KEGG ENZYME: 2.7.1.162

ENZYME: 2.7.1.162

Entry

EC 2.7.1.162                Enzyme

Name

N-acetylhexosamine 1-kinase;
NahK;
LnpB;
N-acetylgalactosamine/N-acetylglucosamine 1-kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:N-acetyl-D-hexosamine 1-phosphotransferase

Reaction(IUBMB)

ATP + N-acetyl-D-hexosamine = ADP + N-acetyl-alpha-D-hexosamine 1-phosphate [RN:R08962]

Reaction(KEGG)

R08962 > R08967 R08968

Substrate

ATP [CPD:C00002];
N-acetyl-D-hexosamine [CPD:C03136]

Product

ADP [CPD:C00008];
N-acetyl-alpha-D-hexosamine 1-phosphate [CPD:C18055]

Comment

This enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.

History

EC 2.7.1.162 created 2008

Orthology

K13059

N-acetylhexosamine 1-kinase

Genes

PSPN:

L1F29_26950

AHE:

Arch_0012

ARCA:

HC352_08700

APHO:

JTE88_08705

APII:

NG665_08265

AHX:	RQN30_08830

TPY:	CQ11_07085

TPYO:

X956_00615

TPEC:

HLG82_09390

TBER:

QPC17_09290

BLO:

BL1642

BLJ:

BLD_1766

BLN:

Blon_2173

BLON:

BLIJ_2250

BLF:

BLIF_1690

BLL:

BLJ_1682

BLB:	BBMN68_1674

BLM:

BLLJ_1622

BLK:	BLNIAS_00371

BLG:

BIL_03760

BLZ:	BLGT_08665

BLX:	GS08_08735

BBP:	BBPR_1052(nahK)

BBI:

BBIF_0997

BBF:

BBB_0978

BBV:	HMPREF9228_1637

BBRU:

Bbr_1586

BBRE:

B12L_1514(nahK)

BBRV:

B689b_1615

BBRJ:

B7017_1781

BBRC:

B7019_1755

BBRN:

B2258_1600

BBRS:

BS27_1568

BBRD:

BBBR_1585

BCHO:

BcFMB_01975

BGX:	ESN35_08715

BLEM:

BL8807_06640

BEU:	BE0216_04970

» show all

Reference

1 [PMID:17720833]

Authors

Nishimoto M, Kitaoka M

Title

Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum.

Journal

Appl Environ Microbiol 73:6444-9 (2007)
DOI:10.1128/AEM.01425-07

Sequence

[blm:BLLJ_1622]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.162

IUBMB Enzyme Nomenclature:

2.7.1.162

ExPASy - ENZYME nomenclature database:

2.7.1.162

BRENDA, the Enzyme Database:

2.7.1.162

All links

Protein sequence (318)   
   UniProt (194)   
   SWISS-PROT (1)   
   RefSeq(pep) (113)   
   PDBSTR (10)   
DNA sequence (1347)   
   RefSeq(nuc) (1077)   
   GenBank (136)   
   EMBL (134)   
3D Structure (10)   
   PDB (10)   
Protein domain (3)   
   InterPro (3)   
All databases (1678)   

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