Entry
Name
D-glycero-beta-D-manno-heptose-7-phosphate kinase;
heptose 7-phosphate kinase;
D-beta-D-heptose 7-phosphotransferase;
D-beta-D-heptose-7-phosphate kinase;
HldE1 heptokinase;
glycero-manno-heptose 7-phosphate kinase;
D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase;
hldE (gene name);
rfaE (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:D-glycero-beta-D-manno-heptose 7-phosphate 1-phosphotransferase
Reaction(IUBMB)
D-glycero-beta-D-manno-heptose 7-phosphate + ATP = D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP [RN:
R05646 ]
Reaction(KEGG)
Substrate
D-glycero-beta-D-manno-heptose 7-phosphate [CPD:
C07836 ];
ATP [CPD:
C00002 ]
Product
D-glycero-beta-D-manno-heptose 1,7-bisphosphate [CPD:
C11472 ];
ADP [CPD:
C00008 ]
Comment
The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC
2.7.7.70 ). The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. The enzyme selectively produces D-glycero-beta-D-manno-heptose 1,7-bisphosphate [5].
History
EC 2.7.1.167 created 2010
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K03272 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase
K21344 D-glycero-beta-D-manno-heptose-7-phosphate kinase
Genes
ECW : EcE24377A_3515(hldE)
EDJ : ECDH1ME8569_2949(rfaE)
ECOI : ECOPMV1_03369(hldE)
RTG : NCTC13098_00883(hldE)
REE : electrica_00629(hldE)
RIP : RIEPE_0585 RIEPE_0589
CLAP : NCTC11466_03963(hldE)
KIE : NCTC12125_04562(hldE)
BAGE : BADSM9389_35320(hldE)
METY : MRY16398_07270(hldE)
PTF : PROFFT_A_01130(hldE)
PSHI : SAMEA2665130_0471(hldE)
YPG : YpAngola_A0292(hldE)
YPI : YpsIP31758_0564(hldE)
SMW : SMWW4_v1c42130(rfaE)
SFJ : SAMEA4384070_4252(hldE)
SOF : NCTC11214_02397(hldE)
PAQU : DMB82_0004420(hldE)
DIC : Dpoa569_000770(hldE)
EHD : ERCIPSTX3056_281(hldE)
PHEI : NCTC12003_03127(hldE)
PRJ : NCTC6933_03230(hldE)
LRI : NCTC12151_02771(hldE)
HIC : NTHIC486_01179(hldE)
HPIT : NCTC13334_01260(hldE)
HHZ : NCTC10839_01336(hldE)
HAEG : NCTC8502_01552(hldE)
PDAG : 4362423_00581(hldE)
ADP : NCTC12871_01672(hldE)
ALIG : NCTC10568_01117(waaE)
ASEG : NCTC10977_01595(hldE)
AVT : NCTC3438_01160(hldE)
PAET : NCTC13378_01088(hldE)
VAU : VANGNB10_cI2201c(rfaE)
VPL : SA104470976_00389(hldE)
PAEB : NCGM1900_5748(rfaE)
PVD : CFBP1590__4801(hldE)
PPRC : PFLCHA0_c05390(hldE)
PFW : PF1751_v1c04520(hldE)
PPUU : PputUW4_00413(rfaE)
PTRT : HU722_0003330(hldE)
PTW : TUM18999_55440(hldE)
PTAE : NCTC10697_04108(hldE)
SCAA : TUM17387_31730(hldE)
SALH : HMF8227_02392(gmhC)
CBS : COXBURSA331_A1838(hldE)
MISZ : MishRS11D_00750(hldE_1) MishRS11D_16880(hldE_2)
TIB : THMIRHAM_04650(hldE)
TSE : THMIRHAS_20000(hldE)
TZO : THMIRHAT_05880(hldE)
TNI : TVNIR_2697(hldE_[H])
AEL : NCTC12917_00461(hldE)
ACII : C4901_12030(rfaE1) C4901_13985
ATY : A9R16_002880(rfaE2) A9R16_004770(rfaE1)
CDIZ : CEDIAZO_00912(hldE)
NMQ : NMBM04240196_1341(hldE_N)
NMZ : NMBNZ0533_0872(hldE_N)
NMX : NMA510612_1153(rfaE)
NWE : SAMEA3174300_0219(rfaE)
NZO : SAMEA4504057_2169(rfaE)
NCI : NCTC10296_02366(rfaE)
NCZ : NCTC10294_00462(rfaE)
NANI : NCTC12227_00228(rfaE)
ECOR : SAMEA4412678_1967(hldE_2)
BMV : BMASAVP1_A2566(rfaE)
