KEGG   ENZYME: 2.7.1.166Help
Entry
EC 2.7.1.166                Enzyme                                 

Name
3-deoxy-D-manno-octulosonic acid kinase;
kdkA (gene name);
Kdo kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:(Kdo)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase
Reaction(IUBMB)
alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP [RN:R09767]
Reaction(KEGG)
Substrate
alpha-Kdo-(2->6)-lipid IVA;
ATP [CPD:C00002]
Product
4-O-phospho-alpha-Kdo-(2->6)-lipid IVA [CPD:C19877];
ADP [CPD:C00008]
Comment
The enzyme phosphorylates the 4-OH position of Kdo in (Kdo)-lipid IVA.
History
EC 2.7.1.166 created 2010, modified 2011
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K11211  3-deoxy-D-manno-octulosonic acid kinase
Genes
HIN: HI0260.1
HIT: NTHI0367(kdkA)
HIP: CGSHiEE_01760
HIQ: CGSHiGG_04085
HIF: HIBPF_02040
HIL: HICON_12130
HIU: HIB_03190
HIE: R2846_0325(kdkA)
HIZ: R2866_0324(kdkA)
HIK: HifGL_000012(kdkA)
HIA: H733_0155
HIW: NTHI477_01300(kdkA)
HIC: NTHIC486_00733(kdkA)
HIX: NTHI723_01437(kdkA)
HDU: HD_1101(kdkA)
HAP: HAPS_0211(kdkA)
HPAZ: K756_05480
HPAS: JL26_04970
HPAK: JT17_02525
PMU: PM1303
PMV: PMCN06_1970(kdtA)
PMP: Pmu_19660(kdkA)
PMUL: DR93_551(kdkA)
PDAG: 4362423_01452(kdkA)
MSU: MS1964(sPS1)
MHQ: D650_8630
MHAT: B824_17690
MHX: MHH_c26070(kdkA)
MHAE: F382_03790
MHAM: J450_02825
MHAO: J451_04035
MHAL: N220_09890
MHAQ: WC39_04305
MHAY: VK67_04305
MVR: X781_7490
MVE: X875_6110
APL: APL_0904(kdkA)
APJ: APJL_0916(kdkA)
APA: APP7_0963(kdkA)
ASU: Asuc_1985
AAT: D11S_0381
AAN: D7S_00859
AACN: AANUM_0597
BTO: WQG_13700
BTRE: F542_8340
BTRH: F543_9630
BTRA: F544_14090
XFA: XF_2153
XFT: PD_1213
XCC: XCC0993
XCB: XC_3251
XCA: xcc-b100_3366(waaP)
XCP: XCR_1193
XCV: XCV1103(kdkA)
XAX: XACM_1053(kdkA)
XAC: XAC1095
XCI: XCAW_01193(sPS1)
XFU: XFF4834R_chr10760(kdkA)
XOO: XOO1057
XOM: XOO0957(XOO0957)
XOP: PXO_02451
XOR: XOC_1150
XAL: XALC_0604(kdkA)
XPH: XppCFBP6546_06085(XppCFBP6546P_06085)
SML: Smlt1004
SMT: Smal_0850
SMZ: SMD_0942
SACZ: AOT14_09660(kdkA)
PSUW: WQ53_02115
PSD: DSC_11970
LEZ: GLE_1666
LEM: LEN_3300
DKO: I596_1882
VCH: VC0227
VCS: MS6_0095
VCI: O3Y_01040
VVU: VV1_0814
VVY: VV0297
VPA: VP0196
VPB: VPBB_0203
VAG: N646_2384
VSP: VS_0192(waaP)
VNI: VIBNI_A3729(kdkA)
VAN: VAA_02464
VAU: VANGNB10_cI2539c(wavC)
VSC: VSVS12_00339(kdkA)
VTA: A3101(kdkA)
VFI: VF_0136(wavC)
VSA: VSAL_I0182(wavC) VSAL_I0241(wavC)
AWD: AWOD_I_0133(wavC)
PPR: PBPRA0210(WAVC)
SON: SO_4677(kdkA)
SDN: Sden_3612
SFR: Sfri_3935
SAZ: Sama_0101
SBL: Sbal_0061
SLO: Shew_3706
SSE: Ssed_0105
SPL: Spea_0110
SHL: Shal_4212
SWD: Swoo_0068
SWP: swp_5062
SVO: SVI_0097(kdkA)
SPSW: Sps_00146
CPS: CPS_0117(kdkA)
