KEGG   ENZYME: 2.7.1.171
Entry
EC 2.7.1.171                Enzyme                                 
Name
protein-fructosamine 3-kinase;
FN3K;
fructosamine 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:[protein]-N6-D-fructosyl-L-lysine 3-phosphotransferase
Reaction(IUBMB)
ATP + [protein]-N6-D-fructosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Substrate
ATP [CPD:C00002];
[protein]-N6-D-fructosyl-L-lysine
Product
ADP [CPD:C00008];
[protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Comment
Non-enzymic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from non-enzymically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC 2.7.1.172, protein-ribulosamine 3-kinase.
History
EC 2.7.1.171 created 2011
Orthology
K15522  protein-fructosamine 3-kinase
Genes
HSA64122(FN3K)
PTR454999(FN3K)
PPS100983475(FN3K)
GGO129533942(FN3K)
PON100432964(FN3K)
PPYG129016636(FN3K)
NLE100601146(FN3K)
HMH116483692(FN3K)
SSYN129461497(FN3K)
MCC106994166(FN3K)
MCF102132233(FN3K)
MTHB126938939
MNI105469354(FN3K)
CSAB103243881(FN3K)
CATY105588545(FN3K)
PANU101024411
TGE112610203(FN3K)
MLEU105553947(FN3K)
RRO115891991(FN3K)
RBB108534066(FN3K)
TFN117066396(FN3K)
PTEH111527673(FN3K)
CANG105502217(FN3K)
CJC100397627(FN3K)
SBQ101053226(FN3K)
CIMI108301557(FN3K)
ANAN105717503(FN3K)
CSYR103253921(FN3K)
MMUR105878089(FN3K)
LCAT123620514(FN3K)
PCOQ105820044(FN3K)
OGA100943115(FN3K)
MMU63828(Fn3k)
MCAL110305314(Fn3k)
MPAH110332434(Fn3k)
RNO498034(Fn3k)
MCOC116078781(Fn3k)
ANU117711339(Fn3k)
MUN110548847(Fn3k)
CGE100751771(Fn3k)
MAUA106021117(Fn3k)
PROB127220737(Fn3k)
PLEU114703926(Fn3k)
MORG121444120 121444635
MFOT126493445
AAMP119813493(Fn3k)
NGI103739318(Fn3k)
HGL101712216(Fn3k)
CPOC100718567(Fn3k)
CCAN109689327(Fn3k)
DORD105998448
DSP122122414
PLOP125366076(Fn3k)
NCAR124981396
MMMA107157817(Fn3k)
OCU100346330
OPI105942223(FN3K)
TUP102490564(FN3K)
GVR103602382(FN3K)
CFA608337(FN3K)
CLUD112672986(FN3K)
VVP112920928(FN3K)
VLG121473606(FN3K)
NPO129503844(FN3K)
AML100466189(FN3K)
UMR103666019(FN3K)
UAH113244461(FN3K)
UAR123777940(FN3K)
ELK111160382
LLV125087974
MPUF101684212(FN3K)
MNP132003596(FN3K)
MLK131816461(FN3K)
NVS122905851(FN3K)
ORO101368258(FN3K)
EJU114216035(FN3K)
ZCA113908231(FN3K)
MLX118024133(FN3K)
NSU110572449(FN3K)
FCA101093222(FN3K)
PYU121018118
PBG122485997(FN3K)
PVIV125151704(FN3K)
LRUF124522579
PTG102972520(FN3K)
PPAD109276725(FN3K)
PUC125926206
AJU106986324
HHV120228082(FN3K)
BTA539709(FN3K)
BOM102280823(FN3K)
BIU109574437(FN3K)
BBUB102406560(FN3K)
BBIS105000607(FN3K)
CHX102184090(FN3K)
OAS101108403(FN3K)
BTAX128065074(FN3K)
ODA120866912(FN3K)
CCAD122439308(FN3K)
MBEZ129544568(FN3K)
SSC100523990(FN3K)
CFR102524293(FN3K)
CBAI105065525(FN3K)
CDK105102232(FN3K)
VPC102533630(FN3K)
BMUS118887421(FN3K)
LVE103083772(FN3K)
OOR101282913(FN3K)
DLE111182657(FN3K)
PCAD102996177(FN3K)
PSIU116745710(FN3K)
NASI112410326(FN3K)
ECB100056532(FN3K)
EPZ103562257(FN3K)
EAI106846356(FN3K)
MYB102254271(FN3K)