BML : BMA10229_A0941(rfaE_1)
BMN : BMA10247_0207(rfaE_1)
BPM : BURPS1710b_2987(rfaE)
BPL : BURPS1106A_2940(rfaE_1)
BPD : BURPS668_2877(rfaE_1)
BPR : GBP346_A3057(rfaE_2)
BUU : WS70_03680 WS70_12600
BSAV : WS86_04870 WS86_05795
BCEW : DM40_1544(rfaE) DM40_1713(rfaE)
BDF : WI26_03905 WI26_04755
BUG : BC1001_1844 BC1001_2626
BGF : BC1003_1507 BC1003_2595
BXB : DR64_1405(rfaE) DR64_3148(rfaE)
BPX : BUPH_02315 BUPH_03199
BPY : Bphyt_0908 Bphyt_2996
PBRY : NDK50_03475(rfaE1) NDK50_16045(rfaE1)
PLG : NCTC10937_00715(hldE)
VTR : MYVALT_G_02470(rfaE)
BTRM : SAMEA390648703841(hldE')
AXX : ERS451415_01615(hldE_2)
RDP : RD2015_2042 RD2015_722
URU : DSM104443_02629(rfaE)
UPL : DSM104440_02355(rfaE)
FPHO : SHINM1_014220(waaE)
RPUS : CFBP5875_22080(rfaE1)
BSEP : HAP48_0047280(rfaE1)
BQB : J4P68_0006470(rfaE1)
BBAN : J4G43_035480(rfaE1)
BCAN : BcanWSM471_26295(rfaE1)
VGO : GJW-30_1_01782(hldE)
BVY : NCTC9239_01317(hldE)
SRF : LHU95_11445(rfaE1) LHU95_23195
RAP : RHOA_2616(hldE) RHOA_3110(hldE)
ABS : AZOBR_40288(rfaE) AZOBR_p60111(rfaE)
NAO : Y958_28115 Y958_29415
SMUC : JL100_016370(rfaE2)
HPO : HMPREF4655_20738(rfaE)
HPX : HMPREF0462_0550(rfaE)
HCL : NCTC13205_00422(waaE)
HSH : NHP194022_13470(hldE)
HPUL : NCTC13154_00047(hldE)
CJV : MTVDSCj20_1157(waaE)
CFV : CFVI03293_1452(waaE)
CAMP : CFT03427_1376(waaE)
CCOC : CCON33237_0838(waaE)
CLR : UPTC16701_0475(waaE)
CLM : UPTC16712_0483(waaE)
CAMR : CAQ16704_0498(waaE)
CHV : CHELV3228_0618(waaE)
CPIN : CPIN18020_0875(waaE)
CAMZ : CVIC12175_0217(waaE)
GBN : GEOBRER4_32680(hldE)
DEP : AOP6_1888(hldE_1) AOP6_1893(hldE_2)
DEF : CNY67_09115(rfaE2) CNY67_12975(rfaE2)
AMIC : Ami3637_06355(rfaE2)
VRM : 44547418_00765(hldE)
VDN : NCTC11831_01192(hldE)
DHO : Dia5BBH33_11420(hldE)
SSG : Selsp_0388 Selsp_0392
SRI : SELR_15090 SELR_26560 SELR_26610
SELE : ADJ74_05165 ADJ74_05190
SELO : AXE86_04700 AXE86_04720
SELT : BCS37_01250 BCS37_01275
MANA : MAMMFC1_02278(hldE_1) MAMMFC1_02290(hldE_3)
PFAC : PFJ30894_00059(hldE)
MNV : MNVI_29030(hldE) MNVI_32420
MFLV : NCTC10271_03893(hldE)
CHN : A605_05485 A605_05505
CSTA : CSTAT_10495 CSTAT_10515
NFR : ERS450000_01687(hldE_1) ERS450000_01708(hldE_2)
NCY : NOCYR_3092(hldE) NOCYR_3101(hldE)
NWL : NWFMUON74_17460 NWFMUON74_43000 NWFMUON74_43780
NGP : LTT66_21630 LTT66_23975
SAMB : SAM23877_5918(hldE)
SLE : sle_14910(sle_14910)
SGM : GCM10017557_15180(hldE)
SAST : CD934_01780(rfaE2) CD934_05560
SCOE : CP976_34445(rfaE2) CP976_40825(rfaE2)
STUI : GCM10017668_56760(hldE)
SVD : CP969_05260(rfaE2) CP969_29910(rfaE2)
SMOB : J7W19_00345(rfaE2) J7W19_01800(rfaE2)
SGOB : test1122_07605(rfaE2)
STRI : C7M71_027485(rfaE2)
CMH : VO01_13820 VO01_13905
CCAP : AES38_12970 AES38_13045
CPHA : FGI33_14495(rfaE2) FGI33_14600
CCAF : FGD68_00680 FGD68_00750(rfaE2)
RTX : TI83_04215 TI83_04250
RTC : APU90_02220 APU90_02255
RTN : A6122_0937 A6122_0942
RRY : C1O28_03860(rfaE2) C1O28_03885(rfaE2)
RIA : C7V51_01350(rfaE2) C7V51_01380
RFS : C1I64_10200 C1I64_10265(rfaE2)
RTE : GSU10_05280(rfaE2) GSU10_05305
CUM : NI26_07895 NI26_07915
CUB : BJK06_17395 BJK06_17415
