Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy

ATP:L-seryl-tRNASec O-phosphotransferase

ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec [RN:R08223]

R08223
Reaction

ATP [CPD:C00002];
L-seryl-tRNA(Sec) [CPD:C06481]

In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).

EC 2.7.1.164 created 2009

1  [PMID:15317934]

Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL

Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.

Proc Natl Acad Sci U S A 101:12848-53 (2004)
DOI:10.1073/pnas.0402636101

[hsa:118672] [mmu:214580]

2  [PMID:18174226]

Sherrer RL, O'Donoghue P, Soll D

Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.

Nucleic Acids Res 36:1247-59 (2008)
DOI:10.1093/nar/gkm1134

3  [PMID:9521673]

Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC

Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.

Biochemistry 37:3518-28 (1998)
DOI:10.1021/bi972177k