KEGG   ENZYME: 2.7.1.171
Entry
EC 2.7.1.171                Enzyme                                 
Name
protein-fructosamine 3-kinase;
FN3K;
fructosamine 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:[protein]-N6-D-fructosyl-L-lysine 3-phosphotransferase
Reaction(IUBMB)
ATP + [protein]-N6-D-fructosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Substrate
ATP [CPD:C00002];
[protein]-N6-D-fructosyl-L-lysine
Product
ADP [CPD:C00008];
[protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Comment
Non-enzymic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from non-enzymically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC 2.7.1.172, protein-ribulosamine 3-kinase.
History
EC 2.7.1.171 created 2011
Orthology
K15522  protein-fructosamine 3-kinase
Genes
HSA: 64122(FN3K)
PTR: 454999(FN3K)
PPS: 100983475(FN3K)
GGO: 129533942(FN3K)
PON: 100432964(FN3K)
PPYG: 129016636(FN3K)
NLE: 100601146(FN3K)
HMH: 116483692(FN3K)
SSYN: 129461497(FN3K)
MCC: 106994166(FN3K)
MCF: 102132233(FN3K)
MTHB: 126938939
MNI: 105469354(FN3K)
CSAB: 103243881(FN3K)
CATY: 105588545(FN3K)
PANU: 101024411
TGE: 112610203(FN3K)
MLEU: 105553947(FN3K)
RRO: 115891991(FN3K)
RBB: 108534066(FN3K)
TFN: 117066396(FN3K)
PTEH: 111527673(FN3K)
CANG: 105502217(FN3K)
CJC: 100397627(FN3K)
SBQ: 101053226(FN3K)
CIMI: 108301557(FN3K)
ANAN: 105717503(FN3K)
CSYR: 103253921(FN3K)
MMUR: 105878089(FN3K)
LCAT: 123620514(FN3K)
PCOQ: 105820044(FN3K)
OGA: 100943115(FN3K)
MMU: 63828(Fn3k)
MCAL: 110305314(Fn3k)
MPAH: 110332434(Fn3k)
RNO: 498034(Fn3k)
MCOC: 116078781(Fn3k)
ANU: 117711339(Fn3k)
ASYL: 127694696(Fn3k)
MUN: 110548847(Fn3k)
CGE: 100751771(Fn3k)
MAUA: 106021117(Fn3k)
PROB: 127220737(Fn3k)
PLEU: 114703926(Fn3k)
MORG: 121444120 121444635
MFOT: 126493445
AAMP: 119813493(Fn3k)
NGI: 103739318(Fn3k)
HGL: 101712216(Fn3k)
CPOC: 100718567(Fn3k)
CCAN: 109689327(Fn3k)
DORD: 105998448
DSP: 122122414
DMER: 138818855 138833292(Fn3k)
PLOP: 125366076(Fn3k)
NCAR: 124981396
MMMA: 107157817(Fn3k)
ITI: 101972752(Fn3k)
OCU: 100346330
OPI: 105942223(FN3K)
TUP: 102490564(FN3K)
GVR: 103602382(FN3K)
CFA: 608337(FN3K)
CLUD: 112672986(FN3K)
VVP: 112920928(FN3K)
VLG: 121473606(FN3K)
NPO: 129503844(FN3K)
AML: 100466189(FN3K)
UMR: 103666019(FN3K)
UAH: 113244461(FN3K)
UAR: 123777940(FN3K)
ELK: 111160382
LLV: 125087974
MPUF: 101684212(FN3K)
MNP: 132003596(FN3K)
MLK: 131816461(FN3K)
NVS: 122905851(FN3K)
ORO: 101368258(FN3K)
EJU: 114216035(FN3K)
ZCA: 113908231(FN3K)
MLX: 118024133(FN3K)
NSU: 110572449(FN3K)
FCA: 101093222(FN3K)
PYU: 121018118
PBG: 122485997(FN3K)
PVIV: 125151704(FN3K)
LRUF: 124522579
LGF: 123604193(FN3K)
AJU: 106986324
PTG: 102972520(FN3K)
PPAD: 109276725(FN3K)
PUC: 125926206
PLEZ: 122206144(FN3K)
HHV: 120228082(FN3K)
BTA: 539709(FN3K)
BOM: 102280823(FN3K)
BIU: 109574437(FN3K)
BBUB: 102406560(FN3K)
BBIS: 105000607(FN3K)
CHX: 102184090(FN3K)
OAS: 101108403(FN3K)
BTAX: 128065074(FN3K)
CSUM: 138083339(FN3K)
ODA: 120866912(FN3K)
CCAD: 122439308(FN3K)
MREE: 136149104(FN3K)
OVR: 110146426(FN3K)
MBEZ: 129544568(FN3K)
SSC: 100523990(FN3K)
CFR: 102524293(FN3K)
CBAI: 105065525(FN3K)
CDK: 105102232(FN3K)
VPC: 102533630(FN3K)
BMUS: 118887421(FN3K)
LVE: 103083772(FN3K)
OOR: 101282913(FN3K)
LALB: 132511371(FN3K)
GMF: 115845389(FN3K)
DDP: 132415070(FN3K)
DLE: 111182657(FN3K)
PCAD: 102996177(FN3K)
PSIU: 116745710(FN3K)
PPHC: 136138088(FN3K)
NASI: 112410326(FN3K)
ECB: 100056532(FN3K)
EPZ: 103562257(FN3K)
EAI: 106846356(FN3K)
MYB: 102254271(FN3K)
MYD: 102773280(FN3K)
MMYO: 118653155(FN3K)
MLF: 102421961(FN3K)
MDT: 132219251(FN3K)
MYUM: 138993657(FN3K)
PKL: 118704540(FN3K)
EFUS: 103298325(FN3K)