ARR : ARUE_c01140(hldE1) ARUE_c01170(hldE2)
ARZ : AUT26_00470 AUT26_00485
ARQ : BWQ92_08045 BWQ92_08065
ARN : CGK93_00785 CGK93_00800(rfaE2)
ARX : ARZXY2_3794 ARZXY2_3797
ACRY : AC20117_03410 AC20117_03430
ARTH : C3B78_02155 C3B78_02170(rfaE2)
AAGI : NCTC2676_1_01792(hldE_1) NCTC2676_1_01796(hldE_2)
AJG : KKR91_16600 KKR91_16620(rfaE2)
ASUF : MNQ99_03355(rfaE2) MNQ99_03375(rfaE2)
AAU : AAur_0116(rfaE) AAur_0119
PUE : FV140_00460(rfaE2) FV140_00475(rfaE2)
APN : Asphe3_04650 Asphe3_04680
PSNI : NIBR502771_02810(rfaE2) NIBR502771_02825
GCR : GcLGCM259_2540 GcLGCM259_2545
RAIN : Rai3103_14165(rfaE2)
NOA : BKM31_06230 BKM31_47610
NOW : GBF35_32270 GBF35_49780(rfaE2)
NCX : Nocox_26265(hldE1) Nocox_40560(hldE2)
NGN : LCN96_35380 LCN96_54500(rfaE2)
AMQ : AMETH_2578 AMETH_5618
AACD : LWP59_11485(rfaE2) LWP59_32465(rfaE2)
ATHM : L1857_15660(rfaE2) L1857_31005(rfaE2)
PBRO : HOP40_26095(rfaE2) HOP40_26140
ACTA : C1701_21510 C1701_21555(rfaE2)
ACTU : Actkin_03546(hldE_2)
STP : Strop_1764 Strop_3975
MAU : Micau_0472 Micau_2224
MICB : MicB006_0485 MicB006_5289
MTUA : CSH63_13645 CSH63_14505(rfaE2)
MTEM : GCE86_03790 GCE86_04550 GCE86_27940(rfaE2)
MCAB : HXZ27_02435(rfaE2) HXZ27_11540
MSAG : GCM10017556_30440 GCM10017556_45700(hldE)
VMA : VAB18032_06470 VAB18032_14350
MCRA : ID554_02655 ID554_10675(rfaE2)
MENO : Jiend_07850(hldE) Jiend_23680
ACTR : Asp14428_09620(hldE)
PLAB : C6361_07540 C6361_19270(rfaE2)
PLAT : C6W10_04125 C6W10_28955(rfaE2) C6W10_32635
PFLA : Pflav_026370(hldE_1) Pflav_050250(hldE_2)
PSUU : Psuf_007790(hldE_1) Psuf_081700(hldE_2)
PRY : Prubr_20530 Prubr_48080(hldE)
DVC : Dvina_28840 Dvina_47565
RMAR : GBA65_11775 GBA65_19700
SBAE : DSM104329_02167(hldE)
LET : O77CONTIG1_00722(hldE)
NCN : BZZ01_00950 BZZ01_14895
KBS : EPA93_20970(rfaE2) EPA93_26800 EPA93_46405
ABIW : Abiwalacus_14370(hldE)
GIM : F1728_11020 F1728_24510(rfaE2)
SDYN : Mal52_56790(hldE_2)
LRS : PX52LOC_08095(rfaE1)
AGV : OJF2_33180(hldE_2) OJF2_34390(hldE_3)
MCAD : Pan265_00520(hldE_1)
ALUS : STSP2_02128(hldE_2)
CTM : Cabther_A0111 Cabther_A2120
CVL : J8C06_00535(rfaE1) J8C06_10565
CHLO : J8C02_00560(rfaE1) J8C02_10420
ABAC : LuPra_04927(hldE_1) LuPra_05052(hldE_3)
FPEI : C4N17_00420(rfaE1) C4N17_09810(rfaE1)
STR : Sterm_0236 Sterm_2407
PPIO : CE91St28_16150(hldE)
BLQ : L21SP5_02093(hldE_1)
STHA : NCTC11429_04546(hldE)
AGD : FRZ59_10775 FRZ59_11310(rfaE2)
PROC : Ptc2401_01074(hldE_2)
NMV : NITMOv2_2851(rfaE) NITMOv2_3312(rfaEa)
» show all
Taxonomy
Reference
Authors
McArthur F, Andersson CE, Loutet S, Mowbray SL, Valvano MA
Title
Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis.
Journal
Sequence
Reference
Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
Journal
Sequence
Reference
Authors
Valvano MA, Messner P, Kosma P
Title
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
Journal
Reference
Authors
Jin UH, Chung TW, Lee YC, Ha SD, Kim CH
Title
Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium.
Journal
Sequence
Reference
Authors
Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D
Title
Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.167