KEGG   ENZYME: 2.7.1.164
Entry
EC 2.7.1.164                Enzyme                                 
Name
O-phosphoseryl-tRNASec kinase;
PSTK;
phosphoseryl-tRNA[Ser]Sec kinase;
phosphoseryl-tRNASec kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:L-seryl-tRNASec O-phosphotransferase
Reaction(IUBMB)
ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec [RN:R08223]
Reaction(KEGG)
R08223
Substrate
ATP [CPD:C00002];
L-seryl-tRNA(Sec) [CPD:C06481]
Product
ADP [CPD:C00008];
O-phospho-L-seryl-tRNASec
Comment
In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).
History
EC 2.7.1.164 created 2009
Pathway
ec00450  Selenocompound metabolism
ec00970  Aminoacyl-tRNA biosynthesis
Orthology
K10837  O-phosphoseryl-tRNA(Sec) kinase
Genes
HSA118672(PSTK)
PTR466225(PSTK)
PPS100991616(PSTK)
GGO101132103(PSTK)
PON100444035(PSTK)
NLE100604256(PSTK)
HMH116482457(PSTK)
MCC707601(PSTK)
MCF101864845(PSTK)
MTHB126963262
MNI105469943(PSTK)
CSAB103216648(PSTK)
CATY105578001(PSTK)
PANU101014912(PSTK)
TGE112631225(PSTK)
MLEU105544120(PSTK)
RRO104657572(PSTK)
RBB108519575(PSTK)
TFN117065401(PSTK)
PTEH111550818(PSTK)
CANG105503351(PSTK)
CJC100395731(PSTK)
SBQ101028456(PSTK)
CIMI108282115(PSTK)
CSYR103273230(PSTK)
MMUR105880342(PSTK)
LCAT123649971(PSTK)
PCOQ105808713(PSTK)
OGA100954013(PSTK)
MMU214580(Pstk)
MCAL110298453(Pstk)
MPAH110330132(Pstk)
RNO361661(Pstk)
MCOC116103097(Pstk)
ANU117708309(Pstk)
MUN110563206(Pstk)
CGE100766247(Pstk)
MAUA101837105(Pstk)
PROB127228446(Pstk)
PLEU114692602(Pstk)
MORG121457578(Pstk)
MFOT126498538
AAMP119805958(Pstk)
NGI103729264(Pstk)
HGL101700708(Pstk)
CPOC100715100(Pstk)
CCAN109691653(Pstk)
DORD105989750(Pstk)
DSP122126798(Pstk)
PLOP125345975(Pstk)
NCAR124985279
MMMA107152909(Pstk)
OCU103345569
OPI101520728(PSTK)
TUP102495932(PSTK)
GVR103607723(PSTK)
CFA477855(PSTK)
CLUD112672449(PSTK)
VVP112928833(PSTK)
VLG121484009(PSTK)
NPO129523353(PSTK)
AML100469975(PSTK)
UMR103657947(PSTK)
UAH113252023(PSTK)
UAR123803903(PSTK)
ELK111145055
LLV125084474
MPUF101675082(PSTK)
MNP132016847(PSTK)
MLK131830591(PSTK)
NVS122901188(PSTK)
ORO101374388(PSTK)
EJU114221856(PSTK)
ZCA113919316(PSTK)
MLX118027391(PSTK)
NSU110592722(PSTK)
LWW102735380(PSTK)
FCA101097176(PSTK)
PYU121037340(PSTK)
PCOO112854495(PSTK)
PBG122493343(PSTK)
PVIV125147402(PSTK)
LRUF124507202
PTG102952756(PSTK)
PPAD109252317(PSTK)
PUC125933477
AJU106969408
HHV120235536(PSTK)
BTA511744(PSTK)
BOM102266938(PSTK)
BIU109579123(PSTK)
BBUB102398808(PSTK)
BBIS105002540(PSTK)
CHX102176662(PSTK)
OAS101113029(PSTK)
BTAX128067985(PSTK)
ODA120873890(PSTK)
CCAD122446717(PSTK)
MBEZ129555277(PSTK)
SSC100517244(PSTK)
CFR102516976(PSTK)
CBAI105067409(PSTK)
CDK105085762(PSTK)
VPC102529762(PSTK)
BACU102998209
BMUS118882334(PSTK)
LVE103077611(PSTK)
OOR101290272(PSTK)
DLE111172228(PSTK)
PCAD102991683(PSTK)
PSIU116741949(PSTK)
NASI112403213(PSTK)
