KEGG ENZYME: 2.7.1.161

ENZYME: 2.7.1.161

Entry

EC 2.7.1.161                Enzyme

Name

CTP-dependent riboflavin kinase;
Methanocaldococcus jannaschii Mj0056;
Mj0056

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

CTP:riboflavin 5'-phosphotransferase

Reaction(IUBMB)

CTP + riboflavin = CDP + FMN [RN:R08574]

Reaction(KEGG)

R08574

Substrate

CTP [CPD:C00063];
riboflavin [CPD:C00255]

Product

CDP [CPD:C00112];
FMN [CPD:C00061]

Comment

This archaeal enzyme differs from EC 2.7.1.26, riboflavin kinase, in using CTP as the donor nucleotide. UTP, but not ATP or GTP, can also act as a phosphate donor but it is at least an order of magnitude less efficient than CTP.

History

EC 2.7.1.161 created 2008

Pathway

ec00740

Riboflavin metabolism

ec01100

Metabolic pathways

Orthology

K07732

riboflavin kinase, archaea type

Genes

HSV:	HNO53_13320

HSX:	HNO51_12725

BSHI:

LGQ02_01885

ADIN:

H7849_19875

MDA:	IPZ59_15350

MJA:

MJ_0056

MFE:	Mefer_0604

MVU:	Metvu_0494

MFS:	MFS40622_0448

MIF:	Metin_1019

MJH:	JH146_0525

MESG:

MLAUSG7_0930(ribK)

MESA:

MLASG1_0087(ribK)

MIG:	Metig_1790

MMP:

MMP0184

MMQ:	MmarC5_1492

MMX:	MmarC6_0768

MMZ:	MmarC7_1183

MMD:

GYY_00935

MMAK:

MMKA1_01880(rfk)

MMAO:

MMOS7_02140(rfk)

MMAD:

MMJJ_09010

MAE:

Maeo_0925

MVN:	Mevan_1186

MVO:

Mvol_1472

MOK:	Metok_0518

METF:

CFE53_02490

MTH:

MTH_1500

MMG:	MTBMA_c00850

MWO:	MWSIV6_0041(ribK)

MTEE:

MTTB_00740

METC:

MTCT_1364

METE:

tca_01447

METZ:

METMT2_1348

METK:

FVF72_04110

MTHM:

FZP57_00150

METJ:

FZP68_01550

MST:

Msp_0177

METB:

AW729_06220

MEIS:

PXD04_04765

MRU:	mru_2174(ribK)

MSI:

Msm_1257

MEB:	Abm4_0017(ribK)

MMIL:

sm9_0008(ribK)

MEYE:

TL18_00100

MOL:

YLM1_1648

MARO:

MarbSA_11180

METV:

K4897_05050

MEL:	Metbo_0045

MEW:	MSWAN_0042

METH:

MBMB1_0035

MFC:	BRM9_0089(ribK)

MFI:	DSM1535_1407

MCUB:

MCBB_0051(ribK)

MSUB:

BK009_09890

METN:

BK008_05550

METT:

CIT01_05850

METO:

CIT02_06895

MEME:

HYG87_06785

MFEG:

GCM10025860_08010

MFV:

Mfer_0343

MKA:

MK1398

AFU:

AF_2106

AFG:	AFULGI_00023740

APO:	Arcpr_1275

AVE:	Arcve_1041

AST:	Asulf_02078

FPL:

Ferp_0920

GAC:

GACE_0050

GAH:

GAH_00799

PFU:

PF0988

PFI:

PFC_04170

PHO:	PH0660(PH0660)

PAB:

PAB0917

PYN:

PNA2_1275

PYA:	PYCH_10250

PYS:

Py04_1099

PYC:	TQ32_04755

TKO:

TK1272

TON:

TON_0557

TGA:

TGAM_0914

TSI:

TSIB_0978

TBA:	TERMP_00567

THE:

GQS_02300

THA:

TAM4_500

THM:

CL1_0129

TLT:

OCC_08510

THS:

TES1_0959

TNU:

BD01_0450

TEU:

TEU_09890

TGY:	X802_08125

THV:	ADU37_CDS08700

TCH:	CHITON_0649

TPEP:

A0127_08575

TPIE:

A7C91_08820

TGG:	A3K92_04470

TCE:	A3L02_02250

TBS:	A3L01_03505

THH:	CDI07_03445

TSL:	A3L11_07455

TTD:	A3L14_05170

TPRF:

A3L09_08180

TRL:	A3L10_03065

TPAF:

A3L08_06650

THY:	A3L12_05430

TIC:	FH039_06140

TCQ:	TIRI35C_0934(ribK)

THEM:

FPV09_03210

THEI:

K1720_08075

PPAC:

PAP_07010

MBA:	Mbar_A1523

MBY:	MSBRM_0443

MBW:	MSBRW_3207

MBAR:

MSBR2_1939

MBAK:

MSBR3_1972

MAC:

MA_0547

MMA:

MM_1709

MMAZ:

MmTuc01_1791

MMJ:	MSMAS_2965

MMAC:

MSMAC_1469

MVC:	MSVAZ_0498

MEK:	MSKOL_0482

MLS:	MSLAZ_0305

METM:

MSMTP_2894

MEF:	MSWH1_2669

MEQ:	MSWHS_2367

MSJ:	MSSAC_0476

MSZ:	MSSIH_0445

MSW:	MSSIT_0470

MTHR:

MSTHT_2081

MTHE:

MSTHC_1203

MHOR:

MSHOH_3670

MFZ:	AOB57_005560

MBU:

Mbur_1724

MMET:

MCMEM_2195

MELO:

J7W08_09985

MMH:

Mmah_2024

MHAZ:

BHR79_03515

MPOT:

BKM01_10390

MEV:	Metev_2203

MZH:	Mzhil_1966

MPY:

Mpsy_1944

MZI:	HWN40_12335

MMAV:

RE476_11020

MSEB:

RE474_07580

MHZ:	Metho_0115

MEHF:

MmiHf6_15780

MEES:

MmiEs2_01320

MCJ:

MCON_0442

MHI:

Mhar_0833

MHU:

Mhun_1259

MRTJ:

KHC33_06705

MLA:

Mlab_1629

MEM:	Memar_2359

MBG:	BN140_2498

MEMA:

MMAB1_3358(ribK)

MCHK:

MchiMG62_00890

MSUM:

OH143_06065

MRC:	R6Y96_01545

MPI:

Mpet_0554

MEND:

L6E24_05790

MEFW:

F1737_08430

MAQE:

RJ40_08465

MFK:	E2N92_08685

MOU:	OU421_08175

MESB:

L1S32_11450

MANQ:

L1994_08655

MBN:

Mboo_0159

MFO:	Metfor_0021

MPL:

Mpal_2512

MPD:

MCP_2669

MEZ:

Mtc_0175

RCI:

RCIX631

HAL:

VNG_2126C

HSL:	OE_3964R(ribK)

HANR:

LJ422_08550

HDL:	HALDL1_15545

HHB:	Hhub_3414(ribK)

HAGS:

JT689_09900

HABO:

JRZ79_08280

HNO:	LT974_13885

HLU:	LT972_00830

HALH:

HTSR_1794

HHSR:

HSR6_1863(rfk)

HSU:	HLASF_0219

HSF:	HLASA_0219

HAHS:

HSRCO_0353

SALR:

FQU85_05560

HALR:

EFA46_002480

HJE:	HacjB3_01970

HDO:	MUK72_00765

HALX:

M0R89_07025

HAXZ:

M0R88_07225

HAYC:

NGM10_09125

HAXY:

NGM07_12985

SALI:

L593_07815

SAIM:

K0C01_04785

HARA:

AArcS_0242

HMA:

rrnAC3074

HHI:

HAH_0329

HHN:	HISP_01730

HAB:	SG26_09545

HTA:	BVU17_01590

HALJ:

G9465_01115

HSIN:

KDQ40_12040

NPH:	NP_0072A(ribK)

NMO:	Nmlp_1367(ribK)

NHO:	HWV23_06560

NSAL:

