KEGG   ENZYME: 2.7.1.164Help
Entry
EC 2.7.1.164                Enzyme                                 

Name
O-phosphoseryl-tRNASec kinase;
PSTK;
phosphoseryl-tRNA[Ser]Sec kinase;
phosphoseryl-tRNASec kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:L-seryl-tRNASec O-phosphotransferase
Reaction(IUBMB)
ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec [RN:R08223]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-seryl-tRNA(Sec) [CPD:C06481]
Product
ADP [CPD:C00008];
O-phospho-L-seryl-tRNASec
Comment
In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).
History
EC 2.7.1.164 created 2009
Pathway
ec00450  Selenocompound metabolism
ec00970  Aminoacyl-tRNA biosynthesis
Orthology
K10837  O-phosphoseryl-tRNA(Sec) kinase
Genes
HSA: 118672(PSTK)
PTR: 466225(PSTK)
PPS: 100991616(PSTK)
GGO: 101132103(PSTK)
PON: 100444035(PSTK)
NLE: 100604256(PSTK)
MCC: 707601(PSTK)
CSAB: 103216648(PSTK)
RRO: 104657572(PSTK)
RBB: 108519575(PSTK)
CJC: 100395731(PSTK)
SBQ: 101028456(PSTK)
MMU: 214580(Pstk)
RNO: 361661(Pstk)
CGE: 100766247(Pstk)
NGI: 103729264(Pstk)
HGL: 101700708(Pstk)
CCAN: 109691653(Pstk)
OCU: 103345569(PSTK)
TUP: 102495932(PSTK)
CFA: 477855(PSTK)
AML: 100469975(PSTK)
UMR: 103657947(PSTK)
ORO: 101374388(PSTK)
FCA: 101097176(PSTK)
PTG: 102952756(PSTK)
AJU: 106969408(PSTK)
BTA: 511744(PSTK)
BOM: 102266938(PSTK)
BIU: 109579123(PSTK)
PHD: 102335060(PSTK)
CHX: 102176662(PSTK)
OAS: 101113029(PSTK)
SSC: 100517244(PSTK)
CFR: 102516976(PSTK)
CDK: 105085762(PSTK)
BACU: 102998209
LVE: 103077611(PSTK)
OOR: 101290272(PSTK)
ECB: 100050336(PSTK)
EPZ: 103560221(PSTK)
EAI: 106826682(PSTK)
MYB: 102256958(PSTK)
MYD: 102770046(PSTK)
HAI: 109396918(PSTK)
RSS: 109436394(PSTK)
PALE: 102883394(PSTK)
LAV: 100658151(PSTK)
TMU: 101360573
MDO: 100025338(PSTK)
SHR: 100928232(PSTK)
OAA: 100087684(PSTK)
GGA: 771778(PSTK)
MGP: 100541977(PSTK)
CJO: 107316259(PSTK)
APLA: 101795083(PSTK)
ACYG: 106038990(PSTK)
TGU: 105759382(PSTK)
GFR: 102040109(PSTK)
FAB: 101818121(PSTK)
PHI: 102100740(PSTK)
PMAJ: 107206823(PSTK)
CCW: 104694581(PSTK)
FPG: 101917794(PSTK)
FCH: 102057982(PSTK)
CLV: 102096798(PSTK)
EGZ: 104128328(PSTK)
AAM: 106494196(PSTK)
ASN: 102369560(PSTK)
AMJ: 102576845(PSTK)
PSS: 102452198(PSTK)
CMY: 102937930(PSTK)
CPIC: 101939133(PSTK)
ACS: 100560637(pstk)
PVT: 110087226(PSTK)
PBI: 103065614(PSTK)
GJA: 107116290(PSTK)
XLA: 444702(pstk.L)
XTR: 100158568(pstk)
NPR: 108784788(PSTK)
DRE: 103911967
SRX: 107736724
SANH: 107674413(pstk)
SGH: 107569516(pstk)
CCAR: 109073713(pstk)
IPU: 108273621(pstk)
AMEX: 103029452(pstk)
TRU: 101079271(pstk)
LCO: 104926807 109143027(pstk)
NCC: 104954038(pstk)
MZE: 101472959(pstk)
OLA: 101163364(pstk)
XMA: 102231130(pstk)
PRET: 103481583(pstk)
NFU: 107387803(pstk)
CSEM: 103381954(pstk)
LCF: 108899017(pstk)
HCQ: 109523991(pstk)
BPEC: 110165471(pstk)
SASA: 106577432
ELS: 105009563(pstk)
SFM: 108939710(pstk)
LCM: 102366882(PSTK)
CMK: 103185460(pstk)
CIN: 100177473
SPU: 100888397
APLC: 110977115
SKO: 100377551
DME: Dmel_CG12788(CG12788)
DSI: Dsimw501_GD24457(Dsim_GD24457)
MDE: 101887591
ZNE: 110833329
FCD: 110852207
TUT: 107360222
CEL: CELE_Y49E10.22(pstk-1)
CBR: CBG11694(Cbr-pstk-1)
TSP: Tsp_10561
MYI: 110466484
OBI: 106872979
LAK: 106151138
SHX: MS3_00477
EPA: 110234511
HMG: 100200454
AQU: 100632695
CRE: CHLREDRAFT_206160(PSK1)
DFA: DFA_05221
SPAR: SPRG_22201
NGR: NAEGRDRAFT_78247(FM175)
MJA: MJ_1538
MMP: MMP1490
MMD: GYY_08290
MAE: Maeo_0491
MVO: Mvol_1610
MKA: MK1679
LOKI: Lokiarch_31880(pstK)
 » show all
Taxonomy
Reference
1  [PMID:15317934]
  Authors
Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
  Title
Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
  Journal
Proc Natl Acad Sci U S A 101:12848-53 (2004)
DOI:10.1073/pnas.0402636101
  Sequence
[hsa:118672] [mmu:214580]
Reference
2  [PMID:18174226]
  Authors
Sherrer RL, O'Donoghue P, Soll D
  Title
Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
  Journal
Nucleic Acids Res 36:1247-59 (2008)
DOI:10.1093/nar/gkm1134
Reference
3  [PMID:9521673]
  Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
  Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
  Journal
Biochemistry 37:3518-28 (1998)
DOI:10.1021/bi972177k
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.164
IUBMB Enzyme Nomenclature: 2.7.1.164
ExPASy - ENZYME nomenclature database: 2.7.1.164
BRENDA, the Enzyme Database: 2.7.1.164
CAS: 91273-83-5

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