KEGG   ENZYME: 2.7.1.162Help
Entry
EC 2.7.1.162                Enzyme                                 

Name
N-acetylhexosamine 1-kinase;
NahK;
LnpB;
N-acetylgalactosamine/N-acetylglucosamine 1-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:N-acetyl-D-hexosamine 1-phosphotransferase
Reaction(IUBMB)
ATP + N-acetyl-D-hexosamine = ADP + N-acetyl-alpha-D-hexosamine 1-phosphate [RN:R08962]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N-acetyl-D-hexosamine [CPD:C03136]
Product
ADP [CPD:C00008];
N-acetyl-alpha-D-hexosamine 1-phosphate [CPD:C18055]
Comment
This enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.
History
EC 2.7.1.162 created 2008
Orthology
K13059  N-acetylhexosamine 1-kinase
Genes
AHE: Arch_0012
BLO: BL1642
BLJ: BLD_1766
BLN: Blon_2173
BLON: BLIJ_2250
BLF: BLIF_1690
BLL: BLJ_1682
BLB: BBMN68_1674
BLM: BLLJ_1622
BLK: BLNIAS_00371
BLG: BIL_03760
BBI: BBIF_0997
BBP: BBPR_1052(nahK)
BBF: BBB_0978
BBRU: Bbr_1586
BBRE: B12L_1514
BBRV: B689b_1615
BBRJ: B7017_1781
BBRC: B7019_1755
BBRN: B2258_1600
BBRS: BS27_1568
 » show all
Taxonomy
Reference
1  [PMID:17720833]
  Authors
Nishimoto M, Kitaoka M.
  Title
Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum.
  Journal
Appl Environ Microbiol 73:6444-9 (2007)
DOI:10.1128/AEM.01425-07
  Sequence
[blm:BLLJ_1622]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.162
IUBMB Enzyme Nomenclature: 2.7.1.162
ExPASy - ENZYME nomenclature database: 2.7.1.162
BRENDA, the Enzyme Database: 2.7.1.162

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