KEGG ENZYME: 2.7.1.162

ENZYME: 2.7.1.162

Entry

EC 2.7.1.162                Enzyme

Name

N-acetylhexosamine 1-kinase;
NahK;
LnpB;
N-acetylgalactosamine/N-acetylglucosamine 1-kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:N-acetyl-D-hexosamine 1-phosphotransferase

Reaction(IUBMB)

ATP + N-acetyl-D-hexosamine = ADP + N-acetyl-alpha-D-hexosamine 1-phosphate [RN:R08962]

Reaction(KEGG)

R08962 > R08967 R08968

Substrate

ATP [CPD:C00002];
N-acetyl-D-hexosamine [CPD:C03136]

Product

ADP [CPD:C00008];
N-acetyl-alpha-D-hexosamine 1-phosphate [CPD:C18055]

Comment

This enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.

History

EC 2.7.1.162 created 2008

Orthology

K13059

N-acetylhexosamine 1-kinase

Genes

AHE:

Arch_0012

ARCA:

HC352_08700

APHO:

JTE88_08705