Orthology |
| K10572 | inositol-pentakisphosphate 2-kinase |
| K19786 | inositol-pentakisphosphate 2-kinase |
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| Genes |
» show all
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| Reference |
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| Authors |
York JD, Odom AR, Murphy R, Ives EB, Wente SR. |
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| Title |
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Phillippy BQ, Ullah AH, Ehrlich KC. |
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| Title |
Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds. |
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| Journal |
J Biol Chem 269:28393-9 (1994) |
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| Reference |
3 |
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| Authors |
Phillippy, B.Q., Ullah, A.H. and Ehrlich, K.C. |
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| Title |
Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds. |
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| Journal |
J Biol Chem 270:7782 (1997) |
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| Reference |
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| Authors |
Ongusaha PP, Hughes PJ, Davey J, Michell RH. |
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| Title |
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation. |
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| Journal |
Biochem J 335 ( Pt 3):671-9 (1998) |
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| Reference |
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| Authors |
Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR. |
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| Title |
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway. |
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| Journal |
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| Reference |
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| Authors |
Stevenson-Paulik J, Odom AR, York JD. |
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| Title |
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.1.158 |
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