ECB100050336(PSTK)
EPZ103560221(PSTK)
EAI106826682(PSTK)
MYB102256958(PSTK)
MYD102770046(PSTK)
MMYO118655620(PSTK)
MLF102426589(PSTK) 102442991
PKL118719617(PSTK)
EFUS103299335(PSTK)
MNA107532660(PSTK)
DRO112300264(PSTK)
SHON118990531(PSTK)
AJM119059548(PSTK)
PDIC114497444(PSTK)
PHAS123828768(PSTK)
MMF118632357(PSTK)
PPAM129077235(PSTK)
HAI109396918(PSTK)
RFQ117035901(PSTK)
PALE102883394(PSTK)
PGIG120608846(PSTK)
PVP105295677(PSTK)
RAY107515972(PSTK)
MJV108390574(PSTK)
TOD119234924(PSTK)
SARA101554345(PSTK)
SETR125994937(PSTK)
LAV100658151(PSTK)
TMU101360573
ETF101644015(PSTK)
DNM101443049(PSTK)
MDO100025338(PSTK)
GAS123238202(PSTK)
SHR100928232(PSTK)
AFZ127551668
PCW110192799(PSTK)
OAA100087684(PSTK)
GGA771778(PSTK)
PCOC116231553(PSTK)
MGP100541977(PSTK)
CJO107316259(PSTK)
TPAI128077650(PSTK)
LMUT125693338(PSTK)
NMEL110399567(PSTK)
APLA101795083(PSTK)
ACYG106038990(PSTK)
CATA118248732(PSTK)
AFUL116491074(PSTK)
TGU105759382(PSTK)
LSR110468449(PSTK)
SCAN103814103(PSTK)
PMOA120500005(PSTK)
OTC121341686(PSTK)
PRUF121350051(PSTK)
GFR102040109(PSTK)
FAB101818121(PSTK)
OMA130255024(PSTK)
PHI102100740(PSTK)
PMAJ107206823(PSTK)
CCAE111931385(PSTK)
CCW104694581(PSTK)
CBRC103621487(PSTK)
ETL114072597(PSTK)
ZAB102062086(PSTK)
ZLE135449353(PSTK)
ACHL103799726(PSTK)
SVG106855151(PSTK)
MMEA130583488(PSTK)
HRT120755916(PSTK)
FPG101917794(PSTK)
FCH102057982(PSTK)
CLV102096798(PSTK)
EGZ104128328(PSTK)
NNI104022113(PSTK)
PCRI104024438(PSTK)
PLET104614497(PSTK)
EHS104504818(PSTK)
PCAO104042059(PSTK)
ACUN113481717(PSTK)
TALA104363955(PSTK)
PADL103918644(PSTK)
AFOR103897934(PSTK)
ACHC115348311(PSTK)
HALD104316764(PSTK)
HLE104840802(PSTK)
AGEN126043214
GCL127017806
CCRI104155944(PSTK)
CSTI104559167(PSTK)
CMAC104484426(PSTK)
MUI104534796(PSTK)
BREG104635918(PSTK)
FGA104070315(PSTK)
GSTE104260236(PSTK)
MNB103772849(PSTK)
OHA104339601(PSTK)
NNT104400748(PSTK)
SHAB115608788(PSTK)
DPUB104309152(PSTK)
PGUU104458316(PSTK)
ACAR104517795(PSTK)
CPEA104389135(PSTK)
AVIT104267664(PSTK)
CVF104293270(PSTK)
RTD128911701(PSTK)
CUCA104058564(PSTK)
TEO104370132(PSTK)
BRHI104498534(PSTK)
AAM106494196(PSTK)
AROW112965993(PSTK)
NPD112947817(PSTK)
TGT104577935(PSTK)
DNE112994033(PSTK)
SCAM104141337(PSTK)
ASN102369560(PSTK)
AMJ102576845(PSTK)
CPOO109323793(PSTK)
GGN109287688(PSTK)
PSS102452198(PSTK)
CMY102937930(PSTK)
CCAY125640432(PSTK)
DCC119859508(PSTK)
TST117880735(PSTK)
CABI116834434(PSTK)
MRV120368566(PSTK)
ACS100560637(pstk)
ASAO132771027(PSTK)
PVT110087226(PSTK)
PBI103065614(PSTK)
PMUR107285943(PSTK)
CTIG120306188(PSTK)
TSR106554070(PSTK)
PGUT117676699(PSTK)
APRI131201498(PSTK)
PTEX113439167(PSTK)
NSS113413139(PSTK)
VKO123031111(PSTK)
PMUA114597409(PSTK)
PRAF128414158(PSTK)
ZVI118096521(PSTK)
HCG128349942(PSTK)
GJA107116290(PSTK)
STOW125438195(PSTK)
EMC129332229(PSTK)
XLA444702(pstk.L)
XTR100158568(pstk)