PHA: PSHAa2319
PAT: Patl_0055
PSM: PSM_A0767
PSEO: OM33_06550
PPHE: PP2015_713
PTN: PTRA_a2809(kdkA)
PEA: PESP_a0948(kdkA)
PSPO: PSPO_a0739(kdkA)
PART: PARC_a3116(kdkA)
PTU: PTUN_a3545(kdkA)
PNG: PNIG_a3002(kdkA)
PTD: PTET_a0865(kdkA)
PSEN: PNC201_14500(kdkA)
MAQ: Maqu_0778
MHC: MARHY0647
MAD: HP15_439
MBS: MRBBS_0656(kdkA)
AMAL: I607_00275
AMAE: I876_00290
AMAO: I634_00275
AMAD: I636_00280
AMAI: I635_00280
AMAG: I533_00275
AMAC: MASE_00280
AAUS: EP12_00315
GNI: GNIT_0061(kdkA)
GPS: C427_0070
SALH: HMF8227_00049(kdkA)
PIN: Ping_0330
FBL: Fbal_0149
MVS: MVIS_0149(wavC)
TEE: Tel_02945
AEH: Mlg_2807
HHA: Hhal_2259
TKM: TK90_0306
TNI: TVNIR_2695(kdkA_[H])
GAI: IMCC3135_06860(kdkA)
CSA: Csal_0015
HAM: HALO4511
HCO: LOKO_01073(kdkA_1)
HBE: BEI_0014(kdkA)
APAC: S7S_02270
KKO: Kkor_2338
KGE: TQ33_0240
AHA: AHA_0043(kdkA)
ASA: ASA_0038(kdtA)
AVR: B565_0032
AMED: B224_5297
ASR: WL1483_2189(kdkA)
ACAV: VI35_00185
TAU: Tola_0135
OCE: GU3_03195
SALN: SALB1_0115
BPE: BP2349
BPC: BPTD_2308
BPER: BN118_2274
BPET: B1917_2262
BPEU: Q425_22790
BPA: BPP1690
BPAR: BN117_1708
BBR: BB3418
BPT: Bpet1947
BAV: BAV2255
BHO: D560_2547
BHM: D558_2530
BHZ: ACR54_03019(kdkA)
BTRM: SAMEA390648703800(kdkA)
AXX: ERS451415_01875(kdkA)
PUT: PT7_0485
AMIM: MIM_c15070(kdkA)
BPSI: IX83_02325
AFQ: AFA_05310
ODI: ODI_R1614
DAT: HRM2_18250(kdkA)
OBG: Verru16b_01924(kdkA)
KST: KSMBR1_3933(kdkA_2)
GAU: GAU_2418
GBA: J421_3869
 » show all
Taxonomy
Reference
1  [PMID:10952982]
  Authors
Brabetz W, Muller-Loennies S, Brade H
  Title
3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout  mutation of Escherichia coli.
  Journal
J Biol Chem 275:34954-62 (2000)
DOI:10.1074/jbc.M005204200
  Sequence
[hin:HI0260.1]
Reference
2  [PMID:17517879]
  Authors
Harper M, Boyce JD, Cox AD, St Michael F, Wilkie IW, Blackall PJ, Adler B
  Title
Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases.
  Journal
Infect Immun 75:3885-93 (2007)
DOI:10.1128/IAI.00212-07
Reference
3  [PMID:9195966]
  Authors
White KA, Kaltashov IA, Cotter RJ, Raetz CR
  Title
A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae.
  Journal
J Biol Chem 272:16555-63 (1997)
DOI:10.1074/jbc.272.26.16555
  Sequence
[hin:HI0260.1]
Reference
4  [PMID:10531340]
  Authors
White KA, Lin S, Cotter RJ, Raetz CR
  Title
A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence.
  Journal
J Biol Chem 274:31391-400 (1999)
DOI:10.1074/jbc.274.44.31391
  Sequence
[hin:HI0260.1]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.166
IUBMB Enzyme Nomenclature: 2.7.1.166
ExPASy - ENZYME nomenclature database: 2.7.1.166
BRENDA, the Enzyme Database: 2.7.1.166

DBGET integrated database retrieval system