MNA: 107539058(FN3K)
DRO: 112298820(FN3K)
SHON: 118999247(FN3K)
AJM: 119058518(FN3K)
PDIC: 114503030(FN3K)
PHAS: 123817170(FN3K)
MMF: 118635066(FN3K)
PPAM: 129086606(FN3K)
HAI: 109393083(FN3K)
RFQ: 117013964(FN3K)
PALE: 102898341(FN3K)
PGIG: 120600044(FN3K)
PVP: 105301119(FN3K)
RAY: 107504036(FN3K)
MJV: 108395008(FN3K)
TOD: 119232577(FN3K)
SARA: 101557755(FN3K)
SFUM: 130024731(FN3K)
SETR: 126013609(FN3K)
LAV: 100669036(FN3K)
TMU: 101360399
ETF: 101643203(FN3K)
DNM: 101444236(FN3K)
OAA: 100079558(FN3K)
TACU: 119937647(FN3K)
GGA: 417335(FN3K)
PCOC: 116232646
MGP: 100547749(FN3K)
CJO: 107322145(FN3K)
TPAI: 128083083(FN3K)
LMUT: 125702328(FN3K)
NMEL: 110407392(FN3K)
APLA: 101790399(FN3K)
ACYG: 106047109(FN3K)
CATA: 118255562(FN3K)
AFUL: 116496622(FN3K)
TGU: 100226491(FN3K)
LSR: 110473357(FN3K)
SCAN: 103819891(FN3K)
PMOA: 120505645(FN3K)
OTC: 121348126(FN3K)
PRUF: 121349246(FN3K)
ATRC: 139602726(FN3K)
GFR: 102032280(FN3K)
FAB: 101809933(FN3K)
OMA: 130260512(FN3K)
PHI: 102111398(FN3K)
PMAJ: 107212391(FN3K)
CCAE: 111937236(FN3K)
CCW: 104695651(FN3K)
CBRC: 103621699(FN3K)
ACOE: 138119941(FN3K)
ETL: 114058574(FN3K)
ZAB: 102072033(FN3K)
ZLE: 135455234(FN3K)
ACHL: 103801337(FN3K)
SVG: 106858410(FN3K)
MMEA: 130578178(FN3K)
HRT: 120761071(FN3K)
SATI: 136369332(FN3K)
CCIC: 134052078(FN3K)
FPG: 101910565(FN3K)
FCH: 102059933(FN3K)
ACUN: 113486879(FN3K)
TALA: 104368172
ACHC: 115342019(FN3K)
AGEN: 126043826
HHAR: 128150895
CSTI: 104556217 104562077
DPUB: 104297894(FN3K)
EGZ: 104125361(FN3K)
NNI: 104022889(FN3K)
PADL: 103918749(FN3K)
FGA: 104070969(FN3K)
PGUU: 104462346(FN3K)
CMAC: 104474415(FN3K)
AAM: 106499386(FN3K)
AROW: 112970845(FN3K)
NPD: 112957685(FN3K)
DNE: 112995575(FN3K)
ASN: 102371989(FN3K)
AMJ: 102571431(FN3K)
CPOO: 109315150
GGN: 109287448(FN3K)
PSS: 102448713(FN3K)
CMY: 102934080
CPIC: 101941575
TST: 117887598(FN3K)
CABI: 116832195(FN3K)
MRV: 120383345(FN3K)
ACS: 100556240
ASAO: 132768539(FN3K)
PVT: 110075083(FN3K)
SUND: 121923376(FN3K)
PBI: 103060185
PMUR: 107282451
CTIG: 120304840(FN3K) 120310462
TSR: 106545152
PGUT: 117660408(FN3K)
PCAE: 139312578(FN3K)
APRI: 131193317(FN3K)
PTEX: 113437216
NSS: 113411950
VKO: 123035473(FN3K)
PMUA: 114590705
PRAF: 128407588(FN3K)
ZVI: 118081480
HCG: 128343825(FN3K)
GJA: 107123117(FN3K)
STOW: 125429215(FN3K)
EMC: 129329207(FN3K)
SGRE: 126355607
ESN: 126993546
PMEO: 129586702
PCAN: 112571010
LSAX: 138951965
HRF: 124120319
HRJ: 124255305
HASI: 137294193
HCRA: 139444204
MYI: 110450667
AIRR: 138331866
MCAF: 127710540
OBI: 106874220
OSN: 115226168
LJP: 135470770
 » show all
Reference
1  [PMID:11522682]
  Authors
Szwergold BS, Howell S, Beisswenger PJ
  Title
Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo.
  Journal
Diabetes 50:2139-47 (2001)
DOI:10.2337/diabetes.50.9.2139
  Sequence
[hsa:64122]
Reference
2  [PMID:11016445]
  Authors
Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E
  Title
Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.
  Journal
Diabetes 49:1627-34 (2000)
DOI:10.2337/diabetes.49.10.1627
  Sequence
[hsa:64122] [mmu:63828]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.171
IUBMB Enzyme Nomenclature: 2.7.1.171
ExPASy - ENZYME nomenclature database: 2.7.1.171
BRENDA, the Enzyme Database: 2.7.1.171

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Gene (69)   
   MGENES (36)   
   RefGene (33)   
Protein sequence (9)   
   UniProt (4)   
   SWISS-PROT (2)   
   RefSeq(pep) (3)   
DNA sequence (20)   
   RefSeq(nuc) (4)   
   GenBank (8)   
   EMBL (8)   
Protein domain (2)   
   InterPro (2)   
All databases (100)   

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