NPR108784788(PSTK)
RTEM120910375(PSTK)
BBUF121005204(PSTK)
MUO115459363 115469850(PSTK)
GSH117358979(PSTK)
DRE101884223 103911967
SRX107736724
SANH107674413(pstk)
SGH107569516(pstk)
CCAR109073713(pstk)
CAUA113055819
CGIB127969083
PTET122333488
LROH127173951
OMC131550703
PPRM120487124
RKG130069719
MAMB125254956
CIDE127523213
MASI127423545 127427025
TROS130569406
TDW130438663
MANU129421498
IPU108273621
IFU128617108
PHYP113527246(pstk)
SMEO124388487
TFD113652182
TVC132842055
TRN134321150
AMEX103029452(pstk)
CMAO118809041
EEE113588403(pstk)
CHAR105905408
TRU101079271(pstk)
TFS130528145
TNGGSTEN00012528G001
LCO109143027(pstk)
NCC104954038(pstk)
TBEN117473635
CGOB115024466(pstk)
PGEO117465149
GACU117543788
EMAC134870556
ELY117247574
EFO125881135
PLEP121959129
SLUC116061443
ECRA117937066
ESP116670779(pstk)
PFLV114548101(pstk)
GAT120819197
PPUG119213164
AFB129091275
CLUM117749167
PSWI130203996
MSAM119915475
SCHU122867338
CUD121528187
ALAT119009332
MZE101472959(pstk)
ONL100699733(pstk)
OAU116328845
OLA101163364(pstk)
OML112154113
CSAI133419898
XMA102231130(pstk)
XCO114151946(pstk)
XHE116727011(pstk)
PRET103481583(pstk)
PFOR103150622(pstk)
PLAI106951748(pstk)
PMEI106922411(pstk)
GAF122823773
PPRL129368251
CVG107090221(pstk)
CTUL119775961
GMU124874699
NFU107387803(pstk)
KMR108249255
ALIM106516589(pstk)
NWH119423719
AOCE111582231(pstk)
MCEP125022915
CSEM103381954(pstk)
POV109627125(pstk)
SSEN122759128
HHIP117753006
HSP118100964
PPLT128427190
SMAU118287518
LCF108899017
SDU111219968 111219969 111240231
SLAL111660230(pstk)
XGL120793986
HCQ109523991(pstk)
SSCV125990962
SBIA133495730
PEE133395194
PTAO133469104
BPEC110165471(pstk)
MALB109962967(pstk)
BSPL114845930
SJO128381408
SASA106577432
STRU115190112 115190113
OTW112236397
OMY110531859 110531886
OGO124018355
OKI109881873 109886755
OKE118380314 127922602
SALP112077272(pstk)
SNH120038504 120038513
CCLU121578424
ELS105009563(pstk)
SFM108939710(pstk)
PKI111853682(pstk)
AANG118217580
LOC102696251(pstk)
PSPA121326124
ARUT117417961
PSEX120539395
LCM102366882(PSTK)
CMK103185460
RTP109927462
CPLA122561392
HOC132826147
LERI129703997
BBEL109462956
CIN100177473
SCLV120347537
SPU100888397
LPIC129273194
APLC110977115
DMEDmel_CG12788(Pstk)
DER6550434
DSE6615020
DSIDsimw501_GD24457(Dsim_GD24457)
DYADyak_GE17373
DSR110180106
DPO6902132
DPE6602902
DMN108152639
DGR6565872
DMODmoj_GI11009
DAZ108620194
DNV108656631
DHE111591998
CCAT105664496
BOD106616554
BDR109579194
AOQ129253152
MDE101887591
SCAC106094461
LCQ111680183
LSQ119604949
GFS119638970
ECOE129938840
CLON129607883
ACOZ120949008
AARA120895200
AMER121592194
ASTE118510276
AFUN125770701
AMOU128302383
AALI118463257
AALB109416978
CQUCpipJ_CPIJ010839
CPII120418875
BCOO119076537
PPYR116172917
CCRN123301354
CLEC106668175
HHAL106684661
NLU111058942
HVI124360441
MQU128992415
PHUPhum_PHUM297960
FOC113208904
