KEGG   ENZYME: 2.7.1.169Help
Entry
EC 2.7.1.169                Enzyme                                 

Name
pantoate kinase;
PoK;
TK2141 protein
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:(R)-pantoate 4-phosphotransferase
Reaction(IUBMB)
ATP + (R)-pantoate = ADP + (R)-4-phosphopantoate [RN:R09378]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-pantoate [CPD:C00522]
Product
ADP [CPD:C00008];
(R)-4-phosphopantoate [CPD:C18911]
Comment
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.
History
EC 2.7.1.169 created 2011
Pathway
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
Orthology
K06982  pantoate kinase
Genes
SSM: Spirs_1723
STA: STHERM_c02170
STQ: Spith_0201
SRU: SRU_1142
SRM: SRM_01322
MJA: MJ_0969
MFE: Mefer_0856
MVU: Metvu_0363
MFS: MFS40622_1020
MIF: Metin_0432
MMP: MMP0398
MMD: GYY_02060
MAE: Maeo_0620
MVO: Mvol_1657
MTH: MTH_577
METC: MTCT_0501
METE: tca_00545
MST: Msp_1187
MSI: Msm_0060
MRU: mru_1010(coaA)
MEB: Abm4_0658(coaA)
MMIL: sm9_1014(coaA)
MEYE: TL18_05355
MOL: YLM1_0554
METH: MBMB1_0614
MFC: BRM9_1621(coaA)
MCUB: MCBB_0501
MFV: Mfer_0599
MKA: MK0733
AFU: AF_1646
FPL: Ferp_0142
GAC: GACE_1884
GAH: GAH_00540
MARC: AR505_1688
ABI: Aboo_0613
PHO: PH1827(PH1827)
PAB: PAB2407
PFU: PF1869
PFI: PFC_09240
PYN: PNA2_0425
PYS: Py04_1757
TKO: TK2141
TON: TON_1516
TGA: TGAM_1716
TSI: TSIB_0883
THE: GQS_07875
THA: TAM4_1508
THM: CL1_1196
TLT: OCC_10140
THS: TES1_1911
TNU: BD01_1573
TEU: TEU_01430
PPAC: PAP_00305
MAC: MA_1279
MBAR: MSBR2_0500
MBAK: MSBR3_0047
MMA: MM_2282
MMAC: MSMAC_2036
METM: MSMTP_0819
MTHE: MSTHC_2319
MTHR: MSTHT_0988
MHOR: MSHOH_1050
MBU: Mbur_1186
MMET: MCMEM_1654
MMH: Mmah_0516
MPY: Mpsy_1000
MTP: Mthe_1433
MCJ: MCON_3479
MHI: Mhar_0609
MHU: Mhun_0831
MLA: Mlab_0921
MEMA: MMAB1_1320
MPI: Mpet_0986
MBN: Mboo_1666
MPL: Mpal_1883
MPD: MCP_2676
MEZ: Mtc_0041
RCI: RCIX620
HAL: VNG_0251C
HSL: OE_1396R
HHB: Hhub_1406
HALH: HTSR_1477
HHSR: HSR6_1549(pok)
HMA: rrnAC1672
HHI: HAH_2213
NPH: NP_0844A
NMO: Nmlp_1448
HUT: Huta_2722
HTI: HTIA_2471
HMU: Hmuk_3219
HWA: HQ_1271A
HWC: Hqrw_1300
HVO: HVO_0675
HME: HFX_0638
HLA: Hlac_0495
HTU: Htur_2679
NMG: Nmag_1073
NAT: NJ7G_1984
SALI: L593_09575
ACJ: ACAM_1212
SMR: Smar_1380
IHO: Igni_0317
IIS: EYM_03770
DKA: DKAM_0337
TAG: Tagg_0655
IAG: Igag_0498
HBU: Hbut_1428
STO: STK_05300
SSO: SSO2397
SOL: Ssol_0204
SSOA: SULA_0196
SSOL: SULB_0197
SSOF: SULC_0196
SAI: Saci_0950
SID: M164_0208
SII: LD85_0193
SIH: SiH_0195
SIR: SiRe_0189
SIC: SiL_0182
MSE: Msed_0613
MCN: Mcup_1490
AHO: Ahos_2192
PAI: PAE3407
PIS: Pisl_1364
PCL: Pcal_0382
PAS: Pars_2002
PYR: P186_1235
POG: Pogu_0120
TNE: Tneu_0312
CMA: Cmaq_1785
TUZ: TUZN_1335
TTN: TTX_1080
VDI: Vdis_0595
VMO: VMUT_1929
TPE: Tpen_1051
ASC: ASAC_0273
NMR: Nmar_1718
NCT: NMSP_1634
NEV: NTE_02599
NCV: NCAV_0021
NBV: T478_1431
NDV: NDEV_2027(pok)
BARB: AOA66_0498
 » show all
Taxonomy
Reference
1  [PMID:19666462]
  Authors
Yokooji Y, Tomita H, Atomi H, Imanaka T
  Title
Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea.
  Journal
J Biol Chem 284:28137-45 (2009)
DOI:10.1074/jbc.M109.009696
  Sequence
[tko:TK2141]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.169
IUBMB Enzyme Nomenclature: 2.7.1.169
ExPASy - ENZYME nomenclature database: 2.7.1.169
BRENDA, the Enzyme Database: 2.7.1.169

DBGET integrated database retrieval system