Entry
Name
O-phosphoseryl-tRNASec kinase;
PSTK;
phosphoseryl-tRNA[Ser]Sec kinase;
phosphoseryl-tRNASec kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:L-seryl-tRNASec O-phosphotransferase
Reaction(IUBMB)
ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec [RN:
R08223 ]
Reaction(KEGG)
Substrate
Product
ADP [CPD:
C00008 ];
O-phospho-L-seryl-tRNASec
Comment
In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC
2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).
History
EC 2.7.1.164 created 2009
Pathway
ec00970 Aminoacyl-tRNA biosynthesis
Orthology
K10837 O-phosphoseryl-tRNA(Sec) kinase
Genes
MLF : 102426589(PSTK) 102442991
MASI : 127423545 127427025
SDU : 111219968 111219969 111240231
STRU : 115190112 115190113
DSI : Dsimw501_GD24457(Dsim_GD24457)
CEL : CELE_Y49E10.22(pstk-1)
CBR : CBG_11694(Cbr-pstk-1)
EHX : EMIHUDRAFT_116308 EMIHUDRAFT_208254
NGR : NAEGRDRAFT_78247(FM175)
LOKI : Lokiarch_31880(pstK)
» show all
Taxonomy
Reference
Authors
Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
Title
Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
Journal
Sequence
Reference
Authors
Sherrer RL, O'Donoghue P, Soll D
Title
Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
Journal
Reference
Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.164