| Entry |
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| Name |
N-acetylhexosamine 1-kinase;
NahK;
LnpB;
N-acetylgalactosamine/N-acetylglucosamine 1-kinase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:N-acetyl-D-hexosamine 1-phosphotransferase
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| Reaction(IUBMB) |
ATP + N-acetyl-D-hexosamine = ADP + N-acetyl-alpha-D-hexosamine 1-phosphate [RN: R08962]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
ADP [CPD: C00008];
N-acetyl-alpha-D-hexosamine 1-phosphate [CPD: C18055]
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| Comment |
This enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.
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| History |
EC 2.7.1.162 created 2008
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| Orthology |
| K13059 | N-acetylhexosamine 1-kinase |
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| Genes |
» show all
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| Reference |
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| Authors |
Nishimoto M, Kitaoka M. |
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| Title |
Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.1.162 |
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