HWV07_07530

HUT:

Huta_2018

HTI:

HTIA_1657

HALA:

Hrd1104_00300

HASV:

SVXHr_2624

HABN:

HBNXHr_2496(rfk)

HMU:

Hmuk_1112

HALZ:

E5139_08740

HALL:

LC1Hm_0127

HAZP:

GBQ70_08735

HALI:

BV210_09075

HSN:	DV733_03135

HDS:	HSR122_1886

HRR:	HZS55_01455

HPEL:

HZS54_01925

HLT:	I7X12_10760

HARC:

HARCEL1_01980

SSAI:

N0B31_12080

HAAD:

MW046_09040

HWA:	HQ_3236A(ribK)

HWC:	Hqrw_3797(ribK)

HVO:	HVO_0326(ribK)

HALE:

G3A49_01845

HLN:	SVXHx_0307(ribK)

HME:

HFX_0311

HGI:	ABY42_01465

HLS:	KU306_06325

HBO:	Hbor_28460

HAQ:	DU484_04415

HAJ:	DU500_04890

HAER:

DU502_02335

HRA:	EI982_11205

HLM:	DV707_02580

HALM:

FCF25_08505

HLA:

Hlac_0355

HALP:

DOS48_01345

HALB:

EKH57_10340

HEZZ:

EO776_01085

HALQ:

Hrr1229_005855

HSS:	J7656_00085

HSAI:

HPS36_05600

HAZZ:

KI388_14775

SRUB:

C2R22_01335

HAE:	halTADL_1959

HALN:

B4589_010495

HALG:

HUG10_18210

HALU:

HUG12_18005

HMP:	K6T50_13345

HRE:	K6T36_13255

HRM:	K6T25_03400

HACB:

Hbl1158_05180

HDF:	AArcSl_1739

HAAA:

AArcCO_0122

HAH:	Halar_2887

HTU:	Htur_2982 Htur_3829

HSAL:

JMJ58_13510

HAKZ:

J0X25_01675

NMG:	Nmag_0941(ribK)

HXA:	Halxa_2284

NAT:

NJ7G_1689

NPE:	Natpe_1021

NVR:	FEJ81_05335

NPL:	FGF80_08495

NAY:	HYG81_04890 HYG81_06660

HALY:

HYG82_08295

HJT:	DVR14_14410

HLO:	J0X27_11390

NGE:	Natgr_2256

HRU:	Halru_2255

SAWL:

NGM29_09910

HALV:

NGM15_02105

NOU:	Natoc_2634

HLR:	HALLA_07320

HLC:	CHINAEXTREME09165

NAJ:	B1756_12385

NAG:	AArcMg_2900

NAN:	AArc1_0803

NARA:

QQ977_02660

NBG:	DV706_10845

NAS:	GCU68_01240

HDA:	BB347_08795

NAC:	AQV86_04640

MELU:

MTLP_08830

MEAM:

MU439_00680

MEAE:

QEN48_01970

TAC:

Ta1064

TVO:	TVG0510159(TVG0510159)

PTO:

PTO0969

FAC:	FACI_IFERC01G0265

FAI:

FAD_1183

CDIV:

CPM_1181

TAR:	TALC_00153

MAX:	MMALV_01480

MER:	MMINT_18460

MEAR:

Mpt1_c13270(ribK)

MEUZ:

KRP56_00850

MARC:

AR505_1679

ABI:

Aboo_1119

ACF:	AciM339_1446

APE:	APE_2112.1

ACJ:

ACAM_1322

SMR:

Smar_1200

SHC:	Shell_1267

IHO:

Igni_0547

IIS:

EYM_00165

IPC:

IPA_00375

DKA:

DKAM_0976

DFD:	Desfe_1094

DMU:	Desmu_0112

TAG:

Tagg_0106

IAG:

Igag_0233

THG:	TCELL_0600

HBU:

Hbut_0506

PFM:	Pyrfu_0197

PABI:

PABY_15050

PARE:

PYJP_01690

STO:

STK_12800

SOH:	D1869_07410

SSO:

SSO0955

SOL:

Ssol_1931

SSOA:

SULA_1963

SSOL:

SULB_1964

SSOF:

SULC_1962

SSHI:

J5U23_02523

SCAS:

SACC_08390

SAI:

Saci_1332

SACN:

SacN8_06495

SACR:

SacRon12I_06485

SACS:

SUSAZ_06365

SIS:	LS215_1358

SIA:	M1425_1271

SIM:	M1627_1321

SID:

M164_1255

SIY:	YG5714_1256

SIN:	YN1551_1592

SII:

LD85_1383

SIH:

SiH_1216

SIR:

SiRe_1134

SIC:

SiL_1131

SULA:

BFU36_01660

SULE:

GFS03_07135

SULO:

GFS33_12545

SULL:

EWF20_08585

MSE:

Msed_1737

MEMJ:

MJ1HA_1982

MCN:

Mcup_0491

MHK:	DFR87_09975

MPRU:

DFR88_09550

MTEN:

GWK48_02300

MJN:	MjAS7_2865

AHO:

Ahos_1402

AMAN:

B6F84_11470

ABRI:

DFR85_10825

ASUL:

DFR86_09785

AAMB:

D1866_01945

ACIH:

HS5_28140

SACD:

HS1genome_1021

SAZO:

D1868_04175

CSTY:

KN1_24240

STEP:

IC006_1163

SMET:

RQ359_000747

SAHS:

HS7_19280

PAI:

PAE2157

PIS:

Pisl_0940

PCL:

Pcal_1071

PAS:

Pars_0815

PYR:

P186_0396

POG:

Pogu_1517

TNE:

Tneu_1345

PYW:	PYWP30_01425

CMA:

Cmaq_1224

TTN:

TTX_0185

TUZ:

TUZN_1162

VDI:

Vdis_2013

VMO:

VMUT_0422

VSO:	Vsou_03060

TPE:

Tpen_0098

THB:	N186_01410

TCB:	TCARB_1366

THF:	MA03_00990

THEL:

IG193_07065

ASC:

ASAC_1027

ACIA:

SE86_06255

CLG:	Calag_0492

FFO:	FFONT_0239

KCR:

Kcr_0996

NMR:

Nmar_1301

NIR:	NSED_07210

NKR:	NKOR_07335

NID:	NPIRD3C_0824(ribK)

NIN:	NADRNF5_0657(ribK)

NIW:	Nisw_07230

NCL:	C5F47_06995

NOX:	C5F49_07005

NUE:	C5F50_09760

NIP:	NsoK4_01540

NZT:	NZOSNM25_000512

NCT:	NMSP_0389(ribK)

NIC:	DSQ20_07960

NGA:	Ngar_c19280(rfk)

NVN:	NVIE_003160(ribK)

NEV:

NTE_01635

TAA:	NMY3_02209

NFN:	NFRAN_2972

NCV:	NCAV_0987(ribK)

CSY:	CENSYa_0128

CSU:	CSUB_C1502

NBV:

T478_1053

TAH:	SU86_009025

NIU:	DSQ19_03165

NDV:	NDEV_1634(ribK)

CCAI:

NAS2_0385

BARC:

AOA65_2401(ribK)

BARB:

AOA66_0539(ribK)

FLT:	Sv326_0640

NCON:

LC1Nh_0881(rfk)

LOKI:

Lokiarch_26640(ribK)

LOB:	NEF87_004351

PSYT:

DSAG12_01900

AGW:	QT03_C0001G0834

» show all

Reference

1 [PMID:18073108]

Authors

Ammelburg M, Hartmann MD, Djuranovic S, Alva V, Koretke KK, Martin J, Sauer G, Truffault V, Zeth K, Lupas AN, Coles M.

Title

A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels.

Journal

Structure 15:1577-90 (2007)
DOI:10.1016/j.str.2007.09.027

Sequence

[mja:MJ_0056]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.161

IUBMB Enzyme Nomenclature:

2.7.1.161

ExPASy - ENZYME nomenclature database:

2.7.1.161

BRENDA, the Enzyme Database:

2.7.1.161

DBGET integrated database retrieval system