MYD102773280(FN3K)
MMYO118653155(FN3K)
MLF102421961(FN3K)
PKL118704540(FN3K)
EFUS103298325(FN3K)
MNA107539058(FN3K)
DRO112298820(FN3K)
SHON118999247(FN3K)
AJM119058518(FN3K)
PDIC114503030(FN3K)
PHAS123817170(FN3K)
MMF118635066(FN3K)
PPAM129086606(FN3K)
HAI109393083(FN3K)
RFQ117013964(FN3K)
PALE102898341(FN3K)
PGIG120600044(FN3K)
PVP105301119(FN3K)
RAY107504036(FN3K)
MJV108395008(FN3K)
TOD119232577(FN3K)
SARA101557755(FN3K)
SETR126013609(FN3K)
LAV100669036(FN3K)
TMU101360399
ETF101643203(FN3K)
DNM101444236(FN3K)
OAA100079558(FN3K)
GGA417335(FN3K)
PCOC116232646
MGP100547749(FN3K)
CJO107322145(FN3K)
TPAI128083083(FN3K)
LMUT125702328(FN3K)
NMEL110407392(FN3K)
APLA101790399(FN3K)
ACYG106047109
CATA118255562(FN3K)
AFUL116496622(FN3K)
TGU100226491(FN3K)
LSR110473357(FN3K)
SCAN103819891(FN3K)
PMOA120505645(FN3K)
OTC121348126(FN3K)
PRUF121349246(FN3K)
GFR102032280(FN3K)
FAB101809933(FN3K)
OMA130260512(FN3K)
PHI102111398(FN3K)
PMAJ107212391(FN3K)
CCAE111937236(FN3K)
CCW104695651(FN3K)
CBRC103621699(FN3K)
ETL114058574(FN3K)
ZAB102072033(FN3K)
ZLE135455234(FN3K)
ACHL103801337(FN3K)
SVG106858410(FN3K)
MMEA130578178(FN3K)
HRT120761071(FN3K)
FPG101910565(FN3K)
FCH102059933(FN3K)
CLV102083783
EGZ104125361(FN3K)
NNI104022889(FN3K)
ACUN113486879(FN3K)
TALA104368172
PADL103918749(FN3K)
ACHC115342019(FN3K)
AGEN126043826
CSTI104556217 104562077
CMAC104474415(FN3K)
FGA104070969(FN3K)
DPUB104297894(FN3K)
PGUU104462346(FN3K)
AAM106499386(FN3K)
AROW112970845(FN3K)
NPD112957685(FN3K)
DNE112995575(FN3K)
ASN102371989(FN3K)
AMJ102571431(FN3K)
CPOO109315150
GGN109287448(FN3K)
PSS102448713(FN3K)
CMY102934080
CPIC101941575
TST117887598(FN3K)
CABI116832195(FN3K)
MRV120383345(FN3K)
ACS100556240
ASAO132768539(FN3K)
PVT110075083(FN3K)
SUND121923376(FN3K)
PBI103060185
PMUR107282451
CTIG120304840(FN3K) 120310462
TSR106545152
PGUT117660408(FN3K)
APRI131193317(FN3K)
PTEX113437216
NSS113411950
VKO123035473(FN3K)
PMUA114590705
PRAF128407588(FN3K)
ZVI118081480
HCG128343825(FN3K)
GJA107123117(FN3K)
STOW125429215(FN3K)
EMC129329207(FN3K)
SGRE126355607
ESN126993546
PMEO129586702
PCAN112571010
HRF124120319
HRJ124255305
MYI110450667
MCAF127710540
OBI106874220
OSN115226168
LJP135470770
ALUCAKAW2_10215S
 » show all
Reference
1  [PMID:11522682]
  Authors
Szwergold BS, Howell S, Beisswenger PJ
  Title
Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo.
  Journal
Diabetes 50:2139-47 (2001)
DOI:10.2337/diabetes.50.9.2139
  Sequence
[hsa:64122]
Reference
2  [PMID:11016445]
  Authors
Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E
  Title
Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.
  Journal
Diabetes 49:1627-34 (2000)
DOI:10.2337/diabetes.49.10.1627
  Sequence
[hsa:64122] [mmu:63828]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.171
IUBMB Enzyme Nomenclature: 2.7.1.171
ExPASy - ENZYME nomenclature database: 2.7.1.171
BRENDA, the Enzyme Database: 2.7.1.171

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