TPAL117649975
ZNE110833329
CSEC111863886
BROR134537364
FCD110852207
DMK116917105
PVM113828387
PJA122261727
PCHN125032729
PMOO119595806
HAME121861227
PCLA123762143
CQD128687319
PTRU123511902
ESN126997093
MNZ135219879
HAZT108679572
EAF111701265
LSM121123181
TCF131877618
PPOI119092525
DSV119461173
RSAN119379060
RMP119175959
VDE111254616
VJA111259397
TUT107360222
CSCU111632000
PTEP107449627
ABRU129966093
SDM118200870
LPOL106459379
PMEO129588226
CELCELE_Y49E10.22(pstk-1)
CBRCBG_11694(Cbr-pstk-1)
CRQGCK72_011070
NAINECAME_03575
LOALOAG_18421
TSPTsp_10561
LGILOTGIDRAFT_232809
PVUL126814327
PCAN112564087
BGT106079838
GAE121384106
HRF124139376
HRJ124274370
CRG105325005
CVN111100356
CANU128181143
OED125658849
MYI110466484
PMAX117339566
MMER123546552
RPHI132741332
OBI106872979
OSN115230201
LJP135466542
LAK106151138
SMMSmp_074770
SHXMS3_00005148
OVIT265_06161
LLON135488906
NVE5508623
ATEN116291250
AMIL114962404
PDAM113670418
SPIS111334283
DGT114515894
XEN124444758
HMG105845147
HSY130641482
TADTRIADDRAFT_58609
AQU100632695
CRECHLRE_06g296000v5
CSLCOCSUDRAFT_62949
CVRCHLNCDRAFT_140755
OLUOSTLU_16752
OTAOT_ostta09g01900
BPGBathy10g02680
MISMICPUN_64194
MPPMICPUCDRAFT_55939(JGI:MicpuC2_55939)
GSLGasu_43110
SREPTSG_02035
DFADFA_05221
ACANACA1_074470
PTIPHATRDRAFT_41418
FCYFRACYDRAFT_238778
PIFPITG_05651
PSOJPHYSODRAFT_556252
SPARSPRG_22201
EHXEMIHUDRAFT_116308 EMIHUDRAFT_208254
GTTGUITHDRAFT_105125
NGRNAEGRDRAFT_78247(FM175)
CBLACBLAS_0018
MJAMJ_1538
MFEMefer_1539
MVUMetvu_0654
MFSMFS40622_0749
MIFMetin_1012
MJHJH146_0135
MESGMLAUSG7_0499(pstK)
MESAMLASG1_0010(pstK)
MIGMetig_0165
MMPMMP1490
MMQMmarC5_0087
MMXMmarC6_1184
MMZMmarC7_0734
MMDGYY_08290
MMAKMMKA1_17140(pstK)
MMAOMMOS7_15960(pstK)
MMADMMJJ_13480(mtaD_2)
MAEMaeo_0491
MVNMevan_0799
MVOMvol_1610
MOKMetok_1516
METFCFE53_04575(pstK)
MKAMK1679
LOKILokiarch_31880(pstK)
LOBNEF87_005019
PSYTDSAG12_02520(pstK)
 » show all
Reference
1  [PMID:15317934]
  Authors
Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
  Title
Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
  Journal
Proc Natl Acad Sci U S A 101:12848-53 (2004)
DOI:10.1073/pnas.0402636101
  Sequence
[hsa:118672] [mmu:214580]
Reference
2  [PMID:18174226]
  Authors
Sherrer RL, O'Donoghue P, Soll D
  Title
Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
  Journal
Nucleic Acids Res 36:1247-59 (2008)
DOI:10.1093/nar/gkm1134
Reference
3  [PMID:9521673]
  Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
  Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
  Journal
Biochemistry 37:3518-28 (1998)
DOI:10.1021/bi972177k
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.164
IUBMB Enzyme Nomenclature: 2.7.1.164
ExPASy - ENZYME nomenclature database: 2.7.1.164
BRENDA, the Enzyme Database: 2.7.1.164
CAS: 91273-83-5

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